Best TWAS P=5.63e-09 · Best GWAS P=5.02e-12 conditioned to 0.000121
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | GTEx | Brain Frontal Cortex BA9 | LINC00476 | 0.27 | 0.14 | lasso | 4 | 0.24 | 5.1e-07 | 5.5 | -5.6 | 2.8e-08 | 0.71 | 0.12 | 0.82 | FALSE |
2 | GTEx | Brain Nucleus accumbens basal ganglia | LINC00476 | 0.32 | 0.31 | lasso | 5 | 0.28 | 2.9e-08 | 5.4 | -5.7 | 9.7e-09 | 0.76 | 0.13 | 0.86 | FALSE |
3 | The Cancer Genome Atlas | Colon Adenocarcinoma | C9orf130 | 0.36 | 0.38 | enet | 13 | 0.38 | 3.7e-23 | -4.2 | -5.5 | 3.3e-08 | 0.73 | 0.61 | 0.39 | FALSE |
4 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | C9orf130 | 0.36 | 0.43 | lasso | 6 | 0.52 | 6.8e-69 | -5.1 | -5.2 | 1.8e-07 | 0.72 | 0.99 | 0.01 | FALSE |
5 | The Cancer Genome Atlas | Brain Lower Grade Glioma | C9orf102 | 0.06 | 0.05 | lasso | 1 | 0.05 | 3.5e-06 | -5.2 | -5.2 | 2.1e-07 | 0.85 | 0.51 | 0.46 | FALSE |
6 | The Cancer Genome Atlas | Soft Tissue Sarcoma | C9orf130 | 0.18 | 0.15 | blup | 73 | 0.17 | 2.6e-10 | -5.1 | -5.8 | 5.6e-09 | 0.74 | 0.26 | 0.74 | TRUE |
7 | The Cancer Genome Atlas | Testicular Germ Cell Tumors | C9orf130 | 0.36 | 0.35 | lasso | 10 | 0.41 | 1.2e-15 | -4.1 | -5.3 | 1.3e-07 | 0.78 | 0.62 | 0.38 | FALSE |