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chr1:235,988,566-237,463,399

Best TWAS P=1.21e-09 · Best GWAS P=3.54e-10 conditioned to 0.0891

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	CommonMind	Brain Pre-frontal Cortex	HEATR1	0.12	0.08	lasso	9	0.06	3.5e-08	5.7	-5.2	2.0e-07	-0.73	0.14	0.86	FALSE
2	CommonMind	Brain Pre-frontal Cortex	LGALS8	0.30	0.39	enet	44	0.42	5.7e-56	5.7	5.8	7.7e-09	0.94	0.07	0.93	FALSE
3	GTEx	Adipose Subcutaneous	RP11-385F5.4	0.15	0.13	enet	13	0.14	4.0e-11	5.6	6.0	2.3e-09	0.92	0.25	0.75	FALSE
4	GTEx	Adipose Visceral Omentum	RP11-385F5.4	0.12	0.06	lasso	2	0.09	2.3e-05	5.7	5.6	2.5e-08	0.88	0.14	0.83	FALSE
5	GTEx	Artery Tibial	RP11-385F5.4	0.08	0.09	lasso	1	0.08	8.8e-07	5.6	5.7	1.6e-08	0.95	0.16	0.83	FALSE
6	GTEx	Brain Cerebellar Hemisphere	RP11-385F5.4	0.36	0.22	lasso	13	0.16	5.4e-05	6.0	-6.1	1.2e-09	-0.93	0.04	0.94	TRUE
7	GTEx	Brain Nucleus accumbens basal ganglia	RP11-385F5.5	0.19	0.08	lasso	5	0.07	5.6e-03	6.0	6.0	1.8e-09	0.96	0.05	0.87	FALSE
8	GTEx	Breast Mammary Tissue	RP11-385F5.4	0.13	0.12	lasso	4	0.09	3.1e-05	5.6	5.8	8.0e-09	0.95	0.09	0.90	FALSE
9	GTEx	Cells EBV-transformed lymphocytes	RP11-385F5.4	0.44	0.20	lasso	9	0.17	3.6e-06	5.7	5.8	5.1e-09	0.94	0.09	0.91	FALSE
10	GTEx	Cells Transformed fibroblasts	RP11-385F5.4	0.17	0.18	enet	13	0.17	5.2e-13	5.7	5.5	3.7e-08	0.92	0.20	0.80	FALSE
11	GTEx	Cells Transformed fibroblasts	RP11-385F5.5	0.13	0.06	lasso	8	0.04	4.1e-04	5.7	-5.8	4.9e-09	-0.96	0.05	0.95	FALSE
12	GTEx	Colon Transverse	LGALS8	0.24	0.13	lasso	2	0.10	1.4e-05	5.6	5.7	1.4e-08	0.94	0.22	0.75	FALSE
13	GTEx	Colon Transverse	RP11-385F5.4	0.31	0.22	lasso	3	0.22	8.7e-11	5.6	5.7	1.4e-08	0.93	0.25	0.75	FALSE
14	GTEx	Esophagus Mucosa	RP11-385F5.4	0.17	0.15	enet	28	0.15	4.2e-10	5.6	5.6	2.6e-08	0.84	0.25	0.75	FALSE
15	GTEx	Esophagus Muscularis	HEATR1	0.12	0.10	lasso	4	0.07	3.8e-05	6.0	-6.0	1.7e-09	-0.96	0.04	0.96	FALSE
16	GTEx	Lung	RP11-385F5.4	0.13	0.10	enet	19	0.09	2.8e-07	5.6	5.5	4.4e-08	0.85	0.15	0.85	FALSE
17	GTEx	Skin Not Sun Exposed Suprapubic	RP11-385F5.4	0.18	0.15	lasso	1	0.12	7.3e-07	5.6	5.7	1.6e-08	0.95	0.09	0.91	FALSE
18	GTEx	Skin Sun Exposed Lower leg	RP11-385F5.4	0.10	0.07	lasso	4	0.07	3.3e-06	5.7	5.5	5.1e-08	0.91	0.11	0.89	FALSE
19	GTEx	Stomach	RP11-385F5.4	0.19	0.07	lasso	6	0.05	2.9e-03	5.6	5.5	3.4e-08	0.94	0.08	0.70	FALSE
20	GTEx	Testis	RP11-385F5.5	0.18	0.08	lasso	5	0.06	1.2e-03	6.0	6.0	2.6e-09	0.95	0.04	0.96	FALSE
21	METSIM	Adipose	LGALS8	0.06	0.09	lasso	10	0.09	9.3e-13	5.7	-5.9	3.6e-09	-0.91	0.05	0.95	FALSE
22	NTR	Blood	LGALS8	0.06	0.07	lasso	4	0.07	5.1e-22	6.0	-5.7	1.2e-08	-0.88	0.03	0.97	FALSE
23	The Cancer Genome Atlas	Brain Lower Grade Glioma	LGALS8	0.07	0.09	enet	10	0.09	3.2e-10	5.8	5.9	2.9e-09	0.97	0.03	0.97	FALSE