Best TWAS P=7.64e-13 · Best GWAS P=8.55e-13 conditioned to 1
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | GTEx | Adipose Subcutaneous | ELMO3 | 0.14 | 0.04 | lasso | 3 | 0.04 | 5.6e-04 | 5.0 | 6.6 | 4.8e-11 | 0.83 | 0.09 | 0.86 | FALSE |
2 | GTEx | Adipose Subcutaneous | LRRC29 | 0.05 | 0.00 | lasso | 5 | 0.00 | 3.9e-01 | 6.9 | -6.3 | 3.7e-10 | -0.78 | 0.04 | 0.41 | FALSE |
3 | GTEx | Adipose Visceral Omentum | ATP6V0D1 | 0.12 | 0.03 | lasso | 6 | 0.03 | 8.3e-03 | 6.8 | -6.4 | 1.7e-10 | -0.83 | 0.03 | 0.75 | FALSE |
4 | GTEx | Artery Aorta | ELMO3 | 0.08 | 0.04 | enet | 16 | 0.06 | 4.4e-04 | 5.0 | 5.8 | 6.2e-09 | 0.67 | 0.06 | 0.28 | FALSE |
5 | GTEx | Lung | LRRC29 | 0.06 | 0.02 | enet | 11 | 0.03 | 4.7e-03 | 6.6 | -6.6 | 5.1e-11 | -0.90 | 0.03 | 0.82 | FALSE |
6 | GTEx | Muscle Skeletal | ATP6V0D1 | 0.11 | 0.03 | enet | 13 | 0.04 | 4.8e-05 | 7.2 | -7.2 | 7.6e-13 | -0.96 | 0.01 | 0.99 | TRUE |
7 | GTEx | Pituitary | LCAT | 0.13 | 0.10 | enet | 10 | 0.04 | 3.9e-02 | -3.8 | 5.5 | 3.2e-08 | 0.46 | 0.05 | 0.33 | FALSE |
8 | GTEx | Prostate | FHOD1 | 0.36 | 0.04 | lasso | 13 | 0.10 | 1.8e-03 | 6.2 | 5.7 | 1.6e-08 | 0.79 | 0.07 | 0.52 | FALSE |
9 | GTEx | Testis | ATP6V0D1 | 0.43 | 0.35 | enet | 12 | 0.41 | 1.9e-19 | 6.6 | -6.3 | 2.5e-10 | -0.95 | 0.08 | 0.92 | FALSE |
10 | YFS | Blood | E2F4 | 0.03 | 0.02 | lasso | 7 | 0.02 | 2.0e-07 | 5.1 | -5.7 | 1.1e-08 | -0.54 | 0.97 | 0.01 | FALSE |
11 | The Cancer Genome Atlas | Bladder Urothelial Carcinoma | B3GNT9 | 0.03 | 0.03 | blup | 26 | 0.02 | 1.3e-02 | 5.0 | 5.4 | 6.5e-08 | 0.62 | 0.06 | 0.41 | FALSE |
12 | The Cancer Genome Atlas | Colon Adenocarcinoma | LRRC29 | 0.05 | 0.05 | blup | 33 | 0.05 | 5.4e-04 | 5.2 | -5.9 | 3.7e-09 | -0.74 | 0.06 | 0.85 | FALSE |
13 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | ATP6V0D1 | 0.03 | 0.00 | enet | 6 | 0.01 | 1.1e-02 | 6.6 | -5.4 | 6.1e-08 | -0.79 | 0.01 | 0.84 | FALSE |
14 | The Cancer Genome Atlas | Thyroid Carcinoma | ATP6V0D1 | 0.04 | 0.01 | enet | 5 | 0.02 | 3.2e-03 | 7.0 | -6.5 | 6.0e-11 | -0.82 | 0.00 | 0.81 | FALSE |