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chr2:23,604,114-26,088,769

Best TWAS P=1.37e-114 · Best GWAS P=2.11e-100 conditioned to NaN

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	CommonMind	Brain Pre-frontal Cortex	ADCY3	0.16	0.12	lasso	10	0.14	3.2e-17	21.122	-22.8	1.4e-114	-0.89	0.00	1.00	TRUE
44	The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	POMC	0.19	0.01	blup	38	0.05	1.5e-04	-15.548	-11.7	2.0e-31	-0.32	0.00	0.77	TRUE
47	The Cancer Genome Atlas	Prostate Adenocarcinoma	POMC	0.11	0.08	enet	7	0.09	1.6e-09	-1.503	-10.7	1.1e-26	-0.23	0.20	0.80	TRUE
24	METSIM	Adipose	EFR3B	0.04	0.00	bslmm	357	0.00	9.7e-02	-1.965	-9.5	2.4e-21	-0.37	0.06	0.08	TRUE
17	GTEx	Lung	NCOA1	0.12	0.04	lasso	7	0.06	1.9e-05	-0.283	8.2	3.8e-16	0.21	0.52	0.02	TRUE
37	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	POMC	0.16	0.05	blup	39	0.11	2.4e-12	-15.548	-7.9	2.6e-15	-0.21	0.00	1.00	TRUE
38	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	NCOA1	0.08	0.07	blup	77	0.05	5.8e-04	-2.099	6.0	1.5e-09	0.19	0.23	0.18	TRUE
11	GTEx	Brain Cerebellum	FAM228B	0.28	0.00	lasso	14	0.01	1.4e-01	2.921	-5.6	1.7e-08	-0.14	0.25	0.05	TRUE
27	ROSMAP	Brain Pre-frontal Cortex	ADCY3	0.17	0.26	enet	32	0.26	6.8e-33	20.653	-22.7	3.8e-114	-0.90	0.86	0.14	FALSE
19	GTEx	Nerve Tibial	ADCY3	0.09	0.05	enet	6	0.03	2.2e-03	18.245	-22.6	7.0e-113	-0.92	0.01	0.99	FALSE
23	GTEx	Whole Blood	RP11-443B20.1	0.21	0.17	enet	32	0.20	1.8e-18	19.837	22.1	2.6e-108	0.87	0.76	0.24	FALSE
22	GTEx	Whole Blood	ADCY3	0.23	0.24	enet	24	0.27	5.5e-25	20.653	22.0	5.0e-107	0.87	1.00	0.00	FALSE
20	GTEx	Nerve Tibial	RP11-443B20.1	0.07	0.03	enet	6	0.02	1.1e-02	18.245	-21.5	9.2e-103	-0.82	0.02	0.97	FALSE
9	GTEx	Artery Tibial	ADCY3	0.21	0.14	lasso	6	0.15	4.3e-12	18.245	21.3	4.8e-101	0.70	0.99	0.01	FALSE
10	GTEx	Artery Tibial	RP11-443B20.1	0.17	0.08	enet	40	0.09	8.2e-08	18.245	21.0	1.3e-97	0.59	0.52	0.44	FALSE
14	GTEx	Cells EBV-transformed lymphocytes	RP11-443B20.1	0.13	0.13	enet	9	0.05	9.2e-03	20.115	-20.7	2.3e-95	-0.93	0.01	0.96	FALSE
21	GTEx	Whole Blood	DNAJC27	0.08	0.10	lasso	1	0.10	2.2e-09	19.837	19.8	1.4e-87	0.80	0.88	0.12	FALSE
4	GTEx	Adipose Subcutaneous	ADCY3	0.07	0.04	lasso	6	0.01	3.2e-02	20.115	19.5	1.8e-84	0.87	0.07	0.91	FALSE
2	CommonMind	Brain Pre-frontal Cortex	CENPO	0.07	0.03	bslmm	322	0.03	7.0e-05	14.392	-19.5	2.1e-84	-0.49	0.48	0.25	FALSE
39	The Cancer Genome Atlas	Brain Lower Grade Glioma	ADCY3	0.03	0.02	blup	81	0.02	7.1e-04	12.519	-18.8	1.9e-78	-0.88	0.03	0.94	FALSE
13	GTEx	Cells EBV-transformed lymphocytes	ADCY3	0.25	0.23	enet	10	0.12	9.2e-05	20.115	-18.0	2.7e-72	-0.84	0.02	0.97	FALSE
36	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	EFR3B	0.03	0.05	lasso	1	0.04	1.9e-05	-17.062	-17.1	2.9e-65	-0.65	0.55	0.06	FALSE
5	GTEx	Adipose Subcutaneous	RP11-443B20.1	0.04	0.00	enet	10	0.00	1.2e-01	10.142	16.5	3.2e-61	0.82	0.04	0.90	FALSE
31	The Cancer Genome Atlas	Breast Invasive Carcinoma	ADCY3	0.05	0.03	blup	81	0.03	5.0e-07	4.759	-13.5	1.6e-41	-0.51	0.57	0.39	FALSE
6	GTEx	Adrenal Gland	PTRHD1	0.32	0.28	lasso	3	0.26	8.3e-10	-12.155	12.8	1.8e-37	0.41	0.98	0.00	FALSE
34	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	POMC	0.06	0.00	enet	12	0.03	9.3e-05	-1.503	-11.5	1.2e-30	-0.26	0.01	0.50	FALSE
30	YFS	Blood	POMC	0.35	0.05	enet	71	0.19	5.7e-59	-15.548	-11.2	7.0e-29	-0.30	1.00	0.00	FALSE
40	The Cancer Genome Atlas	Lung Adenocarcinoma	DNAJC27	0.05	0.01	blup	46	0.04	3.2e-05	4.833	-10.8	5.7e-27	-0.56	0.36	0.58	FALSE
28	ROSMAP	Brain Pre-frontal Cortex	CENPO	0.08	0.04	enet	5	0.05	2.6e-07	-9.326	-10.7	1.2e-26	-0.36	1.00	0.00	FALSE
15	GTEx	Esophagus Muscularis	NCOA1	0.11	0.01	enet	9	0.01	5.8e-02	5.929	10.6	2.8e-26	0.45	0.08	0.12	FALSE
29	YFS	Blood	ADCY3	0.07	0.02	bslmm	343	0.04	7.3e-14	21.265	-10.3	9.7e-25	-0.63	0.00	1.00	FALSE
42	The Cancer Genome Atlas	Lung Adenocarcinoma	POMC	0.14	0.04	enet	7	0.08	5.3e-10	-1.503	-9.3	2.0e-20	-0.21	0.16	0.83	FALSE
8	GTEx	Artery Coronary	DNAJC27	0.12	0.03	lasso	7	0.00	2.4e-01	4.811	8.9	4.9e-19	0.46	0.14	0.22	FALSE
32	The Cancer Genome Atlas	Breast Invasive Carcinoma	POMC	0.08	0.05	lasso	3	0.06	2.6e-12	-1.503	-8.8	1.8e-18	-0.20	0.74	0.26	FALSE
41	The Cancer Genome Atlas	Lung Adenocarcinoma	NCOA1	0.02	0.01	blup	77	0.01	1.2e-02	-6.277	-8.5	2.3e-17	-0.23	0.11	0.03	FALSE
18	GTEx	Muscle Skeletal	POMC	0.38	0.10	lasso	9	0.09	2.9e-09	-2.830	-7.8	5.9e-15	-0.21	1.00	0.00	FALSE
46	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	POMC	0.22	0.05	blup	37	0.03	2.1e-02	-1.261	-7.6	2.5e-14	-0.11	0.02	0.08	FALSE
43	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	ADCY3	0.06	0.01	enet	9	0.02	1.0e-03	4.772	-7.4	1.4e-13	-0.17	0.06	0.04	FALSE
26	ROSMAP	Brain Pre-frontal Cortex	DNAJC27	0.10	0.06	blup	330	0.06	3.7e-08	4.833	-6.7	1.8e-11	-0.36	1.00	0.00	FALSE
33	The Cancer Genome Atlas	Glioblastoma Multiforme	ADCY3	0.36	0.14	enet	7	0.13	8.9e-05	5.793	-6.2	4.8e-10	-0.37	0.04	0.12	FALSE
16	GTEx	Esophagus Muscularis	ITSN2	0.10	0.04	lasso	7	0.09	6.1e-06	-0.704	6.2	7.0e-10	0.09	0.29	0.07	FALSE
7	GTEx	Artery Aorta	NCOA1	0.15	0.00	enet	15	0.01	1.4e-01	11.198	5.8	6.5e-09	0.36	0.06	0.16	FALSE
25	METSIM	Adipose	POMC	0.18	0.06	lasso	9	0.09	5.5e-13	-3.282	-5.7	9.4e-09	-0.16	1.00	0.00	FALSE
48	The Cancer Genome Atlas	Stomach Adenocarcinoma	DNAJC27	0.11	0.01	blup	45	0.02	1.4e-02	4.793	5.7	1.4e-08	0.05	0.02	0.03	FALSE
3	GTEx	Adipose Subcutaneous	TP53I3	0.11	0.03	enet	48	0.04	3.8e-04	2.303	-5.3	8.7e-08	-0.17	0.28	0.18	FALSE
45	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	EFR3B	0.26	0.01	lasso	4	0.05	3.8e-03	5.929	5.3	9.4e-08	0.35	0.03	0.14	FALSE
35	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	ADCY3	0.08	0.03	enet	16	0.03	1.5e-04	4.712	-5.3	1.1e-07	-0.17	0.03	0.04	FALSE
12	GTEx	Breast Mammary Tissue (Male)	NCOA1	0.13	-0.01	lasso	3	0.04	4.8e-02	-0.006	5.2	1.8e-07	0.16	0.04	0.23	FALSE
49	The Cancer Genome Atlas	Thyroid Carcinoma	NCOA1	0.11	0.01	enet	11	0.06	1.9e-06	-1.965	5.2	2.0e-07	0.12	0.01	0.91	FALSE