Hub : Genes

LGALS8

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.3010	0.0390	0.0e+00	0.393	0.396	0.423	0.411	0.411	6.5e-51	2.0e-51	5.7e-56	7.2e-54	6.3e-54
2	GTEx	Cells Transformed fibroblasts	0.1180	0.0460	3.9e-04	0.065	NA	0.042	NA	0.055	1.3e-05	NA	3.9e-04	NA	5.5e-05
3	GTEx	Colon Transverse	0.2410	0.0740	1.4e-04	0.133	NA	0.035	NA	0.103	7.0e-07	NA	8.4e-03	NA	1.4e-05
4	GTEx	Lung	0.0863	0.0350	3.9e-03	0.003	NA	0.019	NA	0.007	1.7e-01	NA	1.2e-02	NA	8.5e-02
5	GTEx	Testis	0.2610	0.0760	1.2e-04	0.127	NA	0.077	NA	0.100	2.9e-06	NA	2.7e-04	NA	3.3e-05
6	METSIM	Adipose	0.0562	0.0150	1.1e-09	0.089	0.069	0.085	0.078	0.085	2.7e-13	1.3e-10	1.2e-12	9.1e-12	9.3e-13
7	NTR	Blood	0.0558	0.0128	3.5e-15	0.067	0.044	0.068	0.059	0.071	1.2e-20	4.3e-14	6.1e-21	1.8e-18	5.1e-22
8	YFS	Blood	0.0420	0.0174	1.4e-05	0.013	0.014	0.007	0.060	0.013	3.5e-05	1.3e-05	1.7e-03	5.7e-19	3.3e-05
9	TCGA	Kidney Renal Clear Cell Carcinoma	0.0505	0.0233	1.9e-03	0.026	0.017	0.018	NA	0.026	5.9e-04	4.7e-03	3.2e-03	NA	5.3e-04
10	TCGA	Brain Lower Grade Glioma	0.0656	0.0262	1.0e-09	0.085	0.076	0.088	NA	0.084	6.1e-10	5.3e-09	3.2e-10	NA	9.2e-10
11	TCGA	Prostate Adenocarcinoma	0.3277	0.0656	5.9e-11	0.179	0.111	0.150	NA	0.169	2.2e-18	1.1e-11	1.7e-15	NA	2.6e-17
12	TCGA	Thyroid Carcinoma	0.1690	0.0610	1.6e-05	0.019	0.067	0.038	NA	0.029	5.7e-03	4.4e-07	1.1e-04	NA	7.3e-04

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7	8	9	10	11	12
Bipolar Disorder (2018)	0.8	1.2	5.2	-0.2	0.5	-0.2	1.6	-0.1	0.2	1.0	2.2	2.3	-0.3	-0.0	0.9
Bipolar Disorder or Schizophrenia	0.1	0.3	1.3	-0.1	0.2	-0.0	0.7	-0.0	-0.0	0.7	1.1	1.2	-0.6	-0.0	-0.3
Depressed Affect (Nagel 2018)	0.5	1.1	3.6	0.4	0.3	0.1	-1.5	0.2	-0.1	-1.3	-1.9	-1.8	0.0	-0.0	-1.3
Depression (Nagel 2018)	0.7	1.1	3.9	-0.5	-0.9	-0.8	-2.0	-1.2	0.5	-0.3	-1.6	-1.4	-0.8	-0.5	-0.7
Intelligence (Savage-Jansen 2018)	0.1	0.4	1.3	0.1	0.5	0.3	0.2	0.5	-1.0	-0.5	-0.5	1.0	0.4	1.1	0.4
Neuroticism (Nagel 2018)	1.4	3.3	12.0	0.0	-0.5	-0.4	-2.8	-0.4	-0.0	-1.6	-3.3	-3.5	-0.2	-0.1	-2.3
Schizophrenia (2018)	0.1	0.2	1.2	0.0	-0.2	0.2	-0.4	0.0	-0.2	0.0	-0.4	-0.3	-0.5	0.0	-1.1
Schizophrenia vs Biploar Disorder	0.2	0.3	0.8	-0.3	-0.3	-0.4	-0.2	-0.3	0.7	0.9	0.2	0.0	-0.9	0.7	-0.3
Worry (Nagel 2018)	1.7	3.5	11.0	-0.0	-0.7	-0.4	-2.9	-0.3	0.0	-1.6	-3.3	-3.3	-0.3	-0.2	-2.9
Alzheimer’s Disease (in mother)	1.4	1.7	3.8	1.6	1.4	1.9	1.7	1.1	-1.4	-0.6	0.9	0.9	1.2	-0.2	1.3
Alzheimer’s Disease (in father)	0.2	0.2	0.7	0.4	0.1	0.5	0.4	0.7	-0.3	-0.8	-0.4	0.2	0.8	0.3	-0.5
Alzheimer’s Disease (including proxy)	1.4	2.0	4.3	1.6	1.7	2.1	1.8	1.5	-1.5	-0.7	0.7	1.0	1.5	1.1	0.7
Crohns Disease (2017)	1.5	3.2	6.2	-2.1	-2.4	-2.1	-1.1	-2.5	2.0	2.2	0.7	0.8	-2.3	-1.2	0.4
Irritable Bowel Disease (IBD)	1.4	3.3	7.3	-2.0	-2.0	-1.6	-0.3	-2.3	2.4	2.7	1.2	1.8	-2.4	-0.5	0.5
Ulcerative Colitis (UC)	0.4	0.8	2.2	-0.8	-0.7	-0.4	-0.0	-1.2	1.5	1.4	0.3	1.2	-1.1	0.3	-0.1
Major Depression (MDD)	1.8	2.1	4.8	-2.2	-1.4	-1.6	-1.3	-2.1	2.2	1.5	-0.0	0.7	-1.7	-0.6	-0.1
Reaction Time	0.0	0.1	0.3	-0.1	-0.4	-0.1	-0.3	0.2	-0.1	0.1	-0.2	-0.2	-0.0	0.2	-0.6
Verbal and Numeric Reasoning (VNR)	0.2	0.6	3.4	0.2	0.3	0.3	0.7	0.3	-0.8	0.2	0.5	1.4	0.3	1.8	0.3
Breast Cancer	0.2	0.4	0.9	0.7	0.5	0.6	0.2	0.7	-0.7	-0.9	-0.5	-0.7	0.7	0.8	-0.4
Ovarian Cancer	0.3	0.4	2.1	-0.4	-0.2	-0.2	-0.3	0.2	0.4	-0.3	-0.2	-0.6	-0.5	1.5	-1.4
Prostate Cancer	2.4	3.4	11.6	0.3	-0.4	0.0	-2.4	0.4	-0.1	-1.7	-3.2	-2.6	0.1	1.9	-3.4
Age at First Birth	0.2	0.3	1.4	-0.2	-0.3	-0.0	-0.7	0.4	0.1	-0.6	-0.7	-0.7	-0.2	-1.2	0.1
Bipolar Disorder (2011)	0.4	0.3	1.7	-0.4	-0.3	-0.5	-0.1	-1.3	0.4	0.6	0.3	0.3	-0.6	0.0	0.9
Body Mass Index (BMI) (2010)	0.4	0.5	1.3	-0.6	-0.5	-0.6	-0.0	-1.1	1.0	0.7	0.5	0.1	-0.6	-1.0	1.1
Coronary Artery Disease (CAD)	0.3	0.3	1.5	-0.4	0.0	-0.3	0.3	-0.4	0.6	0.9	0.6	1.2	-0.2	0.0	0.3
Crohns Disease (2012)	1.1	1.8	4.8	-1.3	-1.1	-1.4	0.0	-2.2	1.2	1.7	1.4	1.6	-1.5	0.0	1.1
Mean Putamen Volume	1.1	1.2	4.4	0.9	2.1	2.0	1.3	0.9	-0.9	-0.4	0.9	0.5	1.1	-0.1	0.3
Fasting Glucose	1.9	2.3	6.7	0.5	0.3	0.5	-1.6	1.4	-0.7	-2.0	-2.2	-2.6	0.7	-2.2	-1.3
HbA1C	1.6	1.8	4.4	-1.3	-1.6	-1.4	-0.3	-2.1	1.9	1.5	1.2	0.1	-1.5	0.2	0.9
HDL Cholesterol	0.9	1.4	3.2	1.1	1.4	1.6	1.5	1.4	-1.8	-0.7	0.7	1.0	1.4	-0.2	0.6
LDL Cholesterol	0.7	1.1	2.1	1.2	1.0	0.7	-0.6	0.8	-1.2	-1.3	-1.4	-0.8	0.8	-0.9	-1.3
Lupus	0.3	0.4	2.9	0.0	-0.5	-0.4	-0.6	-0.5	0.2	-0.3	-0.6	0.1	-0.3	1.7	0.3
Neuroticism (2016)	0.0	0.1	0.2	-0.2	-0.4	-0.3	0.1	0.2	0.3	0.1	0.1	-0.2	-0.3	0.2	0.2
Primary Biliary Cirrhosis	0.7	1.0	2.0	-1.1	-1.0	-1.1	-0.5	-0.7	1.4	1.1	0.6	0.3	-1.4	1.4	-0.7
Rheumatoid Arthritis	0.4	0.5	0.9	-0.7	-0.9	-0.9	-0.7	-0.4	0.9	0.8	0.0	-0.8	-0.8	0.9	0.1
Schizophrenia (2014)	0.1	0.3	0.9	0.1	0.2	0.1	0.6	0.1	-0.0	0.6	1.0	0.9	-0.4	0.7	-0.8
Triglycerides	0.4	0.6	4.0	0.7	0.2	0.1	-0.3	0.6	-0.2	-0.2	-0.6	-0.4	0.2	2.0	-1.3
Type 2 Diabetes (T2D) (2012)	1.0	1.2	5.6	0.4	0.4	0.5	-0.6	-0.5	-0.6	-1.1	-1.3	-1.4	0.6	1.4	-2.4
Ulcerative Colitis	1.7	2.4	4.9	-1.8	-1.6	-1.6	-0.2	-2.2	2.0	2.0	1.2	1.4	-1.8	0.4	1.0
Blood Eosinophil Count	0.1	1.0	3.2	-0.7	-1.4	-1.4	-1.8	-0.6	0.6	0.6	-0.9	-0.9	-1.2	0.3	-0.4
Blood Platelet Count	3.0	35.0	62.9	7.9	7.4	7.3	2.7	7.0	-7.7	-7.6	-3.3	-2.5	7.4	0.1	-2.6
Blood Red Count	0.0	0.5	1.0	1.0	0.7	0.9	0.2	0.5	-0.6	-0.9	-0.5	-0.0	1.0	-0.1	-0.7
Blood White Count	0.7	5.0	9.1	2.7	2.6	2.5	0.0	2.4	-2.8	-3.0	-2.0	-1.9	2.6	-0.2	-1.6
Heel T-Score	0.2	1.3	2.9	1.1	1.6	1.4	1.7	0.3	-0.9	-0.4	1.0	0.7	1.3	1.4	0.8
BMI	0.2	1.1	5.3	0.1	0.6	-0.5	-1.7	-0.2	-0.3	-0.8	-1.8	-2.3	-0.3	-0.2	-0.1
Height	0.2	4.0	8.9	2.2	3.0	2.6	3.0	2.3	-1.1	-0.5	1.7	1.9	2.0	1.0	0.5
Waist Hip Ratio (WHR)	0.5	2.1	7.3	0.7	-0.0	0.3	-1.6	-0.1	-0.6	-2.0	-2.7	-2.3	0.5	-0.1	-2.3
Systolic Blood Pressure	0.8	4.0	10.2	2.4	1.5	2.2	-0.0	1.8	-2.3	-3.2	-2.1	-1.9	2.4	-1.2	-1.1
Smoking Status	1.7	4.1	7.4	-2.6	-2.2	-2.3	-0.6	-1.7	2.6	2.5	1.5	1.4	-2.7	2.0	0.2
Allergy or Eczema	0.2	0.4	1.8	-0.5	-0.8	-0.5	-0.4	-0.6	0.7	0.0	-0.5	-0.6	-0.3	-1.3	0.5
Cardiovascular Disease	0.5	1.5	5.1	0.5	-0.2	-0.2	-1.7	0.2	-0.0	-1.4	-2.1	-2.3	-0.2	-0.3	-1.8
Hypothyroidism (self reported)	0.2	0.5	1.2	-0.9	-0.7	-1.0	-0.8	-0.6	0.7	0.7	-0.0	-0.2	-0.8	1.1	-0.5
Respiratory disease	2.9	6.5	14.7	-3.1	-3.0	-3.4	-2.4	-3.8	3.5	2.4	-0.3	0.1	-3.0	0.0	0.3
Type 2 Diabetes (T2D) (2018)	0.4	0.8	2.7	0.3	0.1	-0.7	-1.6	-0.2	-0.1	-0.2	-1.6	-1.5	-0.6	-0.4	-1.1
Lung FEV1/FVC ratio	0.1	0.8	1.7	1.1	1.0	1.2	0.8	0.9	-1.3	-0.8	0.4	0.1	1.1	0.5	-0.5
Lung FVC	0.4	2.3	5.7	1.7	1.3	2.1	1.7	2.4	-2.0	-1.2	0.6	0.5	1.6	0.1	-1.1
Neuroticism	1.2	3.0	10.0	0.6	0.3	0.2	-2.3	0.2	-0.1	-2.1	-3.2	-3.1	0.4	-0.4	-2.4
Chronotype (morning person)	0.3	0.7	1.2	1.1	1.0	1.1	1.1	0.7	-1.0	-0.8	0.3	0.6	1.0	-0.1	-0.5
Hair Pigment	0.0	0.9	2.0	1.2	1.4	1.1	0.2	1.2	-0.8	-1.0	-0.7	-0.4	1.1	0.9	-0.9
Tanning	0.0	0.4	1.3	0.4	-0.0	0.1	-0.4	1.1	-0.3	-0.9	-0.6	-0.3	0.2	1.0	-0.5
Hand grip strength (left)	0.2	0.4	1.1	0.4	1.0	0.8	0.9	0.4	-0.4	-0.5	0.3	-0.0	0.9	-0.2	1.1
Number of treatments/medications taken	0.1	0.2	0.7	-0.4	-0.7	-0.4	-0.1	0.1	0.4	0.4	0.1	-0.2	-0.4	-0.0	0.9
Average weekly spirits intake	1.0	1.3	2.4	-1.2	-1.5	-1.5	-1.3	-0.9	0.9	0.6	-0.5	-1.1	-1.3	1.4	-0.7
Sensitivity / hurt feelings	1.4	2.3	9.4	-0.3	-0.9	-0.9	-2.5	-1.3	0.2	-0.6	-2.1	-3.1	-0.7	1.1	-1.6
Frequency of depressed mood in last 2 weeks	0.4	0.5	1.8	-0.4	-0.7	-0.6	-1.3	-0.7	0.3	-0.2	-0.9	-0.7	-0.5	-0.9	-0.5
Hearing difficulty/problems: Yes	0.1	0.2	1.1	0.2	0.4	0.3	0.5	-0.2	-0.3	0.2	0.5	0.3	0.1	-0.6	1.0
Relative age of first facial hair	1.0	2.0	4.1	-1.7	-1.7	-2.0	-1.6	-2.0	1.3	0.6	-0.5	-0.9	-1.2	-1.7	-0.2
Other serious medical condition/disability diagnosed by doctor	1.7	2.2	6.4	-0.0	-0.5	-0.5	-2.4	0.3	-0.2	-1.0	-2.4	-2.5	-0.4	-0.4	-2.5
Ever used hormone-replacement therapy (HRT)	3.5	4.5	10.8	-2.8	-2.1	-2.7	-2.0	-2.4	3.3	1.8	-0.0	-0.5	-2.8	1.5	-0.9
Ever had hysterectomy (womb removed)	2.8	3.2	6.1	-2.1	-2.1	-2.0	-0.8	-1.8	2.4	2.5	1.4	1.4	-2.3	0.0	0.5
Systolic blood pressure, automated reading	2.4	7.1	15.1	3.3	2.7	3.0	0.2	2.6	-3.2	-3.9	-2.4	-2.0	3.2	-1.2	-1.7
Eye problems/disorders: Diabetes related eye disease	1.0	1.1	2.3	1.3	1.3	1.5	1.3	0.9	-1.2	-0.7	0.6	0.4	1.4	0.7	-0.2
Angina	0.3	0.4	0.9	0.0	0.4	-0.2	0.3	-0.9	0.6	1.0	0.7	0.8	-0.4	0.9	0.9
Medication for hormone replacement therapy	1.2	1.4	3.8	-1.8	-1.5	-1.2	-0.9	-1.0	2.0	1.0	0.0	0.1	-1.4	1.0	-0.6
Vitamin and mineral supplements	0.8	1.1	2.5	-1.3	-1.2	-1.6	-1.0	-1.2	0.6	1.1	0.3	-0.5	-1.3	-0.9	0.6
Supplements: Zinc	2.8	3.1	6.8	2.4	2.2	2.6	2.1	1.7	-2.0	-1.3	0.5	1.1	2.0	-0.9	-0.1
Medication: Co-codamol	0.1	0.2	1.0	-0.3	-0.4	0.2	0.3	0.0	0.3	0.4	0.5	0.3	-0.2	-0.0	1.0
Medication: Metformin	0.5	0.6	2.3	-0.4	-0.1	-1.1	-1.5	-1.0	0.4	0.3	-1.0	-0.5	-0.9	-0.9	0.0
Diabetes (father)	0.4	0.5	1.2	1.1	0.6	0.1	-0.6	-0.5	-1.1	-0.6	-0.9	-0.6	0.5	-0.4	-0.9
Diabetes (mother)	0.9	1.1	2.7	1.6	0.8	1.2	1.4	1.1	-1.4	-0.5	0.6	0.1	1.1	-1.1	0.5
Severe depression (siblings)	0.3	0.4	2.4	-0.3	-0.0	-0.2	-0.8	-0.2	0.1	-0.4	-0.8	-1.6	-0.2	-0.5	-0.5
Pack years adult smoking proportion	3.6	5.6	13.6	-2.4	-2.3	-2.4	0.0	-1.8	2.7	3.7	2.7	2.0	-2.8	2.2	1.3
Impedance of leg (right)	0.2	1.1	5.7	-0.0	-0.6	0.1	-0.8	0.2	-0.3	-1.0	-1.1	-0.9	0.5	1.6	-2.4
Leg fat-free mass (left)	0.1	0.5	2.9	-0.1	0.8	-0.4	-0.4	-0.4	0.5	0.5	-0.2	-0.1	-0.4	-1.1	1.7
Trunk fat percentage	0.1	0.3	1.1	0.3	0.4	-0.2	-0.9	-0.5	-0.1	-0.4	-1.0	-1.1	-0.1	0.3	-0.1
Hand grip strength (right)	0.4	1.0	1.9	0.8	1.3	1.2	1.2	0.7	-0.9	-0.7	0.4	-0.0	1.4	0.9	1.3
Townsend deprivation index at recruitment	2.1	2.9	5.9	-2.2	-1.6	-1.9	-0.4	-2.0	2.4	1.9	1.0	1.1	-1.9	-0.9	1.9
Current tobacco smoking	2.1	3.4	6.1	-2.0	-2.0	-2.1	-0.5	-1.8	2.4	2.5	1.6	1.3	-2.3	1.6	0.7
Average weekly fortified wine intake	0.6	0.7	2.0	0.3	-0.1	-0.0	-0.9	0.3	-0.3	-1.0	-1.3	-1.4	0.1	-1.2	-1.1
Maternal smoking around birth	3.2	4.6	8.6	-2.9	-2.5	-2.9	-1.8	-2.6	2.6	2.4	0.3	0.8	-2.8	0.7	0.2
Fed-up feelings	0.9	1.7	4.7	-0.9	-0.5	-0.8	-1.9	-0.8	1.0	-0.5	-1.7	-1.8	-0.9	1.2	-2.2
Frequency of unenthusiasm / disinterest in last 2 weeks	1.1	1.5	3.7	-1.5	-1.5	-1.5	-1.9	-0.9	1.3	0.5	-0.9	-0.8	-1.6	-0.2	-0.9
Relative age voice broke	0.3	0.5	1.5	-0.3	-0.5	-0.5	-0.7	-1.2	0.7	-0.2	-0.8	-0.6	-0.0	-1.2	-0.3
Taking other prescription medications	1.0	1.5	3.3	-1.5	-1.8	-1.7	-0.7	-0.7	1.5	1.5	0.6	0.4	-1.7	0.2	0.9
Age when periods started (menarche)	1.0	2.4	6.9	-1.0	-0.2	-0.6	1.3	-0.7	0.6	2.1	2.6	2.6	-0.9	2.1	1.1
Bilateral oophorectomy (both ovaries removed)	0.9	1.1	1.7	-1.3	-0.8	-0.9	-0.0	-1.2	1.0	1.3	1.3	1.0	-1.0	0.7	1.1
Heel bone mineral density (BMD) T-score, automated (left)	0.4	0.9	2.9	1.0	1.7	1.2	1.1	0.2	-0.7	-0.1	0.6	0.8	0.6	-1.3	0.4
Tinnitus: Yes, but not now, but have in the past	0.8	0.8	2.1	-0.9	-1.4	-0.7	0.1	-0.6	1.0	0.7	0.5	0.5	-0.7	-1.4	1.4
Qualifications: CSEs or equivalent	0.1	0.2	1.1	0.1	0.0	-0.0	-0.7	0.0	-0.5	0.1	-0.3	-0.2	-0.2	-1.0	-0.3
Serious illness, injury or assault to yourself	0.4	0.5	1.6	-0.4	-1.0	-0.9	-1.3	0.1	-0.1	0.4	-0.5	-1.1	-0.9	0.3	-0.4
High blood pressure	0.0	0.1	0.2	0.4	0.1	0.3	0.2	0.3	-0.2	-0.3	0.0	0.3	0.1	0.4	0.3
Hayfever, allergic rhinitis or eczema	0.1	0.1	0.8	-0.1	-0.4	0.0	0.1	-0.2	0.1	-0.1	-0.0	-0.4	0.2	-0.9	0.7
Multivitamins +/- minerals	1.0	1.3	3.9	1.3	1.2	1.2	1.6	0.9	-0.6	-0.4	0.7	1.0	0.9	2.0	-0.5
Stomach or abdominal pain in last month	0.2	0.3	0.6	-0.8	-0.5	-0.5	-0.8	-0.3	0.3	-0.1	-0.7	-0.4	-0.4	0.2	-0.6
Supplements: Glucosamine	2.7	3.6	6.2	2.5	2.3	2.2	0.1	1.4	-2.2	-2.5	-1.9	-1.6	2.0	-1.1	-1.4
Diverticular disease/diverticulitis (self-reported)	0.4	0.5	1.8	-0.6	-0.6	-0.6	-1.0	-0.7	0.6	0.3	-0.5	-0.4	-1.0	0.5	-1.3
Medication: Atenolol	1.7	2.1	6.3	-0.8	-0.3	-0.4	1.6	-0.1	1.1	1.9	2.5	2.4	-0.5	0.2	2.2
Medication: Levothyroxine sodium	1.1	1.9	3.9	-1.9	-1.5	-1.9	-1.1	-1.5	1.3	1.9	0.7	0.1	-2.0	0.6	0.3
Sitting height	1.0	7.2	17.3	3.3	4.2	3.6	3.1	3.6	-2.6	-1.9	0.7	0.9	3.3	0.4	0.6
Chronic bronchitis/emphysema (father)	3.1	3.7	9.9	-2.4	-1.9	-2.6	-1.4	-2.0	3.1	2.1	0.5	0.3	-2.7	0.7	0.4
High blood pressure (mother)	1.2	1.7	4.3	0.8	0.7	0.9	2.1	1.3	-0.2	0.6	1.9	1.8	0.9	0.7	1.9
Body mass index (BMI)	0.2	0.9	3.5	-0.1	0.0	-0.8	-1.8	-0.8	-0.0	-0.4	-1.6	-1.9	-0.7	-0.3	0.1
Impedance of leg (left)	0.3	1.3	5.7	0.5	-0.3	0.7	-0.3	0.6	-0.8	-1.4	-1.0	-0.9	1.1	1.6	-2.4
Leg predicted mass (left)	0.1	0.5	3.1	-0.0	0.9	-0.3	-0.4	-0.4	0.4	0.4	-0.2	-0.1	-0.4	-1.2	1.8
Trunk fat mass	0.1	0.6	1.9	0.8	1.0	0.2	-0.8	-0.0	-0.5	-0.8	-1.4	-1.4	0.3	-0.0	0.1
Waist circumference	0.3	1.1	4.0	0.2	0.2	-0.6	-1.8	-0.7	-0.1	-0.8	-2.0	-2.0	-0.5	-0.5	-0.4
Number of incorrect matches in round	0.2	0.3	1.6	-0.5	-0.7	-0.1	-0.0	-0.1	0.7	0.3	-0.0	0.5	-0.4	-1.3	0.4
Past tobacco smoking	0.9	1.7	3.5	1.4	1.6	1.5	1.9	1.5	-1.3	-0.5	1.2	0.5	1.4	-0.4	1.4
Alcohol usually taken with meals	12.2	19.7	35.3	5.8	4.9	5.7	2.2	4.8	-5.9	-5.7	-2.3	-2.4	5.9	-1.0	-2.0
Nervous feelings	1.5	2.7	8.1	-0.1	-0.4	-0.2	-2.5	-0.1	-0.2	-1.5	-2.7	-2.8	-0.3	-0.1	-2.8
Frequency of tenseness / restlessness in last 2 weeks	0.8	1.2	3.3	-0.5	-0.9	-0.5	-1.8	-0.4	0.2	-0.6	-1.7	-1.4	-0.6	-1.8	-0.9
Hearing difficulty/problems with background noise	1.2	1.9	9.4	-1.2	-1.2	-1.1	-1.1	-1.5	0.8	0.9	-0.2	-0.5	-1.2	-3.1	1.5
Hair/balding pattern: Pattern 2	1.8	2.2	4.2	-1.4	-1.6	-1.1	0.6	-1.7	1.4	2.0	1.9	1.6	-1.4	-1.0	1.6
Had menopause	0.6	0.7	1.3	-0.3	-0.9	-0.8	-1.1	-0.9	1.1	0.0	-0.9	-0.7	-0.9	-1.0	-1.1
Had other major operations	0.4	0.5	1.8	-0.3	-1.2	-0.9	-0.7	-1.3	0.5	0.5	-0.4	0.1	-0.8	0.2	-0.5
Forced vital capacity (FVC)	0.2	0.9	2.4	1.0	0.8	1.4	0.9	1.5	-1.2	-0.6	0.1	0.1	1.0	-0.7	-0.3
Heel bone mineral density (BMD) T-score, automated (right)	0.5	1.2	4.2	1.5	2.0	1.5	1.2	0.4	-1.3	-0.7	0.4	0.3	1.1	-0.8	0.0
Ever unenthusiastic/disinterested for a whole week	0.8	1.0	4.7	-1.0	-1.3	-0.8	-0.9	-0.1	1.3	0.1	-0.7	-0.1	-0.6	-2.2	-0.2
Qualifications: None of the above	0.8	1.6	3.5	-1.3	-1.3	-1.5	-0.2	-1.3	1.5	1.9	1.2	0.5	-1.6	0.5	1.3
Financial difficulties in last 2 years	2.2	2.9	5.8	-2.1	-2.4	-2.4	-1.6	-2.2	2.1	1.5	-0.5	-0.2	-2.0	-0.2	0.7
Mouth/teeth dental problems	0.3	0.4	1.5	0.0	0.2	-0.1	-0.5	-0.8	0.3	-0.6	-1.0	-1.0	0.2	-1.2	-0.4
Heart attack	0.4	0.5	1.8	0.5	0.6	0.7	0.7	-0.1	0.0	0.3	0.4	1.1	0.7	1.4	-0.3
Allergy	0.9	2.1	3.7	1.7	1.8	1.4	0.1	1.7	-1.8	-1.8	-1.1	-1.1	1.3	0.4	-1.9
Pain all over the body in last month	3.6	3.8	8.3	-2.1	-1.8	-1.8	-0.1	-2.5	2.3	2.9	1.6	1.5	-2.3	1.0	1.9
Diabetes (self-reported)	0.2	0.4	1.2	0.6	0.8	-0.1	-0.8	0.1	-0.5	-0.2	-0.9	-1.1	-0.3	-0.2	-0.4
Hayfever/allergic rhinitis (self-reported)	0.1	0.2	0.7	-0.0	0.2	-0.1	0.5	-0.0	0.3	0.5	0.6	0.4	0.1	-0.8	0.3
Medication: Ramipril	0.3	0.4	1.3	-0.1	0.3	0.2	0.6	-0.2	0.6	0.3	0.8	1.1	0.0	1.1	0.8
Medication: Simvastatin	0.5	0.8	2.6	-0.0	-0.4	-0.7	-1.2	-0.9	0.9	-0.2	-0.9	-1.6	-0.8	-0.4	-1.0
Fluid intelligence score	0.9	1.9	6.7	0.1	0.7	0.6	1.8	1.3	-0.5	0.7	1.6	2.4	0.3	2.6	1.1
Illnesses of siblings	1.8	2.6	4.6	1.9	2.1	2.1	1.5	2.1	-1.8	-1.7	0.2	0.6	2.0	0.6	-0.9
Neuroticism score	1.4	3.0	10.7	-0.0	-0.3	-0.2	-2.7	-0.3	0.1	-1.6	-3.1	-3.3	-0.1	-0.4	-2.3
Weight	0.1	0.5	1.7	0.5	0.9	-0.2	-1.0	-0.2	-0.3	-0.4	-1.2	-1.3	-0.1	-0.2	0.5
Impedance of arm (right)	0.3	1.6	5.9	-0.6	-0.4	-0.0	1.7	-0.1	0.8	1.4	2.4	2.4	-0.1	1.4	0.2
Arm fat percentage (right)	0.1	0.3	1.0	-0.2	-0.0	-0.7	-1.0	-0.7	0.0	0.2	-0.7	-0.8	-0.7	-0.2	0.5
Trunk fat-free mass	0.1	0.8	2.4	0.9	1.5	0.4	-0.6	0.6	-0.6	-0.7	-1.2	-1.1	0.3	-0.8	0.7
Hip circumference	0.2	0.9	3.2	-0.4	-0.1	-1.1	-1.8	-1.0	0.4	0.0	-1.4	-1.5	-0.8	-0.5	0.1
Time employed in main current job	0.5	0.6	2.4	0.8	0.1	1.0	0.7	0.1	-1.1	-0.7	-0.1	0.1	0.8	-1.6	0.5
Alcohol intake versus 10 years previously	3.4	5.0	10.4	-2.3	-2.4	-2.8	-3.2	-3.1	2.7	1.2	-1.5	-0.7	-2.9	-0.2	-1.3
Father’s age at death	2.7	3.6	8.2	2.1	1.9	2.2	0.3	1.9	-2.2	-2.9	-1.8	-1.8	2.5	-0.5	-0.6
Worrier / anxious feelings	1.6	3.0	8.5	-0.7	-1.6	-1.2	-2.8	-1.4	0.7	-0.7	-2.7	-2.9	-1.0	-0.1	-1.7
Frequency of tiredness / lethargy in last 2 weeks	2.0	3.3	9.5	-0.9	-1.7	-1.6	-3.1	-1.5	1.2	-0.6	-2.8	-2.5	-1.3	-0.7	-1.7
Falls in the last year	0.3	0.4	2.9	-0.1	-0.1	-0.4	-0.3	0.3	0.5	0.5	0.2	0.1	-0.8	1.7	-0.2
Hair/balding pattern: Pattern 3	4.5	6.6	12.9	3.5	3.6	2.8	0.5	3.3	-2.9	-3.1	-1.8	-1.6	2.5	0.6	-2.2
Number of live births	0.2	0.3	1.4	-0.2	0.4	0.1	0.4	0.5	-0.2	0.2	0.8	1.0	0.1	0.2	1.2
Forced expiratory volume in 1-second (FEV1)	0.5	1.6	3.5	1.5	1.3	1.9	1.0	1.8	-1.8	-1.2	-0.2	-0.2	1.5	-0.5	-0.7
Pulse rate	0.4	0.7	1.5	0.4	0.5	1.1	1.2	1.0	0.1	-0.6	0.2	0.9	0.8	-1.0	1.2
Happiness	0.6	0.7	4.5	-0.2	-0.4	-0.3	-0.9	-0.5	0.2	-0.2	-1.0	-1.0	-0.6	-2.1	0.3
Noisy workplace	0.2	0.2	0.8	-0.5	-0.4	-0.5	-0.2	-0.3	0.6	0.5	0.1	0.1	-0.4	-0.9	-0.4
Qualifications: A levels/AS levels or equivalent	0.2	0.5	0.9	1.0	0.5	0.7	0.0	0.3	-0.9	-0.8	-0.7	-0.6	0.9	0.8	-0.6
Serious illness, injury or assault of a close relative in last 2 years	0.1	0.2	0.6	-0.1	-0.5	-0.1	-0.8	-0.0	-0.1	-0.1	-0.7	-0.4	-0.4	0.4	-0.1
Mouth/teeth dental problems: Dentures	0.4	0.6	2.9	-0.5	-0.9	-0.5	-0.3	-0.0	0.1	1.0	0.4	0.7	-1.0	1.7	0.4
Asthma	2.4	4.7	8.2	-2.7	-2.2	-2.6	-0.8	-2.9	2.6	2.9	1.2	1.3	-2.4	0.4	2.2
Medication: Ibuprofen (e.g. Nurofen)	1.1	1.5	2.5	1.4	1.3	1.4	0.7	1.0	-1.5	-1.6	-0.6	-0.1	1.5	-1.4	-0.7
Medication: Cholesterol lowering	0.1	0.2	0.6	0.6	0.7	0.3	-0.2	0.1	-0.0	-0.1	-0.2	-0.7	-0.0	0.8	-0.7
Depression (self-reported)	1.5	1.8	5.5	0.5	-0.2	0.1	-1.5	0.7	-1.0	-1.7	-2.3	-2.2	0.4	-1.8	-0.7
Medication: Lansoprazole	0.5	0.6	1.3	-1.2	-0.9	-0.9	-0.6	-0.5	1.0	0.9	0.0	0.5	-1.0	-0.7	0.4
Prospective memory result	0.9	1.1	2.6	-0.7	-1.1	-0.7	-1.4	-0.6	0.6	-0.2	-1.1	-1.6	-0.9	-1.4	-1.1
Lung cancer (father)	0.5	0.6	1.3	-0.8	-0.2	-1.1	-0.7	-0.9	1.1	1.0	0.2	0.1	-1.1	0.9	0.2
Illnesses of mother	0.7	0.9	3.1	-0.2	0.3	-0.2	-1.1	-0.0	0.0	-0.9	-1.3	-1.5	0.1	1.2	-1.8
Forced expiratory volume in 1-second (FEV1), Best measure	0.4	1.1	2.5	1.2	1.3	1.6	1.1	1.4	-1.4	-0.7	0.4	0.4	1.3	-0.6	-0.4
Pulse wave Arterial Stiffness index	0.9	1.1	2.1	1.4	1.4	1.4	1.2	1.1	-1.0	-0.8	0.3	0.5	1.4	0.6	0.1
Impedance of arm (left)	0.4	1.7	6.2	-0.1	-0.0	0.6	2.1	0.4	0.5	1.0	2.4	2.5	0.4	1.3	0.4
Arm fat mass (right)	0.1	0.5	1.7	0.1	0.4	-0.6	-1.3	-0.7	-0.2	-0.2	-1.2	-1.3	-0.5	-0.1	0.4
Trunk predicted mass	0.1	0.8	2.3	0.9	1.5	0.4	-0.7	0.6	-0.6	-0.8	-1.3	-1.2	0.3	-0.9	0.6
Standing height	0.2	1.8	5.3	1.6	2.3	1.7	1.6	1.6	-0.8	-0.5	0.6	1.1	1.6	0.3	0.9
Length of working week for main job	0.2	0.2	0.5	-0.4	-0.6	-0.5	-0.0	-0.3	0.5	0.7	0.5	0.3	-0.6	-0.7	0.0
Exposure to tobacco smoke at home	1.7	1.9	5.1	-1.6	-1.0	-1.5	-1.3	-2.2	1.6	0.7	-0.3	-0.2	-1.4	-2.2	0.6
Breastfed as a baby	4.2	5.3	8.7	2.9	2.4	2.8	1.2	3.0	-2.9	-2.8	-1.3	-1.6	2.4	0.9	-2.2
Tense / ‘highly strung’	0.8	1.3	4.1	0.5	0.3	0.4	-1.3	-0.1	-0.5	-1.5	-1.9	-2.0	0.6	-1.3	-1.2
Seen doctor (GP) for nerves, anxiety, tension or depression	0.6	0.8	3.3	0.1	0.3	-0.2	-1.4	-0.1	-0.1	-0.8	-1.8	-1.5	-0.1	-0.9	-1.0
Hair/balding pattern: Pattern 4	0.6	1.4	3.3	-1.6	-0.8	-1.3	-0.5	-1.8	1.3	1.4	0.6	0.8	-0.9	-1.4	1.2
Birth weight of first child	0.2	0.4	2.0	0.4	0.7	0.1	-0.4	-0.0	-0.0	-0.3	-0.8	-0.4	0.0	1.4	-1.1
Peak expiratory flow (PEF)	0.3	0.7	1.4	0.7	1.1	1.1	0.9	1.2	-0.9	-0.4	0.4	0.3	0.9	1.0	0.1
Pulse wave reflection index	1.5	1.9	4.2	1.3	1.5	1.7	2.0	1.6	-1.5	-0.2	1.5	1.4	1.4	0.6	0.4
Ever highly irritable/argumentative for 2 days	0.4	0.5	1.7	-0.7	-1.3	-0.4	-0.7	-0.3	0.6	-0.4	-0.8	-0.3	-0.3	-0.8	-1.0
Loud music exposure frequency	1.2	1.4	3.2	-1.1	-1.1	-0.9	0.1	-1.1	1.0	1.7	1.2	1.2	-1.1	1.8	0.8
Qualifications: O levels/GCSEs or equivalent	0.3	0.4	1.2	0.6	0.4	0.7	0.7	0.6	-0.4	-0.3	0.1	1.1	0.6	1.0	-0.6
Mouth/teeth dental problems: Bleeding gums	0.1	0.1	0.6	-0.2	-0.3	-0.3	-0.5	-0.3	-0.3	-0.1	-0.4	-0.8	-0.2	0.0	-0.3
Blood clot in the leg (DVT)	2.0	2.6	8.0	-0.9	-0.7	-0.4	1.4	-0.5	1.3	2.2	2.8	2.8	-1.1	1.4	1.4
Medication: Paracetamol	0.3	0.6	1.1	0.8	0.9	0.9	0.4	0.7	-0.7	-1.1	-0.7	-0.6	1.0	0.7	0.0
Headache pain in last month	0.2	0.3	1.4	0.4	0.2	0.6	0.3	-0.0	-0.3	-1.0	-0.6	-0.3	0.6	-1.2	-0.4
Medication for cholesterol, blood pressure or diabetes	0.1	0.2	0.6	-0.6	-0.7	-0.3	-0.3	0.1	0.1	0.2	-0.1	0.4	-0.2	-0.8	-0.3
Glaucoma (self-reported)	1.3	1.5	5.2	-0.8	-0.7	-0.7	0.9	-0.8	0.5	1.5	1.7	1.9	-0.6	-2.3	1.1
Gout (self-reported)	2.7	3.7	10.7	-1.4	-2.2	-1.9	-3.3	-1.3	0.7	0.3	-2.1	-2.2	-2.0	0.1	-2.6
Hypothyroidism/myxoedema (self-reported)	0.4	0.7	1.7	-1.1	-0.8	-1.3	-0.9	-0.7	0.8	1.1	0.2	-0.0	-1.0	0.8	-0.6
Medication: Amlodipine	0.4	0.5	1.6	-0.9	-0.6	-0.6	-0.2	-1.2	0.8	0.8	0.1	0.2	-0.9	-0.6	0.8
Medication: Ventolin 100micrograms inhaler	1.9	2.4	4.9	-2.2	-2.2	-2.1	-1.0	-1.2	2.1	1.7	0.4	0.7	-1.8	-0.5	1.1
Birth weight	0.4	1.0	2.9	-1.2	-0.2	-0.8	0.2	-0.2	1.7	1.4	1.1	0.7	-1.1	1.1	0.4
Chronic bronchitis/emphysema (mother)	1.4	1.6	4.5	-1.6	-1.4	-1.6	-2.1	-1.1	1.0	0.8	-0.9	-0.9	-1.7	-0.8	-0.3
High blood pressure (siblings)	0.9	1.4	4.4	-1.1	-1.3	-1.1	-0.2	-1.0	0.7	1.4	0.8	0.4	-1.2	-1.5	2.1
Forced vital capacity (FVC), Best measure	0.2	0.6	1.5	0.5	0.8	1.0	1.2	1.1	-0.7	0.2	1.1	1.0	0.6	-0.2	0.3
Body fat percentage	0.2	0.6	2.6	0.4	0.3	-0.2	-1.2	-0.4	-0.4	-0.8	-1.5	-1.6	-0.0	-0.1	-0.3
Leg fat percentage (right)	0.6	2.1	7.9	-0.0	-0.3	-0.8	-2.5	-0.7	-0.5	-1.1	-2.6	-2.8	-0.5	-0.3	-1.1
Arm fat-free mass (right)	0.2	1.2	3.9	0.8	1.1	0.2	-1.4	0.3	-0.6	-1.1	-2.0	-1.8	0.4	-1.1	0.3
Exposure to tobacco smoke outside home	1.2	1.6	3.2	-1.7	-1.6	-1.7	-1.3	-1.3	1.8	1.1	-0.3	-0.2	-1.6	-0.5	-0.1
Comparative body size at age 10	0.3	0.8	5.0	0.4	0.9	0.3	0.2	0.1	-0.5	-0.2	-0.2	0.2	0.3	-2.2	1.7
Number of full brothers	1.4	1.8	4.4	-2.1	-1.3	-1.2	-0.0	-1.6	1.4	1.7	1.3	1.2	-1.3	-0.4	1.2
Worry too long after embarrassment	0.8	1.3	5.2	0.4	-0.0	0.1	-1.7	-0.2	-0.5	-1.1	-2.3	-2.0	0.2	-1.2	-0.8
Seen a psychiatrist for nerves, anxiety, tension or depression	0.1	0.2	0.6	0.0	0.0	0.4	0.8	0.5	-0.2	0.1	0.7	0.5	0.2	-0.0	0.1
Wheeze or whistling in the chest in last year	1.9	3.4	6.4	-2.2	-1.7	-2.2	-2.5	-2.3	2.5	0.9	-1.1	-1.4	-2.4	0.5	-0.3
Number of children fathered	1.4	1.6	3.0	-1.5	-1.4	-1.2	-0.1	-1.1	1.7	1.6	1.1	1.4	-1.3	-0.4	1.2
Reason for reducing amount of alcohol drunk: Health precaution	0.8	0.9	3.6	0.7	1.1	1.0	-0.1	0.6	-0.6	-1.1	-1.2	-0.8	0.7	-1.9	-0.5
Age at first live birth	0.6	1.0	2.2	0.7	0.4	1.0	-0.0	1.4	-1.0	-1.5	-1.1	-0.9	1.2	0.4	-1.4
Pulse wave peak to peak time	0.7	0.8	1.7	-1.2	-1.2	-1.2	-1.0	-0.9	1.0	0.7	-0.1	-0.3	-1.3	-0.4	-0.1
Health satisfaction	3.2	4.1	7.7	-2.2	-2.2	-2.3	-2.8	-2.6	1.6	0.9	-1.6	-1.7	-2.2	-2.5	0.7
Shortness of breath walking on level ground	2.7	3.3	7.4	-1.5	-2.0	-2.1	-2.7	-2.6	1.8	0.8	-1.5	-1.9	-2.0	-0.2	-0.7
Qualifications: College or University degree	0.6	1.8	3.5	1.7	1.8	1.6	0.7	0.9	-1.7	-1.5	-0.6	-0.5	1.9	1.4	-0.4
Eye problems/disorders: None of the above	0.7	0.9	5.8	0.1	-0.0	0.2	0.8	0.8	-0.1	0.7	1.3	1.0	0.2	2.4	-0.0
Mouth/teeth dental problems: Loose teeth	1.8	2.2	4.1	-2.0	-1.8	-1.6	-0.2	-1.2	1.6	2.0	1.1	1.0	-1.6	1.8	0.5
Emphysema/chronic bronchitis	3.9	4.3	7.0	-2.5	-2.6	-2.5	-0.5	-2.0	2.6	2.4	1.3	1.1	-2.5	-1.1	2.4
Medication for pain relief, constipation, heartburn	0.9	1.5	4.0	-1.2	-0.8	-0.9	0.6	-1.0	1.0	1.8	1.9	2.0	-1.1	-0.3	1.0
Neck or shoulder pain in last month	1.8	2.5	5.9	-2.4	-2.2	-2.0	-1.3	-1.7	2.2	1.4	-0.0	0.0	-2.0	-0.2	0.5
Medication: Blood pressure	0.2	0.4	1.6	-0.0	0.3	0.0	0.9	-0.5	0.2	0.5	1.1	0.7	0.0	0.0	1.3
Angina (self-reported)	0.3	0.4	0.9	0.2	0.6	0.0	0.5	-0.7	0.4	0.9	0.8	0.8	-0.2	0.8	0.9
Migraine (self-reported)	0.4	0.5	1.5	0.2	0.3	0.3	1.2	-0.5	-0.2	0.5	1.2	0.9	0.4	-0.6	1.0
Medication: Ibuprofen	1.9	2.3	5.8	1.6	1.5	1.8	1.0	1.0	-1.7	-1.8	-0.7	-0.2	2.0	-2.4	-0.8
Medication: Allopurinol	3.1	4.1	10.7	-1.9	-2.5	-2.3	-3.3	-1.8	1.4	0.5	-2.0	-2.5	-2.1	-0.3	-1.9
Medication: Omeprazole	1.3	1.5	5.4	0.6	-0.3	-0.1	-2.0	-0.2	-0.3	-1.2	-2.3	-2.3	-0.2	-0.1	-1.3
Medication: Seretide 50 evohaler	4.3	4.9	9.1	-3.0	-2.3	-2.3	-0.3	-2.3	2.6	2.7	1.7	1.6	-2.3	-1.1	2.9
Mean time to correctly identify matches	0.1	0.1	0.3	-0.2	-0.4	-0.4	-0.5	-0.1	0.3	0.2	-0.3	-0.2	-0.5	-0.0	-0.5
Heart disease (mother)	1.3	1.6	3.4	-1.3	-1.9	-1.6	-1.4	-1.5	1.3	1.1	-0.3	-0.9	-1.9	-0.5	-0.4
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.6	0.7	1.7	0.5	0.7	1.1	1.3	0.9	-0.4	-0.4	0.8	1.2	1.0	-0.2	0.9
Whole body fat mass	0.2	1.0	3.3	0.8	1.0	0.1	-1.3	-0.0	-0.8	-1.1	-1.8	-1.8	0.3	-0.1	-0.2
Leg fat mass (right)	0.4	1.4	5.4	0.4	0.6	-0.4	-2.0	-0.3	-0.7	-1.1	-2.3	-2.3	-0.0	-0.5	-0.4
Arm predicted mass (right)	0.2	1.1	3.4	0.8	1.2	0.2	-1.2	0.4	-0.5	-1.1	-1.8	-1.7	0.3	-0.9	0.2
Pulse rate, automated reading	0.8	2.7	9.5	-1.2	-0.7	0.1	1.7	-0.2	1.9	1.2	1.8	2.5	-0.6	-1.8	3.1
Alcohol intake frequency.	0.8	1.8	3.4	-1.3	-1.3	-1.7	-1.4	-1.3	1.7	1.5	0.3	0.6	-1.8	1.5	-0.4
Comparative height size at age 10	1.0	5.5	12.1	3.5	3.2	3.1	2.4	3.4	-2.3	-1.8	0.3	0.7	2.7	-0.1	0.6
Number of full sisters	5.0	6.0	10.5	-2.8	-3.0	-3.2	-3.2	-3.2	2.4	1.9	-1.2	-1.7	-3.2	-0.6	0.1
Suffer from ‘nerves’	0.2	0.3	0.9	-0.3	-0.4	-0.1	-0.9	-0.5	0.4	-0.1	-0.7	-0.6	-0.5	1.0	-0.6
Overall health rating	4.2	9.1	18.3	-3.9	-4.1	-3.9	-2.6	-3.2	3.7	3.4	0.5	0.4	-4.3	-0.5	0.9
Chest pain or discomfort	0.3	0.5	1.6	-0.6	-0.5	-0.7	-0.5	-1.3	0.8	0.7	0.1	0.2	-0.7	0.8	0.7
Had major operations	0.7	0.8	1.9	1.0	1.0	1.2	1.4	0.5	-1.4	-0.7	0.5	0.4	1.2	-0.1	0.5
Age at last live birth	0.8	1.2	2.8	0.6	0.7	0.8	-0.7	0.9	-1.1	-1.7	-1.6	-1.4	1.1	0.1	-1.4
Family relationship satisfaction	0.5	0.6	1.3	-0.9	-0.7	-0.4	0.2	-0.9	0.8	1.0	0.9	1.2	-0.6	0.9	0.4
Leg pain on walking	0.1	0.1	0.4	-0.3	-0.3	-0.0	-0.5	0.2	0.4	-0.2	-0.6	-0.5	-0.4	-0.3	-0.5
Qualifications: NVQ or HND or HNC or equivalent	0.8	0.9	3.1	-0.2	-0.3	-0.6	-1.8	-1.0	-0.1	-0.5	-1.6	-1.3	-0.3	0.0	-1.3
Commuting to job workplace: Car/motor vehicle	0.2	0.2	1.0	0.2	0.2	0.1	0.3	1.0	0.1	0.1	0.4	0.4	-0.1	-0.8	0.8
Illness, injury, bereavement, stress in last 2 years	0.6	0.7	2.1	0.7	0.8	1.1	1.5	1.2	-0.4	-0.6	0.7	0.6	1.2	-0.4	-0.1
Medication: Aspirin	0.4	0.5	1.5	-0.5	-0.6	-0.7	0.0	-0.5	1.2	1.1	0.8	-0.2	-0.8	0.4	0.3
Supplements: Vitamin C	0.4	0.4	1.2	0.9	0.8	1.1	0.1	0.6	-0.3	-0.7	-0.6	-0.0	0.5	-0.5	-0.8
Knee pain experienced in last month	0.3	0.5	2.0	0.0	-0.0	-0.3	-0.9	-0.4	0.0	-0.4	-1.1	-1.4	-0.1	-0.3	-1.1
Hypertension (Self-reported)	0.1	0.2	0.5	0.7	0.5	0.7	0.6	0.6	-0.5	-0.5	0.2	0.4	0.4	-0.2	0.3
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.8	2.1	4.0	1.8	2.0	1.7	0.8	1.7	-1.7	-1.7	-0.8	-0.6	2.0	-0.8	0.2
Illnesses of father: Heart disease	2.2	3.1	6.2	-2.1	-2.0	-1.8	-0.4	-1.2	2.3	2.5	1.4	0.8	-2.3	1.2	1.9
Illnesses of siblings: Diabetes	0.2	0.3	1.3	0.5	0.3	0.2	0.5	-0.9	-0.2	0.5	0.5	0.2	-0.1	-1.2	0.3
Smoking status: Previous	0.4	0.6	1.5	-0.8	-1.0	-0.7	-1.1	-0.8	0.7	-0.1	-1.2	-0.5	-0.5	-0.2	-1.2
Forced expiratory volume in 1-second (FEV1), predicted	0.1	0.2	0.8	-0.6	-0.1	-0.4	-0.2	-0.6	0.9	0.3	-0.1	0.1	0.2	-0.6	0.9
Whole body fat-free mass	0.1	0.6	1.7	0.6	1.3	0.1	-0.6	0.2	-0.3	-0.4	-0.9	-0.9	0.1	-1.1	1.1
Leg fat-free mass (right)	0.1	0.6	4.0	0.1	1.0	-0.1	0.1	-0.3	0.2	0.5	0.2	0.2	-0.2	-1.1	2.0
Arm fat percentage (left)	0.1	0.3	0.9	0.0	0.1	-0.5	-0.9	-0.5	-0.1	-0.0	-0.7	-0.9	-0.4	-0.2	0.5
Average weekly red wine intake	5.8	8.5	17.6	3.6	3.2	3.4	0.9	2.5	-4.2	-4.0	-2.2	-2.0	3.9	-1.0	-1.4
Handedness (chirality/laterality): Left-handed	0.4	0.5	1.7	-1.0	-0.7	-0.8	-0.4	-1.3	0.4	0.8	0.2	0.1	-0.9	0.0	-0.4
Mood swings	0.4	0.7	2.2	-0.7	-0.4	-0.8	-1.5	-0.5	0.4	-0.0	-1.1	-1.1	-1.1	-0.3	-0.6
Loneliness, isolation	0.1	0.2	0.4	0.2	0.5	0.4	0.1	0.4	0.2	-0.6	-0.4	-0.2	0.6	-0.7	-0.0
Long-standing illness, disability or infirmity	1.2	1.8	3.6	-1.6	-1.7	-1.7	-1.9	-1.2	1.6	0.9	-0.7	-0.8	-1.7	-0.8	0.0
Ever had bowel cancer screening	0.3	0.3	1.0	0.0	-0.4	-0.5	-0.8	0.3	0.7	0.0	-0.4	-0.8	-0.9	1.0	-0.2
Diabetes diagnosed by doctor	0.5	0.9	3.3	0.7	0.8	-0.2	-1.4	0.2	-0.5	-0.6	-1.7	-1.8	-0.3	0.2	-0.8
Ever had stillbirth, spontaneous miscarriage or termination	1.8	1.9	6.0	0.4	0.6	0.7	2.2	0.3	0.4	1.3	2.4	2.3	0.1	0.6	1.9
Friendships satisfaction	0.1	0.1	0.4	0.0	-0.5	0.1	0.1	-0.0	-0.4	0.2	-0.1	0.2	0.2	0.6	-0.0
Qualifications: nursing, teaching	0.1	0.1	0.7	-0.2	0.4	-0.0	0.3	0.1	0.9	0.4	0.4	0.2	-0.2	-0.2	-0.5
Commuting to job workplace: Walk	0.3	0.3	1.8	-0.2	0.4	0.4	0.3	-0.6	-0.4	-0.6	-0.2	-0.3	0.5	0.2	-1.4
Eye problems/disorders: Cataract	1.6	1.8	4.5	-1.3	-1.4	-1.5	-2.1	-1.5	0.9	0.1	-1.6	-1.5	-1.4	-1.1	-0.8
Mouth/teeth dental problems: Mouth ulcers	0.3	0.4	1.2	0.5	0.2	0.5	0.5	1.1	-0.6	-0.4	0.2	0.8	0.4	0.7	-1.0
Medication for cholesterol	0.8	1.1	2.3	1.1	1.4	1.3	1.3	1.2	-1.5	-0.7	0.4	0.2	1.3	-0.1	0.9
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.0	1.1	3.9	0.3	0.5	0.3	-1.3	-0.5	0.1	-1.2	-2.0	-1.5	-0.0	1.1	-1.7
Back pain experienced in last month	0.2	0.3	2.5	0.2	-0.6	0.2	-0.2	0.9	-0.1	-0.3	-0.2	-0.2	0.1	-1.6	0.1
Mineral and other dietary supplements	2.1	2.8	5.5	-2.3	-2.3	-2.3	-2.3	-2.0	1.1	1.1	-0.8	-1.1	-1.8	0.3	-0.2
Breast cancer (self-reported)	0.2	0.3	0.9	0.9	0.2	0.5	0.3	0.6	-0.8	0.0	0.3	0.7	0.2	0.4	-0.6
Asthma (self-reported)	2.4	4.8	8.6	-2.7	-2.2	-2.6	-0.8	-2.9	2.7	2.8	1.1	1.4	-2.4	0.7	2.1
Osteoporosis (self-reported)	1.3	1.6	4.0	-1.9	-1.3	-1.0	0.2	-1.1	1.7	1.4	1.1	1.0	-1.0	-0.4	2.0
Osteoarthritis (self-reported)	0.5	0.6	1.6	0.7	0.8	0.9	0.0	0.6	-0.4	-1.1	-0.9	-0.7	0.8	-0.4	-1.3
Medication: Aspirin	0.2	0.3	0.9	-0.2	-0.3	-0.4	0.3	-0.1	0.8	0.9	0.9	-0.2	-0.5	0.1	0.4
Medication: Gliclazide	0.6	0.7	1.5	1.2	1.2	0.9	-0.0	1.0	-0.7	-1.0	-1.0	-0.4	0.6	-0.0	-0.8
Illnesses of father: None of the above (group 1)	0.5	0.6	1.3	0.7	0.7	1.0	1.1	1.1	-0.7	-0.7	0.3	0.3	1.1	0.4	0.1
Smoking status: Current	2.5	4.0	7.1	-2.3	-2.2	-2.4	-0.5	-2.0	2.6	2.7	1.8	1.4	-2.5	1.4	1.0
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.3	0.7	1.9	0.7	0.5	1.2	1.4	0.9	-1.0	-0.2	0.9	0.8	0.8	-0.4	0.6
Whole body water mass	0.1	0.6	1.8	0.7	1.3	0.2	-0.6	0.2	-0.4	-0.4	-0.9	-0.8	0.2	-1.1	1.2
Leg predicted mass (right)	0.1	0.6	4.1	0.1	1.0	-0.1	0.1	-0.3	0.2	0.5	0.2	0.2	-0.2	-1.1	2.0
Arm fat mass (left)	0.1	0.4	1.6	0.4	0.7	-0.2	-1.1	-0.2	-0.4	-0.4	-1.2	-1.2	-0.2	-0.2	0.3
Number of self-reported non-cancer illnesses	0.4	0.6	1.8	-0.1	-0.7	-0.8	-1.2	-0.0	0.1	-0.3	-1.0	-1.3	-0.5	0.9	-0.8
Average weekly champagne plus white wine intake	1.3	1.7	3.5	1.3	1.6	1.7	1.6	1.7	-1.9	-0.5	0.7	0.6	1.7	0.7	-0.4
Miserableness	0.5	0.8	1.9	0.7	1.0	0.7	-0.3	1.0	-0.6	-0.9	-0.9	-0.8	0.5	1.3	-1.4
Guilty feelings	0.4	0.6	1.4	-0.9	-0.9	-0.7	-1.1	-0.1	0.9	0.1	-0.9	-0.9	-0.4	-1.2	0.5
Wears glasses or contact lenses	1.8	2.1	7.4	0.3	0.1	-0.2	-2.1	0.8	-0.6	-1.4	-2.5	-2.7	-0.2	-0.9	-1.9
Ever taken oral contraceptive pill	1.4	1.5	4.9	-1.1	-0.5	-0.7	0.7	-1.2	0.5	1.6	1.7	1.4	-0.9	-1.0	2.2
Hearing aid user	0.3	0.3	1.0	0.1	-0.7	-0.6	-0.9	-0.2	-0.1	0.2	-0.4	-1.0	-0.4	-0.3	-1.0
Mother’s age at death	2.7	3.4	8.6	2.8	1.9	2.1	0.4	2.1	-2.9	-2.0	-1.4	-0.8	2.1	0.0	-1.1
Financial situation satisfaction	1.6	2.0	4.1	-1.6	-2.0	-1.7	-1.7	-1.7	1.4	1.2	-0.5	-0.9	-1.6	-0.3	1.5
Tinnitus: Yes, now most or all of the time	0.7	0.8	2.4	-0.8	-0.9	-0.6	0.4	-0.5	0.7	1.1	1.3	1.5	-0.6	-0.8	0.9
Commuting to job workplace: Public transport	0.7	0.8	2.6	-0.3	-0.4	-0.3	-1.2	-0.6	-0.1	-0.6	-1.6	-1.6	0.0	-0.1	-1.3
Eye problems/disorders: Glaucoma	1.0	1.1	2.5	-1.1	-0.9	-1.0	0.5	-0.1	0.9	1.6	1.5	1.4	-0.8	-1.3	0.8
Medication: Blood pressure	0.1	0.3	1.2	-0.4	-1.1	-0.6	-0.5	-0.5	0.6	0.2	-0.4	-0.3	-0.6	-0.1	-0.0
Pain type(s) experienced in last month: Hip pain	0.3	0.3	1.2	0.6	-0.2	0.3	-0.6	0.5	-0.2	-0.6	-0.8	-0.7	0.2	-1.1	-0.1
Supplements: Fish oil (including cod liver oil)	1.4	1.9	4.1	1.7	1.9	1.6	2.0	1.9	-0.5	-0.7	0.9	1.5	1.2	0.5	-0.0
High cholesterol (Self-reported)	0.5	0.9	2.4	1.2	1.2	0.7	-0.4	0.7	-0.4	-1.2	-1.0	-1.5	0.4	0.2	-1.3
Medication: Bendroflumethiazide	0.2	0.3	1.1	0.1	-0.2	0.2	-0.8	0.0	-0.1	-0.6	-1.1	-0.6	0.0	0.3	-0.6
Medication: Paracetamol	0.1	0.2	0.4	0.3	0.6	0.4	0.6	0.4	-0.1	-0.3	-0.0	-0.2	0.5	0.4	0.7
Medication: Lisinopril	0.3	0.4	1.8	-0.0	0.2	-0.5	-0.2	0.6	0.3	0.5	0.1	0.0	-0.7	-1.4	1.1
Medication: Atorvastatin	0.4	0.5	1.0	0.6	1.0	0.5	0.8	0.9	-0.9	0.2	0.8	0.9	0.2	1.0	0.1
Illnesses of father: High blood pressure	1.3	1.6	3.0	1.7	1.1	1.5	-0.1	1.6	-1.7	-1.6	-1.2	-1.3	1.2	-0.3	-0.4
Alcohol drinker status: Never	0.5	0.6	1.8	0.7	0.0	0.3	-0.5	1.0	-0.4	-0.9	-0.8	-0.5	0.3	1.3	-1.0
Ever smoked	1.2	2.1	3.8	-1.5	-1.5	-1.7	-2.0	-1.8	1.3	0.8	-1.0	-0.2	-1.7	1.4	-1.7
Basal metabolic rate	0.1	0.5	1.3	0.5	1.1	-0.0	-0.8	0.0	-0.2	-0.3	-1.0	-1.0	-0.0	-0.9	1.0
Leg fat percentage (left)	0.5	1.9	7.5	0.3	-0.1	-0.5	-2.2	-0.5	-0.8	-1.2	-2.5	-2.7	-0.1	-0.2	-1.1
Arm fat-free mass (left)	0.2	1.1	2.8	1.0	1.4	0.4	-1.0	0.4	-0.8	-1.2	-1.7	-1.5	0.5	-1.0	0.3
Number of operations (self-reported)	0.2	0.2	0.8	-0.3	-0.1	-0.1	0.7	-0.4	0.1	0.4	0.9	0.7	0.1	-0.6	0.6
Average weekly beer plus cider intake	4.5	6.5	12.3	-3.2	-3.2	-3.5	-2.6	-3.5	3.2	2.3	-0.3	-0.1	-3.3	-0.2	0.4
Irritability	1.4	2.4	8.7	0.4	-0.3	0.1	-2.2	0.2	-0.5	-1.7	-2.9	-2.8	0.4	-0.6	-1.9
Risk taking	1.4	2.0	3.3	-1.8	-1.6	-1.8	-1.0	-1.7	1.8	1.4	0.5	0.7	-1.7	1.3	0.9
Ever had prostate specific antigen (PSA) test	1.9	2.2	5.9	1.4	2.4	1.7	1.1	1.9	-1.3	-1.1	0.2	-0.0	1.4	2.3	-0.7
Fractured/broken bones in last 5 years	0.1	0.1	0.7	-0.1	-0.0	0.1	-0.0	0.1	0.2	0.1	0.1	-0.5	-0.1	-0.8	0.8
Age started oral contraceptive pill	0.3	0.4	0.9	0.9	0.4	0.7	0.7	0.2	-0.5	-0.7	0.0	0.9	0.8	-0.3	0.3
Diastolic blood pressure, automated reading	0.2	0.6	1.4	0.6	0.6	1.0	0.4	0.9	-0.6	-1.2	-0.3	0.0	1.1	-1.0	0.1
Ever depressed for a whole week	0.7	0.8	1.8	0.8	0.6	0.9	0.1	0.8	-0.4	-1.3	-1.1	-0.6	1.4	-0.7	-1.3
Unable to work because of sickness or disability	2.6	3.3	5.6	-2.4	-2.1	-2.1	-0.4	-1.5	2.3	2.4	1.4	1.3	-2.4	0.8	1.5
Commuting to job workplace: Cycle	1.3	1.6	3.3	1.4	1.7	1.6	1.2	1.5	-1.6	-1.5	-0.3	-0.0	1.8	-0.0	-0.2
Myopia	0.6	0.8	2.2	-1.3	-1.5	-1.2	-0.4	-1.1	1.0	0.8	0.5	0.6	-0.9	-0.4	0.4
Vascular/heart problems diagnosed by doctor	0.1	0.3	1.3	-0.6	-0.3	-0.6	-0.6	-0.6	0.3	0.3	-0.3	-0.5	-0.3	-1.1	-0.2
Cholesterol lowering medication	0.5	0.7	2.8	0.3	0.1	-0.2	-1.2	-0.4	0.1	-0.6	-1.3	-1.7	-0.2	-0.6	-1.1
Medication: Omeprazole (e.g. Zanprol)	1.8	2.2	8.1	0.9	-0.2	0.1	-2.2	0.1	-0.7	-1.6	-2.8	-2.5	0.1	0.6	-1.6
Pain experienced in last month	0.3	0.5	1.1	-0.6	-0.7	-1.0	-0.4	-0.7	0.6	0.9	0.5	-0.1	-0.6	1.0	0.1
Supplements: Calcium	0.9	1.0	2.9	1.2	0.8	1.4	1.4	1.0	-0.1	-0.3	0.6	0.8	0.9	1.7	-0.2
Basal cell carcinoma (self-reported)	3.4	4.1	9.2	-2.8	-2.2	-2.4	-1.4	-2.3	3.0	2.1	0.2	0.7	-2.6	-1.3	0.7
Heart attack/myocardial infarction (self-reported)	0.4	0.5	2.0	0.4	0.6	0.6	0.9	-0.3	0.2	0.6	0.7	1.4	0.6	1.1	0.1
Deep venous thrombosis (DVT) (self-reported)	1.9	2.4	7.9	-0.8	-0.6	-0.3	1.5	-0.2	1.2	2.1	2.8	2.7	-0.9	1.4	1.5
Heart disease (siblings)	0.6	0.8	2.1	-1.0	-0.5	-1.1	-0.5	-1.1	1.5	1.0	0.2	0.3	-1.4	0.4	0.5
Alcohol drinker status: Previous	0.1	0.2	0.5	0.4	0.7	0.5	0.4	0.1	-0.2	0.0	0.4	0.4	0.5	0.1	0.5
Pack years of smoking	3.3	4.9	12.1	-2.1	-2.0	-2.2	0.2	-1.6	2.5	3.5	2.8	2.0	-2.6	1.9	1.4
Impedance of whole body	0.1	0.7	2.2	0.3	-0.0	0.8	1.0	0.6	-0.2	-0.4	0.7	0.9	0.9	1.5	-1.3
Leg fat mass (left)	0.4	1.5	5.4	0.6	0.7	-0.1	-1.8	-0.1	-0.9	-1.2	-2.3	-2.3	0.1	-0.4	-0.5
Arm predicted mass (left)	0.2	1.2	4.2	0.6	1.1	-0.1	-1.6	-0.1	-0.5	-1.0	-2.0	-1.9	0.1	-1.0	0.1