Best TWAS P=1.06e-18 · Best GWAS P=5.03e-46 conditioned to 1.99e-44
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Adipose Subcutaneous | ADH1B | 0.17 | 0.11 | lasso | 2 | 0.12 | 4.7e-10 | -8.5 | 8.8 | 1.1e-18 | 0.05 | 0.95 | 0.04 | TRUE |
| 4 | The Cancer Genome Atlas | Bladder Urothelial Carcinoma | ADH1C | 0.04 | 0.01 | blup | 78 | 0.03 | 1.7e-03 | 5.8 | 8.7 | 2.8e-18 | -0.02 | 0.25 | 0.03 | TRUE |
| 2 | GTEx | Adipose Visceral Omentum | ADH1B | 0.10 | 0.01 | enet | 19 | 0.02 | 3.8e-02 | 2.6 | 8.3 | 1.4e-16 | 0.06 | 0.13 | 0.04 | TRUE |
| 6 | The Cancer Genome Atlas | Breast Invasive Carcinoma | ADH1B | 0.02 | 0.01 | enet | 4 | 0.02 | 2.4e-04 | -8.1 | 7.6 | 3.0e-14 | -0.04 | 0.36 | 0.01 | FALSE |
| 9 | The Cancer Genome Atlas | Liver Hepatocellular Carcinoma | ADH1C | 0.10 | 0.08 | blup | 79 | 0.10 | 2.4e-05 | -7.9 | 7.2 | 7.6e-13 | -0.05 | 0.29 | 0.03 | FALSE |
| 7 | The Cancer Genome Atlas | Breast Invasive Carcinoma | ADH1C | 0.04 | 0.01 | blup | 79 | 0.05 | 4.7e-11 | 4.7 | 7.1 | 1.4e-12 | -0.06 | 1.00 | 0.00 | FALSE |
| 5 | The Cancer Genome Atlas | Breast Invasive Carcinoma | ADH1A | 0.05 | 0.03 | lasso | 4 | 0.05 | 4.4e-10 | -4.1 | 6.7 | 2.9e-11 | -0.11 | 1.00 | 0.00 | FALSE |
| 8 | The Cancer Genome Atlas | Colon Adenocarcinoma | ADH1C | 0.05 | 0.04 | blup | 79 | 0.04 | 2.2e-03 | 5.7 | 6.3 | 2.5e-10 | -0.05 | 0.30 | 0.03 | FALSE |
| 3 | ROSMAP | Brain Pre-frontal Cortex | ADH1B | 0.10 | 0.01 | bslmm | 485 | 0.05 | 1.8e-07 | -8.5 | 6.3 | 2.7e-10 | 0.07 | 0.42 | 0.04 | FALSE |