Best TWAS P=4.24e-10 · Best GWAS P=2.05e-09 conditioned to 1
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | PM20D1 | 0.27 | 0.41 | enet | 15 | 0.41 | 7.8e-54 | -6.0 | -6.0 | 1.6e-09 | 0.99 | 0.00 | 1.00 | FALSE |
| 2 | CommonMind | Brain Pre-frontal Cortex | SLC26A9 | 0.13 | 0.16 | lasso | 3 | 0.16 | 3.1e-19 | -6.0 | -6.1 | 1.3e-09 | 0.99 | 0.00 | 1.00 | FALSE |
| 3 | GTEx | Adipose Subcutaneous | NUCKS1 | 0.11 | 0.10 | lasso | 3 | 0.08 | 9.4e-07 | -5.3 | 5.4 | 5.3e-08 | -0.90 | 0.02 | 0.98 | FALSE |
| 4 | GTEx | Artery Aorta | NUCKS1 | 0.14 | 0.11 | lasso | 3 | 0.08 | 3.7e-05 | -5.3 | 5.3 | 9.2e-08 | -0.85 | 0.03 | 0.97 | FALSE |
| 5 | GTEx | Artery Tibial | NUCKS1 | 0.13 | 0.03 | lasso | 2 | 0.01 | 4.0e-02 | -5.8 | 5.8 | 5.9e-09 | -0.96 | 0.01 | 0.98 | FALSE |
| 6 | GTEx | Brain Cerebellum | NUCKS1 | 0.22 | 0.13 | lasso | 3 | 0.08 | 2.0e-03 | -5.8 | 6.0 | 2.7e-09 | -0.95 | 0.01 | 0.95 | FALSE |
| 7 | GTEx | Brain Putamen basal ganglia | NUCKS1 | 0.40 | 0.26 | lasso | 4 | 0.27 | 3.2e-07 | -5.3 | 5.4 | 5.4e-08 | -0.90 | 0.05 | 0.87 | FALSE |
| 8 | GTEx | Breast Mammary Tissue | NUCKS1 | 0.15 | 0.05 | lasso | 4 | 0.09 | 2.5e-05 | -5.3 | 5.4 | 7.7e-08 | -0.87 | 0.03 | 0.97 | FALSE |
| 9 | GTEx | Esophagus Muscularis | NUCKS1 | 0.21 | 0.22 | lasso | 5 | 0.20 | 3.6e-12 | -5.1 | 5.2 | 1.6e-07 | -0.88 | 0.07 | 0.93 | FALSE |
| 10 | GTEx | Heart Left Ventricle | NUCKS1 | 0.10 | 0.04 | lasso | 3 | 0.05 | 1.4e-03 | -5.3 | 5.5 | 5.1e-08 | -0.85 | 0.02 | 0.92 | FALSE |
| 11 | GTEx | Lung | NUCKS1 | 0.09 | 0.07 | lasso | 3 | 0.04 | 2.6e-04 | -5.3 | 5.4 | 6.6e-08 | -0.89 | 0.02 | 0.98 | FALSE |
| 12 | GTEx | Nerve Tibial | NUCKS1 | 0.25 | 0.21 | enet | 16 | 0.22 | 7.3e-16 | -5.4 | 5.5 | 4.4e-08 | -0.90 | 0.04 | 0.96 | FALSE |
| 13 | GTEx | Nerve Tibial | SLC41A1 | 0.12 | 0.02 | lasso | 4 | 0.05 | 2.5e-04 | -6.0 | -5.7 | 1.0e-08 | 0.83 | 0.01 | 0.99 | FALSE |
| 14 | GTEx | Pancreas | NUCKS1 | 0.16 | 0.00 | lasso | 4 | 0.00 | 4.5e-01 | 3.6 | 5.2 | 2.1e-07 | -0.81 | 0.03 | 0.76 | FALSE |
| 15 | GTEx | Pancreas | SLC41A1 | 0.24 | 0.21 | lasso | 5 | 0.19 | 1.4e-08 | -6.0 | -6.0 | 1.6e-09 | 1.00 | 0.00 | 1.00 | FALSE |
| 16 | GTEx | Prostate | NUCKS1 | 0.38 | 0.23 | lasso | 8 | 0.32 | 7.5e-09 | 5.6 | -6.0 | 2.7e-09 | 0.85 | 0.04 | 0.90 | FALSE |
| 17 | GTEx | Skin Not Sun Exposed Suprapubic | NUCKS1 | 0.20 | 0.14 | lasso | 4 | 0.13 | 2.0e-07 | -5.3 | 5.4 | 6.5e-08 | -0.91 | 0.03 | 0.97 | FALSE |
| 18 | GTEx | Skin Sun Exposed Lower leg | NUCKS1 | 0.20 | 0.26 | lasso | 5 | 0.26 | 1.5e-21 | -5.3 | 5.4 | 6.9e-08 | -0.91 | 0.06 | 0.94 | FALSE |
| 19 | GTEx | Stomach | NUCKS1 | 0.21 | 0.11 | lasso | 8 | 0.15 | 1.1e-07 | -5.1 | 5.5 | 3.4e-08 | -0.81 | 0.04 | 0.96 | FALSE |
| 20 | GTEx | Testis | NUCKS1 | 0.16 | 0.16 | enet | 15 | 0.16 | 1.3e-07 | -5.5 | 5.7 | 1.3e-08 | -0.88 | 0.02 | 0.98 | FALSE |
| 21 | GTEx | Thyroid | NUCKS1 | 0.26 | 0.16 | lasso | 6 | 0.19 | 1.8e-14 | -5.4 | 5.4 | 6.2e-08 | -0.90 | 0.02 | 0.98 | FALSE |
| 22 | METSIM | Adipose | NUCKS1 | 0.05 | 0.02 | lasso | 6 | 0.01 | 4.3e-03 | -5.5 | 5.3 | 1.1e-07 | -0.86 | 0.03 | 0.96 | FALSE |
| 23 | METSIM | Adipose | PM20D1 | 0.25 | 0.30 | bslmm | 377 | 0.31 | 8.4e-47 | -6.0 | 6.2 | 4.2e-10 | -0.96 | 0.00 | 1.00 | TRUE |
| 24 | METSIM | Adipose | SLC41A1 | 0.07 | 0.08 | lasso | 7 | 0.08 | 1.9e-11 | 5.6 | -5.6 | 2.5e-08 | 0.81 | 0.04 | 0.96 | FALSE |
| 25 | YFS | Blood | NUCKS1 | 0.15 | 0.24 | lasso | 4 | 0.25 | 1.4e-80 | -5.3 | 5.4 | 8.4e-08 | -0.90 | 0.07 | 0.93 | FALSE |
| 26 | YFS | Blood | SLC41A1 | 0.06 | 0.05 | enet | 15 | 0.05 | 2.6e-17 | -5.8 | -5.7 | 1.4e-08 | 0.90 | 0.00 | 1.00 | FALSE |
| 27 | The Cancer Genome Atlas | Bladder Urothelial Carcinoma | PM20D1 | 0.22 | 0.26 | lasso | 5 | 0.26 | 1.7e-22 | -5.8 | 6.1 | 8.9e-10 | -0.97 | 0.00 | 1.00 | FALSE |
| 28 | The Cancer Genome Atlas | Breast Invasive Carcinoma | PM20D1 | 0.24 | 0.37 | lasso | 5 | 0.39 | 4.9e-85 | -6.0 | 6.1 | 1.3e-09 | -0.97 | 0.00 | 1.00 | FALSE |
| 29 | The Cancer Genome Atlas | Cervical Squamous Cell Carcinoma | PM20D1 | 0.18 | 0.19 | blup | 47 | 0.18 | 1.9e-09 | -6.0 | 5.8 | 5.7e-09 | -0.87 | 0.00 | 1.00 | FALSE |
| 30 | The Cancer Genome Atlas | Colon Adenocarcinoma | PM20D1 | 0.26 | 0.13 | enet | 14 | 0.16 | 9.7e-10 | 5.6 | 5.5 | 4.9e-08 | -0.83 | 0.00 | 1.00 | FALSE |
| 31 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | PM20D1 | 0.19 | 0.25 | lasso | 5 | 0.25 | 3.0e-28 | -6.0 | 6.2 | 7.1e-10 | -0.98 | 0.00 | 1.00 | FALSE |
| 32 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | PM20D1 | 0.29 | 0.35 | enet | 18 | 0.35 | 5.1e-41 | -6.0 | 5.6 | 1.8e-08 | -0.95 | 0.00 | 1.00 | FALSE |
| 33 | The Cancer Genome Atlas | Kidney Renal Papillary Cell Carcinoma | PM20D1 | 0.19 | 0.19 | enet | 4 | 0.19 | 4.5e-11 | -6.0 | 6.1 | 1.2e-09 | -0.99 | 0.00 | 1.00 | FALSE |
| 34 | The Cancer Genome Atlas | Brain Lower Grade Glioma | PM20D1 | 0.41 | 0.43 | enet | 20 | 0.44 | 9.2e-55 | -6.0 | 5.9 | 2.9e-09 | -0.96 | 0.00 | 1.00 | FALSE |
| 35 | The Cancer Genome Atlas | Lung Adenocarcinoma | PM20D1 | 0.31 | 0.39 | enet | 16 | 0.41 | 5.1e-52 | -6.0 | 5.8 | 6.3e-09 | -0.97 | 0.00 | 1.00 | FALSE |
| 36 | The Cancer Genome Atlas | Lung Squamous Cell Carcinoma | PM20D1 | 0.26 | 0.34 | lasso | 3 | 0.34 | 1.9e-40 | -6.0 | 6.1 | 1.2e-09 | -0.97 | 0.00 | 1.00 | FALSE |
| 37 | The Cancer Genome Atlas | Lung Squamous Cell Carcinoma | RAB7L1 | 0.06 | 0.05 | enet | 6 | 0.06 | 2.6e-07 | 4.0 | -5.2 | 1.8e-07 | 0.64 | 0.36 | 0.61 | FALSE |
| 38 | The Cancer Genome Atlas | Ovarian Serous Cystadenocarcinoma | PM20D1 | 0.12 | 0.13 | blup | 47 | 0.12 | 9.1e-09 | -6.0 | 6.0 | 2.3e-09 | -0.91 | 0.00 | 1.00 | FALSE |
| 39 | The Cancer Genome Atlas | Ovarian Serous Cystadenocarcinoma | RAB7L1 | 0.06 | 0.06 | blup | 46 | 0.06 | 5.2e-05 | -5.3 | -5.5 | 2.9e-08 | 0.90 | 0.02 | 0.97 | FALSE |
| 40 | The Cancer Genome Atlas | Pancreatic Adenocarcinoma | PM20D1 | 0.32 | 0.34 | lasso | 2 | 0.34 | 9.7e-15 | -5.8 | 5.9 | 3.6e-09 | -0.98 | 0.00 | 1.00 | FALSE |
| 41 | The Cancer Genome Atlas | Pheochromocytoma and Paraganglioma | PM20D1 | 0.34 | 0.13 | enet | 20 | 0.21 | 9.7e-09 | 4.4 | 5.1 | 2.8e-07 | -0.77 | 0.01 | 0.99 | FALSE |
| 42 | The Cancer Genome Atlas | Prostate Adenocarcinoma | NUCKS1 | 0.04 | 0.05 | lasso | 2 | 0.03 | 1.5e-04 | -5.3 | 5.6 | 2.2e-08 | -0.90 | 0.06 | 0.90 | FALSE |
| 43 | The Cancer Genome Atlas | Prostate Adenocarcinoma | PM20D1 | 0.16 | 0.14 | enet | 15 | 0.16 | 5.6e-16 | -6.0 | 6.0 | 1.9e-09 | -0.92 | 0.00 | 1.00 | FALSE |
| 44 | The Cancer Genome Atlas | Rectum Adenocarcinoma | PM20D1 | 0.17 | 0.02 | blup | 47 | 0.01 | 2.2e-01 | -5.8 | 5.4 | 8.3e-08 | -0.85 | 0.00 | 0.73 | FALSE |
| 45 | The Cancer Genome Atlas | Soft Tissue Sarcoma | PM20D1 | 0.23 | 0.24 | lasso | 4 | 0.24 | 1.2e-14 | -6.0 | 5.9 | 4.4e-09 | -0.99 | 0.00 | 1.00 | FALSE |
| 46 | The Cancer Genome Atlas | Skin Cutaneous Melanoma | PM20D1 | 0.17 | 0.11 | lasso | 3 | 0.07 | 5.0e-03 | -6.0 | 6.0 | 1.5e-09 | -1.00 | 0.00 | 0.91 | FALSE |
| 47 | The Cancer Genome Atlas | Stomach Adenocarcinoma | PM20D1 | 0.09 | 0.11 | enet | 6 | 0.10 | 1.3e-07 | 5.5 | 5.7 | 1.5e-08 | -0.84 | 0.01 | 0.99 | FALSE |
| 48 | The Cancer Genome Atlas | Testicular Germ Cell Tumors | PM20D1 | 0.42 | 0.34 | lasso | 3 | 0.34 | 6.9e-13 | -6.0 | 5.2 | 1.6e-07 | -0.94 | 0.00 | 1.00 | FALSE |
| 49 | The Cancer Genome Atlas | Thyroid Carcinoma | NUCKS1 | 0.07 | 0.07 | blup | 59 | 0.07 | 1.3e-07 | -5.4 | 5.5 | 3.1e-08 | -0.86 | 0.02 | 0.98 | FALSE |
| 50 | The Cancer Genome Atlas | Thyroid Carcinoma | PM20D1 | 0.26 | 0.40 | lasso | 4 | 0.41 | 2.0e-42 | -6.0 | 6.1 | 8.2e-10 | -0.99 | 0.00 | 1.00 | FALSE |
| 51 | The Cancer Genome Atlas | Thyroid Carcinoma | RAB7L1 | 0.13 | 0.17 | enet | 15 | 0.21 | 3.6e-20 | 4.4 | -5.4 | 6.1e-08 | 0.86 | 0.05 | 0.95 | FALSE |
| 52 | The Cancer Genome Atlas | Uterine Corpus Endometrial Carcinoma | PM20D1 | 0.19 | 0.09 | lasso | 4 | 0.12 | 4.2e-04 | -5.8 | 6.0 | 1.8e-09 | -0.92 | 0.00 | 0.93 | FALSE |