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chr1:204,982,713-206,329,620

Best TWAS P=4.24e-10 · Best GWAS P=2.05e-09 conditioned to 1

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
23	METSIM	Adipose	PM20D1	0.25	0.30	bslmm	377	0.31	8.4e-47	-6.0	6.2	4.2e-10	-0.96	0.00	1.00	TRUE
31	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	PM20D1	0.19	0.25	lasso	5	0.25	3.0e-28	-6.0	6.2	7.1e-10	-0.98	0.00	1.00	FALSE
50	The Cancer Genome Atlas	Thyroid Carcinoma	PM20D1	0.26	0.40	lasso	4	0.41	2.0e-42	-6.0	6.1	8.2e-10	-0.99	0.00	1.00	FALSE
27	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	PM20D1	0.22	0.26	lasso	5	0.26	1.7e-22	-5.8	6.1	8.9e-10	-0.97	0.00	1.00	FALSE
33	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	PM20D1	0.19	0.19	enet	4	0.19	4.5e-11	-6.0	6.1	1.2e-09	-0.99	0.00	1.00	FALSE
36	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	PM20D1	0.26	0.34	lasso	3	0.34	1.9e-40	-6.0	6.1	1.2e-09	-0.97	0.00	1.00	FALSE
2	CommonMind	Brain Pre-frontal Cortex	SLC26A9	0.13	0.16	lasso	3	0.16	3.1e-19	-6.0	-6.1	1.3e-09	0.99	0.00	1.00	FALSE
28	The Cancer Genome Atlas	Breast Invasive Carcinoma	PM20D1	0.24	0.37	lasso	5	0.39	4.9e-85	-6.0	6.1	1.3e-09	-0.97	0.00	1.00	FALSE
46	The Cancer Genome Atlas	Skin Cutaneous Melanoma	PM20D1	0.17	0.11	lasso	3	0.07	5.0e-03	-6.0	6.0	1.5e-09	-1.00	0.00	0.91	FALSE
1	CommonMind	Brain Pre-frontal Cortex	PM20D1	0.27	0.41	enet	15	0.41	7.8e-54	-6.0	-6.0	1.6e-09	0.99	0.00	1.00	FALSE
15	GTEx	Pancreas	SLC41A1	0.24	0.21	lasso	5	0.19	1.4e-08	-6.0	-6.0	1.6e-09	1.00	0.00	1.00	FALSE
52	The Cancer Genome Atlas	Uterine Corpus Endometrial Carcinoma	PM20D1	0.19	0.09	lasso	4	0.12	4.2e-04	-5.8	6.0	1.8e-09	-0.92	0.00	0.93	FALSE
43	The Cancer Genome Atlas	Prostate Adenocarcinoma	PM20D1	0.16	0.14	enet	15	0.16	5.6e-16	-6.0	6.0	1.9e-09	-0.92	0.00	1.00	FALSE
38	The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	PM20D1	0.12	0.13	blup	47	0.12	9.1e-09	-6.0	6.0	2.3e-09	-0.91	0.00	1.00	FALSE
6	GTEx	Brain Cerebellum	NUCKS1	0.22	0.13	lasso	3	0.08	2.0e-03	-5.8	6.0	2.7e-09	-0.95	0.01	0.95	FALSE
16	GTEx	Prostate	NUCKS1	0.38	0.23	lasso	8	0.32	7.5e-09	5.6	-6.0	2.7e-09	0.85	0.04	0.90	FALSE
34	The Cancer Genome Atlas	Brain Lower Grade Glioma	PM20D1	0.41	0.43	enet	20	0.44	9.2e-55	-6.0	5.9	2.9e-09	-0.96	0.00	1.00	FALSE
40	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	PM20D1	0.32	0.34	lasso	2	0.34	9.7e-15	-5.8	5.9	3.6e-09	-0.98	0.00	1.00	FALSE
45	The Cancer Genome Atlas	Soft Tissue Sarcoma	PM20D1	0.23	0.24	lasso	4	0.24	1.2e-14	-6.0	5.9	4.4e-09	-0.99	0.00	1.00	FALSE
29	The Cancer Genome Atlas	Cervical Squamous Cell Carcinoma	PM20D1	0.18	0.19	blup	47	0.18	1.9e-09	-6.0	5.8	5.7e-09	-0.87	0.00	1.00	FALSE
5	GTEx	Artery Tibial	NUCKS1	0.13	0.03	lasso	2	0.01	4.0e-02	-5.8	5.8	5.9e-09	-0.96	0.01	0.98	FALSE
35	The Cancer Genome Atlas	Lung Adenocarcinoma	PM20D1	0.31	0.39	enet	16	0.41	5.1e-52	-6.0	5.8	6.3e-09	-0.97	0.00	1.00	FALSE
13	GTEx	Nerve Tibial	SLC41A1	0.12	0.02	lasso	4	0.05	2.5e-04	-6.0	-5.7	1.0e-08	0.83	0.01	0.99	FALSE
20	GTEx	Testis	NUCKS1	0.16	0.16	enet	15	0.16	1.3e-07	-5.5	5.7	1.3e-08	-0.88	0.02	0.98	FALSE
26	YFS	Blood	SLC41A1	0.06	0.05	enet	15	0.05	2.6e-17	-5.8	-5.7	1.4e-08	0.90	0.00	1.00	FALSE
47	The Cancer Genome Atlas	Stomach Adenocarcinoma	PM20D1	0.09	0.11	enet	6	0.10	1.3e-07	5.5	5.7	1.5e-08	-0.84	0.01	0.99	FALSE
32	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	PM20D1	0.29	0.35	enet	18	0.35	5.1e-41	-6.0	5.6	1.8e-08	-0.95	0.00	1.00	FALSE
42	The Cancer Genome Atlas	Prostate Adenocarcinoma	NUCKS1	0.04	0.05	lasso	2	0.03	1.5e-04	-5.3	5.6	2.2e-08	-0.90	0.06	0.90	FALSE
24	METSIM	Adipose	SLC41A1	0.07	0.08	lasso	7	0.08	1.9e-11	5.6	-5.6	2.5e-08	0.81	0.04	0.96	FALSE
39	The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	RAB7L1	0.06	0.06	blup	46	0.06	5.2e-05	-5.3	-5.5	2.9e-08	0.90	0.02	0.97	FALSE
49	The Cancer Genome Atlas	Thyroid Carcinoma	NUCKS1	0.07	0.07	blup	59	0.07	1.3e-07	-5.4	5.5	3.1e-08	-0.86	0.02	0.98	FALSE
19	GTEx	Stomach	NUCKS1	0.21	0.11	lasso	8	0.15	1.1e-07	-5.1	5.5	3.4e-08	-0.81	0.04	0.96	FALSE
12	GTEx	Nerve Tibial	NUCKS1	0.25	0.21	enet	16	0.22	7.3e-16	-5.4	5.5	4.4e-08	-0.90	0.04	0.96	FALSE
30	The Cancer Genome Atlas	Colon Adenocarcinoma	PM20D1	0.26	0.13	enet	14	0.16	9.7e-10	5.6	5.5	4.9e-08	-0.83	0.00	1.00	FALSE
10	GTEx	Heart Left Ventricle	NUCKS1	0.10	0.04	lasso	3	0.05	1.4e-03	-5.3	5.5	5.1e-08	-0.85	0.02	0.92	FALSE
3	GTEx	Adipose Subcutaneous	NUCKS1	0.11	0.10	lasso	3	0.08	9.4e-07	-5.3	5.4	5.3e-08	-0.90	0.02	0.98	FALSE
7	GTEx	Brain Putamen basal ganglia	NUCKS1	0.40	0.26	lasso	4	0.27	3.2e-07	-5.3	5.4	5.4e-08	-0.90	0.05	0.87	FALSE
51	The Cancer Genome Atlas	Thyroid Carcinoma	RAB7L1	0.13	0.17	enet	15	0.21	3.6e-20	4.4	-5.4	6.1e-08	0.86	0.05	0.95	FALSE
21	GTEx	Thyroid	NUCKS1	0.26	0.16	lasso	6	0.19	1.8e-14	-5.4	5.4	6.2e-08	-0.90	0.02	0.98	FALSE
17	GTEx	Skin Not Sun Exposed Suprapubic	NUCKS1	0.20	0.14	lasso	4	0.13	2.0e-07	-5.3	5.4	6.5e-08	-0.91	0.03	0.97	FALSE
11	GTEx	Lung	NUCKS1	0.09	0.07	lasso	3	0.04	2.6e-04	-5.3	5.4	6.6e-08	-0.89	0.02	0.98	FALSE
18	GTEx	Skin Sun Exposed Lower leg	NUCKS1	0.20	0.26	lasso	5	0.26	1.5e-21	-5.3	5.4	6.9e-08	-0.91	0.06	0.94	FALSE
8	GTEx	Breast Mammary Tissue	NUCKS1	0.15	0.05	lasso	4	0.09	2.5e-05	-5.3	5.4	7.7e-08	-0.87	0.03	0.97	FALSE
44	The Cancer Genome Atlas	Rectum Adenocarcinoma	PM20D1	0.17	0.02	blup	47	0.01	2.2e-01	-5.8	5.4	8.3e-08	-0.85	0.00	0.73	FALSE
25	YFS	Blood	NUCKS1	0.15	0.24	lasso	4	0.25	1.4e-80	-5.3	5.4	8.4e-08	-0.90	0.07	0.93	FALSE
4	GTEx	Artery Aorta	NUCKS1	0.14	0.11	lasso	3	0.08	3.7e-05	-5.3	5.3	9.2e-08	-0.85	0.03	0.97	FALSE
22	METSIM	Adipose	NUCKS1	0.05	0.02	lasso	6	0.01	4.3e-03	-5.5	5.3	1.1e-07	-0.86	0.03	0.96	FALSE
9	GTEx	Esophagus Muscularis	NUCKS1	0.21	0.22	lasso	5	0.20	3.6e-12	-5.1	5.2	1.6e-07	-0.88	0.07	0.93	FALSE
48	The Cancer Genome Atlas	Testicular Germ Cell Tumors	PM20D1	0.42	0.34	lasso	3	0.34	6.9e-13	-6.0	5.2	1.6e-07	-0.94	0.00	1.00	FALSE
37	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	RAB7L1	0.06	0.05	enet	6	0.06	2.6e-07	4.0	-5.2	1.8e-07	0.64	0.36	0.61	FALSE
14	GTEx	Pancreas	NUCKS1	0.16	0.00	lasso	4	0.00	4.5e-01	3.6	5.2	2.1e-07	-0.81	0.03	0.76	FALSE
41	The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	PM20D1	0.34	0.13	enet	20	0.21	9.7e-09	4.4	5.1	2.8e-07	-0.77	0.01	0.99	FALSE