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chr1:173,103,273-175,663,031

Best TWAS P=1.62e-10 · Best GWAS P=1.21e-10 conditioned to 0.0327

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	CommonMind	Brain Pre-frontal Cortex	DARS2	0.24	0.19	lasso	7	0.18	1.6e-21	5.1	-5.2	2.0e-07	-0.72	0.94	0.06	FALSE
2	CommonMind	Brain Pre-frontal Cortex	RABGAP1L	0.10	0.09	blup	647	0.11	4.0e-13	5.2	5.1	3.1e-07	0.73	0.61	0.39	FALSE
3	GTEx	Adrenal Gland	RABGAP1L	0.18	0.02	lasso	11	0.08	6.5e-04	6.4	6.3	2.7e-10	0.79	0.06	0.72	FALSE
4	GTEx	Brain Caudate basal ganglia	DARS2	0.19	0.02	lasso	5	0.13	1.2e-04	3.5	-5.6	2.3e-08	-0.85	0.03	0.85	FALSE
5	GTEx	Breast Mammary Tissue	RABGAP1L	0.18	0.03	enet	38	0.01	1.1e-01	5.6	6.2	4.8e-10	0.62	0.16	0.71	FALSE
6	GTEx	Cells Transformed fibroblasts	RC3H1	0.17	0.11	lasso	4	0.15	1.8e-11	4.4	-5.3	9.9e-08	-0.74	0.45	0.55	FALSE
7	GTEx	Lung	RABGAP1L	0.14	0.02	lasso	4	0.02	1.4e-02	6.3	6.2	5.6e-10	0.96	0.01	0.97	FALSE
8	METSIM	Adipose	RABGAP1L	0.06	0.05	blup	664	0.05	1.2e-07	5.5	5.6	1.7e-08	0.79	0.64	0.36	FALSE
9	NTR	Blood	ZBTB37	0.01	0.00	blup	268	0.01	4.6e-03	5.6	6.4	1.6e-10	0.81	0.08	0.72	TRUE
10	YFS	Blood	RABGAP1L	0.02	0.01	bslmm	657	0.01	3.1e-05	5.6	5.2	1.8e-07	0.61	0.40	0.40	FALSE
11	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	ANKRD45	0.04	0.00	enet	5	0.03	8.5e-04	6.3	5.4	8.1e-08	0.61	0.00	0.81	FALSE
12	The Cancer Genome Atlas	Esophageal Carcinoma	GPR52	0.16	0.10	lasso	4	0.08	1.4e-03	5.4	5.4	5.8e-08	0.67	0.01	0.90	FALSE
13	The Cancer Genome Atlas	Brain Lower Grade Glioma	SLC9A11	0.05	0.01	enet	8	0.04	3.9e-05	4.9	5.2	2.4e-07	0.57	0.00	0.98	FALSE
14	The Cancer Genome Atlas	Lung Adenocarcinoma	DARS2	0.04	0.01	lasso	2	0.01	3.3e-02	3.1	5.3	9.0e-08	0.86	0.00	0.49	FALSE
15	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	GAS5	0.03	0.03	enet	6	0.03	3.3e-04	6.4	6.1	1.3e-09	0.97	0.01	0.97	FALSE
16	The Cancer Genome Atlas	Prostate Adenocarcinoma	ANKRD45	0.09	0.08	enet	9	0.08	7.2e-09	6.3	5.9	4.2e-09	0.80	0.00	1.00	FALSE
17	The Cancer Genome Atlas	Thyroid Carcinoma	KLHL20	0.05	0.02	blup	13	0.03	8.7e-04	6.3	5.7	1.0e-08	0.76	0.00	0.94	FALSE
18	The Cancer Genome Atlas	Thyroid Carcinoma	RABGAP1L	0.09	0.01	blup	305	0.01	9.0e-02	3.2	5.4	6.9e-08	0.68	0.05	0.58	FALSE