Best TWAS P=2.83e-13 · Best GWAS P=3.17e-17 conditioned to 0.0144
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | GTEx | Adipose Visceral Omentum | RP11-165J3.6 | 0.26 | 0.13 | lasso | 6 | 0.13 | 4.2e-07 | -5.5 | -6.0 | 2.0e-09 | -0.29 | 0.98 | 0.00 | FALSE |
2 | GTEx | Adrenal Gland | RP11-165J3.6 | 0.20 | 0.08 | lasso | 8 | 0.09 | 5.4e-04 | -5.0 | -5.7 | 9.5e-09 | -0.27 | 0.20 | 0.06 | TRUE |
3 | GTEx | Artery Aorta | RP11-165J3.6 | 0.23 | 0.22 | enet | 10 | 0.22 | 2.3e-12 | -5.4 | -5.4 | 5.7e-08 | -0.28 | 1.00 | 0.00 | FALSE |
4 | GTEx | Artery Tibial | RP11-165J3.6 | 0.22 | 0.20 | lasso | 2 | 0.19 | 4.9e-15 | -5.4 | -5.4 | 8.4e-08 | -0.29 | 1.00 | 0.00 | FALSE |
5 | GTEx | Brain Nucleus accumbens basal ganglia | RP11-165J3.6 | 0.31 | 0.11 | lasso | 6 | 0.16 | 5.4e-05 | -5.4 | -5.4 | 8.2e-08 | -0.01 | 0.20 | 0.04 | FALSE |
6 | GTEx | Breast Mammary Tissue | RP11-165J3.6 | 0.28 | 0.11 | enet | 24 | 0.13 | 2.7e-07 | -5.2 | -6.3 | 2.7e-10 | -0.15 | 1.00 | 0.00 | FALSE |
7 | GTEx | Breast Mammary Tissue (Female) | RP11-165J3.6 | 0.21 | 0.02 | lasso | 3 | 0.00 | 2.3e-01 | -5.2 | -5.6 | 2.8e-08 | -0.29 | 0.08 | 0.06 | FALSE |
8 | GTEx | Colon Transverse | RP11-165J3.6 | 0.37 | 0.20 | lasso | 4 | 0.18 | 3.6e-09 | -5.4 | -6.1 | 1.1e-09 | -0.21 | 1.00 | 0.00 | FALSE |
9 | GTEx | Esophagus Gastroesophageal Junction | RP11-165J3.6 | 0.34 | 0.26 | lasso | 8 | 0.27 | 3.0e-10 | -5.4 | -5.6 | 2.5e-08 | -0.30 | 1.00 | 0.00 | FALSE |
10 | GTEx | Heart Atrial Appendage | FAM120AOS | 0.10 | 0.04 | lasso | 3 | 0.04 | 5.1e-03 | 4.9 | 5.4 | 7.1e-08 | 0.73 | 0.14 | 0.49 | FALSE |
11 | GTEx | Heart Atrial Appendage | RP11-165J3.6 | 0.38 | 0.21 | lasso | 7 | 0.25 | 8.7e-12 | -5.5 | -6.1 | 1.3e-09 | -0.27 | 1.00 | 0.00 | FALSE |
12 | GTEx | Lung | RP11-165J3.6 | 0.25 | 0.16 | lasso | 7 | 0.17 | 4.1e-13 | -5.4 | -5.9 | 3.7e-09 | -0.31 | 1.00 | 0.00 | FALSE |
13 | GTEx | Pituitary | RP11-165J3.6 | 0.49 | 0.22 | lasso | 8 | 0.29 | 6.9e-08 | -5.2 | -5.6 | 1.9e-08 | -0.17 | 0.64 | 0.02 | FALSE |
14 | GTEx | Skin Not Sun Exposed Suprapubic | RP11-165J3.6 | 0.27 | 0.14 | lasso | 7 | 0.19 | 1.4e-10 | -6.4 | -5.9 | 2.9e-09 | -0.21 | 1.00 | 0.00 | FALSE |
15 | GTEx | Skin Sun Exposed Lower leg | RP11-165J3.6 | 0.32 | 0.27 | lasso | 5 | 0.35 | 6.8e-30 | -5.2 | -5.9 | 4.7e-09 | -0.25 | 1.00 | 0.00 | FALSE |
16 | GTEx | Thyroid | RP11-165J3.6 | 0.35 | 0.27 | lasso | 3 | 0.29 | 1.2e-22 | -5.4 | -5.7 | 1.3e-08 | -0.33 | 1.00 | 0.00 | FALSE |
17 | YFS | Blood | FAM120AOS | 0.03 | 0.01 | bslmm | 488 | 0.02 | 5.3e-06 | -5.2 | 7.3 | 2.8e-13 | 0.64 | 0.07 | 0.88 | TRUE |
18 | The Cancer Genome Atlas | Soft Tissue Sarcoma | PHF2 | 0.05 | 0.03 | blup | 103 | 0.04 | 3.5e-03 | -4.5 | 6.3 | 3.4e-10 | 0.67 | 0.08 | 0.15 | TRUE |