TWAS hub - SF3B14

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Colon Transverse	0.086	0.035	0.00017	0.047	NA	0.017	NA	0.017	0.0028	NA	0.052	NA	0.048
2	GTEx	Esophagus Gastroesophageal Junction	0.099	0.057	0.00810	0.006	NA	-0.003	NA	-0.001	0.1900	NA	0.450	NA	0.360
3	TCGA	Soft Tissue Sarcoma	0.061	0.044	0.00430	0.014	0.015	0.008	NA	0.010	0.0490	0.042	0.099	NA	0.079

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3
Reaction Time	11.2	21.3	30.4	-5.4	-5.5	-2.1
Sitting height	10.2	72.7	125.4	-9.5	-11.2	-1.6
Medication: Seretide 50 evohaler	9.1	10.5	15.5	-3.9	-3.1	-2.5
Blood White Count	8.5	63.2	102.0	10.1	9.0	2.5
Mean time to correctly identify matches	7.4	14.1	21.4	-4.5	-4.6	-0.2
Fed-up feelings	7.0	12.7	20.7	4.5	3.9	1.4
Alcohol intake frequency.	6.2	14.4	29.1	3.8	5.4	-0.3
Qualifications: O levels/GCSEs or equivalent	5.9	9.3	10.9	-3.3	-3.2	-2.7
Guilty feelings	5.8	8.7	15.9	4.0	3.0	1.2
Had major operations	5.7	6.7	10.2	-2.7	-3.2	-1.6
Height	5.0	95.8	166.4	-10.9	-12.9	-1.5
Eye problems/disorders: Diabetes related eye disease	5.0	5.5	8.4	-2.9	-2.7	-0.9
Leg fat percentage (right)	4.1	15.0	20.7	4.5	4.3	2.5
Serious illness, injury or assault to yourself	4.0	4.9	6.7	-2.6	-1.8	-2.1
Qualifications: A levels/AS levels or equivalent	4.0	8.8	15.2	-3.0	-3.9	-1.5
Leg fat percentage (left)	4.0	14.3	19.4	4.4	4.1	2.6
Supplements: Zinc	3.7	4.0	7.6	-1.8	-2.8	-1.1
Comparative body size at age 10	3.7	10.3	11.7	3.0	3.2	3.4
Depressed Affect (Nagel 2018)	3.6	7.5	15.0	3.9	2.7	0.2
Neuroticism score	3.5	7.2	12.2	3.5	2.7	1.6
Eye problems/disorders: None of the above	3.4	3.9	6.1	2.4	2.5	0.4
Miserableness	3.4	5.8	11.4	3.4	2.5	0.2
Blood Red Count	3.3	32.2	46.5	6.4	6.8	-3.0
Trunk fat-free mass	3.3	19.0	36.5	-4.4	-6.0	1.2
High cholesterol (Self-reported)	3.3	5.9	9.0	3.0	2.3	1.8
Trunk predicted mass	3.2	18.5	35.3	-4.3	-5.9	1.2
Medication: Lansoprazole	3.1	3.5	5.1	1.9	1.2	2.3
Standing height	3.1	30.8	58.7	-5.8	-7.7	-0.0
Risk taking	3.1	4.5	6.5	-2.1	-2.5	-1.6
Neuroticism	2.9	7.1	13.7	3.7	2.5	1.1
Forced expiratory volume in 1-second (FEV1)	2.9	9.8	17.0	-3.1	-4.1	-1.7
Number of full sisters	2.9	3.5	6.5	1.5	1.3	2.6
Whole body fat-free mass	2.9	16.4	31.1	-3.9	-5.6	1.7
Forced expiratory volume in 1-second (FEV1), Best measure	2.8	9.0	13.9	-3.0	-3.7	-2.0
Suffer from ‘nerves’	2.8	4.5	5.2	2.1	2.0	2.3
Qualifications: NVQ or HND or HNC or equivalent	2.8	3.3	5.8	2.4	2.0	-0.3
Supplements: Vitamin C	2.8	3.3	4.8	-1.6	-2.2	-1.5
Whole body water mass	2.8	16.2	31.0	-3.8	-5.6	1.8
Forced vital capacity (FVC)	2.7	10.4	18.4	-3.3	-4.3	-1.4
Forced vital capacity (FVC), Best measure	2.7	9.9	15.1	-3.2	-3.9	-2.1
Friendships satisfaction	2.7	3.3	5.5	-2.1	-2.3	-0.5
Mood swings	2.6	4.6	8.3	2.9	2.3	0.6
Qualifications: CSEs or equivalent	2.5	3.3	5.4	2.3	2.0	-0.6
Emphysema/chronic bronchitis	2.5	2.9	3.6	-1.8	-1.3	-1.9
Leg predicted mass (right)	2.5	13.6	24.6	-3.5	-5.0	1.9
Lung FVC	2.4	12.2	15.4	-3.9	-3.9	-2.4
Alcohol intake versus 10 years previously	2.4	3.5	6.0	2.1	2.5	-0.1
Medication: Cholesterol lowering	2.4	3.8	7.3	2.7	1.6	1.2
Body fat percentage	2.4	9.6	12.5	3.5	2.9	2.8
Leg fat-free mass (right)	2.4	13.1	23.7	-3.4	-4.9	2.0
Average weekly champagne plus white wine intake	2.4	3.3	5.7	-1.9	-2.4	0.9
Ever taken oral contraceptive pill	2.4	2.7	3.3	-1.6	-1.8	-1.5
Alzheimer’s Disease (including proxy)	2.3	3.4	5.0	-2.2	-1.6	-1.6
Angina	2.3	3.0	4.4	1.5	1.5	2.1
Illnesses of mother	2.3	2.8	3.8	1.9	1.5	1.6
Arm fat-free mass (right)	2.3	11.7	24.1	-2.8	-4.9	1.8
Comparative height size at age 10	2.3	12.7	23.1	-3.5	-4.8	1.7
Wears glasses or contact lenses	2.3	2.7	6.6	1.0	0.6	2.6
Systolic blood pressure, automated reading	2.2	6.5	9.9	1.9	3.2	2.4
Leg fat-free mass (left)	2.2	11.8	21.1	-3.2	-4.6	2.0
Angina (self-reported)	2.2	2.9	4.3	1.6	1.4	2.1
Arm predicted mass (right)	2.2	11.1	22.6	-2.7	-4.8	1.8
Basal metabolic rate	2.2	12.0	23.1	-3.0	-4.8	2.0
Severe depression (siblings)	2.1	2.4	4.5	-0.5	-1.5	2.1
Leg predicted mass (left)	2.1	11.4	20.2	-3.1	-4.5	2.0
Prospective memory result	2.1	2.6	4.6	2.2	1.7	-0.0
Worry too long after embarrassment	2.1	3.5	6.0	1.7	1.3	2.4
Average weekly red wine intake	2.1	3.1	6.5	-2.5	-1.6	-0.1
Alzheimer’s Disease (in father)	2.0	2.1	2.8	-1.7	-1.5	-1.2
Neuroticism (2016)	2.0	2.9	4.5	1.9	2.1	0.9
Frequency of depressed mood in last 2 weeks	2.0	2.9	4.2	2.0	1.0	1.8
Current tobacco smoking	2.0	3.3	5.1	2.3	2.1	-0.6
Impedance of leg (left)	2.0	9.9	13.3	3.6	3.6	-1.9
Qualifications: College or University degree	2.0	6.3	11.1	-2.8	-3.3	0.3
Arm fat-free mass (left)	2.0	10.4	21.0	-2.7	-4.6	1.8
Arm predicted mass (left)	2.0	10.3	20.0	-2.6	-4.5	2.0
Hearing difficulty/problems: Yes	1.9	3.0	5.8	2.4	1.7	0.5
Hearing difficulty/problems with background noise	1.9	3.1	4.3	2.1	1.7	1.5
Loud music exposure frequency	1.9	2.1	3.9	2.0	1.2	1.0
Number of operations (self-reported)	1.9	2.8	5.2	-1.8	-2.3	0.4
Alcohol drinker status: Previous	1.9	2.2	4.6	2.1	1.4	0.1
Verbal and Numeric Reasoning (VNR)	1.8	4.3	7.5	-2.3	-2.7	0.4
Coronary Artery Disease (CAD)	1.8	2.1	3.7	1.9	1.6	0.3
Relative age of first facial hair	1.8	3.6	7.1	1.9	2.7	-0.2
Impedance of leg (right)	1.8	8.9	11.4	3.1	3.4	-2.4
Trunk fat percentage	1.8	7.3	9.4	3.1	2.2	2.7
Relative age voice broke	1.8	2.8	6.1	1.2	2.5	-0.8
Illnesses of siblings	1.8	2.6	4.9	-1.5	-2.2	-0.7
Medication: Ibuprofen (e.g. Nurofen)	1.8	2.3	4.2	2.1	1.6	0.2
Pulse wave Arterial Stiffness index	1.8	2.1	3.5	-1.4	-1.9	0.9
Qualifications: nursing, teaching	1.8	2.8	4.2	-1.4	-2.1	1.4
Illnesses of father: None of the above (group 1)	1.8	2.2	4.2	2.0	1.1	1.1
Alzheimer’s Disease (in mother)	1.7	2.0	3.1	-1.8	-1.6	-0.7
Age at First Birth	1.7	2.5	3.1	1.5	1.4	1.8
Fluid intelligence score	1.7	3.5	5.0	-1.9	-2.2	1.4
Medication: Ibuprofen	1.7	2.0	3.1	1.8	1.6	0.7
Arm fat percentage (left)	1.7	6.6	7.6	2.7	2.2	2.8
Mouth/teeth dental problems: Mouth ulcers	1.7	2.8	5.1	-1.2	-2.2	1.4
Forced expiratory volume in 1-second (FEV1), predicted percentage	1.7	3.6	5.7	-2.1	-2.4	-0.9
Financial situation satisfaction	1.7	2.1	3.8	1.9	0.8	1.3
Schizophrenia vs Biploar Disorder	1.6	2.2	3.6	1.9	1.3	1.1
Stomach or abdominal pain in last month	1.6	1.9	2.8	-1.2	-1.7	-1.2
Supplements: Glucosamine	1.6	2.1	3.6	-1.9	-1.6	0.4
Had menopause	1.6	2.0	5.3	-0.2	0.7	2.3
Neck or shoulder pain in last month	1.6	2.2	3.6	1.9	1.7	0.6
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.6	1.9	3.2	-1.8	-1.5	0.3
Smoking status: Current	1.6	2.5	4.2	2.0	1.7	-0.7
Depression (Nagel 2018)	1.5	2.2	2.7	1.6	1.2	1.6
Bilateral oophorectomy (both ovaries removed)	1.5	1.7	2.5	-1.6	-1.1	1.2
Tinnitus: Yes, but not now, but have in the past	1.5	1.6	3.1	1.3	1.8	0.2
Arm fat percentage (right)	1.5	6.1	7.3	2.4	2.2	2.7
Medication for cholesterol, blood pressure or diabetes	1.5	2.6	3.6	-1.8	-0.8	-1.9
Loneliness, isolation	1.5	2.0	5.0	2.2	1.0	-0.4
Fractured/broken bones in last 5 years	1.5	2.0	4.4	1.2	0.3	2.1
Heart disease (siblings)	1.5	1.8	2.1	1.5	1.4	1.2
Leg fat mass (left)	1.5	5.7	9.1	2.4	1.4	3.0
LDL Cholesterol	1.4	2.2	3.8	1.7	0.1	1.9
Medication: Allopurinol	1.4	1.9	3.3	-1.5	-1.8	-0.2
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.4	1.7	2.6	-0.6	-1.4	1.6
Illness, injury, bereavement, stress in last 2 years	1.4	1.7	2.1	-1.5	-1.0	1.4
Medication: Bendroflumethiazide	1.4	2.2	3.5	1.6	0.8	1.9
Pack years of smoking	1.4	2.1	2.7	1.2	1.6	1.5
HbA1C	1.3	1.5	2.9	0.9	0.9	-1.7
Type 2 Diabetes (T2D) (2012)	1.3	1.4	2.3	-1.4	-0.3	-1.5
Pack years adult smoking proportion	1.3	2.1	3.1	1.5	1.8	0.9
Average weekly fortified wine intake	1.3	1.5	1.6	-1.2	-1.3	1.2
Hair/balding pattern: Pattern 3	1.3	1.9	2.4	1.6	1.6	-1.0
Leg fat mass (right)	1.3	5.1	7.9	2.4	1.4	2.8
Heart attack/myocardial infarction (self-reported)	1.3	1.6	2.0	-1.4	-1.0	-1.4
Intelligence (Savage-Jansen 2018)	1.2	3.7	7.1	-1.9	-2.7	0.7
Maternal smoking around birth	1.2	1.7	3.2	1.8	1.2	0.6
Qualifications: None of the above	1.2	2.5	4.9	1.6	2.2	0.1
Peak expiratory flow (PEF)	1.2	2.8	6.5	-1.2	-2.5	0.6
Smoking status: Previous	1.2	1.8	2.7	-0.9	-1.4	1.6
Osteoporosis (self-reported)	1.2	1.5	2.9	0.8	1.7	1.0
Body mass index (BMI)	1.1	4.7	8.1	2.0	1.4	2.8
Father’s age at death	1.1	1.5	4.4	-2.1	-0.1	0.2
Impedance of whole body	1.1	5.6	8.2	2.2	2.9	-1.9
Neuroticism (Nagel 2018)	1.0	2.3	4.7	2.2	1.1	1.0
Other serious medical condition/disability diagnosed by doctor	1.0	1.3	3.2	-0.8	-0.1	-1.8
Frequency of unenthusiasm / disinterest in last 2 weeks	1.0	1.3	2.3	1.5	1.2	0.2
Age when periods started (menarche)	1.0	2.4	4.9	0.4	1.5	-2.2
Ever unenthusiastic/disinterested for a whole week	1.0	1.3	2.0	1.2	1.4	0.6
Financial difficulties in last 2 years	1.0	1.3	3.4	1.8	0.7	-0.2
Breastfed as a baby	1.0	1.3	2.0	-1.4	-1.0	-0.9
Birth weight	1.0	2.2	4.8	-2.2	-1.3	0.5
Medication: Paracetamol	1.0	1.6	4.3	0.7	0.1	-2.1
Ever had prostate specific antigen (PSA) test	1.0	1.2	2.1	-1.5	-1.1	0.4
Breast Cancer	0.9	2.2	4.4	2.1	1.4	0.6
Trunk fat mass	0.9	3.8	8.5	1.6	0.5	2.9
Waist circumference	0.9	3.2	7.4	1.4	0.5	2.7
Had other major operations	0.9	1.1	1.8	-1.1	-1.3	-0.4
Heart attack	0.9	1.2	1.7	-1.1	-0.7	-1.3
Hair/balding pattern: Pattern 4	0.9	2.2	2.8	1.6	1.7	1.0
Pulse wave reflection index	0.9	1.1	2.9	0.7	-0.0	1.7
Gout (self-reported)	0.9	1.3	2.0	-1.1	-1.4	0.7
Reason for reducing amount of alcohol drunk: Health precaution	0.9	1.1	2.8	-0.7	-1.7	-0.0
Pulse wave peak to peak time	0.9	1.1	1.8	1.0	1.4	-0.7
Whole body fat mass	0.9	3.7	8.0	1.6	0.5	2.8
Forced expiratory volume in 1-second (FEV1), predicted	0.9	1.9	4.1	-0.2	-2.0	1.2
Eye problems/disorders: Cataract	0.9	1.0	1.8	-0.4	-1.3	1.1
Deep venous thrombosis (DVT) (self-reported)	0.9	1.2	2.5	-1.0	-1.6	-0.1
BMI	0.8	4.8	9.7	1.8	1.2	3.1
Chronotype (morning person)	0.8	1.8	3.5	1.1	0.8	-1.9
High blood pressure (mother)	0.8	1.1	1.9	-1.1	-0.6	-1.4
Alcohol usually taken with meals	0.8	1.2	3.0	-1.7	-0.8	-0.1
Heel bone mineral density (BMD) T-score, automated (right)	0.8	1.7	2.9	-1.5	-1.7	0.2
Medication: Ramipril	0.8	1.0	1.3	0.8	1.1	1.0
Weight	0.8	3.8	7.6	-0.6	-1.9	2.8
Arm fat mass (right)	0.8	3.2	8.1	1.2	0.3	2.8
Blood clot in the leg (DVT)	0.8	1.1	2.5	-0.8	-1.6	-0.1
Family relationship satisfaction	0.8	1.0	2.2	-0.9	-1.5	0.0
Ever had stillbirth, spontaneous miscarriage or termination	0.8	0.8	2.1	0.5	-0.4	-1.5
Asthma (self-reported)	0.8	1.5	3.6	-0.8	-0.6	1.9
Alcohol drinker status: Never	0.8	1.0	1.9	1.0	1.4	-0.2
Major Depression (MDD)	0.7	0.8	1.4	1.2	0.8	0.6
Lupus	0.7	1.1	1.8	-0.9	-1.4	-0.7
Ulcerative Colitis	0.7	1.0	1.8	-0.8	-1.3	-0.7
Average weekly spirits intake	0.7	0.8	1.3	-0.8	-1.2	0.7
Medication for hormone replacement therapy	0.7	0.8	1.2	1.1	-0.4	1.1
Vitamin and mineral supplements	0.7	0.9	1.5	1.2	1.1	0.2
Medication: Co-codamol	0.7	0.8	0.9	-0.9	-0.7	-1.0
Multivitamins +/- minerals	0.7	0.9	1.5	-1.2	-1.1	0.2
Hip circumference	0.7	3.2	9.2	0.2	-0.5	3.0
Serious illness, injury or assault of a close relative in last 2 years	0.7	0.8	1.9	-0.3	-0.6	-1.4
Asthma	0.7	1.4	2.7	-1.0	-0.7	1.6
Medication: Amlodipine	0.7	1.0	1.6	-1.2	-1.3	-0.2
Exposure to tobacco smoke outside home	0.7	0.9	1.9	0.8	0.5	-1.4
Age at last live birth	0.7	1.0	1.8	-1.3	-0.9	0.7
Mineral and other dietary supplements	0.7	0.9	1.6	1.2	1.0	-0.5
Arm fat mass (left)	0.7	3.0	7.3	1.3	0.2	2.7
Medication: Omeprazole (e.g. Zanprol)	0.7	0.8	1.4	1.2	1.0	-0.2
Heel T-Score	0.6	4.4	5.2	-1.9	-2.3	-2.1
Cardiovascular Disease	0.6	2.1	4.3	2.1	0.7	1.2
Tanning	0.6	7.4	8.9	2.7	2.5	3.0
Ever used hormone-replacement therapy (HRT)	0.6	0.7	1.1	-1.1	-1.0	0.1
Heel bone mineral density (BMD) T-score, automated (left)	0.6	1.3	1.8	-1.1	-1.4	1.0
Nervous feelings	0.6	1.1	1.9	1.2	1.4	0.1
Frequency of tenseness / restlessness in last 2 weeks	0.6	1.0	2.3	1.5	0.6	-0.6
Ever highly irritable/argumentative for 2 days	0.6	0.7	1.5	1.2	0.4	0.7
Medication: Paracetamol	0.6	0.9	2.0	0.9	0.3	-1.4
Leg pain on walking	0.6	0.7	1.6	-0.6	-0.3	-1.3
Handedness (chirality/laterality): Left-handed	0.6	0.8	2.3	0.1	0.0	1.5
Ever had bowel cancer screening	0.6	0.7	1.8	-1.4	-0.3	-0.4
Back pain experienced in last month	0.6	0.9	1.4	1.2	1.0	0.4
Medication: Gliclazide	0.6	0.6	1.2	-1.1	-0.4	-0.8
Diastolic blood pressure, automated reading	0.6	1.8	3.0	1.3	1.7	0.8
Crohns Disease (2017)	0.5	1.2	1.8	1.3	1.3	-0.5
Prostate Cancer	0.5	0.8	1.1	-1.0	-0.4	1.0
Primary Biliary Cirrhosis	0.5	0.7	1.4	0.4	0.6	-1.2
Triglycerides	0.5	0.9	1.7	1.3	1.0	0.0
Systolic Blood Pressure	0.5	2.4	4.8	1.1	2.2	1.1
Allergy or Eczema	0.5	1.4	3.7	-0.7	-1.9	0.2
Number of treatments/medications taken	0.5	0.9	1.7	-0.9	-1.3	-0.6
High blood pressure	0.5	1.3	3.1	0.8	0.3	1.8
Past tobacco smoking	0.5	0.9	2.2	0.2	0.6	-1.5
Impedance of arm (left)	0.5	2.3	3.9	0.9	2.0	-1.4
Birth weight of first child	0.5	0.9	1.3	-0.9	-0.7	-1.1
Mouth/teeth dental problems: Bleeding gums	0.5	0.7	1.5	1.2	0.4	0.7
Medication: Ventolin 100micrograms inhaler	0.5	0.6	1.3	-0.5	0.5	1.1
Chronic bronchitis/emphysema (mother)	0.5	0.6	1.5	0.4	-0.3	-1.2
Long-standing illness, disability or infirmity	0.5	0.8	2.1	0.2	1.5	0.4
Commuting to job workplace: Walk	0.5	0.5	0.9	-1.0	-0.8	0.2
Osteoarthritis (self-reported)	0.5	0.7	1.5	-0.0	0.8	1.2
Commuting to job workplace: Cycle	0.5	0.6	1.6	-0.3	0.1	1.3
Ulcerative Colitis (UC)	0.4	0.8	1.2	-0.9	-0.7	-1.1
Mean Putamen Volume	0.4	0.5	0.6	0.6	0.8	0.6
Smoking Status	0.4	1.0	1.7	1.1	0.5	1.3
Respiratory disease	0.4	0.9	1.8	-0.3	-0.9	1.3
Diabetes (father)	0.4	0.5	1.0	-0.3	-0.7	-1.0
Townsend deprivation index at recruitment	0.4	0.6	1.0	1.0	0.6	0.5
Medication: Atenolol	0.4	0.5	1.1	-0.3	-0.7	1.0
Number of incorrect matches in round	0.4	0.7	1.3	0.6	-0.7	1.1
Mouth/teeth dental problems	0.4	0.6	1.3	-0.3	0.6	-1.1
Allergy	0.4	0.9	2.0	0.4	1.4	-0.8
Impedance of arm (right)	0.4	2.0	3.8	0.8	1.9	-1.2
Frequency of tiredness / lethargy in last 2 weeks	0.4	0.6	1.3	1.2	0.6	-0.2
Lung cancer (father)	0.4	0.5	0.8	0.6	0.6	0.9
Seen doctor (GP) for nerves, anxiety, tension or depression	0.4	0.6	1.5	1.2	0.6	-0.3
Headache pain in last month	0.4	0.6	1.3	1.1	0.8	-0.0
Health satisfaction	0.4	0.5	0.9	-0.7	-1.0	-0.2
Shortness of breath walking on level ground	0.4	0.4	0.7	0.4	0.8	0.7
Pulse rate, automated reading	0.4	1.2	2.3	-1.1	-1.5	-0.3
Hypertension (Self-reported)	0.4	1.2	2.9	0.8	0.2	1.7
Illnesses of father: Heart disease	0.4	0.6	1.4	-0.6	0.3	-1.2
Medication: Aspirin	0.4	0.5	1.1	-0.2	-1.0	0.5
Mother’s age at death	0.4	0.5	1.4	0.2	-0.2	1.2
Supplements: Fish oil (including cod liver oil)	0.4	0.6	1.1	-0.6	-0.5	1.1
Illnesses of father: High blood pressure	0.4	0.5	0.6	-0.8	0.6	-0.8
Age started oral contraceptive pill	0.4	0.5	1.2	-0.2	-0.5	1.1
Unable to work because of sickness or disability	0.4	0.5	0.9	0.2	0.9	0.8
Vascular/heart problems diagnosed by doctor	0.4	1.0	2.6	-0.5	-0.3	-1.6
Cholesterol lowering medication	0.4	0.7	1.0	-1.0	-1.0	0.2
Schizophrenia (2018)	0.3	0.6	1.5	1.2	0.5	0.2
Worry (Nagel 2018)	0.3	0.7	1.7	0.6	0.1	1.3
Irritable Bowel Disease (IBD)	0.3	0.6	1.8	0.1	0.1	-1.4
Bipolar Disorder (2011)	0.3	0.3	0.8	-0.0	-0.9	0.1
HDL Cholesterol	0.3	0.5	1.2	0.3	0.2	1.1
Schizophrenia (2014)	0.3	0.7	1.8	1.4	0.3	-0.5
Sensitivity / hurt feelings	0.3	0.5	0.9	0.3	0.6	1.0
Diabetes (mother)	0.3	0.4	1.2	0.3	1.1	-0.3
Hayfever, allergic rhinitis or eczema	0.3	0.7	1.9	-0.2	-1.4	0.3
Pain all over the body in last month	0.3	0.4	0.7	0.2	0.9	-0.6
Hayfever/allergic rhinitis (self-reported)	0.3	0.4	1.2	-0.2	-1.1	0.2
Happiness	0.3	0.4	0.6	0.7	-0.7	0.0
Length of working week for main job	0.3	0.3	0.8	-0.2	-0.3	0.9
High blood pressure (siblings)	0.3	0.4	0.6	0.0	0.8	-0.8
Number of full brothers	0.3	0.3	0.7	-0.4	-0.2	-0.8
Wheeze or whistling in the chest in last year	0.3	0.5	0.7	0.6	0.8	0.6
Age at first live birth	0.3	0.5	1.1	-0.6	-0.0	1.0
Medication: Omeprazole	0.3	0.3	0.5	0.7	0.5	-0.5
Knee pain experienced in last month	0.3	0.5	1.3	0.3	-0.2	1.1
Breast cancer (self-reported)	0.3	0.4	0.5	-0.7	-0.5	0.5
Number of self-reported non-cancer illnesses	0.3	0.6	1.0	-1.0	-0.7	0.4
Pain type(s) experienced in last month: Hip pain	0.3	0.3	0.9	1.0	0.3	0.0
Medication: Atorvastatin	0.3	0.3	0.5	0.4	0.6	0.7
Ever smoked	0.3	0.5	1.0	0.2	0.6	1.0
Average weekly beer plus cider intake	0.3	0.4	1.2	1.1	0.4	0.2
Ever depressed for a whole week	0.3	0.4	1.1	0.3	0.0	-1.0
Pain experienced in last month	0.3	0.5	0.9	-0.9	-0.7	-0.2
Ovarian Cancer	0.2	0.2	0.4	0.1	-0.6	0.6
Crohns Disease (2012)	0.2	0.3	0.6	0.8	0.3	-0.1
Fasting Glucose	0.2	0.2	0.4	0.3	0.6	0.5
Waist Hip Ratio (WHR)	0.2	1.0	2.8	1.7	0.2	-0.1
Hypothyroidism (self reported)	0.2	0.6	1.2	-0.0	0.7	-1.1
Hair Pigment	0.2	4.9	7.3	1.7	2.7	-2.1
Medication: Metformin	0.2	0.3	0.7	-0.1	0.5	0.9
Medication: Levothyroxine sodium	0.2	0.4	1.1	0.0	0.3	1.0
Hair/balding pattern: Pattern 2	0.2	0.3	0.7	-0.8	-0.1	0.3
Number of live births	0.2	0.3	0.5	-0.6	-0.3	0.7
Noisy workplace	0.2	0.2	0.3	-0.1	0.5	0.5
Exposure to tobacco smoke at home	0.2	0.3	0.5	0.7	0.2	-0.5
Glaucoma (self-reported)	0.2	0.3	0.4	-0.6	-0.4	0.4
Seen a psychiatrist for nerves, anxiety, tension or depression	0.2	0.3	0.3	-0.5	-0.5	0.5
Number of children fathered	0.2	0.2	0.4	-0.3	-0.6	0.3
Medication for pain relief, constipation, heartburn	0.2	0.3	0.9	-0.9	0.1	0.0
Medication: Blood pressure	0.2	0.3	0.7	0.5	0.0	0.8
Migraine (self-reported)	0.2	0.2	0.4	0.5	0.6	0.2
Heart disease (mother)	0.2	0.2	0.3	0.4	0.5	-0.4
Overall health rating	0.2	0.4	0.6	0.3	0.8	0.7
Medication: Aspirin	0.2	0.3	0.6	0.2	-0.8	0.4
Diabetes diagnosed by doctor	0.2	0.3	0.9	-0.9	-0.4	-0.1
Medication for cholesterol	0.2	0.3	0.6	-0.5	0.3	-0.8
Hearing aid user	0.2	0.2	0.3	0.2	0.5	0.5
Eye problems/disorders: Glaucoma	0.2	0.2	0.5	-0.7	-0.3	0.2
Myopia	0.2	0.3	0.5	-0.6	-0.7	-0.2
Supplements: Calcium	0.2	0.2	0.4	0.4	0.6	-0.2
Bipolar Disorder (2018)	0.1	0.2	0.3	-0.5	-0.3	-0.3
Bipolar Disorder or Schizophrenia	0.1	0.1	0.4	0.6	0.1	-0.1
Body Mass Index (BMI) (2010)	0.1	0.1	0.2	-0.2	0.0	0.5
Blood Platelet Count	0.1	1.0	1.5	-0.1	1.2	1.2
Type 2 Diabetes (T2D) (2018)	0.1	0.2	0.4	-0.6	-0.2	-0.4
Hand grip strength (right)	0.1	0.2	0.3	0.5	-0.6	0.4
Taking other prescription medications	0.1	0.1	0.2	-0.5	0.3	0.3
Diverticular disease/diverticulitis (self-reported)	0.1	0.2	0.2	-0.4	-0.5	0.3
Chronic bronchitis/emphysema (father)	0.1	0.1	0.2	-0.3	-0.5	0.0
Diabetes (self-reported)	0.1	0.2	0.3	-0.4	-0.3	0.5
Medication: Simvastatin	0.1	0.1	0.1	0.4	0.3	-0.1
Time employed in main current job	0.1	0.1	0.3	-0.6	-0.0	0.3
Worrier / anxious feelings	0.1	0.2	0.4	-0.2	-0.6	0.4
Mouth/teeth dental problems: Dentures	0.1	0.2	0.4	-0.1	-0.4	0.6
Depression (self-reported)	0.1	0.1	0.1	-0.2	-0.2	-0.4
Tense / ‘highly strung’	0.1	0.2	0.3	-0.3	-0.5	-0.5
Hypothyroidism/myxoedema (self-reported)	0.1	0.2	0.4	-0.2	0.6	0.2
Mouth/teeth dental problems: Loose teeth	0.1	0.2	0.2	0.4	-0.3	0.4
Commuting to job workplace: Car/motor vehicle	0.1	0.1	0.2	0.1	0.4	-0.2
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.1	0.1	0.1	-0.0	-0.4	0.3
Illnesses of siblings: Diabetes	0.1	0.1	0.1	-0.4	-0.2	0.1
Tinnitus: Yes, now most or all of the time	0.1	0.1	0.1	0.2	0.4	0.3
Commuting to job workplace: Public transport	0.1	0.2	0.3	-0.4	0.2	-0.5
Medication: Lisinopril	0.1	0.2	0.3	-0.2	-0.5	-0.5
Irritability	0.1	0.2	0.5	0.7	-0.0	0.5
Basal cell carcinoma (self-reported)	0.1	0.1	0.2	0.1	0.4	0.4
Rheumatoid Arthritis	0.0	0.0	0.0	-0.1	-0.1	0.1
Blood Eosinophil Count	0.0	0.0	0.1	0.2	0.0	-0.1
Lung FEV1/FVC ratio	0.0	0.2	0.2	-0.5	-0.4	-0.5
Hand grip strength (left)	0.0	0.1	0.2	0.3	-0.5	0.2
Ever had hysterectomy (womb removed)	0.0	0.0	0.1	-0.2	-0.0	-0.1
Falls in the last year	0.0	0.0	0.1	0.0	-0.0	0.3
Pulse rate	0.0	0.0	0.1	-0.1	-0.1	-0.2
Chest pain or discomfort	0.0	0.0	0.1	-0.2	0.0	-0.3
Medication: Blood pressure	0.0	0.1	0.2	0.5	0.1	0.0

Hub : Genes

SF3B14

Models

Trait associations