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chr18:20,082,830-21,863,589

Best TWAS P=1.77e-19 · Best GWAS P=7.3e-17 conditioned to 0.944

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
31	GTEx	Skin Sun Exposed Lower leg	NPC1	0.23	0.18	lasso	3	0.27	1.8e-22	-8.3	-9.0	1.8e-19	0.92	0.01	0.99	TRUE
29	GTEx	Skin Not Sun Exposed Suprapubic	NPC1	0.15	0.08	lasso	4	0.12	2.3e-07	-8.1	-8.9	3.9e-19	0.92	0.03	0.97	FALSE
26	GTEx	Nerve Tibial	NPC1	0.19	0.12	lasso	6	0.16	1.1e-11	8.2	-8.9	4.0e-19	0.85	0.02	0.98	FALSE
1	CommonMind	Brain Pre-frontal Cortex	C18orf8	0.26	0.35	lasso	6	0.40	1.9e-52	-8.1	-8.9	5.3e-19	0.87	0.03	0.97	FALSE
9	GTEx	Brain Caudate basal ganglia	C18orf8	0.15	0.16	enet	11	0.11	5.9e-04	-8.3	-8.8	9.6e-19	0.88	0.02	0.95	FALSE
3	GTEx	Adipose Subcutaneous	C18orf8	0.17	0.16	enet	13	0.16	2.6e-13	-8.1	-8.8	1.8e-18	0.90	0.03	0.97	FALSE
37	The Cancer Genome Atlas	Esophageal Carcinoma	NPC1	0.16	0.10	lasso	3	0.10	3.7e-04	8.2	-8.8	2.1e-18	0.77	0.02	0.81	FALSE
32	GTEx	Testis	C18orf8	0.12	0.07	lasso	6	0.08	1.9e-04	-8.1	-8.7	2.2e-18	0.88	0.03	0.92	FALSE
41	The Cancer Genome Atlas	Brain Lower Grade Glioma	NPC1	0.07	0.08	lasso	3	0.10	1.6e-11	8.1	-8.7	3.4e-18	0.80	0.04	0.96	FALSE
6	GTEx	Adipose Visceral Omentum	NPC1	0.20	0.19	lasso	3	0.17	2.9e-09	-8.3	-8.7	3.6e-18	0.99	0.01	0.99	FALSE
11	GTEx	Brain Cerebellum	C18orf8	0.23	0.18	enet	13	0.21	9.9e-07	-8.1	-8.7	3.7e-18	0.86	0.02	0.97	FALSE
16	GTEx	Breast Mammary Tissue	NPC1	0.27	0.13	enet	27	0.19	5.0e-10	-8.3	-8.7	4.2e-18	0.91	0.02	0.98	FALSE
10	GTEx	Brain Cerebellar Hemisphere	C18orf8	0.27	0.34	enet	19	0.34	1.3e-09	-8.1	-8.6	6.8e-18	0.93	0.02	0.98	FALSE
21	GTEx	Esophagus Muscularis	C18orf8	0.14	0.13	lasso	3	0.10	8.0e-07	8.2	-8.6	1.2e-17	0.71	0.03	0.97	FALSE
36	The Cancer Genome Atlas	Breast Invasive Carcinoma	NPC1	0.03	0.03	blup	69	0.04	2.9e-09	-8.2	-8.6	1.2e-17	0.86	0.03	0.97	FALSE
23	GTEx	Heart Left Ventricle	NPC1	0.19	0.15	enet	12	0.17	1.6e-09	-8.3	-8.5	2.8e-17	0.95	0.02	0.98	FALSE
25	GTEx	Nerve Tibial	C18orf8	0.16	0.07	enet	21	0.09	3.9e-07	-7.8	-8.4	4.3e-17	0.87	0.03	0.97	FALSE
4	GTEx	Adipose Subcutaneous	NPC1	0.27	0.27	enet	12	0.30	2.4e-25	-8.3	-8.4	4.6e-17	0.98	0.01	0.99	FALSE
39	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	NPC1	0.03	0.04	lasso	2	0.05	4.2e-06	-7.9	-8.4	5.9e-17	0.96	0.03	0.97	FALSE
30	GTEx	Skin Sun Exposed Lower leg	C18orf8	0.35	0.33	enet	23	0.36	1.7e-30	-8.3	-8.3	7.2e-17	0.91	0.02	0.98	FALSE
40	The Cancer Genome Atlas	Brain Lower Grade Glioma	C18orf8	0.07	0.05	lasso	5	0.03	9.5e-05	8.1	-8.3	9.4e-17	0.67	0.03	0.97	FALSE
8	GTEx	Artery Tibial	NPC1	0.26	0.07	enet	31	0.11	3.7e-09	8.1	-8.3	9.6e-17	0.80	0.03	0.97	FALSE
28	GTEx	Skin Not Sun Exposed Suprapubic	C18orf8	0.21	0.27	enet	6	0.23	6.9e-13	-8.3	-8.3	1.0e-16	0.94	0.02	0.98	FALSE
22	GTEx	Esophagus Muscularis	NPC1	0.11	0.07	enet	4	0.09	7.3e-06	-7.7	-8.3	1.5e-16	0.92	0.03	0.96	FALSE
13	GTEx	Brain Cortex	C18orf8	0.19	0.18	lasso	5	0.13	1.8e-04	-8.2	-8.2	1.9e-16	0.91	0.02	0.95	FALSE
17	GTEx	Breast Mammary Tissue (Female)	NPC1	0.43	0.24	lasso	3	0.27	1.1e-08	-7.8	-8.2	3.3e-16	0.96	0.03	0.97	FALSE
7	GTEx	Artery Tibial	C18orf8	0.18	0.12	lasso	3	0.10	1.5e-08	8.1	-8.1	4.9e-16	0.63	0.03	0.97	FALSE
43	The Cancer Genome Atlas	Prostate Adenocarcinoma	NPC1	0.05	0.02	blup	65	0.03	9.9e-04	-7.9	-8.0	1.5e-15	0.77	0.03	0.71	FALSE
14	GTEx	Brain Frontal Cortex BA9	C18orf8	0.42	0.30	enet	12	0.08	3.4e-03	-8.3	-8.0	1.7e-15	0.92	0.02	0.98	FALSE
35	METSIM	Adipose	NPC1	0.06	0.05	enet	18	0.05	6.4e-08	-8.2	-7.9	3.1e-15	0.82	0.03	0.97	FALSE
20	GTEx	Esophagus Mucosa	NPC1	0.09	0.04	lasso	3	0.05	1.5e-04	-8.3	-7.9	3.2e-15	0.97	0.02	0.96	FALSE
27	GTEx	Pancreas	NPC1	0.33	0.14	lasso	7	0.12	1.1e-05	-8.2	-7.9	3.4e-15	0.93	0.03	0.96	FALSE
44	The Cancer Genome Atlas	Thyroid Carcinoma	NPC1	0.04	0.03	blup	70	0.05	9.4e-06	-8.1	-7.9	3.5e-15	0.86	0.04	0.96	FALSE
33	GTEx	Thyroid	NPC1	0.20	0.10	enet	25	0.13	2.3e-10	-8.1	-7.9	4.0e-15	0.90	0.02	0.98	FALSE
2	CommonMind	Brain Pre-frontal Cortex	NPC1	0.08	0.07	lasso	3	0.08	5.2e-10	8.2	-7.8	6.5e-15	0.65	0.03	0.97	FALSE
24	GTEx	Lung	NPC1	0.11	0.06	enet	11	0.04	2.3e-04	-8.2	-7.7	1.8e-14	0.89	0.03	0.97	FALSE
12	GTEx	Brain Cerebellum	NPC1	0.20	0.10	enet	9	0.12	1.9e-04	-8.2	-7.7	1.9e-14	0.91	0.03	0.94	FALSE
38	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	NPC1	0.05	0.02	blup	66	0.03	1.4e-04	-7.9	-7.0	1.9e-12	0.81	0.03	0.92	FALSE
5	GTEx	Adipose Visceral Omentum	C18orf8	0.18	0.11	enet	10	0.04	4.5e-03	-7.7	-6.8	1.4e-11	0.83	0.03	0.97	FALSE
34	METSIM	Adipose	C18orf8	0.08	0.02	enet	23	0.04	1.0e-06	8.2	-6.5	7.4e-11	0.54	0.03	0.96	FALSE
15	GTEx	Brain Nucleus accumbens basal ganglia	TMEM241	0.17	0.02	lasso	6	-0.01	5.6e-01	-8.1	-6.3	2.9e-10	0.71	0.04	0.62	FALSE
42	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	NPC1	0.14	0.01	enet	14	0.08	3.3e-04	-7.9	-5.5	4.2e-08	0.67	0.03	0.77	FALSE
18	GTEx	Colon Transverse	NPC1	0.21	0.03	enet	23	0.05	3.0e-03	-4.1	-5.3	1.0e-07	0.52	0.06	0.67	FALSE
19	GTEx	Esophagus Gastroesophageal Junction	NPC1	0.19	0.13	lasso	5	0.11	1.1e-04	-4.2	-5.2	1.9e-07	0.68	0.08	0.84	FALSE