TWAS hub - ADCY9

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Whole Blood	0.2150	0.0610	3.6e-05	0.107	NA	0.081	NA	0.087	4.7e-10	NA	6.8e-08	NA	2.0e-08
2	METSIM	Adipose	0.0685	0.0215	1.8e-04	0.023	0.033	0.039	0.040	0.040	1.6e-04	9.6e-06	1.5e-06	1.0e-06	1.2e-06
3	NTR	Blood	0.0776	0.0186	9.9e-09	0.043	0.037	0.058	0.055	0.056	9.0e-14	4.2e-12	3.1e-18	4.3e-17	2.0e-17
4	YFS	Blood	0.3350	0.0324	0.0e+00	0.195	0.260	0.289	0.275	0.289	9.9e-62	9.2e-85	1.1e-95	1.6e-90	1.2e-95

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4
Mouth/teeth dental problems: Mouth ulcers	8.4	13.4	19.6	3.4	1.6	4.4	4.4
Systolic Blood Pressure	6.3	31.3	57.2	-4.7	-7.6	-5.2	-4.4
Crohns Disease (2017)	6.2	13.7	19.0	-2.8	-4.4	-4.3	-3.1
Crohns Disease (2012)	5.9	9.5	14.0	-2.9	-2.9	-3.7	-2.7
Comparative body size at age 10	5.5	15.1	57.9	1.4	7.6	0.7	-0.4
Medication: Amlodipine	4.2	5.9	6.8	-2.5	-2.6	-2.4	-2.2
Schizophrenia (2014)	4.1	9.1	12.7	-3.5	-1.8	-2.9	-3.6
Breast Cancer	3.9	9.4	27.5	-1.6	-5.2	-1.6	-2.3
Cardiovascular Disease	3.9	13.0	18.1	-3.3	-4.3	-3.8	-2.9
Ever had bowel cancer screening	3.8	4.5	8.9	-3.0	-0.0	-2.4	-1.9
High blood pressure (mother)	3.6	5.1	8.2	-1.6	-2.9	-2.1	-2.2
Number of children fathered	3.5	3.9	5.7	2.3	1.2	1.8	2.4
Diastolic blood pressure, automated reading	3.4	10.7	13.7	-2.7	-3.0	-3.5	-3.7
Hypertension (Self-reported)	3.2	9.0	17.6	-2.6	-4.2	-2.7	-2.1
Multivitamins +/- minerals	3.0	3.8	7.9	2.0	2.8	1.4	1.2
Schizophrenia vs Biploar Disorder	2.9	3.9	4.6	-2.0	-1.8	-2.2	-1.8
Type 2 Diabetes (T2D) (2012)	2.9	3.3	5.2	0.8	2.3	2.0	1.9
Diabetes (father)	2.9	3.6	6.3	-2.0	0.3	-2.0	-2.5
Hearing difficulty/problems with background noise	2.9	4.6	5.5	-2.3	-2.2	-2.1	-1.9
Medication: Aspirin	2.9	3.8	6.5	-2.0	-2.6	-1.7	-1.3
Average weekly spirits intake	2.7	3.3	6.6	2.0	2.6	1.4	0.9
Systolic blood pressure, automated reading	2.7	7.7	13.6	-2.2	-3.7	-2.7	-2.2
High blood pressure	2.7	7.6	13.9	-2.4	-3.7	-2.5	-2.1
Birth weight	2.7	5.9	21.2	1.3	4.6	0.8	-0.3
Schizophrenia (2018)	2.6	5.5	7.5	-2.6	-1.9	-2.0	-2.7
Irritable Bowel Disease (IBD)	2.6	6.2	10.5	-2.0	-2.3	-3.2	-2.2
Father’s age at death	2.6	3.5	6.1	1.6	0.9	2.1	2.5
Loud music exposure frequency	2.6	2.9	6.3	-1.7	0.2	-2.5	-1.4
HbA1C	2.5	2.7	4.5	1.6	1.1	1.6	2.1
Medication: Cholesterol lowering	2.5	3.8	6.7	-1.9	-2.6	-2.1	-0.8
Seen a psychiatrist for nerves, anxiety, tension or depression	2.5	3.2	4.3	1.0	2.1	1.9	2.0
Had major operations	2.5	2.9	5.2	-2.3	-1.5	-1.6	-1.3
Illnesses of father: High blood pressure	2.5	3.1	9.5	-1.3	-3.1	-0.5	-0.9
Gout (self-reported)	2.4	3.3	5.3	-1.7	-2.3	-1.8	-1.3
Smoking status: Current	2.3	3.7	10.0	1.9	3.2	0.5	0.8
Vascular/heart problems diagnosed by doctor	2.3	6.2	10.1	2.5	3.2	2.2	1.9
Leg pain on walking	2.2	2.8	8.5	1.2	2.9	0.9	0.7
Medication: Bendroflumethiazide	2.2	3.4	9.3	-1.0	-3.0	-1.6	-0.9
Vitamin and mineral supplements	2.1	2.9	4.2	-1.8	-2.1	-1.4	-1.6
Worry too long after embarrassment	2.1	3.5	6.1	1.5	2.5	1.7	1.7
Eye problems/disorders: None of the above	2.1	2.4	4.1	1.5	1.3	2.0	1.2
Bipolar Disorder or Schizophrenia	2.0	4.8	7.4	-2.0	-2.7	-1.7	-2.2
Leg fat-free mass (left)	2.0	10.4	37.7	-0.1	6.1	0.3	-2.0
Lung cancer (father)	2.0	2.3	6.2	0.4	2.5	1.6	0.7
Arm predicted mass (right)	2.0	10.4	38.9	0.4	6.2	0.4	-1.6
Smoking status: Previous	2.0	3.0	5.0	-1.6	-1.5	-2.2	-1.4
Osteoporosis (self-reported)	2.0	2.5	6.0	-2.4	-1.2	-1.3	-0.9
Basal metabolic rate	2.0	11.1	41.2	0.0	6.4	0.5	-1.7
Arm fat-free mass (left)	2.0	10.0	38.1	0.2	6.2	0.5	-1.3
LDL Cholesterol	1.9	3.0	4.7	1.8	-0.2	2.0	2.2
Leg predicted mass (left)	1.9	10.3	37.3	-0.1	6.1	0.3	-2.0
Trunk fat-free mass	1.9	10.8	41.0	0.5	6.4	0.6	-1.2
Arm fat-free mass (right)	1.9	9.7	35.5	0.2	6.0	0.2	-1.8
Whole body fat-free mass	1.9	11.0	41.2	0.2	6.4	0.4	-1.7
Whole body water mass	1.9	10.6	39.4	-0.1	6.3	0.3	-1.7
Heart attack/myocardial infarction (self-reported)	1.9	2.5	3.4	-1.8	-1.8	-1.6	-0.8
Heel T-Score	1.8	14.0	44.4	2.1	6.7	2.3	-1.4
Heart attack	1.8	2.3	3.6	-1.7	-1.9	-1.5	-0.7
Weight	1.8	8.7	31.8	-0.4	5.6	0.4	-1.6
Hair/balding pattern: Pattern 3	1.8	2.6	5.1	1.3	-0.5	1.8	2.3
Trunk predicted mass	1.8	10.5	40.1	0.5	6.3	0.7	-1.1
Supplements: Vitamin C	1.8	2.2	3.6	1.5	0.4	1.9	1.7
Leg fat-free mass (right)	1.8	9.4	32.5	-0.4	5.7	-0.1	-2.2
Eye problems/disorders: Cataract	1.8	2.0	2.7	-1.1	-1.7	-1.6	-1.3
Leg predicted mass (right)	1.8	9.4	32.7	-0.3	5.7	-0.0	-2.1
Average weekly champagne plus white wine intake	1.8	2.5	3.2	1.8	1.6	1.0	1.7
Arm predicted mass (left)	1.8	9.4	35.0	0.1	5.9	0.4	-1.5
Major Depression (MDD)	1.7	2.0	2.9	1.7	1.4	1.7	0.5
Current tobacco smoking	1.7	2.8	8.5	1.5	2.9	0.3	0.6
Waist circumference	1.7	6.4	23.2	0.1	4.8	1.5	-0.2
Ever unenthusiastic/disinterested for a whole week	1.7	2.0	3.5	1.4	1.9	1.4	0.9
Medication: Lansoprazole	1.7	2.0	2.7	1.0	1.6	1.6	1.2
Medication: Aspirin	1.7	2.3	4.4	-1.6	-2.1	-1.1	-0.9
Friendships satisfaction	1.7	2.1	6.5	-1.3	-2.5	-0.3	-0.3
Body Mass Index (BMI) (2010)	1.6	2.2	8.1	0.1	2.9	0.4	-0.7
Lupus	1.6	2.4	2.9	-1.4	-1.7	-1.4	-1.6
Ever had hysterectomy (womb removed)	1.6	1.8	3.0	1.6	-1.7	0.5	1.2
Medication for cholesterol, blood pressure or diabetes	1.6	2.7	3.8	1.6	1.9	1.9	0.9
Reason for reducing amount of alcohol drunk: Health precaution	1.6	1.9	3.4	-1.3	0.6	-1.9	-1.4
Medication: Lisinopril	1.6	2.0	4.5	-1.5	-2.1	-0.7	-1.0
Unable to work because of sickness or disability	1.6	2.0	4.8	1.0	2.2	1.4	0.6
Fasting Glucose	1.5	1.8	2.8	0.4	-1.7	1.4	1.5
Hair/balding pattern: Pattern 2	1.5	1.9	4.7	-0.9	0.1	-1.5	-2.2
Neck or shoulder pain in last month	1.5	2.1	3.6	-1.5	-0.8	-1.9	-1.4
Medication: Co-codamol	1.4	1.6	3.9	0.7	2.0	1.3	0.4
Serious illness, injury or assault to yourself	1.4	1.7	3.3	-0.4	1.4	-1.1	-1.8
Mouth/teeth dental problems: Bleeding gums	1.4	1.8	4.0	0.3	-2.0	0.8	1.5
Commuting to job workplace: Walk	1.4	1.6	3.6	-1.0	-0.6	-1.1	-1.9
Ever smoked	1.4	2.4	5.1	-1.2	-1.0	-2.3	-1.5
Irritability	1.4	2.4	4.6	0.8	-1.3	1.7	2.1
Supplements: Calcium	1.4	1.6	2.6	-1.6	0.0	-1.2	-1.5
Ever used hormone-replacement therapy (HRT)	1.3	1.7	2.5	-1.0	-1.1	-1.6	-1.4
Trunk fat mass	1.3	5.6	18.5	-1.1	4.3	-0.1	-1.7
Worrier / anxious feelings	1.3	2.4	8.6	-0.5	-2.9	-0.8	0.4
Health satisfaction	1.3	1.7	3.3	-1.8	-0.5	-1.2	-1.4
Medication: Allopurinol	1.3	1.8	3.3	-1.2	-1.8	-1.4	-0.6
Whole body fat mass	1.3	5.4	17.7	-1.0	4.2	-0.0	-1.7
Comparative height size at age 10	1.3	7.1	26.6	-0.6	5.2	0.6	-1.1
Ever had stillbirth, spontaneous miscarriage or termination	1.3	1.3	3.6	1.9	0.5	0.8	1.0
Medication: Blood pressure	1.3	2.4	4.8	-1.4	-2.2	-1.5	-0.9
High cholesterol (Self-reported)	1.3	2.4	5.8	-1.5	-2.4	-1.1	0.2
Alcohol drinker status: Previous	1.3	1.5	1.9	1.4	1.4	1.3	0.7
Alzheimer’s Disease (including proxy)	1.2	1.8	2.8	1.6	-0.4	1.3	1.7
Allergy or Eczema	1.2	3.1	5.7	-2.4	-1.4	-1.1	-1.9
Number of treatments/medications taken	1.2	2.2	4.4	-2.1	-1.3	-1.3	-1.1
Hearing difficulty/problems: Yes	1.2	1.9	2.2	-1.3	-1.3	-1.3	-1.5
Relative age of first facial hair	1.2	2.5	4.9	1.5	0.1	1.7	2.2
Medication: Levothyroxine sodium	1.2	2.0	5.8	-1.2	-2.4	-0.8	-0.3
Past tobacco smoking	1.2	2.3	5.0	1.0	0.9	2.2	1.5
Hip circumference	1.2	5.1	16.6	-1.0	4.1	-0.3	-1.6
Medication: Blood pressure	1.2	2.2	5.0	-1.2	-2.2	-1.2	-0.7
Leg fat mass (right)	1.2	4.7	16.8	-0.4	4.1	0.1	-1.4
Age at last live birth	1.2	1.8	2.4	0.8	1.4	1.5	1.5
Forced expiratory volume in 1-second (FEV1), predicted	1.2	2.4	4.6	1.6	2.1	1.6	-0.0
Long-standing illness, disability or infirmity	1.2	1.8	3.9	-2.0	-0.5	-1.4	-1.0
Mineral and other dietary supplements	1.2	1.6	3.2	1.2	-0.5	1.3	1.8
Leg fat mass (left)	1.2	4.7	16.2	-0.6	4.0	-0.1	-1.6
Eye problems/disorders: Diabetes related eye disease	1.1	1.2	2.3	0.7	1.5	0.4	1.3
Medication for hormone replacement therapy	1.1	1.2	2.3	-0.5	0.3	-1.5	-1.5
Maternal smoking around birth	1.1	1.6	2.7	-1.5	-0.2	-1.2	-1.6
Heel bone mineral density (BMD) T-score, automated (left)	1.1	2.4	7.6	0.8	2.7	0.9	-0.9
Happiness	1.1	1.3	1.9	-1.0	-1.4	-1.0	-1.1
Noisy workplace	1.1	1.4	2.7	-0.9	0.8	-1.2	-1.6
Arm fat mass (right)	1.1	4.7	16.8	-0.7	4.1	0.3	-1.2
Exposure to tobacco smoke at home	1.1	1.2	2.0	-0.5	-1.4	-1.1	-1.2
Knee pain experienced in last month	1.1	1.6	6.2	0.1	2.5	0.5	0.0
Medication for cholesterol	1.1	1.7	2.4	1.6	1.6	1.3	0.4
Arm fat mass (left)	1.1	4.6	16.4	-0.6	4.0	0.3	-1.2
Number of self-reported non-cancer illnesses	1.1	2.0	5.3	-0.9	-2.3	0.8	1.1
Guilty feelings	1.1	1.7	3.4	-1.8	-1.4	-0.7	-0.9
Hearing aid user	1.1	1.2	3.1	-0.6	-1.8	-0.8	-0.9
BMI	1.0	5.6	20.4	-0.2	4.5	-0.5	-1.4
Average weekly fortified wine intake	1.0	1.2	1.6	1.2	0.1	1.3	1.2
Stomach or abdominal pain in last month	1.0	1.2	2.9	-1.0	-1.7	-1.0	-0.3
Chest pain or discomfort	1.0	1.4	4.7	-0.8	-2.2	0.1	0.4
Medication: Gliclazide	1.0	1.2	2.2	0.9	-0.9	0.8	1.5
Eye problems/disorders: Glaucoma	1.0	1.1	1.6	-1.3	-1.3	-1.1	-0.2
Medication: Atorvastatin	1.0	1.2	2.3	-1.5	-1.0	-1.1	-0.6
Cholesterol lowering medication	1.0	1.5	4.8	0.0	-0.1	1.1	2.2
Height	0.9	17.9	59.3	-1.9	7.7	-0.7	-2.9
Hypothyroidism (self reported)	0.9	2.2	7.8	-0.6	-2.8	-0.5	-0.5
Impedance of leg (left)	0.9	4.4	16.3	-0.9	-4.0	-0.5	0.6
Had other major operations	0.9	1.1	1.7	-0.8	-1.2	-1.3	-0.6
Pain all over the body in last month	0.9	0.9	2.1	-1.5	0.7	-0.6	-0.9
Medication: Simvastatin	0.9	1.4	3.8	-0.6	-1.9	-1.1	0.5
Frequency of tiredness / lethargy in last 2 weeks	0.9	1.5	2.1	-1.4	0.8	-1.4	-1.1
Diabetes diagnosed by doctor	0.9	1.5	4.0	0.4	0.8	1.1	2.0
Commuting to job workplace: Public transport	0.9	1.0	2.7	0.8	1.6	0.9	-0.0
Fractured/broken bones in last 5 years	0.9	1.1	1.3	-1.2	-1.1	-1.1	-0.9
Blood White Count	0.8	6.0	10.0	-2.7	-3.2	-1.8	-1.8
Waist Hip Ratio (WHR)	0.8	3.7	6.8	1.0	2.1	2.6	1.7
Neuroticism	0.8	1.9	6.3	0.0	-2.5	0.3	1.1
Body mass index (BMI)	0.8	3.5	12.7	-0.1	3.6	0.2	-1.1
Alcohol usually taken with meals	0.8	1.4	3.4	1.8	0.7	0.8	1.0
Medication: Ramipril	0.8	1.1	1.9	-1.1	-1.0	-1.4	-0.4
Average weekly red wine intake	0.8	1.1	2.6	-0.9	0.1	-1.1	-1.6
Mood swings	0.8	1.4	4.8	0.3	-2.2	-0.1	0.9
Mother’s age at death	0.8	1.0	2.0	1.2	0.3	0.7	1.4
Sensitivity / hurt feelings	0.7	1.3	1.5	-1.2	-0.9	-1.1	-1.2
Trunk fat percentage	0.7	2.8	7.6	-1.3	2.8	-0.2	-1.3
Age when periods started (menarche)	0.7	1.6	4.9	0.1	-2.2	0.4	1.1
Diverticular disease/diverticulitis (self-reported)	0.7	0.8	1.2	-0.9	-0.8	-1.1	-0.7
Illnesses of siblings	0.7	1.0	1.9	0.9	-0.0	1.2	1.4
Illnesses of mother	0.7	0.9	2.4	0.4	1.5	0.7	0.6
Standing height	0.7	7.4	26.8	-0.7	5.2	0.4	-1.4
Tense / ‘highly strung’	0.7	1.1	4.3	-0.1	-2.1	-0.2	0.4
Hair/balding pattern: Pattern 4	0.7	1.6	2.4	1.2	1.4	1.6	0.7
Ever highly irritable/argumentative for 2 days	0.7	0.8	1.3	0.6	0.9	1.2	0.8
Hypothyroidism/myxoedema (self-reported)	0.7	1.3	5.1	-0.5	-2.3	0.0	0.1
Wheeze or whistling in the chest in last year	0.7	1.2	3.0	-1.7	-0.2	-1.0	-0.9
Migraine (self-reported)	0.7	0.8	1.1	-1.0	-1.0	-0.7	-0.9
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.7	0.8	1.8	0.8	-0.8	0.3	1.3
Family relationship satisfaction	0.7	0.9	2.2	-0.9	-1.5	-0.4	-0.6
Illness, injury, bereavement, stress in last 2 years	0.7	0.9	1.2	1.0	-0.5	1.0	1.1
Back pain experienced in last month	0.7	1.0	2.1	0.1	1.5	1.0	1.0
Impedance of whole body	0.7	3.4	12.4	-0.8	-3.5	-0.2	0.7
Bipolar Disorder (2018)	0.6	0.9	3.6	0.1	-1.9	-0.2	-0.1
Worry (Nagel 2018)	0.6	1.3	4.5	0.4	-2.1	-0.4	0.7
Ulcerative Colitis	0.6	0.8	1.8	-0.6	1.3	-1.0	0.2
Other serious medical condition/disability diagnosed by doctor	0.6	0.7	1.9	-1.4	-0.8	-0.3	-0.5
Pack years adult smoking proportion	0.6	0.9	3.3	-1.8	-0.3	-0.4	-0.4
Impedance of leg (right)	0.6	3.1	11.3	-0.4	-3.4	0.1	1.0
Tinnitus: Yes, but not now, but have in the past	0.6	0.7	1.2	-0.7	0.5	-0.9	-1.1
Qualifications: CSEs or equivalent	0.6	0.8	2.1	-0.2	-0.5	-1.0	-1.4
Heel bone mineral density (BMD) T-score, automated (right)	0.6	1.3	4.1	0.8	2.0	0.7	-0.5
Diabetes (self-reported)	0.6	0.9	1.5	-0.2	1.2	0.7	1.2
Impedance of arm (right)	0.6	2.6	8.5	-1.3	-2.9	-0.3	0.4
Arm fat percentage (right)	0.6	2.2	5.8	-1.1	2.4	-0.4	-1.3
Number of live births	0.6	0.9	2.7	0.1	-1.7	-0.7	0.5
Pulse wave Arterial Stiffness index	0.6	0.7	1.3	1.1	1.0	0.4	0.4
Impedance of arm (left)	0.6	2.9	9.9	-1.2	-3.1	-0.4	0.3
Peak expiratory flow (PEF)	0.6	1.3	2.0	1.4	0.5	1.3	1.2
Body fat percentage	0.6	2.5	6.6	-1.2	2.6	-0.4	-1.4
Emphysema/chronic bronchitis	0.6	0.6	0.8	0.6	0.9	0.7	0.9
Arm fat percentage (left)	0.6	2.3	6.5	-0.9	2.5	-0.2	-1.3
Pack years of smoking	0.6	0.8	2.9	-1.7	-0.4	-0.5	-0.1
Alzheimer’s Disease (in mother)	0.5	0.6	1.1	0.9	-0.3	0.6	1.1
Prostate Cancer	0.5	0.6	1.1	-0.7	1.0	-0.8	-0.5
Type 2 Diabetes (T2D) (2018)	0.5	0.9	2.5	0.1	0.7	0.9	1.6
Lung FEV1/FVC ratio	0.5	2.5	4.5	0.9	1.6	1.5	2.1
Townsend deprivation index at recruitment	0.5	0.6	1.1	-0.9	-1.1	-0.2	-0.8
Relative age voice broke	0.5	0.7	1.8	1.3	0.0	0.6	0.8
Taking other prescription medications	0.5	0.7	1.5	-1.2	-1.1	0.1	0.0
Financial difficulties in last 2 years	0.5	0.7	1.8	-1.0	-0.1	-0.2	-1.3
Mouth/teeth dental problems	0.5	0.7	1.9	-0.4	0.4	-0.9	-1.4
Hayfever/allergic rhinitis (self-reported)	0.5	0.6	1.4	-0.6	-1.2	0.2	-0.9
Neuroticism score	0.5	1.0	3.1	-0.2	-1.8	0.3	1.0
Depression (self-reported)	0.5	0.6	1.8	-0.2	0.4	1.3	0.6
Glaucoma (self-reported)	0.5	0.6	1.4	-0.5	-1.2	-0.4	0.6
Leg fat percentage (right)	0.5	1.8	5.4	-0.6	2.3	-0.4	-1.1
Pulse wave peak to peak time	0.5	0.6	1.5	-1.2	-0.6	-0.5	-0.6
Suffer from ‘nerves’	0.5	0.7	2.2	-0.2	-1.5	-0.7	-0.0
Illnesses of siblings: Diabetes	0.5	0.6	1.2	-0.6	-0.1	-0.8	-1.1
Loneliness, isolation	0.5	0.7	2.1	-1.4	0.3	-0.0	-0.9
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.5	0.5	1.0	-0.9	-0.5	-0.2	-1.0
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.5	1.0	1.4	-0.4	-1.2	-0.9	-1.2
Miserableness	0.5	0.9	2.4	-0.5	-1.5	-0.8	-0.6
Leg fat percentage (left)	0.5	1.8	4.5	-0.8	2.1	-0.7	-1.3
Ever had prostate specific antigen (PSA) test	0.5	0.6	1.1	-0.8	-1.0	0.2	0.9
Ever depressed for a whole week	0.5	0.6	1.2	1.1	0.6	0.8	0.6
Depressed Affect (Nagel 2018)	0.4	0.9	3.6	-0.2	-1.9	0.3	0.2
Smoking Status	0.4	1.0	3.1	0.7	1.8	-0.4	-0.3
Lung FVC	0.4	2.0	4.4	0.6	-2.1	-1.6	-0.8
Supplements: Zinc	0.4	0.5	0.8	-0.7	-0.8	-0.0	-0.9
Diabetes (mother)	0.4	0.5	1.0	0.8	1.0	0.5	0.1
Severe depression (siblings)	0.4	0.5	1.2	-0.8	-1.1	0.1	-0.0
Birth weight of first child	0.4	0.8	2.1	0.3	0.6	1.4	0.7
Pulse wave reflection index	0.4	0.5	1.9	1.4	-0.2	0.0	-0.0
Medication: Ventolin 100micrograms inhaler	0.4	0.5	1.3	-0.6	0.3	-0.2	-1.1
Shortness of breath walking on level ground	0.4	0.5	1.4	-1.2	0.1	-0.4	-0.5
Medication: Ibuprofen	0.4	0.5	1.1	-1.1	-0.6	-0.4	-0.7
Number of full sisters	0.4	0.5	1.4	-0.3	-0.1	-0.8	-1.2
Illnesses of father: None of the above (group 1)	0.4	0.5	1.5	0.5	1.2	-0.0	0.3
Supplements: Fish oil (including cod liver oil)	0.4	0.5	1.0	-0.5	0.2	-0.9	-1.0
Alcohol drinker status: Never	0.4	0.5	1.1	-0.5	-0.5	-0.6	-1.0
Number of operations (self-reported)	0.4	0.6	1.0	-1.0	-0.9	-0.6	-0.2
Neuroticism (Nagel 2018)	0.3	0.8	2.7	0.1	-1.6	0.2	0.7
Reaction Time	0.3	0.5	2.1	-0.0	-1.4	-0.2	-0.2
HDL Cholesterol	0.3	0.5	1.7	0.4	1.3	-0.3	0.5
Bilateral oophorectomy (both ovaries removed)	0.3	0.3	0.6	0.8	-0.2	0.8	0.2
Hayfever, allergic rhinitis or eczema	0.3	0.7	1.6	-1.3	-0.8	0.2	-0.7
Supplements: Glucosamine	0.3	0.4	0.7	-0.8	0.2	-0.7	-0.7
Sitting height	0.3	2.2	3.0	-1.7	1.7	-0.4	-1.6
Had menopause	0.3	0.3	0.7	0.5	0.4	0.5	0.8
Time employed in main current job	0.3	0.3	1.2	-0.0	-1.1	0.4	-0.1
Falls in the last year	0.3	0.4	1.0	-0.8	-1.0	0.2	-0.2
Qualifications: O levels/GCSEs or equivalent	0.3	0.5	1.4	0.6	1.2	0.1	-0.6
Blood clot in the leg (DVT)	0.3	0.4	1.4	-0.2	1.2	-0.0	-0.5
Medication: Paracetamol	0.3	0.5	1.0	-0.3	0.7	1.0	0.5
Mouth/teeth dental problems: Loose teeth	0.3	0.4	1.0	0.3	0.7	-1.0	0.2
Pulse rate, automated reading	0.3	0.9	1.9	0.1	0.3	1.3	1.4
Handedness (chirality/laterality): Left-handed	0.3	0.3	0.7	-0.9	-0.6	0.2	0.1
Breast cancer (self-reported)	0.3	0.4	0.7	-0.5	-0.8	0.8	0.0
Financial situation satisfaction	0.3	0.4	0.9	0.0	0.8	-0.2	-0.9
Tinnitus: Yes, now most or all of the time	0.3	0.3	0.6	0.3	-0.7	-0.8	0.3
Pain type(s) experienced in last month: Hip pain	0.3	0.4	0.5	-0.5	0.7	0.6	0.7
Depression (Nagel 2018)	0.2	0.4	0.9	0.4	-0.1	0.9	0.6
Intelligence (Savage-Jansen 2018)	0.2	0.6	0.7	-0.6	-0.7	-0.8	-0.8
Ulcerative Colitis (UC)	0.2	0.5	0.9	-0.5	0.7	-0.9	-0.5
Ovarian Cancer	0.2	0.2	0.8	0.2	-0.9	-0.1	-0.4
Age at First Birth	0.2	0.3	0.9	-0.9	0.2	0.2	-0.3
Triglycerides	0.2	0.3	0.7	-0.1	-0.8	-0.6	-0.3
Blood Eosinophil Count	0.2	1.3	3.3	0.1	-1.8	1.0	1.0
Blood Platelet Count	0.2	2.4	7.1	0.1	-2.7	0.9	1.3
Blood Red Count	0.2	1.8	3.5	-0.5	-0.4	-1.9	-1.9
Chronotype (morning person)	0.2	0.4	0.8	0.3	0.7	0.3	-0.9
Medication: Metformin	0.2	0.3	0.9	0.2	0.4	0.2	0.9
Hand grip strength (right)	0.2	0.5	1.1	0.6	1.1	-0.1	-0.6
Fed-up feelings	0.2	0.3	0.9	-0.9	-0.6	0.2	0.2
Medication: Atenolol	0.2	0.3	0.9	-0.5	-0.9	-0.1	0.4
Chronic bronchitis/emphysema (father)	0.2	0.3	0.6	-0.1	0.5	0.8	0.5
Nervous feelings	0.2	0.4	1.1	0.2	-0.7	0.1	1.1
Frequency of tenseness / restlessness in last 2 weeks	0.2	0.3	1.1	-1.1	-0.0	-0.2	-0.3
Forced vital capacity (FVC)	0.2	0.8	2.2	-0.1	0.4	-0.8	-1.5
Allergy	0.2	0.5	1.4	1.2	0.2	-0.2	0.8
Fluid intelligence score	0.2	0.3	0.7	-0.7	-0.8	0.4	-0.0
Qualifications: A levels/AS levels or equivalent	0.2	0.3	0.9	1.0	-0.1	0.4	0.5
Serious illness, injury or assault of a close relative in last 2 years	0.2	0.2	0.8	-0.2	-0.9	0.1	0.1
Asthma	0.2	0.3	0.6	-0.5	-0.6	-0.3	-0.8
Length of working week for main job	0.2	0.2	0.5	0.3	0.0	0.6	0.7
Breastfed as a baby	0.2	0.2	0.8	0.1	0.9	0.2	-0.1
Seen doctor (GP) for nerves, anxiety, tension or depression	0.2	0.2	0.6	-0.1	-0.0	0.5	0.8
Headache pain in last month	0.2	0.3	0.8	0.9	0.5	0.5	0.3
Chronic bronchitis/emphysema (mother)	0.2	0.3	0.7	-0.1	0.8	-0.2	-0.6
High blood pressure (siblings)	0.2	0.3	0.6	-0.4	-0.6	-0.8	-0.4
Forced vital capacity (FVC), Best measure	0.2	0.6	2.0	0.2	0.5	-0.3	-1.4
Exposure to tobacco smoke outside home	0.2	0.2	0.7	0.4	0.8	-0.1	-0.1
Age at first live birth	0.2	0.3	0.8	-0.9	-0.6	-0.0	-0.2
Angina (self-reported)	0.2	0.2	0.7	-0.4	0.0	-0.8	-0.1
Medication: Omeprazole	0.2	0.2	0.6	0.1	-0.5	-0.7	-0.2
Mean time to correctly identify matches	0.2	0.3	0.8	0.5	-0.9	-0.2	0.4
Heart disease (mother)	0.2	0.2	0.4	-0.6	0.2	0.6	0.2
Commuting to job workplace: Car/motor vehicle	0.2	0.2	0.4	-0.7	-0.3	-0.2	0.4
Wears glasses or contact lenses	0.2	0.3	0.7	-0.4	0.1	-0.9	-0.5
Risk taking	0.2	0.3	0.8	0.9	-0.3	0.6	-0.2
Age started oral contraceptive pill	0.2	0.3	0.8	-0.9	-0.5	-0.3	0.2
Myopia	0.2	0.4	0.8	0.3	0.7	0.9	0.3
Medication: Omeprazole (e.g. Zanprol)	0.2	0.3	0.7	0.3	-0.8	-0.1	0.5
Pain experienced in last month	0.2	0.3	0.7	0.8	-0.9	0.2	-0.1
Basal cell carcinoma (self-reported)	0.2	0.3	0.6	-0.4	-0.1	-0.4	-0.8
Deep venous thrombosis (DVT) (self-reported)	0.2	0.3	0.7	-0.4	0.8	-0.0	-0.5
Heart disease (siblings)	0.2	0.2	0.2	-0.5	0.5	-0.5	-0.5
Verbal and Numeric Reasoning (VNR)	0.1	0.2	0.3	-0.2	-0.5	0.6	0.2
Coronary Artery Disease (CAD)	0.1	0.1	0.2	-0.1	0.4	0.0	-0.4
Mean Putamen Volume	0.1	0.1	0.2	-0.0	-0.5	0.0	-0.3
Neuroticism (2016)	0.1	0.2	0.3	-0.2	-0.6	-0.2	0.5
Primary Biliary Cirrhosis	0.1	0.2	0.6	-0.8	0.0	-0.3	-0.2
Rheumatoid Arthritis	0.1	0.2	0.7	-0.0	0.8	0.2	-0.2
Hair Pigment	0.1	2.4	8.9	0.4	3.0	0.6	-0.0
Tanning	0.1	1.4	5.0	0.2	-2.2	0.5	-0.7
Hand grip strength (left)	0.1	0.3	0.8	0.0	0.9	0.1	-0.6
Frequency of depressed mood in last 2 weeks	0.1	0.1	0.1	-0.2	0.3	0.4	-0.2
Angina	0.1	0.2	0.5	-0.3	-0.1	-0.7	-0.0
Frequency of unenthusiasm / disinterest in last 2 weeks	0.1	0.2	0.5	-0.2	0.6	0.7	0.0
Qualifications: None of the above	0.1	0.3	0.6	-0.4	-0.3	-0.7	-0.7
Alcohol intake versus 10 years previously	0.1	0.2	0.8	-0.1	0.9	0.2	0.1
Forced expiratory volume in 1-second (FEV1)	0.1	0.2	0.3	0.6	0.5	0.3	-0.4
Mouth/teeth dental problems: Dentures	0.1	0.2	0.7	-0.8	0.3	-0.2	-0.3
Medication: Ibuprofen (e.g. Nurofen)	0.1	0.2	0.3	-0.6	-0.5	0.2	0.0
Forced expiratory volume in 1-second (FEV1), Best measure	0.1	0.4	0.6	0.7	0.7	0.4	-0.6
Number of full brothers	0.1	0.2	0.3	0.3	-0.4	0.5	0.3
Qualifications: College or University degree	0.1	0.2	0.3	-0.5	-0.3	0.5	-0.1
Medication for pain relief, constipation, heartburn	0.1	0.2	0.5	0.4	0.7	-0.1	-0.1
Medication: Seretide 50 evohaler	0.1	0.1	0.2	-0.4	-0.4	-0.2	-0.2
Overall health rating	0.1	0.2	0.4	-0.6	0.5	-0.4	-0.4
Qualifications: NVQ or HND or HNC or equivalent	0.1	0.1	0.2	0.3	-0.0	-0.3	-0.4
Illnesses of father: Heart disease	0.1	0.1	0.3	0.2	-0.5	0.4	0.3
Qualifications: nursing, teaching	0.1	0.2	0.6	0.2	0.3	-0.4	-0.8
Asthma (self-reported)	0.1	0.1	0.3	-0.3	-0.4	-0.0	-0.5
Osteoarthritis (self-reported)	0.1	0.1	0.1	-0.3	0.2	0.2	0.3
Ever taken oral contraceptive pill	0.1	0.1	0.3	0.1	0.5	-0.1	0.1
Medication: Paracetamol	0.1	0.2	0.3	-0.5	0.5	0.4	0.1
Average weekly beer plus cider intake	0.1	0.2	0.3	0.2	-0.4	0.3	0.6
Commuting to job workplace: Cycle	0.1	0.1	0.2	0.4	-0.1	0.0	-0.3
Alzheimer’s Disease (in father)	0.0	0.0	0.1	0.1	-0.3	-0.2	0.2
Bipolar Disorder (2011)	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Respiratory disease	0.0	0.0	0.1	0.2	0.0	0.1	-0.3
Number of incorrect matches in round	0.0	0.1	0.1	0.3	-0.1	-0.0	0.3
Pulse rate	0.0	0.1	0.2	-0.5	0.2	0.1	0.1
Prospective memory result	0.0	0.1	0.2	-0.1	0.4	-0.1	-0.2
Alcohol intake frequency.	0.0	0.1	0.3	0.3	-0.0	0.5	-0.3
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.0	0.0	0.1	-0.2	-0.3	-0.2	0.1

Hub : Genes

ADCY9

Models

Trait associations