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chr1:43,073,464-44,618,031

Best TWAS P=6.72e-09 · Best GWAS P=8.89e-08 conditioned to 0.136

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	GTEx	Adipose Subcutaneous	HYI	0.38	0.09	lasso	9	0.07	1.6e-06	-4.9	-5.7	9.4e-09	-0.53	0.08	0.91	FALSE
2	GTEx	Adipose Visceral Omentum	HYI	0.35	0.23	enet	25	0.24	2.0e-12	-5.0	-5.5	4.2e-08	-0.53	0.07	0.93	FALSE
3	GTEx	Breast Mammary Tissue (Female)	TIE1	0.10	0.07	enet	10	0.07	3.5e-03	5.2	-5.4	6.8e-08	-0.80	0.04	0.79	FALSE
4	GTEx	Heart Left Ventricle	MED8	0.08	0.01	lasso	3	0.01	1.2e-01	4.4	-5.2	2.5e-07	-0.75	0.07	0.65	FALSE
5	GTEx	Lung	HYI	0.18	0.04	enet	22	0.06	1.8e-05	4.7	-5.2	2.3e-07	-0.66	0.07	0.92	FALSE
6	GTEx	Nerve Tibial	MED8	0.13	0.07	enet	11	0.16	3.6e-11	5.1	5.3	1.2e-07	0.79	0.04	0.96	FALSE
7	GTEx	Pancreas	HYI	0.22	0.16	enet	9	0.20	9.7e-09	-5.0	-5.3	1.0e-07	-0.64	0.04	0.96	FALSE
8	GTEx	Stomach	HYI	0.16	0.06	lasso	6	0.07	4.1e-04	-4.4	-5.1	2.9e-07	-0.59	0.09	0.79	FALSE
9	GTEx	Testis	MED8	0.21	0.14	lasso	3	0.20	1.8e-09	-4.7	-5.4	6.2e-08	-0.75	0.14	0.85	FALSE
10	GTEx	Thyroid	TIE1	0.10	0.05	lasso	3	0.05	1.3e-04	4.4	-5.3	1.2e-07	-0.74	0.07	0.90	FALSE
11	GTEx	Thyroid	HYI	0.16	0.13	lasso	6	0.12	1.2e-09	-5.0	-5.2	1.7e-07	-0.64	0.08	0.92	FALSE
12	ROSMAP	Brain Pre-frontal Cortex	HYI	0.35	0.35	lasso	7	0.36	8.6e-48	-5.0	-5.1	2.9e-07	-0.53	0.07	0.93	FALSE
13	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	C1orf84	0.02	0.02	blup	44	0.01	2.0e-02	5.2	-5.2	2.2e-07	-0.84	0.02	0.75	FALSE
14	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	MED8	0.03	0.00	blup	38	0.01	2.1e-02	5.1	-5.4	7.1e-08	-0.81	0.01	0.54	FALSE
15	The Cancer Genome Atlas	Breast Invasive Carcinoma	C1orf84	0.02	0.03	blup	46	0.03	3.4e-07	5.1	-5.2	2.1e-07	-0.80	0.04	0.96	FALSE
16	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	HYI	0.02	0.01	blup	34	0.02	6.1e-03	5.1	-5.2	1.8e-07	-0.85	0.02	0.67	FALSE
17	The Cancer Genome Atlas	Rectum Adenocarcinoma	HYI	0.23	0.08	blup	34	0.14	3.1e-04	-5.0	-5.8	6.7e-09	-0.75	0.02	0.55	TRUE
18	The Cancer Genome Atlas	Testicular Germ Cell Tumors	MED8	0.26	0.18	blup	39	0.24	3.5e-09	4.7	-5.3	1.1e-07	-0.78	0.04	0.95	FALSE