Best TWAS P=8.01e-10 · Best GWAS P=2.27e-10 conditioned to 0.316
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Cells EBV-transformed lymphocytes | PFN4 | 0.18 | 0.13 | lasso | 12 | 0.12 | 8.9e-05 | 5.4 | 5.8 | 9.1e-09 | 0.69 | 0.05 | 0.86 | FALSE |
| 2 | GTEx | Colon Transverse | PFN4 | 0.14 | 0.07 | lasso | 2 | 0.04 | 3.3e-03 | 5.5 | 5.5 | 2.8e-08 | 0.61 | 0.04 | 0.66 | FALSE |
| 3 | GTEx | Esophagus Gastroesophageal Junction | SF3B14 | 0.10 | 0.01 | lasso | 8 | 0.00 | 3.5e-01 | 3.2 | 5.4 | 7.2e-08 | 0.56 | 0.05 | 0.61 | FALSE |
| 4 | GTEx | Esophagus Mucosa | PFN4 | 0.16 | 0.15 | lasso | 4 | 0.15 | 3.6e-10 | 5.4 | 5.5 | 4.6e-08 | 0.62 | 0.17 | 0.83 | FALSE |
| 5 | GTEx | Heart Left Ventricle | PFN4 | 0.23 | 0.28 | lasso | 6 | 0.28 | 4.1e-15 | 5.5 | 5.6 | 1.8e-08 | 0.66 | 0.13 | 0.87 | FALSE |
| 6 | GTEx | Muscle Skeletal | PFN4 | 0.12 | 0.09 | lasso | 4 | 0.09 | 5.6e-09 | 5.4 | 5.3 | 9.4e-08 | 0.61 | 0.16 | 0.84 | FALSE |
| 7 | GTEx | Spleen | UBXN2A | 0.31 | 0.11 | enet | 19 | 0.17 | 4.1e-05 | -4.6 | 6.1 | 8.0e-10 | 0.65 | 0.14 | 0.70 | TRUE |
| 8 | ROSMAP | Brain Pre-frontal Cortex | PFN4 | 0.05 | 0.03 | lasso | 1 | 0.03 | 1.7e-04 | 5.4 | 5.4 | 6.5e-08 | 0.61 | 0.12 | 0.71 | FALSE |
| 9 | The Cancer Genome Atlas | Breast Invasive Carcinoma | FKBP1B | 0.04 | 0.02 | blup | 41 | 0.02 | 3.6e-05 | 5.4 | -5.5 | 5.1e-08 | -0.59 | 0.00 | 1.00 | TRUE |
| 10 | The Cancer Genome Atlas | Cervical Squamous Cell Carcinoma | PFN4 | 0.19 | 0.16 | lasso | 2 | 0.15 | 5.5e-08 | 5.4 | 5.4 | 5.5e-08 | 0.61 | 0.00 | 1.00 | FALSE |
| 11 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | PFN4 | 0.13 | 0.07 | lasso | 4 | 0.06 | 4.4e-07 | 5.4 | 5.2 | 1.5e-07 | 0.59 | 0.00 | 1.00 | FALSE |
| 12 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | PFN4 | 0.10 | 0.07 | lasso | 2 | 0.06 | 1.1e-07 | 5.4 | 5.4 | 5.7e-08 | 0.61 | 0.00 | 1.00 | FALSE |
| 13 | The Cancer Genome Atlas | Lung Adenocarcinoma | PFN4 | 0.15 | 0.09 | lasso | 3 | 0.09 | 7.3e-11 | 5.4 | 5.4 | 6.5e-08 | 0.61 | 0.00 | 1.00 | FALSE |
| 14 | The Cancer Genome Atlas | Pancreatic Adenocarcinoma | PFN4 | 0.20 | 0.18 | lasso | 1 | 0.16 | 4.3e-07 | 5.5 | 5.5 | 3.2e-08 | 0.61 | 0.00 | 1.00 | FALSE |
| 15 | The Cancer Genome Atlas | Prostate Adenocarcinoma | PFN4 | 0.12 | 0.08 | lasso | 6 | 0.07 | 6.3e-08 | 5.4 | 5.4 | 7.2e-08 | 0.61 | 0.00 | 1.00 | FALSE |
| 16 | The Cancer Genome Atlas | Rectum Adenocarcinoma | PFN4 | 0.38 | 0.11 | lasso | 5 | 0.05 | 2.8e-02 | 5.4 | 5.3 | 9.2e-08 | 0.61 | 0.00 | 0.83 | FALSE |