[Hub]/) : Traits : Comparative body size at age 10 :

chr3:49,615,624-51,320,800

Best TWAS P=1.83e-11 · Best GWAS P=4.04e-08 conditioned to 0.0016

Associated models

# Study Tissue Gene h2 eQTL R2 model # weights model R2 model R2 P eQTL GWAS Z TWAS Z TWAS P Top SNP corr PP3 PP4 joint
1 GTEx Brain Cerebellar Hemisphere HYAL3 0.32 0.17 lasso 8 0.10 1.4e-03 4.7 -5.2 1.8e-07 -0.78 0.04 0.47 FALSE
2 GTEx Brain Cortex HEMK1 0.16 0.01 enet 19 0.03 6.1e-02 -4.2 6.4 1.9e-10 0.19 0.08 0.29 FALSE
3 GTEx Brain Cortex HYAL3 0.43 0.28 lasso 6 0.34 4.9e-10 4.7 -5.2 2.0e-07 -0.72 0.15 0.77 FALSE
4 GTEx Brain Cortex NAT6 0.32 0.20 enet 11 0.18 1.3e-05 4.7 5.2 1.8e-07 0.72 0.07 0.73 FALSE
5 GTEx Brain Frontal Cortex BA9 NAT6 0.27 0.13 enet 4 0.16 6.3e-05 4.7 5.3 1.2e-07 0.82 0.05 0.69 FALSE
6 GTEx Esophagus Muscularis RASSF1 0.10 0.00 lasso 7 0.01 8.7e-02 -5.1 -5.5 3.4e-08 -0.11 0.05 0.68 FALSE
7 GTEx Esophagus Muscularis SEMA3B-AS1 0.47 0.00 lasso 7 0.00 5.9e-01 -4.8 -5.5 3.8e-08 0.01 0.12 0.41 FALSE
8 GTEx Heart Left Ventricle HYAL1 0.23 0.03 enet 26 0.12 5.8e-07 -4.9 -6.3 3.0e-10 -0.55 0.03 0.94 FALSE
9 GTEx Muscle Skeletal SEMA3B-AS1 0.17 0.01 lasso 7 0.02 8.3e-03 -4.4 -5.9 2.8e-09 -0.24 0.11 0.77 FALSE
10 GTEx Nerve Tibial RASSF1 0.05 0.03 enet 19 0.02 1.0e-02 -5.0 -5.6 2.5e-08 -0.12 0.06 0.89 FALSE
11 GTEx Nerve Tibial HYAL3 0.22 0.10 lasso 5 0.08 2.3e-06 4.7 -5.2 2.1e-07 -0.78 0.15 0.84 FALSE
12 GTEx Skin Not Sun Exposed Suprapubic CYB561D2 0.08 0.01 enet 7 0.02 2.3e-02 -4.1 5.5 2.9e-08 0.13 0.13 0.46 FALSE
13 GTEx Skin Sun Exposed Lower leg CYB561D2 0.13 0.02 lasso 3 0.05 5.7e-05 -4.1 5.2 1.7e-07 0.11 0.34 0.54 FALSE
14 GTEx Skin Sun Exposed Lower leg NAT6 0.10 0.05 lasso 6 0.06 7.0e-06 5.5 5.7 1.1e-08 0.92 0.01 0.99 FALSE
15 GTEx Spleen CACNA2D2 0.18 0.01 enet 43 0.03 5.4e-02 -4.3 -6.6 3.5e-11 -0.32 0.17 0.27 FALSE
16 ROSMAP Brain Pre-frontal Cortex RASSF1 0.03 0.00 bslmm 257 0.02 1.8e-03 -4.2 -6.7 1.8e-11 -0.38 0.04 0.44 TRUE
17 ROSMAP Brain Pre-frontal Cortex C3orf18 0.03 0.00 bslmm 232 0.01 2.7e-02 -4.1 -5.8 8.9e-09 -0.15 0.10 0.46 FALSE
18 ROSMAP Brain Pre-frontal Cortex HYAL1 0.10 0.04 blup 248 0.04 1.3e-05 -4.6 -5.8 6.9e-09 -0.31 0.14 0.82 FALSE
19 ROSMAP Brain Pre-frontal Cortex NAT6 0.28 0.24 lasso 4 0.25 1.6e-31 4.7 5.4 6.9e-08 0.82 0.12 0.87 FALSE
20 YFS Blood NAT6 0.09 0.06 bslmm 295 0.06 9.9e-19 4.7 5.9 3.3e-09 0.68 0.18 0.81 FALSE
21 The Cancer Genome Atlas Pancreatic Adenocarcinoma C3orf45 0.07 0.05 enet 4 0.05 2.9e-03 -4.6 5.5 4.4e-08 0.46 0.00 0.52 FALSE
22 The Cancer Genome Atlas Testicular Germ Cell Tumors CYB561D2 0.08 0.04 blup 17 0.08 9.3e-04 -4.6 5.5 4.4e-08 0.26 0.00 0.33 FALSE