TWAS hub - ADH1C

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Heart Atrial Appendage	0.284	0.0700	2.4e-05	0.000	NA	0.047	NA	0.011	3.3e-01	NA	3.6e-03	NA	9.5e-02
2	GTEx	Thyroid	0.118	0.0450	7.4e-04	0.076	NA	0.032	NA	0.050	2.0e-06	NA	1.7e-03	NA	1.0e-04
3	TCGA	Bladder Urothelial Carcinoma	0.040	0.0190	6.9e-04	0.015	0.029	0.021	NA	0.019	1.8e-02	1.7e-03	5.8e-03	NA	9.3e-03
4	TCGA	Breast Invasive Carcinoma	0.044	0.0154	5.4e-11	0.010	0.053	0.038	NA	0.036	3.0e-03	4.7e-11	2.1e-08	NA	5.1e-08
5	TCGA	Colon Adenocarcinoma	0.055	0.0260	3.6e-04	0.036	0.040	0.008	NA	0.021	3.8e-03	2.2e-03	1.0e-01	NA	2.2e-02
6	TCGA	Kidney Renal Clear Cell Carcinoma	0.103	0.0485	1.4e-05	0.054	0.046	0.044	NA	0.061	8.9e-07	5.5e-06	9.4e-06	NA	1.9e-07
7	TCGA	Liver Hepatocellular Carcinoma	0.104	0.0510	2.7e-04	0.080	0.098	0.054	NA	0.079	1.3e-04	2.4e-05	1.4e-03	NA	1.4e-04
8	TCGA	Ovarian Serous Cystadenocarcinoma	0.079	0.0360	2.2e-04	0.027	0.050	0.043	NA	0.040	6.0e-03	2.7e-04	7.1e-04	NA	1.1e-03
9	TCGA	Stomach Adenocarcinoma	0.082	0.0430	2.5e-03	0.009	0.016	0.015	NA	0.006	6.8e-02	2.2e-02	2.8e-02	NA	1.0e-01

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7	8	9
Alcohol intake frequency.	12.1	28.1	76.0	0.4	1.2	8.7	7.1	6.3	4.3	7.2	3.0	2.4
Average weekly beer plus cider intake	10.4	15.0	28.5	-1.4	-2.5	-5.3	-5.0	-4.5	-3.0	-5.2	-2.6	-3.3
Worry too long after embarrassment	8.4	14.1	22.9	1.5	3.6	4.0	4.4	3.8	4.8	3.7	4.0	3.1
Lupus	7.4	11.2	16.9	1.6	4.1	3.4	3.7	2.5	3.7	3.3	3.4	3.7
Unable to work because of sickness or disability	6.4	8.3	14.5	-1.4	-1.8	-3.3	-3.0	-3.8	-3.3	-3.6	-3.4	-1.0
Triglycerides	6.2	10.2	14.7	2.7	2.0	3.6	3.0	3.8	3.4	3.6	3.8	2.5
Pack years adult smoking proportion	5.1	7.8	12.3	-0.2	-2.1	-3.3	-3.1	-2.9	-3.5	-2.6	-3.1	-2.7
Medication: Lansoprazole	4.6	5.2	8.6	-2.1	-0.9	-2.1	-2.2	-2.9	-2.6	-2.5	-2.7	-1.8
Alcohol intake versus 10 years previously	4.5	6.7	14.1	-0.5	0.7	3.8	3.1	3.0	2.1	2.9	2.4	2.8
Diastolic blood pressure, automated reading	4.5	14.0	24.4	-2.9	-3.2	-4.0	-3.8	-4.5	-4.0	-4.9	-3.8	-1.2
Average weekly spirits intake	4.2	5.2	8.1	-0.9	-2.2	-2.5	-2.9	-2.8	-1.6	-2.8	-2.4	-1.6
Taking other prescription medications	4.0	6.2	8.4	-2.3	-2.3	-2.7	-2.9	-2.5	-2.7	-2.7	-2.0	-2.3
Medication: Ramipril	3.6	4.6	8.7	-1.0	-0.9	-3.0	-2.4	-2.7	-2.2	-2.4	-2.4	-1.2
HbA1C	3.4	3.8	7.5	1.4	1.3	2.7	2.6	2.1	1.5	2.4	1.5	1.1
Qualifications: A levels/AS levels or equivalent	3.4	7.5	11.2	3.3	2.3	2.8	2.7	3.3	2.5	3.2	2.5	1.7
Pack years of smoking	3.4	4.9	8.3	-0.1	-1.7	-2.7	-2.4	-2.3	-2.9	-2.1	-2.5	-1.9
Leg fat mass (right)	3.3	12.6	23.1	-2.5	-3.1	-4.8	-4.1	-3.6	-4.0	-3.8	-2.7	-2.6
Smoking status: Current	3.3	5.2	10.1	0.3	-1.5	-2.0	-2.1	-2.4	-3.2	-2.0	-3.0	-2.6
Leg fat mass (left)	3.2	12.4	22.5	-2.7	-3.1	-4.7	-4.1	-3.6	-3.8	-3.7	-2.7	-2.7
Waist circumference	3.1	11.5	21.1	-3.0	-2.5	-4.6	-3.9	-3.5	-3.5	-3.6	-2.5	-2.7
Leg fat percentage (right)	2.9	10.4	19.3	-2.2	-2.6	-4.4	-3.6	-3.4	-4.0	-3.3	-2.5	-2.2
Exposure to tobacco smoke at home	2.8	3.2	5.9	-1.5	-2.1	-2.0	-2.1	-1.9	-1.3	-2.4	-1.0	-1.3
Leg fat percentage (left)	2.8	10.0	18.0	-2.5	-2.6	-4.2	-3.5	-3.2	-3.8	-3.2	-2.4	-2.3
LDL Cholesterol	2.7	4.3	7.3	2.3	2.6	1.5	1.7	2.2	2.1	2.7	1.6	1.5
Current tobacco smoking	2.7	4.4	9.3	0.6	-1.0	-1.9	-1.8	-2.4	-3.0	-1.8	-3.0	-2.0
Medication for cholesterol, blood pressure or diabetes	2.7	4.4	8.2	1.4	0.9	2.9	2.5	2.4	2.1	1.8	2.3	2.0
Arm fat mass (left)	2.7	11.0	19.8	-2.2	-3.0	-4.5	-3.9	-3.4	-3.5	-3.5	-2.6	-2.7
Age started oral contraceptive pill	2.7	3.3	5.4	1.7	1.8	1.8	1.9	2.0	1.9	2.3	1.9	0.7
Arm fat mass (right)	2.6	10.5	19.8	-2.2	-2.7	-4.5	-3.9	-3.4	-3.3	-3.4	-2.5	-2.6
Severe depression (siblings)	2.4	2.7	4.4	2.1	2.1	1.5	1.4	1.8	-0.2	2.0	1.2	1.5
Qualifications: CSEs or equivalent	2.4	3.2	5.4	-0.2	-1.6	-2.2	-2.3	-1.8	-1.8	-1.9	-1.4	-2.0
Body mass index (BMI)	2.4	10.3	20.6	-2.3	-2.3	-4.5	-3.9	-3.1	-3.5	-3.3	-2.2	-2.9
Body fat percentage	2.4	9.7	16.6	-2.4	-2.5	-4.1	-3.4	-3.5	-3.5	-3.1	-2.7	-2.2
Whole body fat mass	2.4	10.0	18.7	-2.5	-2.7	-4.3	-3.6	-3.4	-3.2	-3.3	-2.5	-2.2
Pain all over the body in last month	2.3	2.5	5.2	-0.3	-0.1	-2.3	-1.9	-1.7	-1.4	-1.6	-2.0	-1.5
Medication: Blood pressure	2.3	4.0	6.5	-1.2	-1.2	-2.6	-2.1	-2.3	-2.0	-1.7	-2.4	-2.0
Arm fat percentage (left)	2.3	9.2	16.3	-2.1	-2.6	-4.0	-3.5	-3.3	-3.3	-3.1	-2.4	-2.5
High cholesterol (Self-reported)	2.3	4.1	7.2	-1.4	-1.3	-2.7	-2.2	-1.9	-2.7	-1.9	-1.9	-1.8
BMI	2.2	13.0	25.4	-3.0	-2.0	-5.0	-4.3	-3.5	-4.5	-3.8	-2.6	-2.7
Trunk fat mass	2.2	9.3	15.7	-2.5	-2.7	-4.0	-3.3	-3.5	-3.3	-3.2	-2.7	-1.9
Neuroticism	2.1	5.1	9.4	0.5	1.8	2.2	2.1	2.7	2.2	2.3	3.1	2.5
Sensitivity / hurt feelings	2.1	3.5	5.0	0.8	2.1	1.8	1.8	1.9	1.9	2.1	2.2	1.9
Arm fat percentage (right)	2.1	8.2	14.8	-1.9	-2.4	-3.9	-3.3	-3.2	-3.1	-3.0	-2.3	-2.3
Overall health rating	2.1	4.5	7.9	-1.2	-2.4	-2.8	-2.5	-2.1	-2.1	-2.3	-1.3	-1.8
Mean Putamen Volume	2.0	2.3	11.0	3.3	1.9	0.9	0.8	1.2	0.5	1.4	0.9	0.4
Trunk fat percentage	2.0	8.1	13.4	-2.1	-2.4	-3.7	-3.0	-3.3	-3.2	-2.8	-2.7	-1.8
Ever unenthusiastic/disinterested for a whole week	2.0	2.4	5.9	1.1	-0.4	-2.2	-1.8	-1.3	-2.4	-1.4	-1.1	-1.2
Falls in the last year	2.0	2.7	4.7	0.1	-1.1	-2.2	-2.1	-1.9	-1.2	-1.8	-1.8	-1.5
Serious illness, injury or assault of a close relative in last 2 years	2.0	2.4	5.2	0.8	2.3	1.9	2.0	1.4	0.9	1.7	0.7	1.3
Neuroticism (Nagel 2018)	1.9	4.6	6.8	0.8	1.8	2.1	2.2	2.3	2.1	2.3	2.6	2.4
Schizophrenia vs Biploar Disorder	1.8	2.3	7.8	0.1	1.5	1.5	1.6	0.9	1.6	0.8	1.5	2.8
Number of treatments/medications taken	1.8	3.2	8.7	-0.1	-0.2	-3.0	-2.5	-1.9	-1.9	-1.6	-1.7	-1.0
Depression (self-reported)	1.8	2.2	4.9	1.3	-0.7	-2.0	-1.7	-1.7	-1.1	-2.2	-1.0	-0.7
Qualifications: nursing, teaching	1.8	2.7	4.3	1.8	1.4	1.9	1.5	2.0	1.5	2.1	1.3	1.0
Commuting to job workplace: Walk	1.8	1.9	3.7	0.2	1.0	1.6	1.9	1.5	1.2	1.3	1.1	1.7
Blood Eosinophil Count	1.7	12.8	24.9	-2.0	-2.4	-4.7	-4.0	-4.8	-2.5	-5.0	-3.3	-1.5
Waist Hip Ratio (WHR)	1.7	7.8	11.5	-1.7	-3.4	-3.3	-3.4	-2.6	-2.0	-3.2	-1.6	-3.1
Medication: Cholesterol lowering	1.7	2.7	6.6	-1.7	-0.5	-2.6	-2.2	-1.7	-1.3	-1.5	-0.9	-1.3
Eye problems/disorders: None of the above	1.7	1.9	3.2	1.8	0.9	1.4	1.5	1.4	1.1	1.6	1.7	0.2
Commuting to job workplace: Car/motor vehicle	1.7	2.0	3.5	-1.5	-0.4	-1.7	-1.8	-1.9	-1.0	-1.5	-1.4	-1.1
Forced expiratory volume in 1-second (FEV1), predicted percentage	1.7	3.7	7.0	1.8	2.0	2.1	1.7	2.6	1.5	2.5	1.4	0.8
Worry (Nagel 2018)	1.6	3.5	6.2	0.2	2.0	1.6	1.9	1.7	1.9	1.8	2.3	2.5
Weight	1.6	7.7	13.8	-1.8	-2.5	-3.7	-3.2	-3.0	-2.9	-3.2	-2.1	-1.9
Father’s age at death	1.6	2.1	4.1	-0.5	0.7	2.0	1.8	1.7	1.9	1.3	1.5	1.1
Qualifications: College or University degree	1.6	5.1	20.8	4.6	1.7	2.0	1.8	2.2	1.9	1.7	1.6	1.0
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.6	1.9	4.6	-2.1	-0.3	-1.4	-1.4	-1.6	-0.7	-2.0	-0.9	-0.6
Body Mass Index (BMI) (2010)	1.5	2.0	4.3	-2.1	-1.5	-1.1	-1.5	-1.3	-1.1	-1.4	-1.0	-1.6
Alcohol usually taken with meals	1.5	2.4	5.5	1.6	0.7	2.3	1.9	1.7	1.3	1.7	0.9	0.8
Financial difficulties in last 2 years	1.5	2.0	3.4	1.3	-1.0	-1.8	-1.8	-1.7	-1.4	-1.3	-1.2	-0.7
Blood Red Count	1.4	13.7	19.3	-0.7	-3.4	-3.7	-4.4	-4.0	-4.2	-3.9	-4.0	-3.7
Cardiovascular Disease	1.4	4.7	10.3	-2.4	-0.9	-3.2	-2.6	-2.0	-2.7	-2.3	-1.4	-0.8
Lung FVC	1.4	7.2	12.7	1.0	1.1	3.5	3.0	3.6	3.1	3.4	2.2	1.6
Chronotype (morning person)	1.4	3.1	5.1	0.4	1.1	2.2	2.2	2.2	1.3	1.5	2.0	2.0
Frequency of depressed mood in last 2 weeks	1.4	2.0	4.3	-0.6	-1.4	-1.9	-2.1	-1.2	-1.0	-1.9	-0.2	-1.1
Frequency of tenseness / restlessness in last 2 weeks	1.4	2.2	3.8	-0.5	-1.9	-1.9	-2.0	-1.6	-1.1	-1.7	-0.7	-1.2
Forced vital capacity (FVC), Best measure	1.4	5.2	8.5	1.1	1.0	2.9	2.5	2.9	2.6	2.4	2.0	2.1
Long-standing illness, disability or infirmity	1.4	2.1	4.4	-0.2	-0.9	-2.1	-1.9	-2.0	-1.1	-2.0	-1.0	-0.4
Ever had stillbirth, spontaneous miscarriage or termination	1.4	1.5	3.6	-0.0	0.3	1.9	1.8	1.3	0.7	1.3	0.6	1.4
Qualifications: None of the above	1.3	2.7	4.5	-2.0	-0.3	-2.1	-1.9	-1.7	-2.0	-1.6	-1.6	-0.7
Length of working week for main job	1.3	1.5	3.6	-0.4	0.8	1.0	1.2	1.9	1.4	1.3	1.5	0.6
Reason for reducing amount of alcohol drunk: Health precaution	1.3	1.5	4.3	-0.6	-0.2	-2.1	-1.7	-1.3	-1.1	-1.5	-0.7	-0.3
Medication: Blood pressure	1.3	2.6	6.2	-0.5	2.5	1.1	1.7	1.3	1.1	1.5	1.7	2.1
Age when periods started (menarche)	1.2	3.0	5.5	1.2	0.0	-1.8	-1.7	-2.0	-1.6	-1.2	-2.3	-2.3
Forced expiratory volume in 1-second (FEV1), Best measure	1.2	3.7	7.1	1.0	0.7	2.3	1.9	2.7	2.3	2.0	2.0	1.5
Qualifications: O levels/GCSEs or equivalent	1.2	1.9	3.8	2.0	0.9	1.7	1.6	1.1	1.8	1.3	0.7	0.7
Exposure to tobacco smoke outside home	1.2	1.5	2.6	-0.7	-1.6	-1.2	-1.6	-1.1	-1.2	-1.4	-0.5	-1.4
Pulse wave peak to peak time	1.2	1.4	2.7	-0.4	-0.3	-1.4	-1.1	-1.4	-1.5	-1.4	-1.6	-0.6
Migraine (self-reported)	1.2	1.5	3.8	-1.9	-1.0	-0.7	-1.2	-1.4	-1.3	-1.0	-1.3	-0.5
Pulse rate, automated reading	1.2	4.0	8.5	-1.1	-1.5	-2.0	-2.2	-2.5	-1.7	-2.9	-2.0	-1.2
Financial situation satisfaction	1.2	1.5	2.6	1.2	-0.7	-1.4	-1.6	-0.9	-1.5	-1.3	-0.9	-1.2
Ovarian Cancer	1.1	1.4	2.9	-1.2	-1.7	-0.0	-0.4	-1.1	-1.4	-1.6	-1.5	-0.5
Type 2 Diabetes (T2D) (2012)	1.1	1.2	2.9	0.2	-0.5	-1.4	-1.6	-1.1	-1.7	-0.9	-0.9	-0.7
Eye problems/disorders: Diabetes related eye disease	1.1	1.2	3.0	-1.2	1.7	-1.7	-1.2	-0.9	-0.7	-0.6	-0.6	0.4
Supplements: Zinc	1.1	1.2	3.5	0.2	0.6	1.4	1.1	1.2	1.1	1.9	1.0	0.5
Number of incorrect matches in round	1.1	1.8	3.6	0.1	0.0	1.8	1.6	1.4	1.9	1.2	1.6	0.7
Lung cancer (father)	1.1	1.3	5.6	1.1	-0.0	-0.6	-1.1	-0.8	-2.4	-0.7	-1.3	-0.6
Ever highly irritable/argumentative for 2 days	1.1	1.3	4.0	2.0	0.8	1.3	1.4	1.0	0.2	1.0	1.0	0.7
Number of children fathered	1.1	1.3	2.6	0.4	0.7	1.1	1.5	1.6	1.0	1.0	1.1	1.2
Had major operations	1.1	1.3	3.5	-0.1	-0.5	-1.5	-1.9	-1.1	-1.2	-0.7	-1.1	-1.2
Tinnitus: Yes, now most or all of the time	1.1	1.3	2.6	0.0	0.7	1.4	1.6	1.3	0.4	1.1	1.1	1.6
Medication: Lisinopril	1.1	1.4	3.5	-0.8	-0.6	-1.9	-1.5	-1.3	-1.2	-1.2	-0.9	-0.8
Diabetes (mother)	1.0	1.2	2.3	-0.6	-1.3	-1.3	-1.3	-0.9	-1.3	-1.5	-0.3	-0.6
Forced vital capacity (FVC)	1.0	3.8	6.8	1.0	0.7	2.5	1.9	2.6	2.2	2.1	1.9	1.9
Neuroticism score	1.0	2.0	3.8	0.2	1.4	1.2	1.3	1.4	1.7	1.4	2.0	1.5
Pulse wave Arterial Stiffness index	1.0	1.2	2.2	0.4	-0.0	1.4	1.0	1.3	1.5	1.3	1.4	0.4
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.0	1.1	4.4	2.1	1.3	0.4	0.7	0.7	0.4	1.0	1.0	0.9
Commuting to job workplace: Public transport	1.0	1.2	2.6	0.7	1.0	1.3	1.4	1.6	0.7	1.3	0.9	0.0
Alcohol drinker status: Never	1.0	1.1	3.5	-1.9	-1.0	1.4	0.6	0.4	-0.1	0.5	-0.7	-1.6
Alzheimer’s Disease (in mother)	0.9	1.1	1.8	0.7	1.1	0.9	0.8	1.3	1.2	1.2	1.4	0.6
Alzheimer’s Disease (in father)	0.9	1.0	6.4	-2.5	0.2	-0.3	-0.4	0.1	0.9	-0.4	1.1	-0.2
Schizophrenia (2014)	0.9	2.1	4.4	-1.2	1.3	0.9	1.0	0.5	2.1	1.2	2.0	2.0
Hand grip strength (left)	0.9	2.3	3.5	1.3	1.4	1.6	1.4	1.9	1.1	1.8	1.4	1.5
Number of live births	0.9	1.3	3.9	-1.7	-1.1	-1.1	-0.8	-1.3	-0.3	-2.0	-0.5	-0.0
Forced expiratory volume in 1-second (FEV1)	0.9	2.9	6.6	0.8	0.4	1.8	1.4	2.6	1.9	1.8	2.1	1.4
Birth weight	0.9	2.1	5.5	-1.9	-1.1	1.1	0.9	1.3	2.3	0.2	2.1	0.1
Shortness of breath walking on level ground	0.9	1.1	2.3	0.6	-0.7	-1.2	-1.2	-1.3	-0.9	-1.5	-0.7	-1.1
Mean time to correctly identify matches	0.9	1.8	3.4	-0.1	1.7	0.9	1.3	1.3	1.8	1.2	1.3	1.4
Illness, injury, bereavement, stress in last 2 years	0.9	1.1	3.0	-0.8	-1.5	-0.6	-0.9	-1.0	-1.2	-0.7	-1.7	-0.8
Hearing aid user	0.9	1.0	2.8	0.2	-1.7	-1.1	-1.0	-0.8	-1.0	-1.0	-0.9	-0.9
Heart attack/myocardial infarction (self-reported)	0.9	1.2	2.7	-1.3	-1.2	-1.4	-1.6	-0.6	-1.0	-0.4	-0.4	-1.2
Coronary Artery Disease (CAD)	0.8	0.9	2.8	1.5	0.2	0.1	0.0	1.0	1.2	0.4	1.7	0.9
Type 2 Diabetes (T2D) (2018)	0.8	1.6	3.8	-1.3	-0.2	-1.9	-1.9	-1.1	-1.3	-1.5	-0.2	-0.0
Bilateral oophorectomy (both ovaries removed)	0.8	1.0	4.6	-2.1	-0.6	-0.7	-1.1	0.2	0.7	-0.3	1.0	-0.4
High blood pressure	0.8	2.2	5.5	-2.3	-0.4	-2.0	-1.3	-1.5	-1.7	-1.3	-1.0	-0.5
Supplements: Glucosamine	0.8	1.0	2.2	-1.1	-1.5	-0.7	-1.1	-1.2	-0.3	-1.4	-0.6	-0.5
Medication: Atenolol	0.8	1.0	3.1	-1.8	0.2	-1.7	-1.3	-0.4	-0.6	-0.0	-0.3	-0.7
Chronic bronchitis/emphysema (father)	0.8	0.9	1.7	1.1	-1.1	-0.9	-1.0	-0.7	-1.3	-1.0	-1.0	-0.4
Hip circumference	0.8	3.3	6.8	-1.9	-0.3	-2.6	-1.7	-2.1	-2.3	-1.9	-1.7	-0.5
Pulse rate	0.8	1.3	4.8	-2.2	-1.7	-0.4	-0.6	-0.9	-0.3	-1.5	-0.5	0.4
Emphysema/chronic bronchitis	0.8	0.9	2.4	-0.2	0.0	-1.0	-0.7	-1.3	-1.2	-1.5	-0.7	0.2
Hypertension (Self-reported)	0.8	2.2	5.3	-2.3	-0.2	-2.2	-1.4	-1.5	-1.5	-1.4	-0.9	-0.6
Ever had bowel cancer screening	0.8	1.0	1.8	-0.0	0.0	1.3	1.0	1.1	1.0	0.9	1.2	1.2
Illnesses of father: High blood pressure	0.8	1.1	2.4	0.2	-1.5	-0.7	-0.9	-0.2	-1.5	-0.8	-0.7	-1.5
Ever had hysterectomy (womb removed)	0.7	0.8	1.9	0.2	1.4	-0.2	-0.3	0.6	1.0	0.4	1.4	1.4
Hand grip strength (right)	0.7	2.0	3.2	0.6	0.5	1.7	1.4	1.8	1.0	1.5	1.7	1.8
Nervous feelings	0.7	1.4	2.4	0.7	1.3	1.2	1.6	0.9	1.2	0.8	1.5	1.2
Heart attack	0.7	1.0	2.2	-1.2	-0.9	-1.4	-1.5	-0.6	-0.9	-0.4	-0.3	-1.0
Frequency of tiredness / lethargy in last 2 weeks	0.7	1.1	2.4	0.1	-1.1	-1.0	-1.1	-0.9	-1.5	-0.9	-0.7	-1.4
Health satisfaction	0.7	1.0	3.1	1.8	-0.1	-1.2	-1.0	-0.2	-1.5	0.1	-0.5	-0.7
Medication: Allopurinol	0.7	0.9	3.9	-0.4	-1.1	0.6	-0.4	1.0	-0.1	1.0	-0.5	-2.0
Medication: Seretide 50 evohaler	0.7	0.8	3.2	1.8	0.8	-0.4	-0.1	-0.8	-1.0	-0.4	-1.0	0.1
Medication for cholesterol	0.7	1.1	1.9	0.6	-1.4	-0.6	-0.9	-1.3	-0.7	-1.4	-1.3	-0.8
Myopia	0.7	1.0	2.2	-0.1	0.4	1.5	0.8	1.1	1.1	0.8	1.5	0.7
Fasting Glucose	0.6	0.7	2.1	1.1	-0.7	-1.5	-0.7	-0.7	-0.9	-1.0	-0.1	-0.1
Smoking Status	0.6	1.5	2.2	-1.2	-1.4	-0.7	-0.9	-1.3	-1.4	-1.1	-1.5	-1.4
Townsend deprivation index at recruitment	0.6	0.8	1.4	-0.2	-1.2	-0.9	-1.2	-0.8	-1.0	-1.0	-0.4	-0.9
Allergy	0.6	1.4	3.6	-0.7	1.2	1.1	0.9	1.6	1.4	1.9	0.9	0.3
Worrier / anxious feelings	0.6	1.2	2.2	-0.3	1.3	0.9	0.8	1.3	1.2	1.5	1.5	0.7
Peak expiratory flow (PEF)	0.6	1.5	3.9	0.2	0.5	1.1	0.6	1.8	1.4	1.2	2.0	0.9
Mouth/teeth dental problems: Loose teeth	0.6	0.7	1.6	-0.1	0.6	-1.3	-0.7	-0.9	-1.1	-0.8	-1.1	-0.5
Medication for pain relief, constipation, heartburn	0.6	1.1	4.4	-2.1	-0.6	-0.2	0.0	-1.2	-0.9	-0.9	-1.3	-0.5
Neck or shoulder pain in last month	0.6	0.9	2.4	-0.6	1.3	0.9	0.6	0.6	0.6	1.1	0.6	1.6
Suffer from ‘nerves’	0.6	0.9	2.1	-0.0	1.1	0.9	1.2	0.7	0.7	0.5	1.2	1.4
Family relationship satisfaction	0.6	0.7	3.3	1.8	-0.5	0.9	0.6	0.2	0.4	0.4	0.3	1.0
Handedness (chirality/laterality): Left-handed	0.6	0.8	1.9	-0.3	-0.8	-0.7	-0.5	-0.9	-1.2	-1.4	-1.1	-0.0
Mouth/teeth dental problems: Mouth ulcers	0.6	1.0	1.9	1.0	1.0	0.8	1.4	0.9	1.0	1.0	1.2	0.4
Osteoarthritis (self-reported)	0.6	0.8	2.2	0.5	1.0	0.6	0.8	1.0	0.4	1.0	0.6	1.5
Eye problems/disorders: Glaucoma	0.6	0.7	2.3	-1.5	-1.4	-0.3	-0.7	-0.6	-0.7	-0.6	-0.5	-0.2
Risk taking	0.6	0.9	2.0	0.6	-0.3	1.4	0.9	1.2	0.5	1.2	0.7	1.1
Basal cell carcinoma (self-reported)	0.6	0.7	2.0	1.4	0.1	0.4	0.7	0.6	0.6	0.2	0.7	1.4
Schizophrenia (2018)	0.5	1.0	2.5	-0.7	0.3	0.5	0.7	0.4	1.6	0.7	1.5	1.3
Alzheimer’s Disease (including proxy)	0.5	0.7	2.9	-0.8	-0.3	0.2	0.0	0.9	1.2	0.2	1.7	-0.3
HDL Cholesterol	0.5	0.8	2.5	0.0	-0.6	-0.8	-0.7	-1.0	-0.8	-0.7	-1.6	-0.9
Neuroticism (2016)	0.5	0.8	2.0	-0.8	-0.2	1.4	0.8	1.3	0.2	1.4	0.4	0.0
Rheumatoid Arthritis	0.5	0.7	1.3	0.5	-0.9	-0.9	-0.9	-1.1	-1.0	-1.1	-0.5	0.5
Ulcerative Colitis	0.5	0.7	2.5	-1.6	0.3	0.8	0.5	1.0	1.0	0.5	0.9	0.1
Heel T-Score	0.5	4.0	9.8	2.1	-0.2	3.1	2.2	2.2	2.2	1.9	1.5	1.1
Ever used hormone-replacement therapy (HRT)	0.5	0.6	1.8	0.9	1.0	0.2	0.6	0.4	0.6	0.5	0.6	1.3
Angina	0.5	0.6	2.1	-0.2	0.6	-1.5	-1.0	-1.0	0.0	-0.4	-0.8	-0.5
Medication for hormone replacement therapy	0.5	0.6	1.1	0.7	0.9	0.5	0.6	0.5	1.0	0.9	0.3	1.1
Average weekly fortified wine intake	0.5	0.5	1.9	-0.2	0.1	-0.6	-0.5	-1.4	-0.8	-1.1	-0.6	0.2
Multivitamins +/- minerals	0.5	0.6	1.9	0.7	-1.0	-0.6	-0.9	-0.3	0.3	-1.0	0.4	1.4
Fluid intelligence score	0.5	1.0	3.5	0.4	-0.9	1.9	1.2	0.8	0.9	1.0	0.4	0.6
Breastfed as a baby	0.5	0.6	2.7	-0.1	-1.6	-0.3	-0.4	-0.1	-0.4	-0.7	-0.6	-1.2
Seen doctor (GP) for nerves, anxiety, tension or depression	0.5	0.7	2.6	-0.4	-0.4	-1.2	-0.6	-1.2	-0.7	-1.6	0.1	0.1
Mouth/teeth dental problems: Bleeding gums	0.5	0.7	2.1	-1.4	0.2	-0.7	-0.3	-1.0	-1.0	-1.0	-0.8	-0.3
Medication: Paracetamol	0.5	0.9	3.2	1.8	0.9	0.2	0.0	1.3	-0.0	1.0	1.0	0.6
Comparative body size at age 10	0.5	1.4	5.9	-1.1	-1.2	-1.1	-1.3	-0.2	-0.7	-0.3	-0.6	-2.4
Angina (self-reported)	0.5	0.7	2.3	0.0	0.5	-1.5	-1.2	-1.0	-0.1	-0.3	-0.9	-0.8
Chest pain or discomfort	0.5	0.7	1.7	0.4	-0.7	-0.7	-0.5	-0.8	-1.2	-0.9	-1.3	-0.3
Mood swings	0.5	1.0	2.5	-1.6	-1.0	-0.9	-0.9	-0.9	-1.2	-0.9	-0.6	-0.3
Loneliness, isolation	0.5	0.7	1.9	0.2	-1.2	-0.9	-1.4	-0.4	-0.7	-0.9	-0.1	-0.9
Breast cancer (self-reported)	0.5	0.7	1.6	-0.9	-1.1	1.3	1.0	0.8	0.5	0.6	0.3	-0.4
Medication: Gliclazide	0.5	0.6	1.1	-0.7	-0.9	-1.0	-0.9	-0.5	-1.0	-0.8	-0.0	-0.5
Illnesses of father: None of the above (group 1)	0.5	0.6	1.7	-0.0	-0.3	1.2	0.6	1.1	0.5	1.3	0.7	0.5
Vascular/heart problems diagnosed by doctor	0.5	1.3	3.3	1.8	-0.2	1.8	0.9	1.1	1.2	0.9	0.7	0.1
Intelligence (Savage-Jansen 2018)	0.4	1.2	2.6	1.3	-0.9	1.6	1.2	1.1	1.4	0.9	0.7	0.4
Major Depression (MDD)	0.4	0.5	1.0	-0.4	0.5	0.6	0.7	0.9	1.0	0.7	0.9	-0.0
Reaction Time	0.4	0.7	2.5	-0.0	1.6	-0.2	0.3	0.8	1.1	0.5	1.1	0.8
Blood White Count	0.4	2.8	4.8	-1.9	-1.8	-1.6	-2.0	-2.2	-0.7	-2.0	-1.3	-0.7
Hypothyroidism (self reported)	0.4	0.9	4.8	-0.1	0.9	0.7	1.0	-0.1	0.9	0.1	0.2	2.2
Hearing difficulty/problems: Yes	0.4	0.6	2.9	-0.7	-0.7	-0.1	-0.1	-0.6	-0.4	-0.3	-0.7	-1.7
Vitamin and mineral supplements	0.4	0.5	1.4	0.3	1.0	0.4	0.6	0.3	-0.7	1.0	-0.4	-1.2
Medication: Metformin	0.4	0.5	2.0	-1.4	-0.0	-0.9	-0.7	-0.4	-0.9	-0.4	-0.1	0.5
Leg fat-free mass (left)	0.4	1.9	4.1	-0.8	-1.5	-2.0	-1.9	-1.2	-1.0	-1.8	-0.5	-1.0
Maternal smoking around birth	0.4	0.6	2.5	0.4	1.4	-0.2	0.1	-0.1	0.0	0.1	0.7	1.6
Serious illness, injury or assault to yourself	0.4	0.5	1.8	0.4	-0.5	-1.2	-1.4	-0.1	-0.1	-0.4	-0.0	-0.6
Stomach or abdominal pain in last month	0.4	0.5	2.0	-0.4	-1.4	-0.7	-0.6	-0.6	-0.4	-0.3	-0.7	-0.8
Leg predicted mass (left)	0.4	2.3	4.5	-0.8	-1.7	-2.1	-2.0	-1.3	-1.1	-1.9	-0.6	-1.2
Hair/balding pattern: Pattern 2	0.4	0.5	1.1	-0.8	-0.3	0.5	0.5	0.9	0.7	1.0	1.0	-0.1
Impedance of arm (right)	0.4	1.7	4.6	1.5	0.5	2.1	2.0	0.6	1.0	1.4	-0.2	1.1
Prospective memory result	0.4	0.4	1.7	-0.4	0.9	-0.6	-0.2	-0.4	-1.3	0.2	-0.7	-0.4
Hair/balding pattern: Pattern 4	0.4	1.0	2.3	1.4	1.3	0.7	0.8	0.8	0.8	1.5	0.2	-0.2
Gout (self-reported)	0.4	0.5	2.7	0.2	-0.9	0.4	-0.3	0.4	0.4	0.7	-0.5	-1.6
Wheeze or whistling in the chest in last year	0.4	0.7	2.2	1.5	-0.0	-0.5	-0.4	-0.9	-1.3	-0.8	-0.3	0.4
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.4	0.5	1.7	-1.3	-0.3	-0.6	-0.6	-0.1	1.2	-0.3	0.7	-0.4
Illnesses of father: Heart disease	0.4	0.5	2.0	0.2	0.9	0.2	0.6	0.2	1.4	0.2	0.8	0.9
Illnesses of siblings: Diabetes	0.4	0.5	2.4	0.7	1.6	-0.5	-0.0	0.4	-0.4	0.2	0.6	0.7
Average weekly red wine intake	0.4	0.5	1.8	0.6	0.4	-1.4	-0.4	-0.9	-0.0	-1.1	-0.3	-0.3
Diabetes diagnosed by doctor	0.4	0.7	1.9	-1.4	0.3	-1.3	-1.0	-0.7	-0.4	-0.6	0.0	0.9
Average weekly champagne plus white wine intake	0.4	0.5	3.5	1.9	0.4	0.3	0.4	0.1	-0.0	0.1	0.2	0.6
Supplements: Fish oil (including cod liver oil)	0.4	0.5	1.9	-1.4	-0.5	0.6	0.5	0.6	0.6	0.1	0.5	0.8
Medication: Atorvastatin	0.4	0.5	1.3	-0.4	-0.4	-1.1	-1.1	-0.6	-0.5	-0.5	-0.3	-0.9
Basal metabolic rate	0.4	2.4	5.1	-0.9	-1.4	-2.3	-2.0	-1.5	-1.3	-2.0	-0.8	-0.9
Arm fat-free mass (left)	0.4	2.1	4.3	-1.6	-1.3	-2.1	-1.9	-1.2	-1.4	-1.7	-0.7	-0.8
Ever depressed for a whole week	0.4	0.6	3.0	1.7	0.9	-0.5	-0.0	-0.3	-0.8	-0.4	-0.1	0.1
Pain experienced in last month	0.4	0.6	2.1	-0.4	-1.3	-0.6	-0.6	-0.2	-0.4	-0.6	-0.6	-1.5
Heart disease (siblings)	0.4	0.5	1.8	0.3	0.5	-0.5	-0.2	0.5	0.8	0.2	1.4	0.8
Bipolar Disorder (2018)	0.3	0.4	1.1	-1.0	-0.1	-0.5	-0.7	-0.6	-0.0	0.1	-0.6	-1.1
Depression (Nagel 2018)	0.3	0.4	1.6	-0.9	-0.6	-0.5	-0.6	0.3	0.4	-0.5	1.3	0.2
Ulcerative Colitis (UC)	0.3	0.5	1.7	-1.3	0.3	0.4	0.2	1.0	0.8	0.2	0.9	0.4
Verbal and Numeric Reasoning (VNR)	0.3	0.7	2.2	-0.1	-1.5	1.4	0.8	0.2	1.1	0.1	0.2	0.6
Age at First Birth	0.3	0.4	1.7	-0.2	-0.6	0.6	0.4	0.1	1.3	-0.2	0.8	0.3
Crohns Disease (2012)	0.3	0.5	2.5	-1.6	-0.5	-0.2	-0.1	-0.3	-0.4	-0.3	-0.0	-1.1
Systolic Blood Pressure	0.3	1.7	7.5	0.3	2.5	-0.2	0.8	0.2	-0.1	0.3	0.6	2.7
Medication: Co-codamol	0.3	0.4	1.1	-0.4	-0.2	-0.8	-0.6	-1.1	-0.3	-0.7	-0.4	0.6
Frequency of unenthusiasm / disinterest in last 2 weeks	0.3	0.4	1.1	-0.7	-1.0	-0.7	-0.8	-0.4	-0.1	-0.8	0.6	0.2
Heel bone mineral density (BMD) T-score, automated (left)	0.3	0.7	2.8	1.7	-0.6	1.2	0.8	0.3	-0.2	0.1	-0.2	1.0
Tinnitus: Yes, but not now, but have in the past	0.3	0.3	0.9	-0.0	0.1	-0.1	0.3	0.4	0.8	0.5	1.0	1.0
Had other major operations	0.3	0.4	0.9	-0.3	0.5	-0.5	-0.5	-0.8	-0.3	0.1	-0.9	-0.9
Mouth/teeth dental problems	0.3	0.5	1.3	0.2	-0.6	1.1	0.4	0.7	1.1	0.6	0.8	0.2
Diabetes (self-reported)	0.3	0.5	1.3	-0.9	0.2	-1.1	-0.9	-0.5	-0.1	-0.6	0.5	0.7
Hayfever/allergic rhinitis (self-reported)	0.3	0.4	1.5	0.5	1.2	0.2	0.4	0.2	1.0	0.2	0.6	0.7
Mouth/teeth dental problems: Dentures	0.3	0.6	1.7	-1.0	-0.5	-0.7	-0.7	-0.5	-1.3	-0.5	-0.9	-0.2
Asthma	0.3	0.6	1.2	0.6	-0.3	-0.8	-1.1	-0.8	-0.8	-1.0	-0.4	-0.5
Medication: Ibuprofen (e.g. Nurofen)	0.3	0.4	1.4	0.8	0.3	0.1	0.1	0.5	1.2	-0.2	0.8	0.8
Impedance of arm (left)	0.3	1.5	3.8	1.7	0.2	1.9	1.8	0.3	0.9	1.3	-0.4	1.0
Birth weight of first child	0.3	0.5	1.4	-0.6	-1.2	0.9	0.9	0.2	0.6	-0.3	0.2	0.7
Pulse wave reflection index	0.3	0.4	1.4	0.9	0.1	-0.1	-0.4	-0.1	-0.8	0.4	-0.5	-1.2
Glaucoma (self-reported)	0.3	0.3	0.7	-0.8	-0.3	0.8	0.3	0.7	-0.2	0.6	0.6	0.6
Medication: Ventolin 100micrograms inhaler	0.3	0.3	0.8	-0.8	-0.9	-0.3	-0.5	0.0	-0.9	-0.7	0.1	0.0
Arm fat-free mass (right)	0.3	1.7	3.9	-1.4	-1.2	-2.0	-1.8	-1.0	-1.1	-1.5	-0.5	-0.7
Medication: Ibuprofen	0.3	0.3	1.1	0.8	0.3	-0.0	-0.0	0.5	1.0	0.0	0.8	0.4
Arm predicted mass (right)	0.3	1.3	3.3	-1.3	-1.0	-1.8	-1.6	-0.8	-0.8	-1.3	-0.1	-0.5
Leg pain on walking	0.3	0.4	1.0	-0.3	-0.6	-1.0	-0.8	-0.1	-0.9	-0.4	0.1	-0.7
Smoking status: Previous	0.3	0.5	2.2	-1.5	-0.8	0.2	-0.1	-0.5	0.6	-0.4	0.2	0.7
Leg fat-free mass (right)	0.3	1.5	2.9	-0.9	-1.4	-1.7	-1.7	-1.1	-0.7	-1.6	-0.3	-0.9
Friendships satisfaction	0.3	0.4	1.3	0.4	-1.1	-0.5	-0.5	-0.7	0.0	-0.8	0.3	0.4
Eye problems/disorders: Cataract	0.3	0.3	0.7	-0.8	-0.8	-0.2	-0.2	-0.4	-0.4	-0.6	-0.8	-0.1
Asthma (self-reported)	0.3	0.6	1.1	0.9	-0.3	-0.8	-1.0	-0.9	-0.8	-1.0	-0.5	-0.4
Medication: Aspirin	0.3	0.4	1.1	0.1	0.2	-1.0	-0.9	-0.1	-0.5	0.2	-0.3	-1.0
Leg predicted mass (right)	0.3	1.5	3.0	-0.9	-1.4	-1.7	-1.7	-1.0	-0.8	-1.6	-0.3	-0.9
Number of self-reported non-cancer illnesses	0.3	0.5	1.0	-1.0	0.5	-1.0	-0.6	-0.6	-0.6	-0.6	0.1	1.0
Guilty feelings	0.3	0.4	1.4	-0.4	-0.7	0.3	0.0	-0.1	1.2	-0.4	0.6	-1.1
Wears glasses or contact lenses	0.3	0.4	1.1	-0.7	0.5	0.4	0.7	0.8	0.1	1.1	0.0	-0.2
Mother’s age at death	0.3	0.4	2.4	-1.6	-0.1	0.6	0.2	-0.3	-0.3	-0.2	-0.2	0.1
Pain type(s) experienced in last month: Hip pain	0.3	0.4	0.7	0.8	-0.4	0.8	0.6	0.6	0.4	0.8	0.6	0.2
Number of operations (self-reported)	0.3	0.4	1.1	-1.0	0.7	-0.6	-0.7	-0.7	0.0	-0.1	-0.9	0.2
Fractured/broken bones in last 5 years	0.3	0.4	2.3	0.6	1.5	-0.9	-0.3	-0.2	0.2	0.3	-0.4	0.1
Arm predicted mass (left)	0.3	1.6	3.5	-1.4	-1.1	-1.9	-1.7	-1.1	-1.1	-1.5	-0.5	-0.6
Bipolar Disorder or Schizophrenia	0.2	0.5	1.6	-1.2	0.2	0.1	0.2	-0.1	1.2	0.6	0.8	0.4
Crohns Disease (2017)	0.2	0.4	1.0	-1.0	-0.4	-0.3	-0.6	-0.3	-0.9	-0.5	-0.5	-1.0
Irritable Bowel Disease (IBD)	0.2	0.4	2.5	-1.6	0.1	0.3	-0.0	0.6	0.3	0.0	0.5	-0.3
Breast Cancer	0.2	0.5	2.1	0.8	0.1	1.0	1.4	0.5	0.1	0.6	0.2	0.1
Bipolar Disorder (2011)	0.2	0.2	1.2	-1.1	-0.7	-0.0	-0.1	-0.2	-0.0	-0.3	0.1	-0.6
Primary Biliary Cirrhosis	0.2	0.3	0.9	-0.9	0.1	0.9	0.5	-0.5	0.1	0.3	-0.4	-0.4
Blood Platelet Count	0.2	2.8	7.4	-1.4	-0.4	1.3	0.8	1.6	2.7	0.4	2.7	1.8
Respiratory disease	0.2	0.3	1.3	0.5	0.8	-0.1	-0.1	-0.1	0.3	-0.3	0.8	1.1
Relative age of first facial hair	0.2	0.4	1.5	-0.2	-1.0	-0.3	-0.6	-0.4	-0.8	-1.2	0.1	-0.3
Systolic blood pressure, automated reading	0.2	0.7	2.9	-0.3	1.4	-1.0	-0.1	-0.1	-0.7	-0.3	0.0	1.7
Diabetes (father)	0.2	0.2	0.7	-0.7	0.8	-0.3	0.0	-0.1	-0.1	0.4	-0.3	-0.6
Fed-up feelings	0.2	0.4	0.9	0.5	-0.1	-0.9	-0.9	-0.5	-0.1	-0.4	0.0	0.9
Relative age voice broke	0.2	0.3	1.3	0.1	-0.7	0.2	0.0	0.6	0.4	-0.2	1.1	0.8
Hayfever, allergic rhinitis or eczema	0.2	0.5	1.6	0.8	-1.0	-0.6	-0.3	-0.9	-0.3	-1.3	-0.4	-0.3
Diverticular disease/diverticulitis (self-reported)	0.2	0.2	0.8	0.2	0.6	-0.3	-0.4	-0.3	-0.0	-0.1	-0.9	-0.6
Past tobacco smoking	0.2	0.4	1.4	1.2	1.1	-0.5	-0.1	0.4	-0.2	0.4	0.1	-0.7
Hearing difficulty/problems with background noise	0.2	0.4	0.9	0.3	0.8	0.6	1.0	0.4	0.7	0.6	0.6	0.1
Heel bone mineral density (BMD) T-score, automated (right)	0.2	0.3	1.1	1.1	-0.3	0.9	0.4	0.1	-0.3	0.0	-0.6	0.7
Illnesses of siblings	0.2	0.3	0.8	0.3	-0.8	0.6	0.0	-0.3	-0.2	0.1	-0.8	-0.9
Hair/balding pattern: Pattern 3	0.2	0.3	2.3	-1.5	-0.7	0.5	0.0	0.1	0.0	-0.2	-0.1	-0.3
Happiness	0.2	0.3	1.3	1.1	-0.5	-0.1	-0.6	0.2	0.2	-0.5	0.6	0.1
Noisy workplace	0.2	0.3	1.3	0.5	1.1	0.2	0.4	-0.2	-0.7	0.2	-0.3	0.6
Illnesses of mother	0.2	0.2	0.6	0.2	0.8	0.1	0.3	0.6	0.2	0.2	0.6	0.8
Hypothyroidism/myxoedema (self-reported)	0.2	0.4	2.3	-0.6	0.5	0.2	0.4	-0.3	0.5	-0.1	-0.3	1.5
Number of full brothers	0.2	0.3	0.8	0.1	0.4	-0.6	-0.4	0.4	-0.5	-0.3	0.7	0.9
Medication: Omeprazole	0.2	0.2	1.1	0.1	0.5	-0.5	-0.2	-0.1	1.0	0.1	0.6	-0.1
Comparative height size at age 10	0.2	0.9	1.8	-1.2	-0.7	1.3	1.1	0.5	1.2	1.0	0.0	0.7
Number of full sisters	0.2	0.2	0.7	0.2	0.3	-0.9	-0.1	-0.7	0.1	-0.5	-0.1	0.4
Age at last live birth	0.2	0.3	1.6	1.3	-0.4	0.7	0.1	0.3	-0.1	0.0	-0.1	-0.6
Supplements: Vitamin C	0.2	0.3	0.8	-0.9	0.4	-0.3	-0.1	-0.6	0.8	-0.0	-0.6	-0.5
Forced expiratory volume in 1-second (FEV1), predicted	0.2	0.4	1.1	-0.4	-0.7	-0.4	-0.5	-0.8	-0.5	-1.0	-0.7	-0.4
Whole body fat-free mass	0.2	1.1	2.4	-0.8	-1.0	-1.6	-1.4	-0.8	-0.6	-1.4	-0.2	-0.5
Mineral and other dietary supplements	0.2	0.3	1.3	1.1	-0.0	-0.1	0.1	-0.2	-0.5	0.2	-0.5	-0.9
Whole body water mass	0.2	1.0	2.3	-0.7	-1.0	-1.5	-1.4	-0.8	-0.6	-1.4	-0.1	-0.5
Miserableness	0.2	0.3	1.1	0.8	0.2	-0.2	-0.2	-0.3	-1.1	0.2	-0.6	-0.2
Medication: Bendroflumethiazide	0.2	0.3	1.8	-0.5	-0.0	-0.2	0.2	-0.1	-1.4	0.0	-0.4	0.2
Medication: Paracetamol	0.2	0.3	1.0	0.7	0.4	-0.1	-0.4	1.0	-0.3	0.6	0.8	0.1
Ever smoked	0.2	0.3	1.3	-0.6	-0.6	0.6	0.5	-0.5	-0.1	-0.3	-0.2	1.2
Ever had prostate specific antigen (PSA) test	0.2	0.3	1.0	0.6	0.3	0.6	0.7	-0.3	-0.1	0.2	-1.0	-0.0
Commuting to job workplace: Cycle	0.2	0.2	0.7	0.8	-0.3	0.8	0.5	0.2	-0.2	-0.0	0.4	0.3
Medication: Omeprazole (e.g. Zanprol)	0.2	0.3	0.9	-0.0	0.2	-1.0	-0.8	-0.6	0.3	-0.5	0.1	-0.7
Supplements: Calcium	0.2	0.2	1.0	1.0	-0.1	0.3	0.2	0.5	0.1	0.7	-0.0	-0.3
Deep venous thrombosis (DVT) (self-reported)	0.2	0.2	0.8	0.5	-0.1	-0.4	-0.4	-0.3	-0.9	-0.3	-0.4	-0.1
Alcohol drinker status: Previous	0.2	0.3	1.5	0.2	0.5	0.4	0.4	0.6	0.2	1.2	0.3	0.1
Impedance of whole body	0.2	1.1	3.0	0.9	0.1	1.7	1.7	0.2	0.5	1.1	-0.3	1.2
Depressed Affect (Nagel 2018)	0.1	0.2	0.7	0.0	0.2	-0.0	-0.1	0.5	-0.0	0.4	0.8	0.8
Prostate Cancer	0.1	0.1	0.2	-0.3	0.5	-0.5	-0.4	0.3	-0.4	0.1	0.2	0.3
Height	0.1	1.1	3.5	-0.8	-0.7	-0.5	-0.2	-1.9	0.3	-1.3	-1.0	1.4
Allergy or Eczema	0.1	0.3	1.0	1.0	-0.9	-0.0	0.2	-0.2	0.3	-0.6	0.1	0.6
Lung FEV1/FVC ratio	0.1	0.7	2.9	-0.1	-0.3	-0.1	-0.1	1.4	0.1	0.8	1.7	-0.9
Other serious medical condition/disability diagnosed by doctor	0.1	0.2	0.9	0.6	-0.1	0.3	0.1	0.0	-0.0	-0.3	-0.1	0.9
Impedance of leg (right)	0.1	0.5	1.0	1.0	0.2	0.3	0.6	-0.5	-0.7	0.3	-1.0	0.9
Medication: Levothyroxine sodium	0.1	0.2	1.1	-0.5	0.1	-0.1	0.3	-0.1	0.1	-0.0	-0.2	1.0
Sitting height	0.1	0.9	3.7	1.0	0.0	1.0	0.7	0.0	1.3	0.1	0.5	1.9
High blood pressure (mother)	0.1	0.1	0.4	-0.6	0.2	0.2	0.2	-0.2	-0.0	0.0	-0.4	0.0
Impedance of leg (left)	0.1	0.4	0.9	0.7	0.2	0.6	0.8	-0.3	-0.5	0.5	-0.8	1.0
Had menopause	0.1	0.1	0.4	0.0	0.0	0.3	0.7	0.3	0.1	0.5	-0.3	0.1
Medication: Simvastatin	0.1	0.2	0.5	-0.3	0.6	-0.7	-0.3	0.4	-0.4	0.2	0.5	-0.1
Trunk fat-free mass	0.1	0.5	1.4	-0.3	-0.7	-1.2	-1.1	-0.5	-0.4	-1.1	-0.1	-0.1
Time employed in main current job	0.1	0.1	0.3	-0.2	-0.2	0.5	0.4	0.5	-0.5	0.1	-0.1	0.3
Trunk predicted mass	0.1	0.4	1.2	-0.2	-0.6	-1.1	-1.0	-0.5	-0.4	-1.0	-0.0	-0.1
Standing height	0.1	0.7	1.9	0.6	-1.0	1.1	0.9	-0.2	0.7	-0.1	-0.4	1.4
Tense / ‘highly strung’	0.1	0.2	0.5	-0.5	0.2	0.3	0.2	0.5	0.5	0.4	0.7	0.2
Loud music exposure frequency	0.1	0.1	0.4	0.6	0.5	0.3	0.1	-0.2	-0.2	-0.0	-0.3	-0.4
Blood clot in the leg (DVT)	0.1	0.1	0.8	0.0	0.0	-0.2	-0.3	-0.2	-0.9	-0.2	-0.4	-0.1
Headache pain in last month	0.1	0.2	1.1	0.5	1.0	0.5	0.4	-0.0	0.4	0.5	0.2	0.1
Medication: Amlodipine	0.1	0.2	0.4	-0.6	-0.4	-0.6	-0.4	0.3	-0.4	0.0	0.5	0.4
Chronic bronchitis/emphysema (mother)	0.1	0.1	0.6	-0.8	0.1	-0.1	-0.0	-0.3	-0.4	-0.3	-0.0	0.6
High blood pressure (siblings)	0.1	0.1	0.4	0.1	0.7	-0.3	-0.1	0.0	-0.3	-0.2	-0.3	-0.3
Seen a psychiatrist for nerves, anxiety, tension or depression	0.1	0.2	0.5	0.2	0.7	0.3	0.6	0.3	-0.1	0.0	0.6	0.2
Age at first live birth	0.1	0.3	0.9	0.7	-0.3	0.9	0.4	0.4	-0.4	0.5	0.0	-0.5
Heart disease (mother)	0.1	0.1	0.4	-0.5	0.2	0.3	0.3	-0.4	0.2	0.2	0.0	-0.6
Qualifications: NVQ or HND or HNC or equivalent	0.1	0.1	0.4	0.4	-0.0	-0.5	-0.4	0.0	-0.3	0.4	0.6	0.1
Medication: Aspirin	0.1	0.1	0.5	-0.2	0.3	-0.5	-0.5	0.0	-0.2	0.2	-0.3	-0.7
Knee pain experienced in last month	0.1	0.2	0.7	0.3	0.4	-0.6	-0.8	-0.2	-0.2	-0.2	0.3	0.7
Back pain experienced in last month	0.1	0.1	0.4	-0.1	-0.5	0.1	0.1	0.1	-0.6	0.1	-0.2	0.1
Osteoporosis (self-reported)	0.1	0.1	0.6	0.4	0.1	0.5	0.3	0.2	0.0	0.8	0.0	-0.4
Ever taken oral contraceptive pill	0.1	0.1	0.3	0.1	-0.1	0.2	0.5	-0.1	-0.2	-0.3	-0.5	0.4
Irritability	0.1	0.3	0.6	-0.6	-0.7	0.7	0.6	0.4	0.3	0.0	0.1	0.6
Cholesterol lowering medication	0.1	0.1	0.4	-0.5	-0.7	0.0	-0.1	0.2	-0.1	-0.1	0.5	-0.1
Hair Pigment	0.0	0.2	0.8	0.9	-0.2	0.3	0.2	0.0	-0.4	0.4	0.1	0.3
Tanning	0.0	0.3	0.8	-0.0	-0.8	0.9	0.5	0.6	-0.0	0.0	-0.6	-0.8

Hub : Genes

ADH1C

Models

Trait associations