Best TWAS P=1.07e-08 · Best GWAS P=1.11e-08 conditioned to 1
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | FADS1 | 0.14 | 0.16 | lasso | 2 | 0.16 | 7.2e-19 | 5.7 | -5.7 | 1.5e-08 | -0.97 | 0.01 | 0.99 | FALSE |
| 2 | CommonMind | Brain Pre-frontal Cortex | FEN1 | 0.07 | 0.06 | lasso | 4 | 0.06 | 1.1e-07 | 5.7 | 5.7 | 1.5e-08 | 0.97 | 0.01 | 0.99 | FALSE |
| 3 | GTEx | Artery Tibial | TMEM258 | 0.08 | 0.05 | lasso | 5 | 0.02 | 1.1e-02 | 5.7 | 5.7 | 1.1e-08 | 0.98 | 0.01 | 0.99 | TRUE |
| 4 | NTR | Blood | C11orf10 | 0.06 | 0.08 | bslmm | 399 | 0.08 | 1.3e-24 | 5.5 | 5.5 | 5.1e-08 | 0.91 | 0.02 | 0.98 | FALSE |
| 5 | ROSMAP | Brain Pre-frontal Cortex | TMEM258 | 0.14 | 0.16 | lasso | 4 | 0.15 | 4.7e-19 | 5.5 | 5.5 | 3.3e-08 | 0.93 | 0.02 | 0.98 | FALSE |
| 6 | ROSMAP | Brain Pre-frontal Cortex | FADS1 | 0.08 | 0.08 | enet | 10 | 0.09 | 1.5e-11 | 5.7 | -5.4 | 8.4e-08 | -0.96 | 0.01 | 0.99 | FALSE |
| 7 | The Cancer Genome Atlas | Thyroid Carcinoma | C11orf10 | 0.02 | 0.02 | blup | 44 | 0.02 | 1.8e-03 | 5.0 | 5.4 | 7.6e-08 | 0.95 | 0.02 | 0.73 | FALSE |