Hub : Traits :

Average weekly champagne plus white wine intake

11 significantly associated models · 8 unique genes.

Significant Loci

# chr p0 p1 # assoc genes # joint genes best TWAS P best SNP P cond SNP P % var exp joint genes
1 11 60839578 62290719 4 1 1.1e-08 1.1e-08 1.000 100 TMEM258
2 17 42884538 43913030 2 1 2.7e-07 1.3e-06 1.000 100 LRRC37A4P
3 17 44788310 45597098 1 1 2.4e-07 6.5e-08 0.089 90 WNT3

Pleiotropic Associations

Trait chisq ratio # genes+ # genes++ % genes++ corr corr P genes
Bipolar Disorder (2018) 4.85 1 0 0.0 0 1 TMEM258
Bipolar Disorder or Schizophrenia 2.73 1 0 0.0 0 1 TMEM258
Depressed Affect (Nagel 2018) 24.22 2 2 4.4 0 1 LRRC37A4P WNT3
Depression (Nagel 2018) 6.19 2 0 0.0 0 1 LRRC37A4P WNT3
Intelligence (Savage-Jansen 2018) 6.64 3 0 0.0 0 1 LRRC37A4P TMEM258 WNT3
Neuroticism (Nagel 2018) 27.31 2 2 4.4 0 1 LRRC37A4P WNT3
Schizophrenia (2018) 2.69 1 0 0.0 0 1 WNT3
Schizophrenia vs Biploar Disorder 8.95 3 0 0.0 0 1 LRRC37A4P TMEM258 WNT3
Worry (Nagel 2018) 14.24 2 2 4.4 0 1 LRRC37A4P WNT3
Crohns Disease (2017) 5.34 1 0 0.0 0 1 TMEM258
Irritable Bowel Disease (IBD) 3.39 1 0 0.0 0 1 TMEM258
Verbal and Numeric Reasoning (VNR) 7.12 3 0 0.0 0 1 LRRC37A4P TMEM258 WNT3
Breast Cancer 8.25 2 1 2.2 0 1 LRRC37A4P WNT3
Ovarian Cancer 23.37 2 2 4.4 0 1 LRRC37A4P WNT3
Bipolar Disorder (2011) 4.72 1 0 0.0 0 1 TMEM258
Crohns Disease (2012) 9.89 3 0 0.0 0 1 LRRC37A4P TMEM258 WNT3
Mean Putamen Volume 7.43 2 0 0.0 0 1 LRRC37A4P WNT3
Fasting Glucose 11.61 1 1 2.2 0 1 TMEM258
HDL Cholesterol 19.59 1 1 2.2 0 1 TMEM258
LDL Cholesterol 21.92 1 1 2.2 0 1 TMEM258
Lupus 5.07 1 0 0.0 0 1 LRRC37A4P
Neuroticism (2016) 10.86 2 1 2.2 0 1 LRRC37A4P WNT3
Primary Biliary Cirrhosis 8.38 2 0 0.0 0 1 LRRC37A4P WNT3
Schizophrenia (2014) 4.60 2 0 0.0 0 1 LRRC37A4P WNT3
Triglycerides 20.22 1 1 2.2 0 1 TMEM258
Type 2 Diabetes (T2D) (2012) 3.31 1 0 0.0 0 1 TMEM258
Blood Eosinophil Count 16.03 3 3 6.7 0 1 LRRC37A4P TMEM258 WNT3
Blood Platelet Count 14.82 3 3 6.7 0 1 LRRC37A4P TMEM258 WNT3
Blood Red Count 41.83 3 3 6.7 0 1 LRRC37A4P TMEM258 WNT3
Blood White Count 5.77 3 2 4.4 0 1 LRRC37A4P TMEM258 WNT3
Heel T-Score 9.79 3 3 6.7 0 1 LRRC37A4P TMEM258 WNT3
Height 5.08 3 3 6.7 0 1 LRRC37A4P TMEM258 WNT3
Waist Hip Ratio (WHR) 13.85 3 2 4.4 0 1 LRRC37A4P TMEM258 WNT3
Systolic Blood Pressure 3.01 2 1 2.2 0 1 LRRC37A4P WNT3
Smoking Status 3.01 1 0 0.0 0 1 LRRC37A4P
Hypothyroidism (self reported) 7.36 1 1 2.2 0 1 TMEM258
Respiratory disease 7.82 1 1 2.2 0 1 TMEM258
Lung FEV1/FVC ratio 2.94 2 0 0.0 0 1 LRRC37A4P WNT3
Lung FVC 26.86 2 2 4.4 0 1 LRRC37A4P WNT3
Neuroticism 26.44 2 2 4.4 0 1 LRRC37A4P WNT3
Hair Pigment 0.94 3 1 2.2 0 1 LRRC37A4P TMEM258 WNT3
Tanning 0.77 2 0 0.0 0 1 LRRC37A4P WNT3
Hand grip strength (left) 10.64 2 2 4.4 0 1 LRRC37A4P WNT3
Number of treatments/medications taken 4.36 1 0 0.0 0 1 TMEM258
Sensitivity / hurt feelings 28.33 2 2 4.4 0 1 LRRC37A4P WNT3
Frequency of depressed mood in last 2 weeks 6.95 2 0 0.0 0 1 LRRC37A4P WNT3
Hearing difficulty/problems: Yes 4.07 1 0 0.0 0 1 LRRC37A4P
Relative age of first facial hair 34.17 2 2 4.4 0 1 LRRC37A4P WNT3
Systolic blood pressure, automated reading 5.50 2 1 2.2 0 1 LRRC37A4P WNT3
Vitamin and mineral supplements 9.59 3 0 0.0 0 1 LRRC37A4P TMEM258 WNT3
Impedance of leg (right) 2.15 2 0 0.0 0 1 LRRC37A4P WNT3
Trunk fat percentage 4.73 2 1 2.2 0 1 LRRC37A4P WNT3
Hand grip strength (right) 8.53 2 2 4.4 0 1 LRRC37A4P WNT3
Townsend deprivation index at recruitment 2.28 1 0 0.0 0 1 TMEM258
Fed-up feelings 15.05 2 2 4.4 0 1 LRRC37A4P WNT3
Relative age voice broke 21.85 2 2 4.4 0 1 LRRC37A4P WNT3
Taking other prescription medications 2.74 1 0 0.0 0 1 TMEM258
Age when periods started (menarche) 3.77 2 0 0.0 0 1 LRRC37A4P WNT3
Heel bone mineral density (BMD) T-score, automated (left) 5.44 3 0 0.0 0 1 LRRC37A4P TMEM258 WNT3
Qualifications: CSEs or equivalent 8.01 2 0 0.0 0 1 LRRC37A4P WNT3
High blood pressure 3.27 2 0 0.0 0 1 LRRC37A4P WNT3
Diverticular disease/diverticulitis (self-reported) 4.79 1 0 0.0 0 1 WNT3
Medication: Levothyroxine sodium 7.48 1 1 2.2 0 1 TMEM258
Sitting height 12.28 3 2 4.4 0 1 LRRC37A4P TMEM258 WNT3
Body mass index (BMI) 0.82 1 0 0.0 0 1 TMEM258
Impedance of leg (left) 2.48 2 0 0.0 0 1 LRRC37A4P WNT3
Trunk fat mass 2.88 2 0 0.0 0 1 LRRC37A4P WNT3
Past tobacco smoking 3.85 1 0 0.0 0 1 LRRC37A4P
Nervous feelings 11.64 2 2 4.4 0 1 LRRC37A4P WNT3
Frequency of tenseness / restlessness in last 2 weeks 17.91 2 2 4.4 0 1 LRRC37A4P WNT3
Hearing difficulty/problems with background noise 7.29 2 0 0.0 0 1 LRRC37A4P WNT3
Hair/balding pattern: Pattern 2 12.74 2 1 2.2 0 1 LRRC37A4P WNT3
Forced vital capacity (FVC) 22.10 2 2 4.4 0 1 LRRC37A4P WNT3
Heel bone mineral density (BMD) T-score, automated (right) 5.95 2 0 0.0 0 1 LRRC37A4P TMEM258
Ever unenthusiastic/disinterested for a whole week 13.97 3 0 0.0 0 1 LRRC37A4P TMEM258 WNT3
Financial difficulties in last 2 years 4.83 1 0 0.0 0 1 WNT3
Mouth/teeth dental problems 4.88 1 0 0.0 0 1 LRRC37A4P
Allergy 2.84 1 0 0.0 0 1 TMEM258
Medication: Simvastatin 3.86 1 0 0.0 0 1 TMEM258
Fluid intelligence score 6.51 3 0 0.0 0 1 LRRC37A4P TMEM258 WNT3
Neuroticism score 23.37 2 2 4.4 0 1 LRRC37A4P WNT3
Impedance of arm (right) 5.23 2 2 4.4 0 1 LRRC37A4P WNT3
Arm fat percentage (right) 1.16 1 0 0.0 0 1 TMEM258
Trunk fat-free mass 0.60 1 0 0.0 0 1 TMEM258
Hip circumference 1.20 1 0 0.0 0 1 LRRC37A4P
Time employed in main current job 8.19 2 0 0.0 0 1 LRRC37A4P WNT3
Worrier / anxious feelings 8.98 2 1 2.2 0 1 LRRC37A4P WNT3
Frequency of tiredness / lethargy in last 2 weeks 3.13 1 0 0.0 0 1 LRRC37A4P
Falls in the last year 4.64 1 0 0.0 0 1 TMEM258
Hair/balding pattern: Pattern 3 37.27 2 2 4.4 0 1 LRRC37A4P WNT3
Number of live births 14.51 3 0 0.0 0 1 LRRC37A4P TMEM258 WNT3
Forced expiratory volume in 1-second (FEV1) 23.64 3 2 4.4 0 1 LRRC37A4P TMEM258 WNT3
Pulse rate 10.15 1 1 2.2 0 1 TMEM258
Noisy workplace 5.86 1 0 0.0 0 1 LRRC37A4P
Qualifications: A levels/AS levels or equivalent 5.77 2 0 0.0 0 1 LRRC37A4P WNT3
Asthma 6.54 1 1 2.2 0 1 TMEM258
Medication: Ibuprofen (e.g. Nurofen) 11.24 3 0 0.0 0 1 LRRC37A4P TMEM258 WNT3
Forced expiratory volume in 1-second (FEV1), Best measure 21.19 2 2 4.4 0 1 LRRC37A4P WNT3
Impedance of arm (left) 6.68 2 2 4.4 0 1 LRRC37A4P WNT3
Standing height 4.20 3 3 6.7 0 1 LRRC37A4P TMEM258 WNT3
Exposure to tobacco smoke at home 3.20 1 0 0.0 0 1 TMEM258
Tense / 'highly strung' 4.23 2 0 0.0 0 1 LRRC37A4P WNT3
Seen doctor (GP) for nerves, anxiety, tension or depression 2.66 1 0 0.0 0 1 TMEM258
Hair/balding pattern: Pattern 4 68.36 3 3 6.7 0 1 LRRC37A4P TMEM258 WNT3
Peak expiratory flow (PEF) 13.00 2 2 4.4 0 1 LRRC37A4P WNT3
Ever highly irritable/argumentative for 2 days 5.05 1 0 0.0 0 1 LRRC37A4P
Blood clot in the leg (DVT) 3.20 1 0 0.0 0 1 TMEM258
Medication: Paracetamol 21.17 2 2 4.4 0 1 LRRC37A4P WNT3
Headache pain in last month 22.18 3 2 4.4 0 1 LRRC37A4P TMEM258 WNT3
Glaucoma (self-reported) 3.56 1 0 0.0 0 1 LRRC37A4P
Hypothyroidism/myxoedema (self-reported) 6.02 1 1 2.2 0 1 TMEM258
High blood pressure (siblings) 4.61 2 0 0.0 0 1 LRRC37A4P WNT3
Forced vital capacity (FVC), Best measure 21.32 2 2 4.4 0 1 LRRC37A4P WNT3
Body fat percentage 2.65 2 0 0.0 0 1 LRRC37A4P WNT3
Leg fat percentage (right) 1.47 1 0 0.0 0 1 TMEM258
Exposure to tobacco smoke outside home 5.62 1 0 0.0 0 1 LRRC37A4P
Comparative body size at age 10 2.22 1 0 0.0 0 1 WNT3
Number of full brothers 5.34 2 0 0.0 0 1 LRRC37A4P WNT3
Worry too long after embarrassment 8.04 2 0 0.0 0 1 LRRC37A4P WNT3
Seen a psychiatrist for nerves, anxiety, tension or depression 4.35 1 0 0.0 0 1 TMEM258
Wheeze or whistling in the chest in last year 5.80 1 0 0.0 0 1 TMEM258
Age at first live birth 4.30 2 0 0.0 0 1 LRRC37A4P WNT3
Qualifications: College or University degree 9.11 2 2 4.4 0 1 LRRC37A4P WNT3
Emphysema/chronic bronchitis 6.29 1 0 0.0 0 1 LRRC37A4P
Medication for pain relief, constipation, heartburn 12.80 3 1 2.2 0 1 LRRC37A4P TMEM258 WNT3
Medication: Ibuprofen 10.06 3 0 0.0 0 1 LRRC37A4P TMEM258 WNT3
Whole body fat mass 1.52 1 0 0.0 0 1 LRRC37A4P
Pulse rate, automated reading 17.93 1 1 2.2 0 1 TMEM258
Alcohol intake frequency. 9.39 2 2 4.4 0 1 LRRC37A4P WNT3
Comparative height size at age 10 4.27 3 1 2.2 0 1 LRRC37A4P TMEM258 WNT3
Suffer from 'nerves' 4.57 1 0 0.0 0 1 LRRC37A4P
Leg pain on walking 5.66 2 0 0.0 0 1 LRRC37A4P WNT3
Qualifications: NVQ or HND or HNC or equivalent 4.41 1 0 0.0 0 1 TMEM258
Commuting to job workplace: Car/motor vehicle 5.10 1 0 0.0 0 1 TMEM258
Supplements: Vitamin C 7.23 2 0 0.0 0 1 LRRC37A4P WNT3
Hypertension (Self-reported) 2.84 2 0 0.0 0 1 LRRC37A4P WNT3
Illnesses of father: Heart disease 4.62 1 0 0.0 0 1 LRRC37A4P
Smoking status: Previous 3.58 1 0 0.0 0 1 LRRC37A4P
Forced expiratory volume in 1-second (FEV1), predicted 2.35 1 0 0.0 0 1 TMEM258
Handedness (chirality/laterality): Left-handed 13.58 2 1 2.2 0 1 LRRC37A4P WNT3
Mood swings 20.32 2 2 4.4 0 1 LRRC37A4P WNT3
Loneliness, isolation 6.92 2 0 0.0 0 1 LRRC37A4P WNT3
Long-standing illness, disability or infirmity 2.84 1 0 0.0 0 1 TMEM258
Ever had bowel cancer screening 4.54 1 0 0.0 0 1 LRRC37A4P
Mouth/teeth dental problems: Mouth ulcers 16.31 2 2 4.4 0 1 LRRC37A4P WNT3
Medication for cholesterol 5.07 2 0 0.0 0 1 LRRC37A4P WNT3
Mineral and other dietary supplements 3.68 1 0 0.0 0 1 TMEM258
Breast cancer (self-reported) 5.09 1 0 0.0 0 1 LRRC37A4P
Asthma (self-reported) 7.17 1 1 2.2 0 1 TMEM258
Osteoporosis (self-reported) 5.31 1 0 0.0 0 1 LRRC37A4P
Forced expiratory volume in 1-second (FEV1), predicted percentage 19.41 2 2 4.4 0 1 LRRC37A4P WNT3
Number of self-reported non-cancer illnesses 2.38 1 0 0.0 0 1 TMEM258
Miserableness 14.19 3 2 4.4 0 1 LRRC37A4P TMEM258 WNT3
Guilty feelings 8.86 2 0 0.0 0 1 LRRC37A4P WNT3
Eye problems/disorders: Glaucoma 4.06 1 0 0.0 0 1 LRRC37A4P
Medication: Blood pressure 7.05 2 0 0.0 0 1 LRRC37A4P WNT3
Supplements: Fish oil (including cod liver oil) 4.71 1 0 0.0 0 1 TMEM258
High cholesterol (Self-reported) 4.06 1 0 0.0 0 1 TMEM258
Medication: Paracetamol 21.43 2 2 4.4 0 1 LRRC37A4P WNT3
Leg fat percentage (left) 1.35 1 0 0.0 0 1 TMEM258
Irritability 16.55 3 2 4.4 0 1 LRRC37A4P TMEM258 WNT3
Fractured/broken bones in last 5 years 7.59 2 0 0.0 0 1 LRRC37A4P WNT3
Diastolic blood pressure, automated reading 3.69 3 0 0.0 0 1 LRRC37A4P TMEM258 WNT3
Ever depressed for a whole week 8.49 2 0 0.0 0 1 LRRC37A4P WNT3
Myopia 9.55 3 0 0.0 0 1 LRRC37A4P TMEM258 WNT3
Vascular/heart problems diagnosed by doctor 2.36 1 0 0.0 0 1 LRRC37A4P
Cholesterol lowering medication 3.42 1 0 0.0 0 1 TMEM258
Pain experienced in last month 4.34 1 0 0.0 0 1 LRRC37A4P
Heart attack/myocardial infarction (self-reported) 2.24 1 0 0.0 0 1 TMEM258
Deep venous thrombosis (DVT) (self-reported) 2.94 1 0 0.0 0 1 TMEM258
Heart disease (siblings) 6.16 2 0 0.0 0 1 LRRC37A4P WNT3
Impedance of whole body 5.74 2 2 4.4 0 1 LRRC37A4P WNT3

Associations by panel

study tissue # hits % hits/tests avg chisq
GTEx Adipose Subcutaneous 0 0.000 1.3
GTEx Adipose Visceral Omentum 0 0.000 1.4
GTEx Adrenal Gland 0 0.000 1.5
GTEx Artery Aorta 0 0.000 1.5
GTEx Artery Coronary 1 0.085 1.5
GTEx Artery Tibial 1 0.027 1.4
GTEx Brain Caudate basal ganglia 0 0.000 1.4
GTEx Brain Cerebellar Hemisphere 0 0.000 1.4
GTEx Brain Cerebellum 0 0.000 1.4
GTEx Brain Cortex 0 0.000 1.5
GTEx Brain Frontal Cortex BA9 0 0.000 1.5
GTEx Brain Hippocampus 0 0.000 1.5
GTEx Brain Hypothalamus 0 0.000 1.5
GTEx Brain Nucleus accumbens basal ganglia 0 0.000 1.5
GTEx Brain Putamen basal ganglia 0 0.000 1.7
GTEx Breast Mammary Tissue 0 0.000 1.5
GTEx Breast Mammary Tissue (Male) 0 0.000 1.4
GTEx Breast Mammary Tissue (Female) 1 0.061 1.5
GTEx Cells EBV-transformed lymphocytes 0 0.000 1.5
GTEx Cells Transformed fibroblasts 0 0.000 1.4
GTEx Colon Sigmoid 0 0.000 1.4
GTEx Colon Transverse 0 0.000 1.5
GTEx Esophagus Gastroesophageal Junction 0 0.000 1.5
GTEx Esophagus Mucosa 0 0.000 1.4
GTEx Esophagus Muscularis 0 0.000 1.4
GTEx Heart Atrial Appendage 1 0.063 1.4
GTEx Heart Left Ventricle 0 0.000 1.5
GTEx Liver 0 0.000 1.4
GTEx Lung 0 0.000 1.4
GTEx Muscle Skeletal 0 0.000 1.4
GTEx Nerve Tibial 0 0.000 1.3
GTEx Ovary 0 0.000 1.5
GTEx Pancreas 0 0.000 1.5
GTEx Pituitary 0 0.000 1.4
GTEx Prostate 0 0.000 1.4
GTEx Skin Not Sun Exposed Suprapubic 0 0.000 1.3
GTEx Skin Sun Exposed Lower leg 0 0.000 1.4
GTEx Small Intestine Terminal Ileum 0 0.000 1.5
GTEx Spleen 0 0.000 1.4
GTEx Stomach 0 0.000 1.4
GTEx Testis 0 0.000 1.5
GTEx Thyroid 0 0.000 1.4
GTEx Uterus 0 0.000 1.5
GTEx Vagina 0 0.000 1.6
GTEx Whole Blood 0 0.000 1.4
METSIM Adipose 0 0.000 1.3
NTR Blood 1 0.042 1.3
ROSMAP Brain Pre-frontal Cortex 2 0.046 1.4
YFS Blood 0 0.000 1.3
CommonMind Brain Pre-frontal Cortex 2 0.037 1.3
The Cancer Genome Atlas Bladder Urothelial Carcinoma 0 0.000 1.3
The Cancer Genome Atlas Breast Invasive Carcinoma 0 0.000 1.3
The Cancer Genome Atlas Cervical Squamous Cell Carcinoma 0 0.000 1.4
The Cancer Genome Atlas Colon Adenocarcinoma 0 0.000 1.3
The Cancer Genome Atlas Esophageal Carcinoma 0 0.000 1.4
The Cancer Genome Atlas Glioblastoma Multiforme 0 0.000 1.4
The Cancer Genome Atlas Head and Neck Squamous Cell Carcinoma 0 0.000 1.3
The Cancer Genome Atlas Kidney Renal Clear Cell Carcinoma 0 0.000 1.3
The Cancer Genome Atlas Kidney Renal Papillary Cell Carcinoma 0 0.000 1.3
The Cancer Genome Atlas Brain Lower Grade Glioma 0 0.000 1.3
The Cancer Genome Atlas Liver Hepatocellular Carcinoma 0 0.000 1.5
The Cancer Genome Atlas Lung Adenocarcinoma 0 0.000 1.3
The Cancer Genome Atlas Lung Squamous Cell Carcinoma 0 0.000 1.3
The Cancer Genome Atlas Ovarian Serous Cystadenocarcinoma 0 0.000 1.4
The Cancer Genome Atlas Pancreatic Adenocarcinoma 0 0.000 1.4
The Cancer Genome Atlas Pheochromocytoma and Paraganglioma 0 0.000 1.3
The Cancer Genome Atlas Prostate Adenocarcinoma 0 0.000 1.4
The Cancer Genome Atlas Rectum Adenocarcinoma 1 0.145 1.5
The Cancer Genome Atlas Soft Tissue Sarcoma 0 0.000 1.4
The Cancer Genome Atlas Skin Cutaneous Melanoma 0 0.000 1.3
The Cancer Genome Atlas Stomach Adenocarcinoma 0 0.000 1.3
The Cancer Genome Atlas Testicular Germ Cell Tumors 0 0.000 1.3
The Cancer Genome Atlas Thyroid Carcinoma 1 0.019 1.3
The Cancer Genome Atlas Uterine Corpus Endometrial Carcinoma 0 0.000 1.4