Hub : Traits :

Average weekly champagne plus white wine intake

11 significantly associated models · 8 unique genes.

Significant Loci

#	chr	p0	p1	# assoc genes	# joint genes	best TWAS P	best SNP P	cond SNP P	% var exp	joint genes
1	11	60839578	62290719	4	1	1.1e-08	1.1e-08	1.000	100	TMEM258
2	17	42884538	43913030	2	1	2.7e-07	1.3e-06	1.000	100	LRRC37A4P
3	17	44788310	45597098	1	1	2.4e-07	6.5e-08	0.089	90	WNT3

Pleiotropic Associations

Trait	chisq ratio	# genes⁺	# genes⁺⁺	% genes⁺⁺	corr P	genes
Hair/balding pattern: Pattern 4	68.36	3	3	6.7	1	LRRC37A4P TMEM258 WNT3
Blood Red Count	41.83	3	3	6.7	1	LRRC37A4P TMEM258 WNT3
Hair/balding pattern: Pattern 3	37.27	2	2	4.4	1	LRRC37A4P WNT3
Relative age of first facial hair	34.17	2	2	4.4	1	LRRC37A4P WNT3
Sensitivity / hurt feelings	28.33	2	2	4.4	1	LRRC37A4P WNT3
Neuroticism (Nagel 2018)	27.31	2	2	4.4	1	LRRC37A4P WNT3
Lung FVC	26.86	2	2	4.4	1	LRRC37A4P WNT3
Neuroticism	26.44	2	2	4.4	1	LRRC37A4P WNT3
Depressed Affect (Nagel 2018)	24.22	2	2	4.4	1	LRRC37A4P WNT3
Forced expiratory volume in 1-second (FEV1)	23.64	3	2	4.4	1	LRRC37A4P TMEM258 WNT3
Ovarian Cancer	23.37	2	2	4.4	1	LRRC37A4P WNT3
Neuroticism score	23.37	2	2	4.4	1	LRRC37A4P WNT3
Headache pain in last month	22.18	3	2	4.4	1	LRRC37A4P TMEM258 WNT3
Forced vital capacity (FVC)	22.10	2	2	4.4	1	LRRC37A4P WNT3
LDL Cholesterol	21.92	1	1	2.2	1	TMEM258
Relative age voice broke	21.85	2	2	4.4	1	LRRC37A4P WNT3
Medication: Paracetamol	21.43	2	2	4.4	1	LRRC37A4P WNT3
Forced vital capacity (FVC), Best measure	21.32	2	2	4.4	1	LRRC37A4P WNT3
Forced expiratory volume in 1-second (FEV1), Best measure	21.19	2	2	4.4	1	LRRC37A4P WNT3
Medication: Paracetamol	21.17	2	2	4.4	1	LRRC37A4P WNT3
Mood swings	20.32	2	2	4.4	1	LRRC37A4P WNT3
Triglycerides	20.22	1	1	2.2	1	TMEM258
HDL Cholesterol	19.59	1	1	2.2	1	TMEM258
Forced expiratory volume in 1-second (FEV1), predicted percentage	19.41	2	2	4.4	1	LRRC37A4P WNT3
Pulse rate, automated reading	17.93	1	1	2.2	1	TMEM258
Frequency of tenseness / restlessness in last 2 weeks	17.91	2	2	4.4	1	LRRC37A4P WNT3
Irritability	16.55	3	2	4.4	1	LRRC37A4P TMEM258 WNT3
Mouth/teeth dental problems: Mouth ulcers	16.31	2	2	4.4	1	LRRC37A4P WNT3
Blood Eosinophil Count	16.03	3	3	6.7	1	LRRC37A4P TMEM258 WNT3
Fed-up feelings	15.05	2	2	4.4	1	LRRC37A4P WNT3
Blood Platelet Count	14.82	3	3	6.7	1	LRRC37A4P TMEM258 WNT3
Number of live births	14.51	3	0	0.0	1	LRRC37A4P TMEM258 WNT3
Worry (Nagel 2018)	14.24	2	2	4.4	1	LRRC37A4P WNT3
Miserableness	14.19	3	2	4.4	1	LRRC37A4P TMEM258 WNT3
Ever unenthusiastic/disinterested for a whole week	13.97	3	0	0.0	1	LRRC37A4P TMEM258 WNT3
Waist Hip Ratio (WHR)	13.85	3	2	4.4	1	LRRC37A4P TMEM258 WNT3
Handedness (chirality/laterality): Left-handed	13.58	2	1	2.2	1	LRRC37A4P WNT3
Peak expiratory flow (PEF)	13.00	2	2	4.4	1	LRRC37A4P WNT3
Medication for pain relief, constipation, heartburn	12.80	3	1	2.2	1	LRRC37A4P TMEM258 WNT3
Hair/balding pattern: Pattern 2	12.74	2	1	2.2	1	LRRC37A4P WNT3
Sitting height	12.28	3	2	4.4	1	LRRC37A4P TMEM258 WNT3
Nervous feelings	11.64	2	2	4.4	1	LRRC37A4P WNT3
Fasting Glucose	11.61	1	1	2.2	1	TMEM258
Medication: Ibuprofen (e.g. Nurofen)	11.24	3	0	0.0	1	LRRC37A4P TMEM258 WNT3
Neuroticism (2016)	10.86	2	1	2.2	1	LRRC37A4P WNT3
Hand grip strength (left)	10.64	2	2	4.4	1	LRRC37A4P WNT3
Pulse rate	10.15	1	1	2.2	1	TMEM258
Medication: Ibuprofen	10.06	3	0	0.0	1	LRRC37A4P TMEM258 WNT3
Crohns Disease (2012)	9.89	3	0	0.0	1	LRRC37A4P TMEM258 WNT3
Heel T-Score	9.79	3	3	6.7	1	LRRC37A4P TMEM258 WNT3
Vitamin and mineral supplements	9.59	3	0	0.0	1	LRRC37A4P TMEM258 WNT3
Myopia	9.55	3	0	0.0	1	LRRC37A4P TMEM258 WNT3
Alcohol intake frequency.	9.39	2	2	4.4	1	LRRC37A4P WNT3
Qualifications: College or University degree	9.11	2	2	4.4	1	LRRC37A4P WNT3
Worrier / anxious feelings	8.98	2	1	2.2	1	LRRC37A4P WNT3
Schizophrenia vs Biploar Disorder	8.95	3	0	0.0	1	LRRC37A4P TMEM258 WNT3
Guilty feelings	8.86	2	0	0.0	1	LRRC37A4P WNT3
Hand grip strength (right)	8.53	2	2	4.4	1	LRRC37A4P WNT3
Ever depressed for a whole week	8.49	2	0	0.0	1	LRRC37A4P WNT3
Primary Biliary Cirrhosis	8.38	2	0	0.0	1	LRRC37A4P WNT3
Breast Cancer	8.25	2	1	2.2	1	LRRC37A4P WNT3
Time employed in main current job	8.19	2	0	0.0	1	LRRC37A4P WNT3
Worry too long after embarrassment	8.04	2	0	0.0	1	LRRC37A4P WNT3
Qualifications: CSEs or equivalent	8.01	2	0	0.0	1	LRRC37A4P WNT3
Respiratory disease	7.82	1	1	2.2	1	TMEM258
Fractured/broken bones in last 5 years	7.59	2	0	0.0	1	LRRC37A4P WNT3
Medication: Levothyroxine sodium	7.48	1	1	2.2	1	TMEM258
Mean Putamen Volume	7.43	2	0	0.0	1	LRRC37A4P WNT3
Hypothyroidism (self reported)	7.36	1	1	2.2	1	TMEM258
Hearing difficulty/problems with background noise	7.29	2	0	0.0	1	LRRC37A4P WNT3
Supplements: Vitamin C	7.23	2	0	0.0	1	LRRC37A4P WNT3
Asthma (self-reported)	7.17	1	1	2.2	1	TMEM258
Verbal and Numeric Reasoning (VNR)	7.12	3	0	0.0	1	LRRC37A4P TMEM258 WNT3
Medication: Blood pressure	7.05	2	0	0.0	1	LRRC37A4P WNT3
Frequency of depressed mood in last 2 weeks	6.95	2	0	0.0	1	LRRC37A4P WNT3
Loneliness, isolation	6.92	2	0	0.0	1	LRRC37A4P WNT3
Impedance of arm (left)	6.68	2	2	4.4	1	LRRC37A4P WNT3
Intelligence (Savage-Jansen 2018)	6.64	3	0	0.0	1	LRRC37A4P TMEM258 WNT3
Asthma	6.54	1	1	2.2	1	TMEM258
Fluid intelligence score	6.51	3	0	0.0	1	LRRC37A4P TMEM258 WNT3
Emphysema/chronic bronchitis	6.29	1	0	0.0	1	LRRC37A4P
Depression (Nagel 2018)	6.19	2	0	0.0	1	LRRC37A4P WNT3
Heart disease (siblings)	6.16	2	0	0.0	1	LRRC37A4P WNT3
Hypothyroidism/myxoedema (self-reported)	6.02	1	1	2.2	1	TMEM258
Heel bone mineral density (BMD) T-score, automated (right)	5.95	2	0	0.0	1	LRRC37A4P TMEM258
Noisy workplace	5.86	1	0	0.0	1	LRRC37A4P
Wheeze or whistling in the chest in last year	5.80	1	0	0.0	1	TMEM258
Blood White Count	5.77	3	2	4.4	1	LRRC37A4P TMEM258 WNT3
Qualifications: A levels/AS levels or equivalent	5.77	2	0	0.0	1	LRRC37A4P WNT3
Impedance of whole body	5.74	2	2	4.4	1	LRRC37A4P WNT3
Leg pain on walking	5.66	2	0	0.0	1	LRRC37A4P WNT3
Exposure to tobacco smoke outside home	5.62	1	0	0.0	1	LRRC37A4P
Systolic blood pressure, automated reading	5.50	2	1	2.2	1	LRRC37A4P WNT3
Heel bone mineral density (BMD) T-score, automated (left)	5.44	3	0	0.0	1	LRRC37A4P TMEM258 WNT3
Crohns Disease (2017)	5.34	1	0	0.0	1	TMEM258
Number of full brothers	5.34	2	0	0.0	1	LRRC37A4P WNT3
Osteoporosis (self-reported)	5.31	1	0	0.0	1	LRRC37A4P
Impedance of arm (right)	5.23	2	2	4.4	1	LRRC37A4P WNT3
Commuting to job workplace: Car/motor vehicle	5.10	1	0	0.0	1	TMEM258
Breast cancer (self-reported)	5.09	1	0	0.0	1	LRRC37A4P
Height	5.08	3	3	6.7	1	LRRC37A4P TMEM258 WNT3
Lupus	5.07	1	0	0.0	1	LRRC37A4P
Medication for cholesterol	5.07	2	0	0.0	1	LRRC37A4P WNT3
Ever highly irritable/argumentative for 2 days	5.05	1	0	0.0	1	LRRC37A4P
Mouth/teeth dental problems	4.88	1	0	0.0	1	LRRC37A4P
Bipolar Disorder (2018)	4.85	1	0	0.0	1	TMEM258
Financial difficulties in last 2 years	4.83	1	0	0.0	1	WNT3
Diverticular disease/diverticulitis (self-reported)	4.79	1	0	0.0	1	WNT3
Trunk fat percentage	4.73	2	1	2.2	1	LRRC37A4P WNT3
Bipolar Disorder (2011)	4.72	1	0	0.0	1	TMEM258
Supplements: Fish oil (including cod liver oil)	4.71	1	0	0.0	1	TMEM258
Falls in the last year	4.64	1	0	0.0	1	TMEM258
Illnesses of father: Heart disease	4.62	1	0	0.0	1	LRRC37A4P
High blood pressure (siblings)	4.61	2	0	0.0	1	LRRC37A4P WNT3
Schizophrenia (2014)	4.60	2	0	0.0	1	LRRC37A4P WNT3
Suffer from 'nerves'	4.57	1	0	0.0	1	LRRC37A4P
Ever had bowel cancer screening	4.54	1	0	0.0	1	LRRC37A4P
Qualifications: NVQ or HND or HNC or equivalent	4.41	1	0	0.0	1	TMEM258
Number of treatments/medications taken	4.36	1	0	0.0	1	TMEM258
Seen a psychiatrist for nerves, anxiety, tension or depression	4.35	1	0	0.0	1	TMEM258
Pain experienced in last month	4.34	1	0	0.0	1	LRRC37A4P
Age at first live birth	4.30	2	0	0.0	1	LRRC37A4P WNT3
Comparative height size at age 10	4.27	3	1	2.2	1	LRRC37A4P TMEM258 WNT3
Tense / 'highly strung'	4.23	2	0	0.0	1	LRRC37A4P WNT3
Standing height	4.20	3	3	6.7	1	LRRC37A4P TMEM258 WNT3
Hearing difficulty/problems: Yes	4.07	1	0	0.0	1	LRRC37A4P
Eye problems/disorders: Glaucoma	4.06	1	0	0.0	1	LRRC37A4P
High cholesterol (Self-reported)	4.06	1	0	0.0	1	TMEM258
Medication: Simvastatin	3.86	1	0	0.0	1	TMEM258
Past tobacco smoking	3.85	1	0	0.0	1	LRRC37A4P
Age when periods started (menarche)	3.77	2	0	0.0	1	LRRC37A4P WNT3
Diastolic blood pressure, automated reading	3.69	3	0	0.0	1	LRRC37A4P TMEM258 WNT3
Mineral and other dietary supplements	3.68	1	0	0.0	1	TMEM258
Smoking status: Previous	3.58	1	0	0.0	1	LRRC37A4P
Glaucoma (self-reported)	3.56	1	0	0.0	1	LRRC37A4P
Cholesterol lowering medication	3.42	1	0	0.0	1	TMEM258
Irritable Bowel Disease (IBD)	3.39	1	0	0.0	1	TMEM258
Type 2 Diabetes (T2D) (2012)	3.31	1	0	0.0	1	TMEM258
High blood pressure	3.27	2	0	0.0	1	LRRC37A4P WNT3
Exposure to tobacco smoke at home	3.20	1	0	0.0	1	TMEM258
Blood clot in the leg (DVT)	3.20	1	0	0.0	1	TMEM258
Frequency of tiredness / lethargy in last 2 weeks	3.13	1	0	0.0	1	LRRC37A4P
Systolic Blood Pressure	3.01	2	1	2.2	1	LRRC37A4P WNT3
Smoking Status	3.01	1	0	0.0	1	LRRC37A4P
Lung FEV1/FVC ratio	2.94	2	0	0.0	1	LRRC37A4P WNT3
Deep venous thrombosis (DVT) (self-reported)	2.94	1	0	0.0	1	TMEM258
Trunk fat mass	2.88	2	0	0.0	1	LRRC37A4P WNT3
Allergy	2.84	1	0	0.0	1	TMEM258
Hypertension (Self-reported)	2.84	2	0	0.0	1	LRRC37A4P WNT3
Long-standing illness, disability or infirmity	2.84	1	0	0.0	1	TMEM258
Taking other prescription medications	2.74	1	0	0.0	1	TMEM258
Bipolar Disorder or Schizophrenia	2.73	1	0	0.0	1	TMEM258
Schizophrenia (2018)	2.69	1	0	0.0	1	WNT3
Seen doctor (GP) for nerves, anxiety, tension or depression	2.66	1	0	0.0	1	TMEM258
Body fat percentage	2.65	2	0	0.0	1	LRRC37A4P WNT3
Impedance of leg (left)	2.48	2	0	0.0	1	LRRC37A4P WNT3
Number of self-reported non-cancer illnesses	2.38	1	0	0.0	1	TMEM258
Vascular/heart problems diagnosed by doctor	2.36	1	0	0.0	1	LRRC37A4P
Forced expiratory volume in 1-second (FEV1), predicted	2.35	1	0	0.0	1	TMEM258
Townsend deprivation index at recruitment	2.28	1	0	0.0	1	TMEM258
Heart attack/myocardial infarction (self-reported)	2.24	1	0	0.0	1	TMEM258
Comparative body size at age 10	2.22	1	0	0.0	1	WNT3
Impedance of leg (right)	2.15	2	0	0.0	1	LRRC37A4P WNT3
Whole body fat mass	1.52	1	0	0.0	1	LRRC37A4P
Leg fat percentage (right)	1.47	1	0	0.0	1	TMEM258
Leg fat percentage (left)	1.35	1	0	0.0	1	TMEM258
Hip circumference	1.20	1	0	0.0	1	LRRC37A4P
Arm fat percentage (right)	1.16	1	0	0.0	1	TMEM258
Hair Pigment	0.94	3	1	2.2	1	LRRC37A4P TMEM258 WNT3
Body mass index (BMI)	0.82	1	0	0.0	1	TMEM258
Tanning	0.77	2	0	0.0	1	LRRC37A4P WNT3
Trunk fat-free mass	0.60	1	0	0.0	1	TMEM258

Associations by panel

study	tissue	# hits	% hits/tests	avg chisq
GTEx	Brain Putamen basal ganglia	0	0.000	1.7
GTEx	Vagina	0	0.000	1.6
GTEx	Adrenal Gland	0	0.000	1.5
GTEx	Artery Aorta	0	0.000	1.5
GTEx	Artery Coronary	1	0.085	1.5
GTEx	Brain Cortex	0	0.000	1.5
GTEx	Brain Frontal Cortex BA9	0	0.000	1.5
GTEx	Brain Hippocampus	0	0.000	1.5
GTEx	Brain Hypothalamus	0	0.000	1.5
GTEx	Brain Nucleus accumbens basal ganglia	0	0.000	1.5
GTEx	Breast Mammary Tissue	0	0.000	1.5
GTEx	Breast Mammary Tissue (Female)	1	0.061	1.5
GTEx	Cells EBV-transformed lymphocytes	0	0.000	1.5
GTEx	Colon Transverse	0	0.000	1.5
GTEx	Esophagus Gastroesophageal Junction	0	0.000	1.5
GTEx	Heart Left Ventricle	0	0.000	1.5
GTEx	Ovary	0	0.000	1.5
GTEx	Pancreas	0	0.000	1.5
GTEx	Small Intestine Terminal Ileum	0	0.000	1.5
GTEx	Testis	0	0.000	1.5
GTEx	Uterus	0	0.000	1.5
The Cancer Genome Atlas	Liver Hepatocellular Carcinoma	0	0.000	1.5
The Cancer Genome Atlas	Rectum Adenocarcinoma	1	0.145	1.5
GTEx	Adipose Visceral Omentum	0	0.000	1.4
GTEx	Artery Tibial	1	0.027	1.4
GTEx	Brain Caudate basal ganglia	0	0.000	1.4
GTEx	Brain Cerebellar Hemisphere	0	0.000	1.4
GTEx	Brain Cerebellum	0	0.000	1.4
GTEx	Breast Mammary Tissue (Male)	0	0.000	1.4
GTEx	Cells Transformed fibroblasts	0	0.000	1.4
GTEx	Colon Sigmoid	0	0.000	1.4
GTEx	Esophagus Mucosa	0	0.000	1.4
GTEx	Esophagus Muscularis	0	0.000	1.4
GTEx	Heart Atrial Appendage	1	0.063	1.4
GTEx	Liver	0	0.000	1.4
GTEx	Lung	0	0.000	1.4
GTEx	Muscle Skeletal	0	0.000	1.4
GTEx	Pituitary	0	0.000	1.4
GTEx	Prostate	0	0.000	1.4
GTEx	Skin Sun Exposed Lower leg	0	0.000	1.4
GTEx	Spleen	0	0.000	1.4
GTEx	Stomach	0	0.000	1.4
GTEx	Thyroid	0	0.000	1.4
GTEx	Whole Blood	0	0.000	1.4
ROSMAP	Brain Pre-frontal Cortex	2	0.046	1.4
The Cancer Genome Atlas	Cervical Squamous Cell Carcinoma	0	0.000	1.4
The Cancer Genome Atlas	Esophageal Carcinoma	0	0.000	1.4
The Cancer Genome Atlas	Glioblastoma Multiforme	0	0.000	1.4
The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	0	0.000	1.4
The Cancer Genome Atlas	Pancreatic Adenocarcinoma	0	0.000	1.4
The Cancer Genome Atlas	Prostate Adenocarcinoma	0	0.000	1.4
The Cancer Genome Atlas	Soft Tissue Sarcoma	0	0.000	1.4
The Cancer Genome Atlas	Uterine Corpus Endometrial Carcinoma	0	0.000	1.4
GTEx	Adipose Subcutaneous	0	0.000	1.3
GTEx	Nerve Tibial	0	0.000	1.3
GTEx	Skin Not Sun Exposed Suprapubic	0	0.000	1.3
METSIM	Adipose	0	0.000	1.3
NTR	Blood	1	0.042	1.3
YFS	Blood	0	0.000	1.3
CommonMind	Brain Pre-frontal Cortex	2	0.037	1.3
The Cancer Genome Atlas	Bladder Urothelial Carcinoma	0	0.000	1.3
The Cancer Genome Atlas	Breast Invasive Carcinoma	0	0.000	1.3
The Cancer Genome Atlas	Colon Adenocarcinoma	0	0.000	1.3
The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	0	0.000	1.3
The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	0	0.000	1.3
The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	0	0.000	1.3
The Cancer Genome Atlas	Brain Lower Grade Glioma	0	0.000	1.3
The Cancer Genome Atlas	Lung Adenocarcinoma	0	0.000	1.3
The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	0	0.000	1.3
The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	0	0.000	1.3
The Cancer Genome Atlas	Skin Cutaneous Melanoma	0	0.000	1.3
The Cancer Genome Atlas	Stomach Adenocarcinoma	0	0.000	1.3
The Cancer Genome Atlas	Testicular Germ Cell Tumors	0	0.000	1.3
The Cancer Genome Atlas	Thyroid Carcinoma	1	0.019	1.3