TWAS
hub
About
Usage
Models
Genes
Traits
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Traits
:
Comparative body size at age 10
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chr16:3,301,360-4,855,279
Best TWAS P=4.02e-15 · Best GWAS P=1.15e-24 conditioned to 2.1e-13
3.4M
3.6M
3.8M
4M
4.2M
4.4M
4.6M
4.8M
0
5
10
15
20
25
physical position
-log10 P
Marginal
▼
Associated models
#
Study
Tissue
Gene
h2
eQTL R2
model
# weights
model R2
model R2 P
eQTL GWAS Z
TWAS Z
TWAS P
Top SNP corr
PP3
PP4
joint
2
ROSMAP
Brain Pre-frontal Cortex
RP11-462G12.1
0.11
0.07
enet
18
0.06
1.1e-08
-10.2
-7.8
4.0e-15
0.86
0.00
1.00
TRUE
1
METSIM
Adipose
ADCY9
0.07
0.02
bslmm
409
0.04
1.0e-06
1.6
7.6
2.8e-14
-0.44
0.52
0.46
TRUE
4
The Cancer Genome Atlas
Colon Adenocarcinoma
BTBD12
0.05
0.01
blup
41
0.02
1.5e-02
-4.5
5.6
2.6e-08
0.14
0.01
0.52
TRUE
3
The Cancer Genome Atlas
Cervical Squamous Cell Carcinoma
NLRC3
0.07
0.02
blup
39
0.01
7.4e-02
-4.5
-5.5
3.5e-08
-0.12
0.02
0.69
FALSE