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chr2:23,453,834-25,040,082

Best TWAS P=8.01e-10 · Best GWAS P=2.27e-10 conditioned to 0.316

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
7	GTEx	Spleen	UBXN2A	0.31	0.11	enet	19	0.17	4.1e-05	-4.6	6.1	8.0e-10	0.65	0.14	0.70	TRUE
9	The Cancer Genome Atlas	Breast Invasive Carcinoma	FKBP1B	0.04	0.02	blup	41	0.02	3.6e-05	5.4	-5.5	5.1e-08	-0.59	0.00	1.00	TRUE
1	GTEx	Cells EBV-transformed lymphocytes	PFN4	0.18	0.13	lasso	12	0.12	8.9e-05	5.4	5.8	9.1e-09	0.69	0.05	0.86	FALSE
5	GTEx	Heart Left Ventricle	PFN4	0.23	0.28	lasso	6	0.28	4.1e-15	5.5	5.6	1.8e-08	0.66	0.13	0.87	FALSE
2	GTEx	Colon Transverse	PFN4	0.14	0.07	lasso	2	0.04	3.3e-03	5.5	5.5	2.8e-08	0.61	0.04	0.66	FALSE
14	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	PFN4	0.20	0.18	lasso	1	0.16	4.3e-07	5.5	5.5	3.2e-08	0.61	0.00	1.00	FALSE
4	GTEx	Esophagus Mucosa	PFN4	0.16	0.15	lasso	4	0.15	3.6e-10	5.4	5.5	4.6e-08	0.62	0.17	0.83	FALSE
10	The Cancer Genome Atlas	Cervical Squamous Cell Carcinoma	PFN4	0.19	0.16	lasso	2	0.15	5.5e-08	5.4	5.4	5.5e-08	0.61	0.00	1.00	FALSE
12	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	PFN4	0.10	0.07	lasso	2	0.06	1.1e-07	5.4	5.4	5.7e-08	0.61	0.00	1.00	FALSE
8	ROSMAP	Brain Pre-frontal Cortex	PFN4	0.05	0.03	lasso	1	0.03	1.7e-04	5.4	5.4	6.5e-08	0.61	0.12	0.71	FALSE
13	The Cancer Genome Atlas	Lung Adenocarcinoma	PFN4	0.15	0.09	lasso	3	0.09	7.3e-11	5.4	5.4	6.5e-08	0.61	0.00	1.00	FALSE
3	GTEx	Esophagus Gastroesophageal Junction	SF3B14	0.10	0.01	lasso	8	0.00	3.5e-01	3.2	5.4	7.2e-08	0.56	0.05	0.61	FALSE
15	The Cancer Genome Atlas	Prostate Adenocarcinoma	PFN4	0.12	0.08	lasso	6	0.07	6.3e-08	5.4	5.4	7.2e-08	0.61	0.00	1.00	FALSE
16	The Cancer Genome Atlas	Rectum Adenocarcinoma	PFN4	0.38	0.11	lasso	5	0.05	2.8e-02	5.4	5.3	9.2e-08	0.61	0.00	0.83	FALSE
6	GTEx	Muscle Skeletal	PFN4	0.12	0.09	lasso	4	0.09	5.6e-09	5.4	5.3	9.4e-08	0.61	0.16	0.84	FALSE
11	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	PFN4	0.13	0.07	lasso	4	0.06	4.4e-07	5.4	5.2	1.5e-07	0.59	0.00	1.00	FALSE