Best TWAS P=2.45e-12 · Best GWAS P=2.74e-17 conditioned to 0.000274
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Adipose Subcutaneous | LIN7C | 0.08 | 0.06 | lasso | 1 | 0.04 | 4.1e-04 | 6.0 | 6.0 | 2.4e-09 | 0.63 | 0.74 | 0.15 | FALSE |
| 2 | GTEx | Cells Transformed fibroblasts | LIN7C | 0.26 | 0.22 | lasso | 6 | 0.25 | 1.4e-18 | 6.0 | 5.5 | 2.9e-08 | 0.62 | 1.00 | 0.00 | FALSE |
| 3 | GTEx | Esophagus Muscularis | LIN7C | 0.14 | 0.08 | enet | 11 | 0.07 | 5.4e-05 | 3.2 | 5.1 | 3.1e-07 | 0.60 | 0.67 | 0.18 | FALSE |
| 4 | GTEx | Thyroid | LIN7C | 0.08 | 0.04 | lasso | 4 | 0.04 | 6.0e-04 | 6.0 | 6.4 | 1.6e-10 | 0.69 | 0.48 | 0.41 | FALSE |
| 5 | NTR | Blood | LIN7C | 0.01 | 0.00 | lasso | 3 | 0.01 | 2.2e-03 | 6.8 | -7.0 | 2.4e-12 | -0.72 | 0.09 | 0.82 | TRUE |
| 6 | ROSMAP | Brain Pre-frontal Cortex | METTL15 | 0.04 | 0.03 | blup | 364 | 0.03 | 4.6e-05 | -3.5 | -5.2 | 2.0e-07 | -0.19 | 0.72 | 0.01 | TRUE |
| 7 | The Cancer Genome Atlas | Colon Adenocarcinoma | LIN7C | 0.10 | 0.03 | blup | 32 | 0.08 | 2.8e-05 | 6.3 | 5.9 | 4.1e-09 | 0.57 | 0.01 | 0.93 | FALSE |
| 8 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | LIN7C | 0.05 | 0.02 | lasso | 3 | 0.03 | 2.9e-04 | 6.3 | 6.0 | 1.7e-09 | 0.63 | 0.01 | 0.97 | FALSE |