Best TWAS P=8.95e-16 · Best GWAS P=4.97e-83 conditioned to NaN
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | CommonMind | Brain Pre-frontal Cortex | FAM110C | 0.09 | 0.00 | bslmm | 232 | 0.01 | 8.2e-03 | 3.2 | 5.3 | 1.1e-07 | -0.05 | 0.41 | 0.02 | FALSE |
2 | GTEx | Adipose Subcutaneous | TMEM18 | 0.32 | 0.21 | lasso | 9 | 0.25 | 4.7e-20 | 6.4 | 7.5 | 5.1e-14 | -0.23 | 1.00 | 0.00 | FALSE |
3 | GTEx | Adipose Subcutaneous | AC092159.2 | 0.29 | 0.14 | lasso | 14 | 0.19 | 4.2e-15 | 4.2 | 6.6 | 3.5e-11 | -0.17 | 1.00 | 0.00 | FALSE |
4 | GTEx | Adipose Visceral Omentum | TMEM18 | 0.23 | 0.14 | lasso | 4 | 0.17 | 5.7e-09 | 6.0 | 5.9 | 4.6e-09 | -0.15 | 0.99 | 0.00 | TRUE |
5 | GTEx | Artery Aorta | TMEM18 | 0.32 | 0.16 | lasso | 5 | 0.15 | 1.4e-08 | 6.4 | 6.8 | 8.8e-12 | -0.19 | 1.00 | 0.00 | FALSE |
6 | GTEx | Artery Aorta | AC092159.2 | 0.29 | 0.19 | enet | 9 | 0.23 | 9.7e-13 | 6.2 | 6.8 | 1.2e-11 | -0.19 | 1.00 | 0.00 | TRUE |
7 | GTEx | Artery Tibial | SH3YL1 | 0.10 | 0.02 | lasso | 3 | 0.01 | 2.9e-02 | -3.2 | -5.9 | 3.4e-09 | 0.09 | 0.65 | 0.02 | FALSE |
8 | GTEx | Artery Tibial | TMEM18 | 0.35 | 0.08 | enet | 28 | 0.19 | 9.2e-15 | 6.2 | 6.5 | 7.1e-11 | -0.19 | 1.00 | 0.00 | FALSE |
9 | GTEx | Artery Tibial | AC092159.2 | 0.38 | 0.24 | lasso | 5 | 0.30 | 5.6e-24 | 5.4 | 6.6 | 5.0e-11 | -0.19 | 1.00 | 0.00 | FALSE |
10 | GTEx | Cells Transformed fibroblasts | TMEM18 | 0.30 | 0.17 | enet | 10 | 0.23 | 2.5e-17 | 6.0 | 5.3 | 1.1e-07 | -0.11 | 1.00 | 0.00 | TRUE |
11 | GTEx | Cells Transformed fibroblasts | AC092159.2 | 0.26 | 0.17 | enet | 5 | 0.21 | 1.8e-15 | 6.0 | 6.0 | 1.9e-09 | -0.16 | 1.00 | 0.00 | FALSE |
12 | GTEx | Esophagus Mucosa | TMEM18 | 0.37 | 0.20 | lasso | 7 | 0.20 | 2.3e-13 | 6.4 | 6.7 | 1.5e-11 | -0.20 | 1.00 | 0.00 | FALSE |
13 | GTEx | Esophagus Mucosa | AC092159.2 | 0.27 | 0.18 | enet | 5 | 0.20 | 2.5e-13 | 6.0 | 6.9 | 7.0e-12 | -0.20 | 1.00 | 0.00 | FALSE |
14 | GTEx | Esophagus Muscularis | TMEM18 | 0.37 | 0.20 | lasso | 8 | 0.18 | 2.0e-11 | 5.4 | 7.8 | 8.2e-15 | -0.28 | 1.00 | 0.00 | FALSE |
15 | GTEx | Esophagus Muscularis | AC092159.2 | 0.26 | 0.16 | enet | 7 | 0.20 | 5.3e-12 | 5.4 | 6.6 | 3.6e-11 | -0.30 | 1.00 | 0.00 | FALSE |
16 | GTEx | Heart Atrial Appendage | TMEM18 | 0.26 | 0.16 | lasso | 7 | 0.09 | 5.0e-05 | 6.4 | 6.8 | 1.2e-11 | -0.24 | 0.86 | 0.04 | FALSE |
17 | GTEx | Heart Left Ventricle | TMEM18 | 0.22 | 0.19 | lasso | 7 | 0.16 | 8.3e-09 | 6.0 | 8.0 | 8.9e-16 | -0.19 | 0.99 | 0.00 | TRUE |
18 | GTEx | Heart Left Ventricle | AC092159.2 | 0.35 | 0.24 | lasso | 6 | 0.23 | 2.3e-12 | 6.0 | 7.0 | 2.5e-12 | -0.20 | 1.00 | 0.00 | FALSE |
19 | GTEx | Lung | TMEM18 | 0.13 | 0.11 | lasso | 2 | 0.10 | 4.5e-08 | 6.0 | 6.0 | 1.7e-09 | -0.17 | 0.99 | 0.00 | FALSE |
20 | GTEx | Lung | AC092159.2 | 0.22 | 0.17 | lasso | 3 | 0.18 | 1.1e-13 | 6.0 | 6.1 | 1.3e-09 | -0.13 | 1.00 | 0.00 | FALSE |
21 | GTEx | Muscle Skeletal | TMEM18 | 0.40 | 0.30 | lasso | 7 | 0.33 | 2.0e-33 | 5.4 | 5.9 | 4.5e-09 | -0.17 | 1.00 | 0.00 | FALSE |
22 | GTEx | Muscle Skeletal | AC092159.2 | 0.46 | 0.34 | enet | 18 | 0.39 | 1.1e-40 | 5.4 | 6.1 | 1.3e-09 | -0.17 | 1.00 | 0.00 | TRUE |
23 | GTEx | Nerve Tibial | TMEM18 | 0.22 | 0.01 | lasso | 8 | 0.05 | 3.2e-04 | 6.4 | 5.5 | 3.5e-08 | -0.21 | 0.64 | 0.02 | FALSE |
24 | GTEx | Nerve Tibial | AC092159.2 | 0.18 | 0.09 | lasso | 5 | 0.10 | 1.5e-07 | 5.4 | 5.9 | 4.3e-09 | -0.16 | 0.99 | 0.00 | FALSE |
25 | GTEx | Ovary | SH3YL1 | 0.48 | 0.29 | enet | 18 | 0.34 | 3.2e-09 | -3.1 | -6.4 | 2.0e-10 | 0.15 | 0.66 | 0.04 | TRUE |
26 | GTEx | Skin Sun Exposed Lower leg | AC092159.2 | 0.18 | 0.10 | enet | 15 | 0.13 | 1.4e-10 | 5.4 | 5.1 | 2.7e-07 | -0.08 | 0.99 | 0.00 | TRUE |
27 | METSIM | Adipose | TMEM18 | 0.20 | 0.12 | lasso | 6 | 0.12 | 9.2e-17 | 6.0 | 6.5 | 1.0e-10 | -0.19 | 1.00 | 0.00 | FALSE |
28 | The Cancer Genome Atlas | Bladder Urothelial Carcinoma | TMEM18 | 0.06 | 0.04 | lasso | 3 | 0.04 | 2.8e-04 | 6.0 | 5.3 | 1.1e-07 | -0.11 | 0.14 | 0.14 | FALSE |
29 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | TMEM18 | 0.12 | 0.05 | blup | 74 | 0.04 | 3.1e-05 | 6.0 | 6.0 | 2.0e-09 | -0.19 | 0.59 | 0.02 | TRUE |
30 | The Cancer Genome Atlas | Stomach Adenocarcinoma | TMEM18 | 0.11 | 0.01 | blup | 74 | 0.04 | 1.3e-03 | 6.4 | 7.4 | 1.3e-13 | -0.23 | 0.11 | 0.03 | FALSE |