Hub : Genes

TMEM241

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Adipose Subcutaneous	0.067	0.0290	2.9e-03	-0.001	NA	0.011	NA	0.004	0.39000	NA	4.1e-02	NA	1.5e-01
2	GTEx	Brain Cortex	0.369	0.0900	3.1e-06	0.119	NA	0.215	NA	0.191	0.00036	NA	1.3e-06	NA	5.5e-06
3	GTEx	Brain Nucleus accumbens basal ganglia	0.170	0.0860	4.5e-03	0.020	NA	-0.011	NA	-0.007	0.09600	NA	9.0e-01	NA	5.6e-01
4	GTEx	Esophagus Mucosa	0.140	0.0510	1.7e-03	0.037	NA	0.051	NA	0.006	0.00160	NA	2.6e-04	NA	1.2e-01
5	GTEx	Nerve Tibial	0.160	0.0632	4.4e-04	0.045	NA	0.067	NA	0.066	0.00039	NA	1.8e-05	NA	2.1e-05

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5
Bipolar Disorder (2018)	0.8	1.2	2.0	1.2	0.2	0.8	1.3	1.4
Bipolar Disorder or Schizophrenia	0.2	0.6	1.8	-0.7	-0.2	-0.0	1.3	-0.7
Depressed Affect (Nagel 2018)	0.2	0.3	0.9	0.2	0.4	-0.9	-0.3	-0.7
Depression (Nagel 2018)	0.6	0.9	2.7	-0.5	-0.7	-1.7	0.7	-0.8
Intelligence (Savage-Jansen 2018)	1.1	3.5	6.0	1.7	1.6	2.5	0.8	2.3
Neuroticism (Nagel 2018)	1.3	3.1	5.2	-2.2	-1.6	-0.3	1.7	-2.3
Schizophrenia (2018)	0.8	1.8	4.4	-1.9	-0.5	-0.7	0.4	-2.1
Schizophrenia vs Biploar Disorder	3.3	4.4	9.5	-1.7	-1.0	-2.0	-2.1	-3.1
Worry (Nagel 2018)	3.8	8.1	17.8	-3.6	-2.4	-1.4	1.5	-4.2
Alzheimer’s Disease (in mother)	1.1	1.3	3.3	0.8	1.4	1.8	-0.8	0.2
Alzheimer’s Disease (in father)	1.0	1.1	2.8	-1.7	-1.0	0.5	1.0	-0.5
Alzheimer’s Disease (including proxy)	0.8	1.1	3.2	0.6	1.2	1.8	-0.8	-0.0
Crohns Disease (2017)	1.0	2.2	4.8	-1.6	-2.2	-1.3	1.0	-0.9
Irritable Bowel Disease (IBD)	1.2	2.9	5.5	-1.5	-2.3	-1.0	2.3	-0.3
Ulcerative Colitis (UC)	0.8	1.4	5.5	-0.4	-1.2	-0.2	2.3	0.2
Major Depression (MDD)	0.9	1.1	2.0	1.4	1.4	1.0	0.6	0.4
Reaction Time	0.6	1.2	3.0	-1.0	-0.4	-0.2	-1.7	-1.3
Verbal and Numeric Reasoning (VNR)	0.9	2.2	4.0	1.1	0.3	1.8	1.5	2.0
Breast Cancer	0.4	1.1	3.7	0.3	0.8	-0.2	-0.9	-1.9
Ovarian Cancer	1.1	1.5	3.5	1.5	1.0	0.5	0.7	1.9
Prostate Cancer	0.8	1.1	2.2	-1.0	-1.3	-0.8	-0.2	-1.5
Age at First Birth	1.2	1.8	3.5	1.2	1.7	0.8	-0.7	1.9
Bipolar Disorder (2011)	2.6	2.5	5.6	1.0	0.6	1.7	1.7	2.4
Body Mass Index (BMI) (2010)	2.7	3.6	5.2	-2.0	-2.0	-2.3	-1.4	-1.8
Coronary Artery Disease (CAD)	0.4	0.4	1.1	0.5	1.0	0.1	-0.8	0.3
Crohns Disease (2012)	0.1	0.2	0.7	-0.3	-0.8	-0.5	0.3	-0.1
Mean Putamen Volume	0.2	0.3	0.9	0.3	-0.4	-0.9	-0.4	0.1
Fasting Glucose	2.3	2.7	5.9	-1.9	-2.4	-1.3	-0.4	-1.6
HbA1C	0.7	0.8	1.3	-1.1	-0.9	-0.7	0.5	-1.0
HDL Cholesterol	6.3	10.6	16.9	3.8	3.5	2.4	-1.9	4.1
LDL Cholesterol	1.5	2.3	3.8	-1.5	-1.9	-1.6	-0.7	-1.6
Lupus	2.0	3.0	4.1	-1.3	-1.5	-1.8	-2.0	-2.0
Neuroticism (2016)	0.9	1.3	2.2	-1.5	-1.4	0.1	1.3	-0.8
Primary Biliary Cirrhosis	0.1	0.1	0.2	0.3	0.4	0.4	0.4	0.3
Rheumatoid Arthritis	3.6	5.0	10.9	-3.3	-1.9	-2.3	-0.1	-2.2
Schizophrenia (2014)	0.2	0.5	1.7	-0.8	0.2	-0.2	-0.4	-1.3
Triglycerides	2.3	3.7	7.7	-1.7	-1.5	-2.4	-0.0	-2.8
Type 2 Diabetes (T2D) (2012)	1.4	1.6	4.6	-1.1	-0.9	-2.1	0.3	-1.1
Ulcerative Colitis	1.0	1.5	3.6	0.5	0.5	1.6	1.9	0.9
Blood Eosinophil Count	0.2	1.3	3.4	-1.0	-0.4	-1.9	1.4	-0.4
Blood Platelet Count	0.8	8.9	33.7	-0.5	1.0	3.1	-0.2	5.8
Blood Red Count	0.0	0.5	1.1	-0.8	-0.5	-0.4	1.1	-0.4
Blood White Count	0.9	7.0	18.9	0.9	0.8	4.4	2.0	3.3
Heel T-Score	0.9	7.3	17.0	2.6	2.0	2.9	-0.3	4.1
BMI	5.3	30.7	47.6	-6.0	-6.8	-6.9	-0.2	-4.8
Height	6.3	121.7	295.8	-11.5	-9.3	-7.6	5.9	-17.2
Waist Hip Ratio (WHR)	3.7	16.6	26.6	-5.1	-3.6	-2.1	3.7	-5.2
Systolic Blood Pressure	0.9	4.6	8.8	-1.9	-1.3	-1.2	-3.0	-2.7
Smoking Status	1.9	4.6	14.7	-1.8	-1.7	1.1	3.8	0.8
Allergy or Eczema	1.3	3.3	8.3	-0.8	-1.5	-2.9	2.3	-0.0
Cardiovascular Disease	2.4	7.9	23.4	-1.4	-2.0	-4.8	-1.9	-2.6
Hypothyroidism (self reported)	1.2	2.7	4.3	-1.6	-1.9	-0.0	2.1	-1.7
Respiratory disease	0.6	1.3	3.1	-0.8	-0.6	-1.5	1.8	-0.1
Type 2 Diabetes (T2D) (2018)	2.7	5.0	11.7	-2.3	-1.7	-2.2	0.0	-3.4
Lung FEV1/FVC ratio	0.1	0.5	2.4	-0.4	-1.5	0.2	-0.4	0.0
Lung FVC	2.0	10.3	26.1	3.3	1.8	3.4	-0.1	5.1
Neuroticism	0.7	1.6	3.5	-1.4	-1.0	0.6	1.1	-1.9
Chronotype (morning person)	1.3	3.0	8.0	1.4	0.9	2.8	1.6	1.4
Hair Pigment	0.0	0.7	1.8	-0.0	-0.8	-1.4	0.6	-0.7
Tanning	0.1	1.1	3.3	-0.1	-0.2	1.5	0.2	1.8
Hand grip strength (left)	2.2	5.7	15.6	-2.3	-2.0	-0.9	1.6	-3.9
Number of treatments/medications taken	2.0	3.5	8.3	-1.3	-0.8	-2.6	-0.4	-2.9
Average weekly spirits intake	0.9	1.1	2.7	0.7	0.7	1.6	-0.5	1.2
Sensitivity / hurt feelings	1.0	1.7	3.2	-1.2	-1.7	-0.2	1.8	-0.8
Frequency of depressed mood in last 2 weeks	2.0	2.8	5.2	-1.8	-1.6	-1.2	1.2	-2.3
Hearing difficulty/problems: Yes	1.4	2.1	3.3	-1.8	-1.5	0.5	1.3	-1.8
Relative age of first facial hair	2.9	6.0	10.7	3.3	2.9	2.3	0.2	2.3
Other serious medical condition/disability diagnosed by doctor	0.7	0.9	1.9	-1.0	-1.1	-0.6	0.1	-1.4
Ever used hormone-replacement therapy (HRT)	0.7	0.9	2.3	0.1	0.1	1.2	1.5	0.8
Ever had hysterectomy (womb removed)	0.5	0.6	1.6	-0.9	-1.3	-0.4	0.3	-0.5
Systolic blood pressure, automated reading	0.6	1.7	3.8	-1.1	-2.0	-0.7	-0.6	-1.5
Eye problems/disorders: Diabetes related eye disease	1.4	1.6	4.7	-1.4	-0.8	-0.4	-0.6	-2.2
Angina	0.7	0.9	2.3	-0.1	-0.3	-1.4	-1.5	-0.2
Medication for hormone replacement therapy	1.4	1.5	4.4	-0.8	-0.4	-1.5	-0.3	-2.1
Vitamin and mineral supplements	1.9	2.6	6.6	-1.1	-2.6	-1.9	1.1	0.6
Supplements: Zinc	1.5	1.6	4.5	0.5	1.7	0.5	-2.1	0.5
Medication: Co-codamol	2.7	3.2	9.3	-1.4	-1.5	-1.5	0.2	-3.1
Medication: Metformin	2.2	3.1	6.7	-1.6	-1.2	-1.8	1.2	-2.6
Diabetes (father)	0.6	0.7	1.3	-0.2	-0.9	-1.2	-1.1	0.3
Diabetes (mother)	0.3	0.4	1.8	-0.4	-0.4	0.0	-1.3	-0.3
Severe depression (siblings)	1.2	1.3	1.9	-1.3	-1.4	-0.6	1.0	-1.2
Pack years adult smoking proportion	2.8	4.2	6.5	-2.6	-2.1	-2.5	-0.8	-1.8
Impedance of leg (right)	0.2	1.0	2.6	0.7	1.6	1.2	0.1	-0.4
Leg fat-free mass (left)	6.3	33.2	56.8	-5.9	-5.8	-6.2	1.7	-7.5
Trunk fat percentage	4.7	18.8	27.0	-4.6	-4.4	-5.1	-0.7	-5.2
Hand grip strength (right)	2.5	6.9	15.1	-2.4	-2.1	-1.0	2.9	-3.9
Townsend deprivation index at recruitment	0.9	1.2	3.3	0.4	1.3	1.8	0.6	-0.8
Current tobacco smoking	1.7	2.8	6.7	-2.6	-2.2	-0.3	0.9	-1.1
Average weekly fortified wine intake	0.9	1.0	2.3	1.2	1.0	-0.0	1.5	0.5
Maternal smoking around birth	0.4	0.6	1.8	-0.3	-0.3	-1.3	1.0	0.4
Fed-up feelings	0.5	0.9	1.8	-0.7	-0.8	-1.1	1.3	-0.6
Frequency of unenthusiasm / disinterest in last 2 weeks	1.6	2.1	2.9	-1.3	-1.7	-1.7	1.1	-1.4
Relative age voice broke	1.7	2.6	5.8	1.7	1.8	2.4	-0.9	0.7
Taking other prescription medications	2.6	4.0	8.2	-2.1	-1.3	-2.3	0.5	-2.9
Age when periods started (menarche)	1.0	2.3	3.8	1.9	1.4	1.9	1.2	1.1
Bilateral oophorectomy (both ovaries removed)	1.0	1.1	2.9	-0.6	-0.8	-0.7	-1.7	-1.2
Heel bone mineral density (BMD) T-score, automated (left)	0.4	0.9	3.8	-0.8	-0.0	0.3	-1.9	-0.4
Tinnitus: Yes, but not now, but have in the past	2.1	2.2	4.0	-1.2	-1.6	-0.7	-1.6	-2.0
Qualifications: CSEs or equivalent	2.4	3.2	6.4	-1.4	-0.7	-1.3	-2.3	-2.5
Serious illness, injury or assault to yourself	4.5	5.4	9.1	-2.9	-2.9	-1.1	0.4	-3.0
High blood pressure	1.3	3.6	8.3	-0.8	-1.5	-2.9	-1.3	-2.3
Hayfever, allergic rhinitis or eczema	2.2	4.7	9.0	-1.3	-1.9	-2.9	3.0	-0.9
Multivitamins +/- minerals	1.6	2.1	4.4	0.2	1.4	1.2	-2.1	-1.6
Stomach or abdominal pain in last month	0.7	0.8	2.3	-0.1	0.7	-0.8	-1.5	-0.9
Supplements: Glucosamine	0.1	0.2	0.4	0.4	0.7	0.5	-0.1	0.3
Diverticular disease/diverticulitis (self-reported)	0.4	0.5	0.9	-0.6	-0.7	0.2	0.9	-0.9
Medication: Atenolol	1.6	2.0	5.6	0.3	-1.0	-2.4	-1.8	0.3
Medication: Levothyroxine sodium	1.2	2.1	4.5	-1.4	-0.9	-0.1	2.1	-1.8
Sitting height	1.6	11.5	23.1	-3.5	-2.9	-3.5	1.2	-4.8
Chronic bronchitis/emphysema (father)	0.4	0.5	1.7	-0.6	-0.5	-0.4	0.1	-1.3
High blood pressure (mother)	1.8	2.6	8.6	-0.3	-1.4	-2.9	-0.9	-1.1
Body mass index (BMI)	3.7	15.6	26.6	-3.7	-4.6	-5.2	0.2	-4.0
Impedance of leg (left)	0.1	0.6	1.5	0.3	1.2	1.2	0.2	-0.4
Leg predicted mass (left)	6.2	32.9	56.7	-5.8	-5.8	-6.1	1.7	-7.5
Trunk fat mass	8.1	34.6	53.7	-6.1	-6.2	-6.6	0.2	-7.3
Waist circumference	10.4	38.1	58.2	-6.5	-6.5	-6.7	1.9	-7.6
Number of incorrect matches in round	1.4	2.4	4.5	-1.6	-1.7	-0.8	1.1	-2.1
Past tobacco smoking	2.7	5.0	20.9	-0.2	0.0	-1.5	-4.6	-1.3
Alcohol usually taken with meals	0.7	1.1	5.2	0.1	-0.3	0.1	2.3	0.3
Nervous feelings	1.9	3.5	5.9	-2.4	-1.8	-0.8	1.5	-2.4
Frequency of tenseness / restlessness in last 2 weeks	2.2	3.4	5.8	-2.1	-1.7	-1.0	2.4	-1.6
Hearing difficulty/problems with background noise	1.6	2.6	6.4	-1.6	-1.1	1.0	2.5	-1.3
Hair/balding pattern: Pattern 2	1.3	1.6	3.3	-1.6	-1.0	-1.0	0.6	-1.8
Had menopause	0.5	0.7	2.2	0.3	0.6	1.5	0.8	0.1
Had other major operations	2.2	2.7	4.8	-2.2	-1.7	-1.8	-0.9	-1.2
Forced vital capacity (FVC)	0.2	0.7	2.6	0.2	-0.3	0.8	1.6	-0.0
Heel bone mineral density (BMD) T-score, automated (right)	0.3	0.6	1.8	-0.9	-0.6	0.1	-1.4	0.0
Ever unenthusiastic/disinterested for a whole week	0.1	0.2	0.5	0.2	0.4	-0.1	0.7	-0.4
Qualifications: None of the above	1.6	3.3	8.9	-1.3	-2.0	-3.0	-0.4	-1.3
Financial difficulties in last 2 years	0.4	0.5	0.9	-0.9	-0.6	0.2	0.7	-1.0
Mouth/teeth dental problems	1.3	2.0	6.1	2.5	1.8	-0.0	0.2	1.0
Heart attack	2.7	3.5	9.2	-1.3	-2.0	-3.0	-1.2	-1.2
Allergy	1.6	3.8	7.3	1.5	1.6	2.4	-2.7	0.8
Pain all over the body in last month	1.7	1.9	3.3	-1.3	-1.8	-1.1	1.5	-1.0
Diabetes (self-reported)	2.2	3.5	9.2	-1.7	-1.6	-1.3	0.9	-3.0
Hayfever/allergic rhinitis (self-reported)	1.3	1.8	5.4	-1.0	-0.9	-2.3	-0.7	-1.1
Medication: Ramipril	0.6	0.8	1.9	0.2	-0.5	-1.4	-0.9	-0.9
Medication: Simvastatin	1.0	1.5	2.7	1.5	1.6	-0.5	-1.6	0.1
Fluid intelligence score	0.6	1.2	4.4	0.6	0.0	2.1	0.9	0.7
Illnesses of siblings	3.3	4.6	8.5	2.1	2.0	2.9	1.0	2.2
Neuroticism score	0.9	1.8	3.2	-1.8	-1.3	0.4	1.1	-1.7
Weight	9.2	45.1	76.0	-6.7	-6.8	-7.4	1.4	-8.7
Impedance of arm (right)	2.0	9.1	12.8	2.2	3.6	3.5	-2.2	3.4
Arm fat percentage (right)	3.0	11.8	18.7	-3.6	-4.1	-4.3	-0.7	-3.2
Trunk fat-free mass	8.6	49.2	94.7	-6.8	-7.0	-6.7	3.4	-9.7
Hip circumference	6.9	29.9	55.7	-5.0	-5.4	-7.5	0.7	-6.3
Time employed in main current job	0.6	0.7	1.6	-0.6	0.4	-0.5	-1.3	-1.1
Alcohol intake versus 10 years previously	2.3	3.4	12.5	-0.6	-1.1	-3.5	-0.3	-1.7
Father’s age at death	4.5	6.0	13.7	2.6	2.3	2.1	0.0	3.7
Worrier / anxious feelings	1.5	2.8	7.1	-2.2	-1.1	-0.0	0.6	-2.7
Frequency of tiredness / lethargy in last 2 weeks	0.4	0.7	2.3	-0.3	0.1	0.2	-0.9	-1.5
Falls in the last year	3.2	4.4	8.3	-2.5	-2.0	0.5	2.9	-1.8
Hair/balding pattern: Pattern 3	1.4	2.1	4.9	0.6	1.0	2.2	0.3	2.0
Number of live births	0.5	0.6	1.2	1.0	1.1	0.9	0.3	0.3
Forced expiratory volume in 1-second (FEV1)	0.1	0.3	0.5	0.7	-0.4	0.6	0.6	0.1
Pulse rate	0.3	0.5	0.7	0.7	0.9	-0.8	-0.8	0.4
Happiness	1.6	1.9	5.1	0.4	0.7	2.3	1.7	1.0
Noisy workplace	2.3	2.8	6.0	1.5	2.5	0.7	-1.8	1.5
Qualifications: A levels/AS levels or equivalent	1.8	4.0	9.5	1.9	1.7	1.8	0.6	3.1
Serious illness, injury or assault of a close relative in last 2 years	5.9	6.7	13.5	-2.7	-2.6	-1.4	2.0	-3.7
Mouth/teeth dental problems: Dentures	0.7	1.1	2.2	-1.1	-0.4	0.6	-1.5	-1.3
Asthma	0.3	0.7	2.7	-0.5	0.6	-0.0	1.6	0.1
Medication: Ibuprofen (e.g. Nurofen)	0.5	0.6	1.4	0.1	0.7	-1.2	-1.2	0.2
Medication: Cholesterol lowering	0.9	1.5	3.5	1.3	0.9	-1.1	-1.9	0.2
Depression (self-reported)	0.3	0.3	1.1	0.6	0.0	0.3	1.0	-0.0
Medication: Lansoprazole	0.5	0.6	1.1	-0.7	-0.6	-1.0	0.1	-1.1
Prospective memory result	2.3	2.8	7.4	-0.2	0.1	-2.7	2.3	-1.2
Lung cancer (father)	0.5	0.5	2.2	0.4	-0.6	-1.5	0.0	-0.1
Illnesses of mother	0.5	0.6	1.7	-0.1	0.7	0.9	1.3	0.3
Forced expiratory volume in 1-second (FEV1), Best measure	0.1	0.4	1.0	0.4	-0.7	0.1	1.0	0.0
Pulse wave Arterial Stiffness index	0.4	0.5	1.0	0.5	-0.3	-1.0	1.0	0.3
Impedance of arm (left)	2.1	9.9	16.2	2.6	4.0	3.6	-2.0	3.1
Arm fat mass (right)	7.0	28.7	39.4	-5.5	-6.0	-6.3	0.5	-6.1
Trunk predicted mass	8.5	48.4	92.7	-6.8	-6.9	-6.7	3.3	-9.6
Standing height	5.0	49.7	123.2	-7.3	-5.6	-5.6	2.9	-11.1
Length of working week for main job	0.3	0.3	0.5	-0.5	-0.7	-0.5	0.7	-0.3
Exposure to tobacco smoke at home	1.3	1.5	3.6	-0.7	-1.1	-1.1	1.0	-1.9
Breastfed as a baby	0.8	1.0	2.3	0.7	0.3	1.2	1.5	0.8
Tense / ‘highly strung’	1.1	1.8	4.2	-1.8	-1.1	-0.3	0.7	-2.0
Seen doctor (GP) for nerves, anxiety, tension or depression	0.4	0.6	1.2	-0.7	-0.7	-0.4	0.8	-1.1
Hair/balding pattern: Pattern 4	0.9	2.1	5.5	0.9	1.5	1.0	-2.3	1.1
Birth weight of first child	0.4	0.8	2.4	0.8	-0.2	-0.7	0.5	1.5
Peak expiratory flow (PEF)	0.1	0.2	0.5	0.7	-0.2	0.1	0.6	-0.4
Pulse wave reflection index	1.3	1.5	2.5	1.3	1.3	0.9	1.1	1.6
Ever highly irritable/argumentative for 2 days	0.5	0.6	2.0	-0.7	-0.8	-0.1	1.4	-0.0
Loud music exposure frequency	0.4	0.4	2.0	-0.1	-0.2	-0.1	-1.4	0.0
Qualifications: O levels/GCSEs or equivalent	0.3	0.5	1.8	-1.4	-0.1	-0.2	0.2	-0.7
Mouth/teeth dental problems: Bleeding gums	1.5	1.9	5.5	-1.8	-2.3	-0.4	0.8	0.1
Blood clot in the leg (DVT)	1.2	1.5	2.1	-1.4	-1.4	-1.2	-0.7	-1.3
Medication: Paracetamol	0.5	0.9	1.9	-1.4	-0.7	-0.5	-0.1	-1.3
Headache pain in last month	0.9	1.5	4.3	-0.8	0.5	-1.3	-2.1	-0.8
Medication for cholesterol, blood pressure or diabetes	1.2	2.0	4.8	-1.1	-0.5	1.9	2.2	0.2
Glaucoma (self-reported)	0.7	0.8	2.8	-0.7	-0.0	-0.5	0.6	-1.7
Gout (self-reported)	0.8	1.1	4.3	0.9	0.3	0.2	-2.1	-0.5
Hypothyroidism/myxoedema (self-reported)	0.9	1.8	4.2	-1.3	-1.2	0.2	2.0	-1.3
Medication: Amlodipine	0.9	1.2	2.9	0.7	1.3	0.5	-1.7	-0.9
Medication: Ventolin 100micrograms inhaler	1.7	2.2	5.0	-2.2	-1.0	-1.1	-0.3	-1.9
Birth weight	0.2	0.5	1.2	0.2	0.2	-0.9	0.6	-1.1
Chronic bronchitis/emphysema (mother)	0.3	0.4	1.5	0.3	0.0	1.2	0.4	0.3
High blood pressure (siblings)	2.0	2.8	5.7	-1.1	-1.5	-2.4	-1.6	-1.6
Forced vital capacity (FVC), Best measure	0.3	0.9	3.6	-0.3	-0.9	0.2	1.9	-0.4
Body fat percentage	5.5	21.8	31.6	-4.8	-5.1	-5.6	-0.4	-5.3
Leg fat percentage (right)	5.4	19.7	34.5	-4.0	-4.8	-5.9	0.5	-4.9
Arm fat-free mass (right)	9.8	50.1	97.0	-7.0	-7.0	-7.0	2.6	-9.8
Exposure to tobacco smoke outside home	1.6	2.2	3.5	-1.3	-0.8	-1.3	-1.8	-1.9
Comparative body size at age 10	1.8	5.0	8.0	-1.8	-2.7	-2.8	-1.2	-2.3
Number of full brothers	1.0	1.3	4.0	-1.3	-0.7	-0.5	-0.1	-2.0
Worry too long after embarrassment	5.2	8.7	13.4	-3.7	-3.5	0.6	3.3	-2.5
Seen a psychiatrist for nerves, anxiety, tension or depression	0.5	0.7	1.0	0.7	0.8	-1.0	0.6	-0.9
Wheeze or whistling in the chest in last year	2.6	4.6	7.3	-2.6	-1.5	-2.2	1.2	-2.7
Number of children fathered	0.6	0.7	3.0	-0.5	-0.3	1.7	0.3	-0.1
Reason for reducing amount of alcohol drunk: Health precaution	0.6	0.7	1.4	0.0	-1.0	1.0	1.2	0.2
Age at first live birth	1.7	3.1	6.3	1.7	2.5	1.9	0.0	1.6
Pulse wave peak to peak time	0.5	0.6	1.2	-1.1	-0.3	0.6	-0.6	-1.0
Health satisfaction	0.2	0.2	0.4	-0.0	-0.2	-0.6	-0.7	-0.6
Shortness of breath walking on level ground	2.7	3.2	11.1	0.0	-0.3	-3.3	-1.7	-1.4
Qualifications: College or University degree	2.4	7.7	15.5	1.8	2.0	3.9	2.2	3.3
Eye problems/disorders: None of the above	0.4	0.4	1.3	-0.2	-0.3	1.1	0.7	0.4
Mouth/teeth dental problems: Loose teeth	1.8	2.1	4.1	-2.0	-1.3	-0.9	-0.0	-2.0
Emphysema/chronic bronchitis	1.0	1.1	3.5	-0.7	-1.0	-1.9	-0.2	-0.6
Medication for pain relief, constipation, heartburn	2.2	3.7	6.2	2.0	1.2	2.3	1.2	2.5
Neck or shoulder pain in last month	0.8	1.1	2.1	-1.5	-1.4	-0.9	-0.2	-0.8
Medication: Blood pressure	1.1	1.9	5.3	0.4	0.2	-1.4	-2.3	-1.4
Angina (self-reported)	1.0	1.3	3.2	-0.4	-0.6	-1.8	-1.6	-0.5
Migraine (self-reported)	0.4	0.4	1.1	0.2	1.1	-1.0	0.2	-0.2
Medication: Ibuprofen	0.6	0.7	2.3	-0.8	0.0	-1.5	-0.8	-0.2
Medication: Allopurinol	0.7	0.9	3.1	1.2	-0.2	-0.4	-1.7	0.0
Medication: Omeprazole	2.0	2.4	4.3	-1.4	-1.2	-2.1	0.9	-1.8
Medication: Seretide 50 evohaler	0.8	0.9	3.8	-0.5	0.3	0.5	1.9	0.4
Mean time to correctly identify matches	0.3	0.6	2.0	-0.6	-0.0	0.7	-0.6	-1.4
Heart disease (mother)	1.9	2.3	3.5	-1.5	-1.6	0.1	1.9	-1.7
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.6	0.8	2.9	0.1	-0.6	-0.6	1.7	0.5
Whole body fat mass	9.0	37.4	55.6	-6.3	-6.5	-7.0	0.7	-7.5
Leg fat mass (right)	8.1	31.3	46.5	-5.4	-6.1	-6.8	1.0	-6.5
Arm predicted mass (right)	9.9	50.4	93.9	-6.9	-7.0	-7.3	2.7	-9.7
Pulse rate, automated reading	0.7	2.3	3.7	-1.6	-1.1	-0.8	1.8	-1.9
Alcohol intake frequency.	7.8	18.1	39.7	-3.6	-3.9	-6.3	-2.0	-4.3
Comparative height size at age 10	8.2	45.2	99.6	-7.4	-6.3	-5.3	2.0	-10.0
Number of full sisters	2.1	2.5	4.8	-1.6	-1.4	-2.2	-0.7	-1.7
Suffer from ‘nerves’	1.5	2.4	7.2	-1.9	-0.9	-0.5	0.0	-2.7
Overall health rating	3.9	8.3	20.2	-2.9	-2.0	-2.8	-1.0	-4.5
Chest pain or discomfort	2.3	3.3	7.0	-1.4	-0.6	-2.5	-0.8	-2.7
Had major operations	0.9	1.1	3.0	-0.8	-0.8	-0.5	-1.7	-1.0
Age at last live birth	3.8	5.6	14.1	2.6	3.8	2.2	-1.0	1.1
Family relationship satisfaction	1.0	1.2	2.8	0.1	0.4	1.7	1.7	0.5
Leg pain on walking	0.6	0.8	2.8	-0.7	-0.7	-1.7	0.3	0.1
Qualifications: NVQ or HND or HNC or equivalent	0.6	0.8	3.1	0.3	0.5	0.7	-1.8	-0.2
Commuting to job workplace: Car/motor vehicle	1.0	1.2	2.8	-0.9	-1.5	-1.7	-0.1	0.2
Illness, injury, bereavement, stress in last 2 years	4.6	5.6	8.2	2.5	2.9	2.3	-0.7	2.9
Medication: Aspirin	1.1	1.4	2.7	-1.3	-1.2	-1.0	-0.6	-1.6
Supplements: Vitamin C	3.2	3.8	8.9	1.6	3.0	2.3	-0.8	1.2
Knee pain experienced in last month	0.8	1.2	2.8	-0.6	-1.1	-1.7	0.4	-1.3
Hypertension (Self-reported)	1.3	3.7	10.4	-0.6	-1.5	-3.2	-1.1	-2.0
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.8	1.0	3.8	-0.7	0.0	-0.0	1.9	-0.7
Illnesses of father: Heart disease	2.9	4.0	7.3	-2.7	-2.2	-1.4	-0.6	-2.3
Illnesses of siblings: Diabetes	0.1	0.2	0.6	-0.1	-0.3	-0.7	-0.1	0.5
Smoking status: Previous	3.1	4.6	18.8	0.6	0.2	1.4	4.3	1.4
Forced expiratory volume in 1-second (FEV1), predicted	5.2	10.9	30.4	-3.5	-1.9	-2.7	0.9	-5.5
Whole body fat-free mass	8.1	46.6	85.9	-6.8	-6.9	-6.8	2.7	-9.3
Leg fat-free mass (right)	5.6	29.8	51.1	-5.7	-5.6	-5.6	1.5	-7.2
Arm fat percentage (left)	3.0	12.0	20.4	-3.4	-4.0	-4.5	-0.7	-3.4
Average weekly red wine intake	7.9	11.7	20.0	3.2	2.1	4.5	3.9	3.0
Handedness (chirality/laterality): Left-handed	0.3	0.3	1.2	1.1	-0.1	-0.3	0.5	0.3
Mood swings	0.2	0.4	0.7	0.0	0.8	-0.5	-0.9	-0.4
Loneliness, isolation	0.3	0.4	1.1	1.0	0.8	-0.0	-0.4	-0.0
Long-standing illness, disability or infirmity	3.1	4.7	8.3	-2.9	-2.3	-1.8	0.7	-2.5
Ever had bowel cancer screening	0.8	0.9	1.6	-0.6	-1.3	0.9	1.0	-0.9
Diabetes diagnosed by doctor	2.4	4.0	10.6	-2.2	-1.7	-1.3	0.4	-3.3
Ever had stillbirth, spontaneous miscarriage or termination	1.0	1.1	2.6	-1.2	-0.8	-0.6	-1.6	-0.6
Friendships satisfaction	3.6	4.5	12.0	1.3	1.8	3.5	1.2	2.0
Qualifications: nursing, teaching	0.2	0.4	1.5	0.0	-0.3	0.3	0.4	1.2
Commuting to job workplace: Walk	1.1	1.2	1.8	1.3	0.9	1.4	0.0	1.2
Eye problems/disorders: Cataract	0.8	0.9	1.3	1.1	1.1	-0.8	-1.0	0.7
Mouth/teeth dental problems: Mouth ulcers	0.3	0.5	1.1	-1.0	-0.8	-0.6	0.4	0.4
Medication for cholesterol	1.7	2.6	6.2	1.0	1.6	1.6	0.6	2.5
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.8	2.1	3.6	-1.6	-1.9	-1.7	-0.3	-1.3
Back pain experienced in last month	2.8	4.1	7.3	-2.7	-1.9	-1.9	-0.8	-2.3
Mineral and other dietary supplements	1.0	1.3	2.3	-1.4	-1.5	-1.3	0.3	-0.5
Breast cancer (self-reported)	0.4	0.4	0.9	1.0	0.7	-0.1	-0.8	0.4
Asthma (self-reported)	0.4	0.7	3.0	-0.6	0.5	-0.2	1.7	0.0
Osteoporosis (self-reported)	0.6	0.8	3.4	0.2	0.6	1.9	-0.3	0.2
Osteoarthritis (self-reported)	7.0	9.0	13.7	-3.2	-3.3	-3.7	1.1	-3.0
Medication: Aspirin	0.9	1.2	1.8	-1.4	-1.2	-0.9	-0.6	-1.3
Medication: Gliclazide	3.3	3.7	6.3	-2.3	-1.9	-1.7	0.6	-2.5
Illnesses of father: None of the above (group 1)	1.2	1.4	2.9	1.2	1.5	1.7	0.4	0.5
Smoking status: Current	1.3	2.0	5.1	-2.3	-1.8	0.1	1.0	-0.8
Forced expiratory volume in 1-second (FEV1), predicted percentage	1.9	4.1	9.6	2.3	1.0	2.1	0.5	3.1
Whole body water mass	8.1	46.4	85.0	-6.8	-6.8	-6.8	2.7	-9.2
Leg predicted mass (right)	5.6	29.9	50.6	-5.8	-5.6	-5.6	1.6	-7.1
Arm fat mass (left)	6.4	26.2	37.9	-5.1	-5.6	-6.2	0.5	-6.0
Number of self-reported non-cancer illnesses	2.3	4.0	11.8	-1.2	-1.5	-3.4	0.3	-2.2
Average weekly champagne plus white wine intake	1.2	1.6	3.9	0.8	0.9	1.6	2.0	0.5
Miserableness	0.1	0.2	0.6	0.2	0.6	0.8	-0.5	-0.1
Guilty feelings	1.6	2.4	6.9	-0.8	-0.0	2.6	2.1	-0.3
Wears glasses or contact lenses	1.6	1.8	5.8	0.5	0.8	1.4	2.4	0.7
Ever taken oral contraceptive pill	1.3	1.4	2.1	1.1	1.5	1.1	-1.4	0.9
Hearing aid user	1.5	1.7	2.5	1.5	0.8	-1.4	-1.6	1.0
Mother’s age at death	0.3	0.3	1.1	0.6	0.5	0.0	-0.1	1.1
Financial situation satisfaction	0.8	1.0	2.9	0.3	0.5	1.3	1.7	0.3
Tinnitus: Yes, now most or all of the time	3.5	4.1	13.9	-1.4	-2.0	0.7	3.7	-0.0
Commuting to job workplace: Public transport	0.2	0.3	1.1	0.3	0.5	1.0	0.3	-0.2
Eye problems/disorders: Glaucoma	0.4	0.5	0.8	-0.6	0.7	0.1	0.9	-0.9
Medication: Blood pressure	2.2	4.2	7.6	-1.5	-2.1	-2.5	0.4	-2.8
Pain type(s) experienced in last month: Hip pain	2.0	2.5	6.8	-1.0	-1.3	-1.7	0.1	-2.6
Supplements: Fish oil (including cod liver oil)	0.3	0.4	1.2	0.6	0.4	-0.0	1.1	-0.4
High cholesterol (Self-reported)	0.5	0.9	2.4	-0.4	-1.1	-1.5	-0.0	-0.9
Medication: Bendroflumethiazide	0.8	1.2	3.9	0.7	0.0	-2.0	-0.5	-1.1
Medication: Paracetamol	0.7	1.0	2.2	-1.5	-0.9	-0.4	0.4	-1.4
Medication: Lisinopril	0.3	0.4	1.0	1.0	-0.2	-0.8	0.4	0.4
Medication: Atorvastatin	1.5	1.9	5.2	-1.3	-2.3	-0.9	0.2	-1.2
Illnesses of father: High blood pressure	1.8	2.2	6.6	-0.6	-0.8	-2.6	-1.4	-1.3
Alcohol drinker status: Never	2.4	2.9	5.6	-1.5	-2.4	-2.0	-0.5	-1.5
Ever smoked	2.0	3.6	13.2	0.1	-0.3	1.6	3.6	1.5
Basal metabolic rate	9.0	49.9	90.6	-7.1	-7.1	-7.1	2.5	-9.5
Leg fat percentage (left)	5.5	19.8	33.3	-4.2	-5.0	-5.8	0.6	-4.8
Arm fat-free mass (left)	10.5	53.5	93.9	-7.5	-7.5	-7.2	2.8	-9.7
Number of operations (self-reported)	1.1	1.6	3.2	-1.8	-1.6	-0.8	-0.5	-1.2
Average weekly beer plus cider intake	0.6	0.9	1.9	-0.9	-1.1	-1.4	0.8	0.3
Irritability	0.7	1.3	5.1	0.5	0.6	2.3	0.2	0.7
Risk taking	1.6	2.3	8.5	-0.3	-1.0	0.7	2.9	1.1
Ever had prostate specific antigen (PSA) test	1.3	1.5	4.2	0.3	-0.8	0.5	2.1	1.6
Fractured/broken bones in last 5 years	1.8	2.3	3.4	-1.4	-1.9	-1.1	1.7	-1.3
Age started oral contraceptive pill	2.8	3.5	5.1	2.2	1.3	2.1	1.1	2.3
Diastolic blood pressure, automated reading	3.3	10.1	20.0	-3.4	-3.3	-2.8	-0.7	-4.5
Ever depressed for a whole week	0.7	0.9	2.3	-0.1	0.2	1.4	1.5	-0.3
Unable to work because of sickness or disability	0.9	1.2	2.7	-0.8	-0.1	-1.4	-0.7	-1.6
Commuting to job workplace: Cycle	0.7	0.9	2.8	0.9	0.1	0.2	1.7	0.8
Myopia	1.0	1.5	5.0	-0.0	-0.6	1.1	2.2	1.0
Vascular/heart problems diagnosed by doctor	1.2	3.4	8.8	0.2	0.9	3.0	1.9	1.9
Cholesterol lowering medication	0.3	0.5	1.7	-0.6	-1.3	-0.1	0.0	-0.7
Medication: Omeprazole (e.g. Zanprol)	1.9	2.3	3.2	-1.6	-1.3	-1.7	1.0	-1.8
Pain experienced in last month	1.5	2.4	5.0	1.3	1.3	2.2	1.3	1.4
Supplements: Calcium	0.6	0.7	1.7	-0.6	-0.3	0.3	-1.3	-1.0
Basal cell carcinoma (self-reported)	1.5	1.8	3.1	1.7	1.8	0.3	-1.8	0.4
Heart attack/myocardial infarction (self-reported)	2.4	3.0	8.6	-1.1	-1.8	-2.9	-1.1	-0.9
Deep venous thrombosis (DVT) (self-reported)	1.5	2.0	3.6	-1.6	-1.9	-1.4	-0.2	-1.2
Heart disease (siblings)	2.6	3.2	5.1	-1.9	-1.8	-1.9	0.6	-2.3
Alcohol drinker status: Previous	1.3	1.5	2.7	-1.5	-0.0	-1.6	0.3	-1.6
Pack years of smoking	2.4	3.6	6.0	-2.3	-2.1	-2.5	-0.5	-1.4
Impedance of whole body	1.0	5.1	9.7	1.6	3.1	2.8	-1.5	1.7
Leg fat mass (left)	8.2	32.0	46.2	-5.6	-6.2	-6.8	1.1	-6.6
Arm predicted mass (left)	9.4	48.0	87.9	-6.9	-7.0	-7.0	2.7	-9.4