TWAS hub - C9orf102

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.1580	0.0440	6.1e-08	0.089	0.056	0.074	0.063	0.073	5.4e-11	2.0e-07	2.3e-09	3.8e-08	3.0e-09
2	TCGA	Breast Invasive Carcinoma	0.1336	0.0581	3.6e-06	0.002	0.020	0.025	NA	0.022	9.3e-02	3.7e-05	4.5e-06	NA	1.9e-05
3	TCGA	Kidney Renal Clear Cell Carcinoma	0.0651	0.0309	4.2e-06	0.045	0.057	0.050	NA	0.049	7.2e-06	5.2e-07	2.3e-06	NA	3.1e-06
4	TCGA	Brain Lower Grade Glioma	0.0568	0.0398	6.7e-05	0.054	0.037	0.041	NA	0.048	8.3e-07	4.8e-05	1.8e-05	NA	3.5e-06
5	TCGA	Lung Squamous Cell Carcinoma	0.0516	0.0299	6.1e-04	0.033	0.031	0.027	NA	0.032	1.2e-04	1.9e-04	4.7e-04	NA	1.5e-04
6	TCGA	Prostate Adenocarcinoma	0.0617	0.0337	9.3e-05	0.022	0.032	0.032	NA	0.029	1.8e-03	2.3e-04	2.4e-04	NA	4.6e-04

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6
Sensitivity / hurt feelings	5.2	8.9	12.9	1.8	3.6	3.6	2.9	2.4	3.2
Noisy workplace	4.0	5.0	7.3	2.2	2.2	2.7	2.0	1.9	2.3
Forced expiratory volume in 1-second (FEV1), Best measure	3.8	12.0	17.9	1.6	3.9	4.2	4.2	2.4	3.6
Forced vital capacity (FVC), Best measure	3.3	12.1	18.2	-0.2	4.3	4.3	3.6	2.8	3.9
Forced expiratory volume in 1-second (FEV1), predicted percentage	3.3	7.0	14.5	1.2	2.7	3.3	3.8	1.4	2.5
Average weekly beer plus cider intake	3.3	4.7	9.7	3.1	2.6	1.9	1.8	1.4	1.8
Sitting height	3.2	22.8	36.1	2.1	5.5	6.0	4.0	3.9	5.8
Alcohol usually taken with meals	3.2	5.2	9.1	-1.4	-2.4	-2.4	-0.1	-3.0	-2.8
Comparative body size at age 10	3.1	8.6	26.9	-3.6	-0.7	-2.9	-5.2	0.6	-1.6
Pain all over the body in last month	3.0	3.2	7.6	2.8	1.5	1.7	1.3	1.4	1.6
Forced expiratory volume in 1-second (FEV1)	3.0	10.0	16.3	0.6	3.5	3.9	4.0	2.1	3.3
Medication for hormone replacement therapy	2.8	3.1	6.2	0.4	1.6	2.5	1.6	1.3	2.4
Had major operations	2.8	3.3	4.3	-1.9	-2.1	-1.9	-1.8	-1.5	-1.6
Mother’s age at death	2.8	3.5	6.5	-2.1	2.0	1.6	-0.3	2.5	1.8
Forced vital capacity (FVC)	2.7	10.5	17.0	-1.0	4.1	3.9	3.5	2.4	3.5
Worry too long after embarrassment	2.6	4.4	6.5	1.8	2.1	2.5	2.0	1.7	2.2
Forced expiratory volume in 1-second (FEV1), predicted	2.6	5.4	9.7	1.0	2.1	3.1	2.5	1.7	2.8
Relative age voice broke	2.4	3.6	5.4	2.3	0.8	2.2	2.0	1.4	2.1
Had other major operations	2.4	3.0	4.8	-1.6	1.9	1.7	0.2	2.2	1.9
Hair/balding pattern: Pattern 4	2.4	5.9	12.0	-1.8	-1.9	-2.8	-3.5	-2.0	-2.1
Worry (Nagel 2018)	2.3	4.7	9.8	-0.2	2.3	2.6	3.1	1.8	1.9
Ever had hysterectomy (womb removed)	2.3	2.5	6.5	0.8	2.6	1.7	1.4	1.0	1.4
Standing height	2.3	22.6	37.0	2.1	6.1	5.9	5.1	2.5	5.2
Medication for cholesterol, blood pressure or diabetes	2.3	3.8	6.9	-0.6	-2.6	-2.1	-1.3	-2.6	-1.6
Number of treatments/medications taken	2.2	4.0	8.5	-1.4	2.7	1.7	-0.1	2.9	1.8
Hair/balding pattern: Pattern 2	2.2	2.9	3.8	1.3	1.8	1.9	1.7	1.3	1.9
Neuroticism (Nagel 2018)	2.1	5.0	7.2	0.5	2.7	2.7	2.5	2.1	2.2
Alzheimer’s Disease (in mother)	2.1	2.5	3.7	-1.1	-1.9	-1.8	-1.3	-1.6	-1.6
Alzheimer’s Disease (including proxy)	2.1	3.0	3.7	-1.9	-1.8	-1.9	-1.6	-1.3	-1.9
Bilateral oophorectomy (both ovaries removed)	2.1	2.4	4.8	1.2	1.4	1.9	2.2	0.9	1.3
Peak expiratory flow (PEF)	2.1	5.0	6.1	1.9	2.3	2.5	2.5	2.0	2.2
Neuroticism score	2.0	4.2	6.9	0.8	2.5	2.3	0.7	2.6	2.4
Fed-up feelings	1.9	3.4	5.0	1.2	2.2	2.0	0.9	2.1	2.2
Nervous feelings	1.9	3.5	5.5	-0.4	1.8	2.4	2.1	1.9	2.0
Height	1.8	34.4	59.9	3.0	7.7	7.1	6.8	2.2	6.0
Average weekly spirits intake	1.8	2.3	4.3	0.2	1.9	0.9	-1.5	2.1	1.7
Ever used hormone-replacement therapy (HRT)	1.8	2.3	3.3	-1.1	1.8	1.8	1.2	1.1	1.8
Age at First Birth	1.7	2.4	4.0	1.0	1.0	2.0	1.5	1.7	1.9
Neuroticism	1.7	4.1	7.5	0.3	2.7	2.3	0.9	2.4	2.4
Medication: Cholesterol lowering	1.7	2.6	5.2	-0.6	1.9	1.7	1.3	2.3	1.3
Pulse wave peak to peak time	1.7	2.0	5.3	-0.1	0.7	1.7	0.4	2.3	1.8
Major Depression (MDD)	1.6	1.9	5.1	-1.9	0.8	0.8	-0.7	2.3	1.1
Seen a psychiatrist for nerves, anxiety, tension or depression	1.5	1.9	3.4	1.6	1.8	1.4	1.3	0.7	1.2
Lung FVC	1.4	7.4	20.3	-4.5	3.1	2.0	2.4	1.5	1.7
Taking other prescription medications	1.4	2.2	5.9	0.3	2.4	1.5	0.1	1.5	1.6
Headache pain in last month	1.4	2.4	4.8	-1.6	-2.2	-1.3	-1.6	-1.3	-0.9
High blood pressure (siblings)	1.4	2.0	3.1	-1.8	-1.1	-1.6	-1.6	-0.7	-1.5
Number of full sisters	1.4	1.8	3.0	1.1	1.1	1.6	0.5	1.6	1.7
Qualifications: NVQ or HND or HNC or equivalent	1.4	1.6	2.0	1.4	1.3	1.3	1.3	1.2	1.2
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.4	1.6	3.3	-0.0	0.1	-1.8	-1.3	-1.3	-1.7
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.4	1.6	4.6	1.6	0.7	1.2	2.1	-0.3	0.8
Schizophrenia (2014)	1.3	3.0	7.6	0.9	1.5	1.7	0.1	2.8	2.0
Worrier / anxious feelings	1.3	2.5	4.6	1.0	2.1	1.6	0.9	1.7	1.7
Number of live births	1.3	1.8	3.3	0.1	-1.2	-1.8	-1.1	-1.3	-1.8
Birth weight of first child	1.3	2.3	4.0	-1.8	-1.5	-1.7	-2.0	-0.4	-1.2
Age at last live birth	1.3	2.0	3.7	-0.7	-1.9	-1.5	-1.3	-1.5	-1.1
Illnesses of father: Heart disease	1.3	1.8	4.5	-1.6	-2.1	-0.8	0.4	-1.2	-1.2
Average weekly red wine intake	1.3	2.0	3.9	-0.9	-1.1	-1.6	0.2	-1.9	-2.0
Alcohol drinker status: Previous	1.3	1.5	2.5	0.3	-1.5	-1.3	-0.3	-1.4	-1.6
Cardiovascular Disease	1.2	4.0	7.6	1.6	2.6	1.9	0.8	2.8	1.6
Serious illness, injury or assault to yourself	1.2	1.5	2.5	0.8	1.6	1.4	1.6	0.4	1.1
Multivitamins +/- minerals	1.2	1.6	2.3	-1.4	0.0	1.5	0.7	1.5	1.5
Diverticular disease/diverticulitis (self-reported)	1.2	1.5	3.2	0.2	1.7	1.0	-0.3	1.8	1.3
Pulse rate	1.2	2.0	2.5	-1.6	-1.3	-1.4	-1.5	-1.4	-1.4
Birth weight	1.2	2.7	6.6	-2.6	-1.2	-1.3	-2.3	-0.7	-0.8
Exposure to tobacco smoke outside home	1.2	1.5	3.5	0.6	-1.4	-1.4	-1.9	-0.6	-1.0
Reason for reducing amount of alcohol drunk: Health precaution	1.2	1.4	3.8	0.5	0.9	1.3	0.6	2.0	1.3
Medication: Allopurinol	1.2	1.5	3.8	0.8	1.0	1.5	1.9	0.5	1.2
Smoking status: Current	1.2	1.8	4.4	-0.3	-1.6	-1.3	0.5	-2.1	-1.5
Ever had prostate specific antigen (PSA) test	1.2	1.4	4.0	-0.6	2.0	0.9	-0.2	1.5	1.1
HbA1C	1.1	1.2	1.9	-0.2	-1.4	-1.2	-1.3	-1.4	-0.8
Neuroticism (2016)	1.1	1.6	2.2	1.4	0.7	1.4	1.5	1.2	1.2
Type 2 Diabetes (T2D) (2012)	1.1	1.2	2.2	0.4	0.5	1.4	1.2	1.2	1.5
Leg fat-free mass (left)	1.1	5.7	13.3	-0.2	3.6	2.0	-0.7	2.8	2.8
Tinnitus: Yes, but not now, but have in the past	1.1	1.2	5.7	0.9	0.0	0.6	2.4	-0.5	-0.3
Heel bone mineral density (BMD) T-score, automated (right)	1.1	2.5	3.6	1.7	1.7	1.7	1.9	1.2	1.2
Medication: Ramipril	1.1	1.4	4.5	-1.1	0.6	0.6	-1.2	2.1	0.8
Time employed in main current job	1.1	1.3	4.2	-1.1	-1.4	-0.7	-2.1	-0.1	0.1
Breastfed as a baby	1.1	1.3	1.8	1.3	-1.2	-1.2	-1.3	-0.9	-0.8
Ever highly irritable/argumentative for 2 days	1.1	1.3	1.9	-0.6	-1.1	-1.4	-1.3	-1.2	-1.2
Leg fat percentage (right)	1.1	3.9	7.1	-0.8	-0.9	-2.6	-2.7	-1.8	-2.2
Smoking status: Previous	1.1	1.6	3.4	-1.1	1.8	1.1	0.1	1.5	1.1
Leg fat-free mass (right)	1.1	6.1	13.9	-0.1	3.7	2.2	-0.5	2.9	3.0
Loneliness, isolation	1.1	1.5	2.8	0.5	1.7	1.3	0.2	1.5	1.5
Leg predicted mass (right)	1.1	5.9	13.5	-0.1	3.7	2.2	-0.5	2.9	3.0
Supplements: Fish oil (including cod liver oil)	1.1	1.5	2.7	-1.5	0.6	1.1	-0.4	1.6	1.5
Bipolar Disorder (2018)	1.0	1.6	2.9	0.8	1.5	1.3	0.2	1.2	1.7
Bipolar Disorder or Schizophrenia	1.0	2.5	6.1	0.3	1.3	1.6	-0.2	2.5	2.1
Hearing difficulty/problems: Yes	1.0	1.5	2.7	-1.4	-1.6	-1.2	-1.4	-0.3	-0.9
Age when periods started (menarche)	1.0	2.3	4.5	-0.2	1.4	2.1	1.3	1.1	2.1
Leg predicted mass (left)	1.0	5.4	13.0	-0.2	3.6	1.9	-0.8	2.7	2.7
Hayfever/allergic rhinitis (self-reported)	1.0	1.3	2.8	0.5	-0.6	-1.6	-0.7	-1.7	-1.2
Medication: Ibuprofen (e.g. Nurofen)	1.0	1.2	2.9	0.2	1.3	0.8	-0.6	1.7	1.3
Pulse wave Arterial Stiffness index	1.0	1.1	3.6	0.2	-0.1	-1.2	-0.1	-1.9	-1.4
Medication: Ibuprofen	1.0	1.2	2.9	-0.1	1.2	1.0	0.0	1.7	1.3
Friendships satisfaction	1.0	1.3	3.0	-0.2	0.4	1.3	0.2	1.7	1.7
Whole body water mass	1.0	5.6	15.3	0.1	3.9	2.0	-0.5	2.4	2.8
Wears glasses or contact lenses	1.0	1.2	2.1	-0.4	1.1	1.3	0.6	1.2	1.4
Leg fat percentage (left)	1.0	3.5	7.0	-1.0	-0.9	-2.4	-2.6	-1.7	-1.9
Pain experienced in last month	1.0	1.7	2.5	1.0	1.6	1.5	1.4	0.6	1.4
Supplements: Calcium	1.0	1.1	2.7	-1.6	0.8	0.3	-0.9	1.2	0.9
Basal cell carcinoma (self-reported)	1.0	1.2	2.7	-1.4	0.7	0.3	-1.0	1.6	0.8
Reaction Time	0.9	1.7	6.9	2.6	0.1	1.1	0.8	0.6	1.0
Breast Cancer	0.9	2.3	4.0	-2.0	-0.7	-1.6	-1.9	-0.9	-1.4
Diabetes (mother)	0.9	1.1	2.1	0.8	-0.3	-1.3	-0.7	-1.4	-1.3
Impedance of leg (left)	0.9	4.5	10.7	1.4	-1.5	-0.1	3.1	-3.3	-1.4
Had menopause	0.9	1.1	1.5	-1.0	1.0	1.2	1.1	1.1	1.0
Illnesses of siblings	0.9	1.3	2.2	1.0	1.1	1.3	1.5	0.1	1.2
Impedance of arm (left)	0.9	4.1	17.6	0.9	-0.6	2.2	4.2	-0.5	0.8
Emphysema/chronic bronchitis	0.9	1.0	1.4	-1.0	-1.0	-1.0	-0.5	-1.2	-1.1
Whole body fat-free mass	0.9	5.0	14.3	-0.0	3.8	1.9	-0.6	2.2	2.6
Back pain experienced in last month	0.9	1.3	2.9	-0.9	-0.7	-1.5	-0.7	-1.0	-1.7
Commuting to job workplace: Cycle	0.9	1.1	3.8	2.0	0.7	0.6	-0.6	0.5	1.1
HDL Cholesterol	0.8	1.4	3.0	-1.5	-1.3	-0.9	-1.7	-0.6	-0.5
Rheumatoid Arthritis	0.8	1.1	3.2	1.8	0.6	0.2	1.4	-1.0	-0.1
BMI	0.8	4.5	13.3	-1.8	-0.5	-2.7	-3.6	-0.9	-1.5
Lung FEV1/FVC ratio	0.8	4.1	15.5	3.9	0.3	1.6	2.4	-0.4	0.9
Hand grip strength (left)	0.8	2.2	4.1	0.2	1.8	1.2	-1.2	1.8	2.0
Impedance of leg (right)	0.8	3.7	9.0	1.2	-1.4	-0.2	2.7	-3.0	-1.5
Heel bone mineral density (BMD) T-score, automated (left)	0.8	1.9	3.7	1.2	1.2	1.6	1.9	1.0	1.0
Medication: Atenolol	0.8	1.0	4.5	2.1	-0.0	0.5	0.5	0.9	0.5
Body mass index (BMI)	0.8	3.5	13.8	-1.2	-0.1	-2.2	-3.7	0.0	-1.2
Impedance of arm (right)	0.8	3.9	15.4	0.8	-0.2	2.4	3.9	-0.0	1.2
Trunk fat-free mass	0.8	4.6	14.2	0.1	3.8	1.9	-0.3	1.9	2.5
Happiness	0.8	1.0	2.2	-0.1	0.6	0.8	-0.8	1.4	1.5
Trunk predicted mass	0.8	4.6	14.1	0.2	3.8	1.9	-0.3	1.9	2.5
Seen doctor (GP) for nerves, anxiety, tension or depression	0.8	1.3	2.1	0.5	1.4	1.4	0.7	1.1	1.4
Number of children fathered	0.8	0.9	2.3	0.5	0.2	1.0	-0.1	1.5	1.2
Illnesses of siblings: Diabetes	0.8	1.0	2.2	-0.2	-1.5	-1.1	-0.8	-0.8	-1.1
Eye problems/disorders: Cataract	0.8	0.9	1.4	1.1	0.6	0.9	1.2	1.1	0.6
Medication: Aspirin	0.8	1.0	1.8	-0.5	1.3	1.0	1.3	0.9	0.6
Number of self-reported non-cancer illnesses	0.8	1.4	3.7	0.8	1.9	1.2	0.5	1.0	1.0
High cholesterol (Self-reported)	0.8	1.4	3.4	1.0	1.6	0.9	1.8	0.8	0.2
Alcohol drinker status: Never	0.8	0.9	3.8	0.3	0.1	1.1	1.9	0.2	0.7
Basal metabolic rate	0.8	4.6	13.2	-0.1	3.6	1.7	-0.8	2.1	2.5
Number of operations (self-reported)	0.8	1.2	2.3	-0.9	1.5	1.2	0.3	0.9	1.3
Irritability	0.8	1.3	2.9	-0.0	1.7	1.1	0.2	1.5	1.2
Age started oral contraceptive pill	0.8	1.1	4.0	-2.0	-0.3	-0.9	-0.5	-0.5	-0.9
Heart disease (siblings)	0.8	1.0	2.9	-0.8	1.3	0.4	-0.7	1.7	0.5
Schizophrenia (2018)	0.7	1.4	4.8	-0.4	0.4	1.0	-0.5	2.2	1.4
Other serious medical condition/disability diagnosed by doctor	0.7	1.0	1.6	0.7	-1.1	-0.9	0.1	-1.3	-1.2
Hand grip strength (right)	0.7	1.8	3.5	-0.6	1.6	0.7	-1.2	1.9	1.4
Chronic bronchitis/emphysema (father)	0.7	0.8	1.5	-0.5	1.1	0.5	-0.7	1.2	1.0
Hearing difficulty/problems with background noise	0.7	1.1	2.6	-0.3	-0.9	-1.3	-1.6	-0.5	-1.0
Alcohol intake versus 10 years previously	0.7	1.0	2.3	0.5	0.5	1.2	0.5	1.5	1.4
Prospective memory result	0.7	0.9	1.7	1.2	0.5	1.0	1.3	0.5	0.9
Illnesses of mother	0.7	0.9	2.5	0.7	0.5	1.1	1.6	0.4	0.8
Length of working week for main job	0.7	0.8	1.9	0.0	0.3	1.0	-0.2	1.3	1.4
Loud music exposure frequency	0.7	0.8	1.9	1.4	-0.6	-0.4	0.5	-1.3	-0.5
Health satisfaction	0.7	0.9	4.1	2.0	-0.6	-0.3	0.3	-0.7	-0.4
Medication: Omeprazole	0.7	0.8	1.7	0.7	-0.7	-1.1	-0.1	-0.8	-1.3
Arm predicted mass (right)	0.7	3.5	12.2	0.5	3.5	1.3	-0.6	1.6	2.0
Commuting to job workplace: Public transport	0.7	0.8	2.6	-1.6	-0.5	-0.8	-1.0	-0.3	-0.6
Impedance of whole body	0.7	3.8	15.8	1.0	-1.1	1.2	4.0	-1.8	-0.3
Arm predicted mass (left)	0.7	3.5	13.0	0.3	3.6	1.3	-0.6	1.5	1.9
Depressed Affect (Nagel 2018)	0.6	1.3	2.0	0.6	1.4	1.3	1.0	1.2	1.1
Coronary Artery Disease (CAD)	0.6	0.7	1.5	0.7	-1.2	-0.9	-0.4	-0.8	-1.0
Mean Putamen Volume	0.6	0.6	1.3	-0.2	0.3	-1.0	-1.0	-1.1	-0.6
Heel T-Score	0.6	4.9	10.8	3.3	1.8	2.2	1.8	1.9	2.0
Eye problems/disorders: Diabetes related eye disease	0.6	0.6	1.3	-0.9	1.2	-0.1	-0.9	0.8	0.2
Current tobacco smoking	0.6	1.0	2.5	-0.2	-1.1	-0.9	0.7	-1.6	-1.1
Qualifications: CSEs or equivalent	0.6	0.8	2.4	0.8	-0.4	1.0	1.6	-0.3	0.7
Frequency of tenseness / restlessness in last 2 weeks	0.6	0.9	2.2	-0.9	0.0	0.4	-1.1	1.5	0.9
Depression (self-reported)	0.6	0.7	1.3	0.3	1.1	1.0	0.7	0.5	0.9
Lung cancer (father)	0.6	0.7	1.8	-0.1	1.3	0.8	-0.0	1.0	0.9
Tense / ‘highly strung’	0.6	1.0	1.9	-0.1	1.1	1.2	0.7	1.4	1.0
Arm fat-free mass (right)	0.6	3.0	10.4	0.0	3.2	1.1	-0.8	1.5	1.8
Number of full brothers	0.6	0.8	1.5	0.7	-0.1	1.0	-0.4	1.2	1.2
Wheeze or whistling in the chest in last year	0.6	1.0	4.5	-0.3	0.0	-1.0	-2.1	-0.5	-0.3
Shortness of breath walking on level ground	0.6	0.7	1.7	1.3	0.0	-0.8	-0.7	-0.8	-0.6
Eye problems/disorders: None of the above	0.6	0.7	1.1	-0.7	-0.8	-1.0	-1.1	-0.7	-0.6
Medication: Seretide 50 evohaler	0.6	0.7	3.3	1.8	-0.6	0.0	0.3	0.5	-0.0
Mean time to correctly identify matches	0.6	1.1	4.0	2.0	0.4	1.0	0.5	0.6	0.8
Leg pain on walking	0.6	0.7	1.3	1.1	-0.3	-1.0	-0.7	-0.9	-0.9
Illnesses of father: None of the above (group 1)	0.6	0.7	3.5	1.9	0.5	0.3	-0.2	0.1	0.6
Miserableness	0.6	1.0	2.9	0.3	0.8	1.1	0.1	1.7	1.2
Guilty feelings	0.6	1.0	3.3	-0.2	1.0	-0.1	-1.8	1.0	0.6
Ever taken oral contraceptive pill	0.6	0.7	1.1	-0.6	-0.9	-0.6	0.6	-1.0	-1.0
Tinnitus: Yes, now most or all of the time	0.6	0.7	1.5	0.1	-0.6	-1.1	-0.1	-1.2	-1.1
Pain type(s) experienced in last month: Hip pain	0.6	0.7	1.1	-1.0	-0.3	-0.9	-0.6	-0.9	-1.0
Arm fat-free mass (left)	0.6	3.2	11.1	0.2	3.3	1.2	-0.9	1.5	1.9
Vascular/heart problems diagnosed by doctor	0.6	1.6	4.4	-0.6	-1.9	-0.8	0.3	-2.1	-0.7
Cholesterol lowering medication	0.6	0.8	1.6	1.2	0.4	-0.4	1.2	-1.0	-0.9
Schizophrenia vs Biploar Disorder	0.5	0.6	2.0	-1.0	-0.1	0.8	0.0	1.4	0.5
Body Mass Index (BMI) (2010)	0.5	0.7	1.7	1.3	0.3	0.8	0.4	0.8	1.0
LDL Cholesterol	0.5	0.8	1.8	0.2	-0.8	-1.1	-0.6	-0.7	-1.3
Lupus	0.5	0.8	2.7	0.3	-0.2	-0.1	1.6	-1.1	-0.9
Supplements: Zinc	0.5	0.6	1.4	-0.2	0.1	0.8	-0.6	1.2	1.0
Frequency of unenthusiasm / disinterest in last 2 weeks	0.5	0.7	1.4	-0.6	0.8	0.7	-0.7	1.2	0.9
High blood pressure	0.5	1.3	4.1	0.8	1.5	0.6	-0.6	2.0	0.5
Supplements: Glucosamine	0.5	0.6	1.4	-0.8	0.7	0.9	0.0	1.2	0.8
Financial difficulties in last 2 years	0.5	0.6	2.5	-0.7	-0.5	-0.6	-1.6	0.3	-0.0
Heart attack	0.5	0.7	2.6	1.6	0.2	-0.6	-0.3	-0.5	-0.7
Blood clot in the leg (DVT)	0.5	0.7	2.0	-0.8	-0.0	-0.9	-1.4	-0.4	-0.6
Neck or shoulder pain in last month	0.5	0.8	2.2	-0.6	-0.0	-1.1	-1.5	-0.3	-0.9
Migraine (self-reported)	0.5	0.6	1.1	0.9	-1.0	-0.5	0.1	-1.1	-0.6
Heart disease (mother)	0.5	0.6	2.6	-1.6	0.9	0.2	0.2	0.2	0.2
Ever had bowel cancer screening	0.5	0.6	1.0	-1.0	0.6	0.9	0.7	0.9	0.6
Medication for cholesterol	0.5	0.8	1.4	-0.4	-0.9	-1.1	-0.7	-1.2	-0.9
Mineral and other dietary supplements	0.5	0.7	1.6	1.1	-0.4	-0.8	0.0	-1.3	-0.9
Breast cancer (self-reported)	0.5	0.5	2.1	-1.4	-0.2	-0.5	-0.7	0.6	-0.3
Osteoarthritis (self-reported)	0.5	0.6	3.4	1.8	-0.6	0.1	0.1	-0.2	0.1
Illnesses of father: High blood pressure	0.5	0.7	1.9	1.4	-1.0	-0.4	-1.0	0.1	0.1
Medication: Omeprazole (e.g. Zanprol)	0.5	0.6	1.2	1.0	-0.2	-0.9	0.1	-0.6	-1.1
Depression (Nagel 2018)	0.4	0.7	1.5	-0.4	0.5	1.0	0.2	1.2	1.0
Waist Hip Ratio (WHR)	0.4	1.8	5.9	1.5	0.6	0.2	2.4	-1.1	-0.9
Chronotype (morning person)	0.4	0.9	4.2	-2.0	-0.7	-0.5	-0.2	-0.1	-0.5
Tanning	0.4	5.2	6.4	1.6	2.5	2.5	1.9	2.4	2.5
Frequency of depressed mood in last 2 weeks	0.4	0.6	1.4	-0.9	0.4	0.5	-0.6	1.2	0.8
Medication: Levothyroxine sodium	0.4	0.7	1.4	-0.3	1.1	0.8	0.0	1.2	0.9
High blood pressure (mother)	0.4	0.6	1.0	-0.6	-0.8	-1.0	-1.0	0.1	-0.8
Ever unenthusiastic/disinterested for a whole week	0.4	0.5	1.1	-0.0	0.8	0.3	-0.9	1.0	0.7
Diabetes (self-reported)	0.4	0.6	1.1	-0.7	0.7	-0.9	-0.1	-0.6	-1.1
Medication: Simvastatin	0.4	0.6	2.3	0.6	1.5	0.3	0.7	0.7	-0.1
Weight	0.4	1.8	6.5	-0.1	2.6	0.6	-1.3	1.1	1.2
Arm fat percentage (right)	0.4	1.4	5.5	-1.0	-0.3	-1.2	-2.3	0.1	-0.7
Frequency of tiredness / lethargy in last 2 weeks	0.4	0.7	2.1	-1.4	-1.0	-0.4	-0.9	-0.1	-0.2
Falls in the last year	0.4	0.5	1.9	-0.8	0.2	-0.7	-1.4	0.0	-0.4
Glaucoma (self-reported)	0.4	0.4	1.7	-0.1	-1.3	-0.5	-0.1	-0.7	-0.5
Gout (self-reported)	0.4	0.5	2.2	-0.4	0.7	0.6	1.5	-0.3	0.2
Medication: Amlodipine	0.4	0.6	1.8	-0.1	0.9	0.6	-0.2	1.3	0.7
Age at first live birth	0.4	0.8	2.6	-1.6	-1.1	-0.6	-0.5	-0.2	-0.4
Medication for pain relief, constipation, heartburn	0.4	0.6	1.5	0.2	-1.2	-0.1	0.8	-1.1	-0.4
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.4	0.5	2.4	1.6	-0.3	-0.1	0.5	-0.1	-0.2
Leg fat mass (right)	0.4	1.7	6.0	-0.8	0.6	-1.4	-2.4	-0.5	-0.9
Pulse rate, automated reading	0.4	1.4	2.7	-0.4	-1.6	-1.2	-1.3	-1.3	-1.0
Alcohol intake frequency.	0.4	1.0	2.9	0.9	0.1	1.1	1.7	0.6	0.8
Chest pain or discomfort	0.4	0.6	2.8	1.7	0.1	-0.2	0.5	-0.4	-0.4
Illness, injury, bereavement, stress in last 2 years	0.4	0.5	1.4	0.7	-0.6	0.8	1.2	0.1	0.5
Supplements: Vitamin C	0.4	0.4	0.9	-0.6	-0.9	-0.5	-0.9	-0.1	-0.5
Hypertension (Self-reported)	0.4	1.1	3.1	0.9	1.4	0.5	-0.5	1.8	0.4
Arm fat percentage (left)	0.4	1.7	5.5	-1.2	-0.5	-1.4	-2.3	-0.1	-0.9
Medication: Lisinopril	0.4	0.5	1.3	-0.4	-0.9	-0.8	-0.0	-0.2	-1.1
Ever depressed for a whole week	0.4	0.5	0.7	0.8	0.3	0.8	0.6	0.8	0.7
Deep venous thrombosis (DVT) (self-reported)	0.4	0.5	1.6	-0.5	-0.1	-0.8	-1.2	-0.3	-0.5
Leg fat mass (left)	0.4	1.4	5.2	-0.9	0.8	-1.2	-2.3	-0.3	-0.6
Intelligence (Savage-Jansen 2018)	0.3	1.1	4.6	-0.6	0.7	-0.7	-2.2	0.5	-0.0
Alzheimer’s Disease (in father)	0.3	0.3	1.3	0.2	0.1	0.5	1.1	0.2	0.1
Bipolar Disorder (2011)	0.3	0.3	0.8	0.5	0.2	0.5	0.3	0.9	0.6
Crohns Disease (2012)	0.3	0.4	1.6	0.1	-0.8	-0.5	-1.3	0.4	-0.1
Triglycerides	0.3	0.5	1.0	0.2	-0.9	-0.4	0.7	-1.0	-0.7
Smoking Status	0.3	0.8	2.0	-1.4	0.8	0.7	1.1	0.4	0.4
Allergy or Eczema	0.3	0.8	1.7	0.5	1.3	1.1	0.8	0.2	0.9
Vitamin and mineral supplements	0.3	0.4	0.7	0.6	0.3	-0.8	-0.0	-0.8	-0.8
Medication: Co-codamol	0.3	0.4	1.8	1.3	0.4	0.0	-0.6	-0.3	0.2
Medication: Metformin	0.3	0.4	1.1	-1.0	0.3	-0.7	-0.1	-0.3	-0.9
Townsend deprivation index at recruitment	0.3	0.5	1.5	1.0	0.3	-0.1	-1.2	0.1	0.6
Maternal smoking around birth	0.3	0.5	0.9	-0.1	0.3	-0.8	-0.9	-0.7	-0.7
Stomach or abdominal pain in last month	0.3	0.4	1.0	0.0	0.7	0.7	1.0	0.5	0.4
Fluid intelligence score	0.3	0.6	2.5	-0.5	-0.2	-0.7	-1.6	0.5	-0.2
Hip circumference	0.3	1.4	3.5	-0.8	1.4	0.4	-1.9	0.9	1.3
Hair/balding pattern: Pattern 3	0.3	0.4	0.6	0.5	-0.8	0.2	-0.7	0.7	0.6
Medication: Lansoprazole	0.3	0.3	0.6	-0.0	0.8	0.5	0.8	0.6	0.3
Arm fat mass (right)	0.3	1.3	5.4	-0.8	1.0	-0.7	-2.3	0.6	0.0
Exposure to tobacco smoke at home	0.3	0.3	1.1	1.1	-0.5	0.4	0.1	0.0	0.4
Pulse wave reflection index	0.3	0.4	1.0	0.2	0.3	-0.6	0.2	-1.0	-0.7
Qualifications: O levels/GCSEs or equivalent	0.3	0.5	1.5	-1.0	-1.2	-0.0	0.1	-0.5	0.1
Medication: Paracetamol	0.3	0.5	2.0	-0.2	-0.6	-0.8	-1.4	0.1	-0.6
Body fat percentage	0.3	1.1	3.4	-0.6	-0.3	-1.3	-1.8	-0.6	-1.0
Comparative height size at age 10	0.3	1.8	5.0	0.1	2.2	1.5	1.4	-0.1	1.2
Suffer from ‘nerves’	0.3	0.5	1.1	0.3	0.0	0.8	1.0	1.0	0.6
Medication: Aspirin	0.3	0.3	0.9	-0.5	0.9	0.4	0.8	0.3	0.1
Handedness (chirality/laterality): Left-handed	0.3	0.3	0.8	0.9	0.8	0.0	-0.7	0.0	0.4
Mood swings	0.3	0.5	1.3	-1.0	0.6	-0.5	-1.2	0.2	-0.2
Arm fat mass (left)	0.3	1.2	5.0	-0.9	0.9	-0.7	-2.2	0.5	-0.0
Hearing aid user	0.3	0.3	0.5	0.6	-0.1	0.7	0.4	0.7	0.6
Medication: Blood pressure	0.3	0.6	2.0	-0.8	-0.2	-0.6	-1.4	0.7	-0.3
Medication: Bendroflumethiazide	0.3	0.5	1.0	-0.3	-0.1	-1.0	-1.0	-0.2	-1.0
Diastolic blood pressure, automated reading	0.3	1.0	2.8	1.3	1.7	0.8	-0.2	0.3	1.1
Heart attack/myocardial infarction (self-reported)	0.3	0.4	1.8	1.3	0.4	-0.4	-0.1	-0.4	-0.6
Primary Biliary Cirrhosis	0.2	0.2	1.2	1.1	-0.3	0.0	0.1	0.3	0.0
Blood White Count	0.2	1.1	2.0	1.2	-0.6	-1.3	-1.4	-1.1	-0.6
Hypothyroidism (self reported)	0.2	0.5	1.7	-0.3	0.2	0.4	-1.3	0.7	0.8
Respiratory disease	0.2	0.3	0.9	0.4	0.4	0.7	-0.2	0.6	0.9
Relative age of first facial hair	0.2	0.5	1.1	-1.1	0.6	0.3	0.2	1.0	0.4
Angina	0.2	0.3	0.6	0.7	0.6	0.1	0.8	-0.1	-0.3
Severe depression (siblings)	0.2	0.2	0.8	0.7	-0.9	0.2	0.2	-0.2	0.2
Waist circumference	0.2	0.6	1.8	-0.3	1.0	-0.6	-1.4	-0.2	-0.2
Father’s age at death	0.2	0.2	0.4	0.1	0.6	0.5	0.3	0.4	0.6
Qualifications: A levels/AS levels or equivalent	0.2	0.5	1.3	-1.2	-1.0	-0.3	-0.3	-0.4	-0.2
Serious illness, injury or assault of a close relative in last 2 years	0.2	0.2	0.7	0.8	0.4	0.2	0.5	-0.1	0.1
Mouth/teeth dental problems: Dentures	0.2	0.3	0.5	-0.6	0.7	0.5	0.4	0.3	0.6
Asthma	0.2	0.4	0.8	0.9	-0.4	-0.7	-0.7	-0.6	-0.5
Mouth/teeth dental problems: Bleeding gums	0.2	0.3	0.6	-0.7	-0.5	-0.4	-0.7	-0.2	-0.4
Hypothyroidism/myxoedema (self-reported)	0.2	0.3	0.7	-0.6	0.1	0.3	-0.8	0.7	0.5
Medication: Ventolin 100micrograms inhaler	0.2	0.3	0.9	0.9	0.6	-0.3	-0.4	0.0	-0.1
Whole body fat mass	0.2	0.8	2.9	-0.7	1.0	-0.5	-1.7	0.2	0.0
Knee pain experienced in last month	0.2	0.3	0.8	0.2	0.5	0.6	-0.0	0.9	0.6
Long-standing illness, disability or infirmity	0.2	0.3	0.7	0.7	0.8	-0.3	-0.2	-0.1	-0.4
Diabetes diagnosed by doctor	0.2	0.3	0.7	-0.6	0.8	-0.3	0.5	-0.0	-0.5
Commuting to job workplace: Walk	0.2	0.2	0.8	0.9	0.0	0.2	0.4	0.1	0.1
Asthma (self-reported)	0.2	0.4	0.6	0.6	-0.5	-0.7	-0.7	-0.8	-0.5
Osteoporosis (self-reported)	0.2	0.3	0.9	-1.0	0.2	0.3	0.6	-0.6	0.1
Medication: Gliclazide	0.2	0.2	0.5	0.7	-0.2	-0.5	-0.2	-0.3	-0.5
Average weekly champagne plus white wine intake	0.2	0.3	1.0	-0.3	0.5	-0.5	-1.0	0.2	-0.1
Eye problems/disorders: Glaucoma	0.2	0.3	0.6	0.4	-0.8	-0.4	-0.5	-0.6	-0.2
Medication: Atorvastatin	0.2	0.3	0.8	-0.9	-0.6	-0.5	-0.3	0.2	-0.5
Unable to work because of sickness or disability	0.2	0.2	0.8	0.9	0.3	-0.1	0.1	-0.6	-0.2
Irritable Bowel Disease (IBD)	0.1	0.1	0.4	0.6	0.5	-0.0	0.3	-0.1	-0.2
Ulcerative Colitis (UC)	0.1	0.1	0.3	0.3	0.1	-0.4	0.1	-0.1	-0.6
Verbal and Numeric Reasoning (VNR)	0.1	0.2	0.4	0.0	0.4	0.2	-0.5	0.6	0.5
Ovarian Cancer	0.1	0.1	0.7	-0.9	-0.1	0.1	-0.0	0.1	0.3
Fasting Glucose	0.1	0.1	0.1	0.0	0.1	0.4	-0.3	0.3	0.4
Ulcerative Colitis	0.1	0.2	0.4	-0.1	-0.6	-0.4	-0.4	-0.1	-0.4
Blood Eosinophil Count	0.1	0.9	2.4	-1.6	-0.6	-0.8	-1.3	-0.4	-0.4
Blood Platelet Count	0.1	0.7	1.3	-0.7	-1.0	-0.8	-0.4	-1.1	-0.7
Blood Red Count	0.1	0.6	2.3	1.5	-0.3	-0.3	-0.5	-1.0	0.0
Systolic Blood Pressure	0.1	0.4	1.1	1.1	0.6	0.3	-0.4	0.7	0.4
Type 2 Diabetes (T2D) (2018)	0.1	0.2	0.9	0.4	0.9	-0.2	0.3	0.1	-0.3
Hair Pigment	0.1	3.9	9.5	-2.3	-0.8	-2.1	-3.1	-1.2	-1.3
Systolic blood pressure, automated reading	0.1	0.3	1.0	0.5	1.0	-0.2	-0.0	-0.8	-0.2
Diabetes (father)	0.1	0.1	0.6	0.8	0.4	0.2	0.1	0.4	-0.0
Trunk fat percentage	0.1	0.3	0.9	-0.5	0.5	-0.5	-1.0	-0.1	-0.3
Hayfever, allergic rhinitis or eczema	0.1	0.2	0.6	-0.1	0.8	0.6	0.3	-0.2	0.6
Trunk fat mass	0.1	0.6	2.2	-0.5	1.5	0.1	-1.0	0.4	0.4
Number of incorrect matches in round	0.1	0.1	0.4	0.2	0.3	0.4	0.3	0.6	0.2
Past tobacco smoking	0.1	0.3	1.3	1.1	-0.6	0.0	0.1	-0.1	0.1
Qualifications: None of the above	0.1	0.1	0.4	-0.7	0.5	-0.1	-0.2	0.2	-0.3
Mouth/teeth dental problems	0.1	0.2	0.4	0.7	-0.1	-0.2	0.5	-0.4	-0.3
Allergy	0.1	0.1	0.6	0.1	-0.8	-0.2	0.3	0.2	-0.4
Chronic bronchitis/emphysema (mother)	0.1	0.1	0.5	-0.1	0.3	-0.0	-0.7	-0.1	0.4
Qualifications: College or University degree	0.1	0.2	0.5	0.7	0.2	0.1	-0.5	0.3	0.4
Medication: Blood pressure	0.1	0.2	0.5	0.7	0.5	0.1	0.1	0.5	-0.4
Angina (self-reported)	0.1	0.2	0.4	0.6	0.4	0.0	0.6	-0.1	-0.3
Overall health rating	0.1	0.2	0.5	0.5	0.2	0.0	0.4	-0.7	-0.1
Commuting to job workplace: Car/motor vehicle	0.1	0.1	0.3	-0.4	0.6	0.3	0.4	-0.1	0.2
Ever had stillbirth, spontaneous miscarriage or termination	0.1	0.1	0.2	-0.0	0.0	0.4	0.5	0.5	-0.1
Qualifications: nursing, teaching	0.1	0.2	0.7	0.5	0.2	0.0	-0.8	0.3	0.4
Mouth/teeth dental problems: Mouth ulcers	0.1	0.2	0.8	-0.3	0.2	0.1	-0.6	0.9	0.0
Financial situation satisfaction	0.1	0.1	0.4	-0.6	0.4	-0.1	-0.0	-0.0	0.0
Medication: Paracetamol	0.1	0.2	0.4	0.5	-0.5	-0.3	-0.6	-0.1	-0.2
Ever smoked	0.1	0.1	0.2	-0.5	0.3	-0.1	-0.1	-0.5	0.0
Risk taking	0.1	0.2	0.8	-0.2	0.9	-0.1	-0.1	0.3	-0.0
Myopia	0.1	0.2	0.8	0.0	-0.9	0.3	0.3	-0.1	0.3
Crohns Disease (2017)	0.0	0.1	0.1	0.4	0.3	0.1	-0.1	0.2	0.1
Prostate Cancer	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Pack years adult smoking proportion	0.0	0.0	0.1	0.3	-0.1	0.0	-0.2	-0.1	0.2
Average weekly fortified wine intake	0.0	0.1	0.2	-0.3	0.4	-0.2	0.0	-0.1	-0.2
Mouth/teeth dental problems: Loose teeth	0.0	0.0	0.1	0.4	0.0	0.1	0.0	-0.1	-0.1
Family relationship satisfaction	0.0	0.1	0.2	-0.1	-0.1	-0.3	-0.5	0.2	0.0
Fractured/broken bones in last 5 years	0.0	0.0	0.1	-0.3	-0.1	-0.1	-0.1	0.2	-0.2
Pack years of smoking	0.0	0.0	0.1	0.3	0.1	0.2	-0.2	-0.0	0.4

Hub : Genes

C9orf102

Models

Trait associations