TWAS hub - FHOD1

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Prostate	0.3610	0.0900	6.0e-06	0.044	NA	0.083	NA	0.100	2.9e-02	NA	4.2e-03	NA	1.8e-03
2	METSIM	Adipose	0.1231	0.0676	5.8e-04	0.009	0.015	0.030	NA	0.023	1.2e-02	2.1e-03	2.0e-05	NA	1.6e-04
3	YFS	Blood	0.1436	0.0405	1.3e-06	0.052	0.019	0.048	0.051	0.049	1.0e-16	5.8e-07	2.0e-15	3.2e-16	8.1e-16
4	TCGA	Breast Invasive Carcinoma	0.0329	0.0242	1.3e-03	0.005	0.013	0.014	NA	0.015	2.5e-02	1.0e-03	5.1e-04	NA	3.1e-04
5	TCGA	Kidney Renal Clear Cell Carcinoma	0.2357	0.0823	1.7e-05	0.065	0.058	0.060	NA	0.058	8.3e-08	4.2e-07	2.3e-07	NA	3.6e-07
6	TCGA	Prostate Adenocarcinoma	0.0806	0.0345	3.7e-09	0.076	0.083	0.085	NA	0.086	2.5e-08	5.4e-09	3.3e-09	NA	2.4e-09

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6
HDL Cholesterol	12.5	20.8	39.6	4.8	1.2	2.6	6.3	5.2	5.2
Birth weight	6.8	14.8	25.1	-2.9	-2.1	-4.3	-4.8	-5.0	-3.0
Lung FEV1/FVC ratio	6.2	31.2	79.2	8.9	1.7	2.2	4.6	0.6	8.9
Birth weight of first child	5.7	10.3	19.2	-1.7	-2.3	-4.0	-4.4	-4.0	-1.6
Ovarian Cancer	5.0	6.7	9.9	-2.4	-1.4	-2.7	-3.1	-2.6	-2.9
Schizophrenia vs Biploar Disorder	4.6	6.1	10.9	2.7	0.8	2.1	3.3	2.6	2.6
Average weekly champagne plus white wine intake	4.6	6.3	11.3	3.1	1.4	2.0	3.4	1.4	3.0
Comparative body size at age 10	3.8	10.4	31.9	5.7	-0.8	0.0	2.7	-2.4	4.1
Medication for cholesterol	3.8	5.7	12.5	-0.8	-1.6	-3.1	-2.9	-3.5	-0.6
Medication: Blood pressure	3.8	7.3	14.4	1.7	1.9	3.3	3.2	3.8	1.2
Alcohol intake versus 10 years previously	3.6	5.4	10.5	-0.6	-2.4	-2.8	-2.3	-3.2	-1.8
Ever unenthusiastic/disinterested for a whole week	3.4	4.1	8.7	-0.8	1.4	2.9	2.2	2.9	0.1
Basal cell carcinoma (self-reported)	3.2	3.8	9.2	-1.2	1.5	3.0	1.8	2.5	-0.7
Illnesses of siblings	3.0	4.2	8.0	2.0	-2.2	-2.4	-1.2	-2.8	1.1
Falls in the last year	3.0	4.0	11.6	-3.1	-1.0	0.4	-1.3	0.5	-3.4
Length of working week for main job	3.0	3.3	6.6	0.3	-1.9	-2.6	-1.8	-2.5	0.1
Reproduciblity of spirometry measurement using ERS/ATS criteria	2.8	3.3	5.9	1.3	2.1	2.4	2.0	1.6	1.1
Ever had prostate specific antigen (PSA) test	2.7	3.1	6.0	-1.5	-0.6	-1.4	-2.4	-2.0	-2.0
Blood Red Count	2.6	25.5	52.9	3.4	3.4	6.7	4.5	7.3	3.4
Severe depression (siblings)	2.5	2.8	5.3	1.2	0.9	1.6	2.3	1.8	1.8
High blood pressure (siblings)	2.5	3.6	7.7	-2.1	1.8	2.2	0.4	2.8	-1.1
Illnesses of father: High blood pressure	2.5	3.1	4.6	0.8	1.4	2.1	2.1	2.1	1.6
Deep venous thrombosis (DVT) (self-reported)	2.5	3.2	6.5	2.1	1.0	1.0	2.2	1.2	2.5
Illness, injury, bereavement, stress in last 2 years	2.4	2.9	5.8	-0.3	-1.1	-2.4	-2.3	-2.2	-0.0
Chronic bronchitis/emphysema (mother)	2.3	2.6	6.5	0.7	2.5	1.1	1.6	1.1	2.0
Prostate Cancer	2.2	3.1	10.0	-3.2	0.7	-0.2	-1.2	0.1	-2.6
Mood swings	2.2	4.0	6.7	2.6	-0.3	1.6	2.4	1.8	2.4
Noisy workplace	2.1	2.6	5.1	-0.8	-1.2	-2.3	-2.0	-2.1	-0.7
Age at First Birth	2.0	2.8	8.2	-1.0	-2.9	-1.0	-1.6	-0.7	-1.9
Serious illness, injury or assault to yourself	2.0	2.4	7.4	-2.3	-0.3	-0.4	-1.3	-0.1	-2.7
Alcohol usually taken with meals	2.0	3.2	5.0	1.7	0.8	1.9	2.1	1.6	2.2
Loneliness, isolation	2.0	2.8	7.7	2.8	-0.1	0.4	1.9	-0.6	2.2
Systolic Blood Pressure	1.9	9.6	23.1	1.1	1.5	4.8	3.7	4.1	0.3
Lung FVC	1.9	9.5	31.0	-5.6	0.4	-0.6	-2.6	0.8	-4.2
Had other major operations	1.9	2.3	5.6	2.0	-1.0	-1.4	0.3	-1.1	2.4
Blood clot in the leg (DVT)	1.9	2.5	5.1	1.8	0.8	0.8	1.9	1.2	2.3
Ever depressed for a whole week	1.9	2.4	5.1	1.2	0.7	1.9	2.3	1.4	1.2
Schizophrenia (2014)	1.8	4.1	6.1	1.8	0.4	2.0	2.5	2.3	2.4
Diabetes (father)	1.8	2.2	4.1	1.1	0.3	1.3	1.7	2.0	1.8
Stomach or abdominal pain in last month	1.8	2.3	3.4	1.8	0.8	1.2	1.8	1.4	1.6
Financial difficulties in last 2 years	1.8	2.4	5.4	2.2	1.2	0.9	2.3	0.4	1.4
Number of live births	1.8	2.5	6.3	2.5	-0.2	-0.8	0.6	-1.6	2.3
Schizophrenia (2018)	1.7	3.4	6.5	1.5	-0.6	0.9	2.6	2.3	2.4
Fluid intelligence score	1.7	3.6	5.4	-2.3	2.0	2.0	0.7	2.0	-2.0
Number of full sisters	1.7	2.1	5.8	-0.4	-0.6	-2.4	-1.8	-1.5	-0.9
Friendships satisfaction	1.7	2.1	4.2	-0.3	-0.8	2.0	1.4	2.0	-1.4
Qualifications: nursing, teaching	1.7	2.6	6.7	0.4	0.9	2.6	1.8	2.1	0.6
Diastolic blood pressure, automated reading	1.7	5.2	11.2	1.0	1.4	3.0	2.5	3.4	1.2
Fasting Glucose	1.6	1.9	5.7	-1.1	0.8	-0.9	-1.4	-1.0	-2.4
Loud music exposure frequency	1.6	1.7	3.2	0.1	1.2	1.7	1.6	1.8	0.6
Pulse rate, automated reading	1.6	5.1	10.1	-3.2	-0.9	-2.0	-3.0	0.0	-2.6
Bipolar Disorder or Schizophrenia	1.5	3.6	6.0	1.2	0.2	1.5	2.4	2.4	2.4
Current tobacco smoking	1.5	2.5	7.7	2.8	0.5	0.6	2.2	-0.7	1.2
Prospective memory result	1.5	1.9	4.8	2.2	-0.7	-0.7	0.5	-1.5	1.7
Age at first live birth	1.5	2.6	4.7	-2.2	0.2	1.7	-0.3	2.1	-1.8
Qualifications: NVQ or HND or HNC or equivalent	1.5	1.8	5.0	1.7	-2.2	-0.9	-0.1	-1.2	0.6
Vascular/heart problems diagnosed by doctor	1.5	4.0	8.7	-0.5	-1.6	-2.9	-2.1	-3.0	0.2
Intelligence (Savage-Jansen 2018)	1.4	4.2	5.8	-2.4	2.1	2.2	0.2	2.4	-2.1
Crohns Disease (2012)	1.4	2.2	4.2	-1.1	-0.2	-0.1	-1.9	-2.0	-2.0
Blood Eosinophil Count	1.4	10.5	19.7	4.4	2.6	0.5	4.4	1.0	4.0
Number of treatments/medications taken	1.4	2.6	4.0	1.7	1.6	1.3	2.0	1.1	1.8
Tinnitus: Yes, but not now, but have in the past	1.4	1.5	5.2	-0.5	1.1	1.1	0.1	2.3	-0.9
Sitting height	1.4	9.8	26.4	-1.6	-0.7	4.5	1.3	2.7	-5.1
Illnesses of siblings: Diabetes	1.4	1.7	2.6	0.0	1.3	1.6	1.6	1.5	1.1
Ever had bowel cancer screening	1.4	1.6	4.0	0.5	-1.3	-2.0	-1.3	-1.5	0.1
Smoking status: Current	1.4	2.3	7.0	2.6	0.5	0.4	2.1	-0.6	1.3
Medication: Paracetamol	1.4	2.1	5.0	1.3	-0.7	-2.1	-1.0	-2.2	0.4
Fed-up feelings	1.3	2.3	4.6	1.7	0.7	0.9	1.8	1.3	2.1
High blood pressure	1.3	3.6	8.6	0.2	1.7	2.6	1.7	2.9	-0.3
Ever highly irritable/argumentative for 2 days	1.3	1.6	2.5	-0.3	-1.4	-1.4	-1.0	-1.6	-1.3
Hypothyroidism/myxoedema (self-reported)	1.3	2.5	11.6	1.7	-0.1	-0.1	0.5	0.2	3.4
Wheeze or whistling in the chest in last year	1.3	2.3	4.2	0.5	1.6	1.8	2.1	1.7	1.0
Medication: Allopurinol	1.3	1.8	4.3	-0.2	-0.5	-2.1	-1.6	-1.8	0.4
Chest pain or discomfort	1.3	1.8	5.1	-2.3	2.2	0.3	-0.0	0.7	-0.7
Knee pain experienced in last month	1.3	2.0	6.2	2.5	-0.9	-0.3	0.5	-1.3	1.7
Pain experienced in last month	1.3	2.2	7.6	-2.8	0.4	0.8	-0.7	1.3	-1.6
Crohns Disease (2017)	1.2	2.6	8.5	-0.8	-2.9	-0.6	-1.3	-1.0	-1.9
Primary Biliary Cirrhosis	1.2	1.7	4.2	1.2	0.3	1.6	2.1	1.4	0.5
Hypothyroidism (self reported)	1.2	2.8	13.5	1.8	0.2	-0.2	0.3	0.1	3.7
Frequency of depressed mood in last 2 weeks	1.2	1.7	3.4	1.0	0.6	1.6	1.8	1.4	1.0
Diverticular disease/diverticulitis (self-reported)	1.2	1.5	3.0	0.2	1.1	1.7	1.2	1.7	0.5
Medication: Levothyroxine sodium	1.2	2.0	8.8	1.2	0.3	0.6	0.8	0.9	3.0
Forced vital capacity (FVC)	1.2	4.5	16.3	-2.9	-0.4	-0.5	-1.3	-0.4	-4.0
Seen a psychiatrist for nerves, anxiety, tension or depression	1.2	1.6	2.6	-1.6	-0.7	1.3	0.4	1.4	-1.6
Number of children fathered	1.2	1.3	3.2	-0.9	0.5	1.8	0.5	1.4	-1.2
Migraine (self-reported)	1.2	1.5	2.1	1.4	0.6	1.1	1.4	1.2	1.4
Medication: Ibuprofen	1.2	1.4	2.0	1.2	1.1	1.0	1.4	1.0	1.4
Smoking status: Previous	1.2	1.8	4.5	-1.7	-0.8	-0.3	-2.1	0.1	-1.6
Medication: Aspirin	1.2	1.6	4.6	2.1	-0.3	0.8	1.6	0.4	1.3
Pain type(s) experienced in last month: Hip pain	1.2	1.5	3.1	1.2	0.1	-1.4	-0.6	-1.8	1.4
Depressed Affect (Nagel 2018)	1.1	2.2	5.5	2.3	0.2	0.6	1.8	0.6	2.0
Verbal and Numeric Reasoning (VNR)	1.1	2.5	4.8	-1.4	2.0	1.8	1.0	2.2	-0.7
Waist Hip Ratio (WHR)	1.1	5.1	12.7	-1.5	-0.5	-2.5	-1.9	-2.4	-3.6
Hand grip strength (left)	1.1	2.8	9.3	1.2	0.3	-2.0	-1.0	-3.1	1.1
Hair/balding pattern: Pattern 4	1.1	2.6	7.6	-1.0	1.0	0.8	1.5	1.8	-2.8
Irritability	1.1	1.8	4.6	1.8	0.2	-1.2	0.1	-1.3	2.1
Cholesterol lowering medication	1.1	1.6	3.2	0.7	1.0	1.5	1.8	1.5	0.1
Irritable Bowel Disease (IBD)	1.0	2.5	7.8	0.0	-2.8	-1.5	-1.2	-1.6	-0.8
Triglycerides	1.0	1.7	2.8	-0.8	-1.7	-1.0	-1.3	-1.6	-1.1
BMI	1.0	5.5	15.4	3.9	1.0	-0.5	1.3	-1.4	3.6
Cardiovascular Disease	1.0	3.4	6.1	1.6	1.0	2.4	2.5	2.2	0.6
Other serious medical condition/disability diagnosed by doctor	1.0	1.2	2.5	-0.9	-1.6	-1.5	-1.2	-0.4	-0.6
Ever used hormone-replacement therapy (HRT)	1.0	1.3	4.2	-1.5	-0.7	0.9	-0.2	0.5	-2.1
Hand grip strength (right)	1.0	2.6	7.6	1.2	0.5	-2.1	-1.1	-2.7	1.1
Maternal smoking around birth	1.0	1.5	4.4	1.1	-2.1	-0.9	-0.5	-1.4	-0.3
Heel bone mineral density (BMD) T-score, automated (right)	1.0	2.3	4.8	-1.0	-1.5	0.8	-1.7	-1.5	-2.2
Hayfever/allergic rhinitis (self-reported)	1.0	1.3	2.3	-1.5	0.9	1.3	0.6	1.2	-1.0
Mouth/teeth dental problems: Bleeding gums	1.0	1.3	3.2	1.8	-1.2	-0.6	-0.2	-1.6	-0.1
Medication: Seretide 50 evohaler	1.0	1.2	3.7	-0.9	1.9	0.7	0.6	0.1	-1.3
Family relationship satisfaction	1.0	1.3	3.6	-0.4	-1.9	0.7	0.3	0.3	-1.8
Hypertension (Self-reported)	1.0	2.7	6.6	0.6	1.2	2.3	1.6	2.6	0.0
Average weekly beer plus cider intake	1.0	1.4	2.4	-1.1	0.1	-1.1	-1.6	-1.4	-1.3
Major Depression (MDD)	0.9	1.1	2.5	-1.2	1.6	1.4	0.1	1.0	-0.3
Rheumatoid Arthritis	0.9	1.3	4.7	0.7	-1.3	-2.2	0.2	-0.3	0.8
Qualifications: CSEs or equivalent	0.9	1.2	5.7	1.0	-0.2	0.2	0.1	0.7	2.4
Hearing difficulty/problems with background noise	0.9	1.4	4.8	-2.2	0.9	0.3	-0.6	1.2	-0.9
Peak expiratory flow (PEF)	0.9	2.1	2.9	1.1	1.7	1.7	1.6	1.7	0.7
Medication: Paracetamol	0.9	1.5	4.1	0.6	-0.3	-1.9	-0.9	-2.0	0.0
Ever had stillbirth, spontaneous miscarriage or termination	0.9	0.9	2.0	0.0	-0.6	1.3	1.2	1.4	-0.6
Illnesses of father: None of the above (group 1)	0.9	1.1	3.4	0.4	0.1	-1.8	-1.0	-1.3	0.6
Heart disease (siblings)	0.9	1.1	2.8	-1.0	1.7	0.7	0.0	0.9	-1.3
Bipolar Disorder (2018)	0.8	1.3	3.7	0.1	1.3	1.9	0.7	1.0	0.9
Alzheimer’s Disease (in mother)	0.8	0.9	3.4	-1.8	-0.2	-0.5	-0.8	-0.3	-1.1
Mean Putamen Volume	0.8	0.9	2.4	-0.7	0.8	-0.2	-1.6	-1.2	0.4
Hearing difficulty/problems: Yes	0.8	1.2	4.0	-2.0	0.5	-0.7	-1.3	0.4	-0.6
Neuroticism score	0.8	1.6	6.2	1.3	0.5	-0.1	1.2	0.0	2.5
Happiness	0.8	0.9	1.5	0.3	-1.0	1.0	0.7	1.2	-1.2
Asthma	0.8	1.7	5.8	-2.4	0.6	0.5	-0.8	1.0	-1.4
Glaucoma (self-reported)	0.8	0.9	2.4	-0.2	-0.5	1.0	1.0	1.6	-0.8
Forced vital capacity (FVC), Best measure	0.8	2.9	9.2	-2.4	-0.4	-0.7	-1.2	-0.7	-3.0
Neck or shoulder pain in last month	0.8	1.1	2.1	1.5	-0.7	-0.8	-0.0	-1.2	1.4
Suffer from ‘nerves’	0.8	1.3	4.0	0.3	1.3	0.6	1.0	0.7	2.0
Had major operations	0.8	0.9	2.2	0.5	1.5	0.9	1.3	0.7	0.2
Arm fat percentage (left)	0.8	3.3	8.4	2.9	0.5	-1.6	0.3	-1.5	2.5
Long-standing illness, disability or infirmity	0.8	1.1	3.3	-1.8	-0.1	0.2	-0.6	0.5	-1.7
Osteoporosis (self-reported)	0.8	1.0	3.8	-0.5	-0.7	-1.9	-1.0	-0.7	0.3
Guilty feelings	0.8	1.3	2.2	1.5	-0.0	-0.4	1.1	-1.3	1.5
Supplements: Fish oil (including cod liver oil)	0.8	1.0	1.8	1.2	-1.1	-0.6	-0.3	-1.3	1.1
Medication: Lisinopril	0.8	1.1	2.6	1.0	-0.3	-1.6	-0.7	-1.6	0.0
Alcohol drinker status: Never	0.8	1.0	3.8	0.5	-1.9	-0.5	0.3	0.1	1.2
Supplements: Calcium	0.8	0.8	1.9	-0.8	0.8	1.0	0.9	1.4	0.3
Neuroticism (2016)	0.7	1.1	2.7	1.6	0.6	0.2	0.9	0.2	1.6
Allergy or Eczema	0.7	1.8	5.4	-2.3	1.1	0.7	-0.0	1.6	-0.9
Bilateral oophorectomy (both ovaries removed)	0.7	0.8	2.5	0.3	-0.3	1.1	0.7	1.6	0.4
Body mass index (BMI)	0.7	3.1	7.5	2.7	1.1	-0.9	0.5	-1.2	2.7
Number of incorrect matches in round	0.7	1.2	2.7	0.8	0.1	1.4	1.6	1.2	0.6
Arm fat percentage (right)	0.7	2.6	6.7	2.6	0.5	-1.5	0.1	-1.3	2.2
Qualifications: O levels/GCSEs or equivalent	0.7	1.1	2.3	-1.0	0.5	1.5	0.9	1.4	-0.4
Headache pain in last month	0.7	1.2	2.1	1.4	-0.5	-1.5	-0.2	-1.2	1.2
Medication: Omeprazole	0.7	0.8	2.8	1.7	0.1	-0.2	0.9	-1.1	0.0
Leg fat mass (right)	0.7	2.7	9.9	3.1	0.3	-0.9	0.8	-1.9	1.1
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.7	0.9	1.7	-0.9	-0.7	-0.9	-0.7	-1.3	-1.0
Asthma (self-reported)	0.7	1.4	5.1	-2.3	0.4	0.2	-0.9	0.8	-1.3
Medication: Gliclazide	0.7	0.8	1.4	1.0	-0.5	0.6	1.0	0.7	1.2
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.7	1.4	2.9	-1.0	-1.2	-1.4	-1.7	-1.0	-0.4
Miserableness	0.7	1.3	2.5	0.9	0.5	0.9	1.6	1.2	1.4
Leg fat percentage (left)	0.7	2.5	9.2	3.0	0.3	-0.9	0.7	-1.5	1.4
Leg fat mass (left)	0.7	2.8	10.6	3.2	0.3	-0.7	0.9	-1.8	1.2
Alzheimer’s Disease (in father)	0.6	0.7	1.1	0.2	-0.4	-1.0	-1.0	-1.0	0.9
Alzheimer’s Disease (including proxy)	0.6	0.9	2.0	-1.4	-0.5	-1.0	-1.2	-0.8	-0.4
Reaction Time	0.6	1.1	3.7	-0.9	1.9	0.7	0.5	0.4	-1.1
Type 2 Diabetes (T2D) (2012)	0.6	0.7	2.5	-1.6	0.6	0.3	-0.8	0.3	-0.8
Blood White Count	0.6	4.4	9.0	-0.3	1.6	2.4	2.7	3.0	-1.4
Heel T-Score	0.6	4.8	14.2	-1.1	-1.6	3.8	-1.3	-0.3	-3.0
Average weekly spirits intake	0.6	0.7	2.0	-0.8	0.6	0.6	0.1	1.0	-1.4
Systolic blood pressure, automated reading	0.6	1.7	3.9	0.4	0.1	2.0	1.5	1.9	0.4
Impedance of leg (right)	0.6	2.7	9.5	-0.9	-2.2	0.5	0.3	0.8	-3.1
Trunk fat percentage	0.6	2.3	7.8	2.8	-0.3	-1.3	0.5	-1.5	1.1
Townsend deprivation index at recruitment	0.6	0.8	2.1	-1.1	1.4	-0.6	-0.8	-0.2	-0.7
Heel bone mineral density (BMD) T-score, automated (left)	0.6	1.4	3.5	-0.4	-0.8	1.3	-1.1	-1.0	-1.9
Hayfever, allergic rhinitis or eczema	0.6	1.3	3.3	-1.1	1.3	0.8	0.9	1.8	0.6
Chronic bronchitis/emphysema (father)	0.6	0.7	1.4	-0.9	-1.2	-0.6	-0.9	-0.2	-1.0
High blood pressure (mother)	0.6	0.8	1.9	0.2	1.4	0.8	0.7	0.7	1.1
Trunk fat mass	0.6	2.4	8.9	3.0	-0.1	-1.0	0.7	-1.9	0.6
Hair/balding pattern: Pattern 2	0.6	0.7	2.2	-0.1	-1.2	0.7	-0.4	-0.1	-1.5
Time employed in main current job	0.6	0.7	1.7	-1.0	-0.7	-0.4	-1.3	-0.4	-0.8
Qualifications: A levels/AS levels or equivalent	0.6	1.4	4.1	-1.5	0.5	1.1	0.3	0.5	-2.0
Arm fat mass (right)	0.6	2.6	8.5	2.9	0.5	-1.0	0.5	-1.7	1.6
Standing height	0.6	5.5	23.8	0.5	-1.9	0.8	0.5	-2.0	-4.9
Body fat percentage	0.6	2.5	9.1	3.0	-0.1	-1.1	0.7	-1.4	1.4
Leg fat percentage (right)	0.6	2.3	7.7	2.8	-0.0	-1.3	0.3	-1.7	1.2
Shortness of breath walking on level ground	0.6	0.7	1.5	-0.6	1.2	0.6	0.6	1.2	-0.0
Qualifications: College or University degree	0.6	2.0	6.8	-1.3	-0.4	1.7	0.3	0.8	-2.6
Medication: Blood pressure	0.6	1.0	2.4	-1.5	0.8	0.2	-0.9	0.2	-1.5
Mean time to correctly identify matches	0.6	1.1	3.8	-1.1	1.9	0.6	0.1	0.2	-1.1
Whole body fat mass	0.6	2.7	10.3	3.2	0.1	-0.8	0.9	-1.8	1.1
Eye problems/disorders: Cataract	0.6	0.7	1.8	0.2	1.1	0.7	0.5	1.4	0.6
Breast cancer (self-reported)	0.6	0.7	2.8	-0.0	-0.3	-1.7	-0.6	-0.2	1.1
Arm fat mass (left)	0.6	2.4	8.0	2.8	0.3	-1.0	0.5	-1.7	1.4
Commuting to job workplace: Public transport	0.6	0.7	2.0	-0.8	0.1	-0.6	-0.9	-0.7	-1.4
Eye problems/disorders: Glaucoma	0.6	0.7	1.4	-0.9	-0.5	0.5	0.4	1.2	-1.0
Fractured/broken bones in last 5 years	0.6	0.8	1.8	-0.7	-0.6	-1.3	-0.8	-0.7	-1.0
Myopia	0.6	0.8	2.2	0.5	0.2	1.1	0.5	1.5	1.0
Medication: Omeprazole (e.g. Zanprol)	0.6	0.7	2.7	1.7	0.4	-0.2	0.8	-0.7	0.2
Depression (Nagel 2018)	0.5	0.7	1.6	0.8	0.3	0.8	1.3	1.0	0.4
Ulcerative Colitis (UC)	0.5	1.0	1.7	0.7	-1.2	-1.3	-0.5	-1.3	0.5
Breast Cancer	0.5	1.2	1.9	-1.3	0.8	-0.7	-1.3	-1.0	-1.4
LDL Cholesterol	0.5	0.9	2.2	-1.4	-0.5	-1.5	-0.3	0.8	-0.0
Neuroticism	0.5	1.3	4.1	1.6	0.5	-0.2	1.0	-0.2	2.0
Chronotype (morning person)	0.5	1.2	3.2	0.6	-1.7	-0.7	0.3	-1.8	-0.7
Mouth/teeth dental problems	0.5	0.7	2.4	-0.4	0.8	0.6	0.7	1.6	0.4
Allergy	0.5	1.1	2.8	1.1	-1.1	-0.7	-0.7	-1.7	-0.7
Gout (self-reported)	0.5	0.7	1.9	0.1	1.3	-0.7	-0.1	-0.2	1.4
Alcohol intake frequency.	0.5	1.2	3.7	1.1	-0.5	-1.2	-0.4	-0.7	1.9
Comparative height size at age 10	0.5	2.7	7.2	1.0	-2.0	-0.3	0.4	-1.9	-2.7
Age at last live birth	0.5	0.7	2.0	-0.3	0.6	1.0	0.5	1.4	-0.8
Medication: Aspirin	0.5	0.6	1.9	1.4	-0.5	0.2	0.9	0.1	0.8
Average weekly red wine intake	0.5	0.7	1.9	1.4	-0.8	0.1	0.7	-0.8	0.8
Diabetes diagnosed by doctor	0.5	0.8	1.8	0.2	1.3	0.8	1.1	1.0	0.1
Back pain experienced in last month	0.5	0.7	1.7	1.1	-0.3	-1.1	0.1	-1.3	0.7
Number of self-reported non-cancer illnesses	0.5	0.9	1.7	-1.1	1.0	0.7	0.1	1.3	-1.0
Ever taken oral contraceptive pill	0.5	0.5	0.8	-0.9	0.8	0.0	-0.7	-0.6	-0.8
Medication: Bendroflumethiazide	0.5	0.7	1.1	0.4	1.0	0.9	0.7	1.1	-0.8
Alcohol drinker status: Previous	0.5	0.6	1.9	-1.4	0.6	-0.5	-1.0	0.3	-0.4
Coronary Artery Disease (CAD)	0.4	0.4	2.0	0.2	0.6	-0.0	-0.1	-1.4	-0.4
Ulcerative Colitis	0.4	0.6	1.3	-0.4	1.0	-0.4	-0.6	-1.1	-0.6
Height	0.4	7.7	37.0	0.6	-1.5	0.9	0.4	-2.3	-6.1
Smoking Status	0.4	0.9	3.3	1.8	-0.8	0.2	0.7	-0.7	0.5
Respiratory disease	0.4	0.9	3.1	-1.8	0.9	0.6	-0.1	0.8	-0.4
Relative age of first facial hair	0.4	0.8	3.6	0.1	1.9	0.3	-0.2	0.2	-1.1
Ever had hysterectomy (womb removed)	0.4	0.5	1.4	0.8	-1.2	-0.6	-0.1	-0.7	-0.1
Vitamin and mineral supplements	0.4	0.5	2.1	-0.4	1.5	0.2	-0.1	0.2	-0.7
Supplements: Zinc	0.4	0.5	0.7	0.7	0.1	0.6	0.8	0.8	0.7
Medication: Co-codamol	0.4	0.5	0.9	0.3	0.6	-0.9	-0.4	-0.9	0.9
Diabetes (mother)	0.4	0.5	0.9	0.9	0.3	0.0	0.7	-0.9	0.8
Pack years adult smoking proportion	0.4	0.6	1.6	-0.1	1.3	0.8	0.9	0.4	-0.5
Impedance of leg (left)	0.4	2.2	7.7	-0.4	-1.6	0.9	0.8	1.0	-2.8
Past tobacco smoking	0.4	0.8	1.7	1.3	0.2	-0.1	1.1	-0.2	1.3
Weight	0.4	2.0	7.2	2.7	0.2	-0.5	0.6	-2.0	0.4
Pulse rate	0.4	0.7	1.7	-1.2	0.2	-0.5	-1.0	-0.2	-1.3
Breastfed as a baby	0.4	0.6	1.9	-0.4	0.5	-0.1	0.2	1.0	1.4
Medication: Ventolin 100micrograms inhaler	0.4	0.5	0.9	-0.9	0.7	0.7	0.4	1.0	0.4
Medication for pain relief, constipation, heartburn	0.4	0.7	1.8	-1.3	-0.1	1.0	-0.3	1.0	-0.7
Heart disease (mother)	0.4	0.5	0.9	0.4	0.6	0.4	0.8	1.0	0.7
Forced expiratory volume in 1-second (FEV1), predicted	0.4	0.7	2.3	1.5	-1.0	0.2	0.2	-1.0	-0.5
Mineral and other dietary supplements	0.4	0.5	1.0	-1.0	1.0	-0.3	-0.5	0.7	-0.6
Wears glasses or contact lenses	0.4	0.4	1.0	0.6	0.6	1.0	0.5	0.7	-0.3
Mother’s age at death	0.4	0.5	1.2	-0.5	-1.1	0.5	-0.0	0.7	-1.0
Unable to work because of sickness or disability	0.4	0.5	1.2	-0.2	1.1	0.6	0.8	0.5	-0.4
Impedance of whole body	0.4	2.0	5.7	-1.1	-2.1	-0.4	-0.3	0.7	-2.4
Neuroticism (Nagel 2018)	0.3	0.7	1.8	1.2	0.1	0.1	0.9	0.3	1.3
Body Mass Index (BMI) (2010)	0.3	0.5	1.5	0.5	1.2	0.8	-0.1	0.4	0.5
HbA1C	0.3	0.3	0.7	-0.6	0.5	0.1	-0.6	-0.5	-0.8
Lupus	0.3	0.5	1.0	0.4	-0.7	-1.0	-0.8	-0.8	0.5
Leg fat-free mass (left)	0.3	1.6	5.9	1.8	-0.1	-0.7	-0.1	-2.4	0.2
Multivitamins +/- minerals	0.3	0.4	0.6	0.5	-0.8	0.7	0.8	0.3	0.7
Leg predicted mass (left)	0.3	1.6	5.8	1.7	-0.0	-0.7	-0.1	-2.4	0.1
Waist circumference	0.3	1.2	3.2	1.4	0.5	-1.2	-0.3	-1.8	-0.5
Nervous feelings	0.3	0.6	2.0	-1.4	0.2	-0.1	-0.6	1.1	0.4
Frequency of tenseness / restlessness in last 2 weeks	0.3	0.5	1.3	1.1	0.3	0.6	1.0	0.2	0.8
Pain all over the body in last month	0.3	0.3	1.5	0.4	1.2	0.2	0.5	-0.1	0.1
Diabetes (self-reported)	0.3	0.5	0.9	0.1	0.7	0.8	1.0	1.0	0.1
Impedance of arm (right)	0.3	1.4	3.5	-0.7	-1.9	-1.3	-0.8	0.4	-1.3
Trunk fat-free mass	0.3	1.5	4.5	1.4	0.2	0.6	0.5	-2.1	-1.5
Hip circumference	0.3	1.1	2.7	1.6	0.5	-0.9	-0.2	-1.5	0.7
Medication: Ibuprofen (e.g. Nurofen)	0.3	0.3	0.7	0.2	0.6	0.6	0.9	0.7	0.4
Medication: Lansoprazole	0.3	0.4	0.8	0.8	0.5	0.0	0.6	0.4	0.9
Impedance of arm (left)	0.3	1.4	3.5	-0.9	-1.9	-1.4	-0.8	0.3	-1.1
Trunk predicted mass	0.3	1.6	4.8	1.3	0.2	0.6	0.4	-2.2	-1.6
Seen doctor (GP) for nerves, anxiety, tension or depression	0.3	0.4	1.0	-1.0	1.0	0.1	-0.3	0.2	-0.7
Medication for cholesterol, blood pressure or diabetes	0.3	0.6	1.7	0.7	-1.3	-0.9	-0.2	-0.3	0.6
Medication: Amlodipine	0.3	0.5	1.1	-0.8	1.0	0.2	-0.3	1.1	0.1
Arm fat-free mass (right)	0.3	1.6	3.9	1.9	0.2	0.7	0.9	-2.0	-0.7
Number of full brothers	0.3	0.3	0.9	-0.2	0.9	0.5	0.7	0.4	0.5
Reason for reducing amount of alcohol drunk: Health precaution	0.3	0.3	1.0	-0.1	0.8	0.3	0.3	1.0	0.1
Eye problems/disorders: None of the above	0.3	0.4	1.8	-0.3	-0.1	-0.3	-0.4	-1.3	-0.4
Arm predicted mass (right)	0.3	1.6	4.1	2.0	0.5	1.1	1.3	-1.5	-0.6
Supplements: Vitamin C	0.3	0.4	1.7	0.3	-0.5	-0.1	0.2	0.5	1.3
Illnesses of father: Heart disease	0.3	0.5	1.4	0.4	0.5	1.2	0.9	0.3	0.1
Leg fat-free mass (right)	0.3	1.5	5.4	1.8	0.3	-0.6	-0.1	-2.3	0.3
Whole body water mass	0.3	1.5	5.3	1.7	0.1	0.1	0.3	-2.3	-0.7
Leg predicted mass (right)	0.3	1.4	5.1	1.8	0.2	-0.5	-0.0	-2.3	0.2
Financial situation satisfaction	0.3	0.4	1.3	0.5	-0.7	0.7	1.1	0.3	-0.1
Tinnitus: Yes, now most or all of the time	0.3	0.3	0.8	0.0	-0.1	-0.7	-0.9	-0.0	0.8
Basal metabolic rate	0.3	1.5	5.1	1.9	0.2	-0.0	0.4	-2.3	-0.7
Arm fat-free mass (left)	0.3	1.4	3.0	1.7	0.2	0.8	0.8	-1.6	-1.1
Risk taking	0.3	0.4	0.7	0.9	-0.6	0.7	0.5	-0.3	-0.9
Pack years of smoking	0.3	0.5	1.8	-0.0	1.3	0.6	0.7	0.1	-0.4
Arm predicted mass (left)	0.3	1.3	2.8	1.7	0.0	0.8	0.7	-1.7	-1.1
Tanning	0.2	3.0	7.2	2.4	-0.7	-1.4	-0.0	-2.7	1.7
Sensitivity / hurt feelings	0.2	0.3	1.3	1.1	-0.0	-0.0	0.6	-0.0	0.4
Medication for hormone replacement therapy	0.2	0.2	0.7	-0.3	0.0	0.6	0.4	0.8	-0.1
Medication: Metformin	0.2	0.3	0.5	-0.0	0.6	-0.7	-0.3	-0.7	0.5
Relative age voice broke	0.2	0.3	1.0	0.2	1.0	-0.5	-0.4	-0.2	0.2
Supplements: Glucosamine	0.2	0.3	0.9	-0.3	-0.5	0.4	0.2	-0.3	-1.0
Medication: Atenolol	0.2	0.2	0.9	0.9	-0.4	0.0	0.4	0.0	0.2
Qualifications: None of the above	0.2	0.5	1.5	0.7	-0.2	-1.2	-0.3	-0.8	0.4
Frequency of tiredness / lethargy in last 2 weeks	0.2	0.3	0.8	0.1	0.9	-0.7	-0.5	-0.7	-0.2
Hair/balding pattern: Pattern 3	0.2	0.4	1.8	-0.0	-0.3	-0.5	-0.3	-0.2	1.3
Serious illness, injury or assault of a close relative in last 2 years	0.2	0.2	0.5	-0.1	0.6	0.3	0.7	0.5	-0.0
Mouth/teeth dental problems: Dentures	0.2	0.4	2.0	-0.2	1.4	0.1	0.1	-0.1	-0.2
Depression (self-reported)	0.2	0.2	0.5	-0.1	0.7	0.4	0.6	0.2	0.4
Lung cancer (father)	0.2	0.2	0.7	0.4	-0.3	-0.6	-0.1	0.3	0.8
Pulse wave Arterial Stiffness index	0.2	0.2	0.5	0.5	0.4	0.5	0.7	-0.5	-0.1
Exposure to tobacco smoke at home	0.2	0.2	0.3	-0.4	-0.6	0.2	0.4	0.4	0.5
Worry too long after embarrassment	0.2	0.3	0.5	-0.7	0.6	-0.4	-0.6	-0.2	-0.4
Pulse wave peak to peak time	0.2	0.2	0.5	-0.3	-0.6	-0.5	-0.7	0.2	-0.3
Health satisfaction	0.2	0.3	0.8	-0.6	0.3	-0.0	-0.1	0.6	-0.9
Emphysema/chronic bronchitis	0.2	0.3	0.9	-0.9	-0.2	0.1	-0.1	0.4	-0.6
Overall health rating	0.2	0.4	1.6	-0.2	1.3	-0.7	-0.2	0.1	-0.6
Commuting to job workplace: Car/motor vehicle	0.2	0.2	0.4	-0.5	0.4	0.3	-0.4	0.6	-0.6
Whole body fat-free mass	0.2	1.4	4.7	1.6	0.2	0.2	0.4	-2.2	-0.9
Mouth/teeth dental problems: Mouth ulcers	0.2	0.3	1.4	-0.1	-1.2	0.1	-0.4	-0.6	-0.3
Medication: Atorvastatin	0.2	0.3	0.5	0.5	-0.4	-0.7	-0.4	-0.7	-0.4
Ever smoked	0.2	0.4	0.9	-0.0	0.9	0.9	0.5	0.5	0.0
Worry (Nagel 2018)	0.1	0.2	0.5	-0.7	0.2	0.2	0.1	0.7	0.5
Blood Platelet Count	0.1	0.9	3.4	1.1	-1.9	-0.4	0.5	0.0	-0.4
Type 2 Diabetes (T2D) (2018)	0.1	0.3	0.6	0.1	0.8	-0.8	-0.1	-0.6	-0.1
Eye problems/disorders: Diabetes related eye disease	0.1	0.2	0.6	-0.0	-0.8	-0.2	-0.4	0.3	-0.1
Angina	0.1	0.1	0.6	-0.0	0.1	0.3	0.1	0.2	-0.8
Average weekly fortified wine intake	0.1	0.1	0.3	-0.2	0.3	0.6	0.6	0.2	0.1
Frequency of unenthusiasm / disinterest in last 2 weeks	0.1	0.1	0.2	0.3	0.4	0.0	0.4	0.2	0.4
Taking other prescription medications	0.1	0.1	0.2	0.4	0.5	-0.3	0.1	-0.4	0.5
Age when periods started (menarche)	0.1	0.1	0.3	-0.3	-0.3	-0.3	-0.5	-0.4	-0.4
Had menopause	0.1	0.1	0.3	-0.5	-0.3	0.1	0.3	0.4	-0.5
Heart attack	0.1	0.1	0.3	0.5	0.2	0.2	0.3	0.1	0.0
Medication: Ramipril	0.1	0.1	0.3	0.5	-0.3	-0.3	0.0	-0.2	-0.1
Medication: Simvastatin	0.1	0.1	0.3	-0.0	-0.1	0.5	0.5	0.2	-0.2
Father’s age at death	0.1	0.1	0.4	0.7	0.1	-0.2	-0.1	-0.0	0.4
Worrier / anxious feelings	0.1	0.2	0.7	-0.6	-0.6	0.3	0.2	0.8	0.0
Medication: Cholesterol lowering	0.1	0.2	0.7	-0.3	0.9	0.4	0.3	0.1	0.1
Illnesses of mother	0.1	0.1	0.5	0.7	-0.0	0.4	0.2	-0.1	-0.1
Tense / ‘highly strung’	0.1	0.2	0.5	-0.2	0.7	0.1	0.3	0.4	0.4
Pulse wave reflection index	0.1	0.1	0.3	0.1	-0.4	0.3	0.5	-0.6	0.1
Exposure to tobacco smoke outside home	0.1	0.1	0.4	0.1	-0.7	0.1	0.0	-0.3	-0.2
Mouth/teeth dental problems: Loose teeth	0.1	0.1	0.3	-0.4	0.3	0.3	-0.3	-0.2	-0.6
Angina (self-reported)	0.1	0.2	0.3	0.2	0.3	0.5	0.4	0.4	-0.5
Leg pain on walking	0.1	0.2	0.3	0.6	0.2	-0.2	0.2	-0.6	-0.5
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.1	0.2	0.4	-0.3	-0.3	-0.6	-0.5	-0.2	-0.5
Handedness (chirality/laterality): Left-handed	0.1	0.2	0.6	-0.5	-0.2	-0.2	-0.7	0.0	-0.3
Commuting to job workplace: Walk	0.1	0.1	0.3	0.5	-0.2	0.6	0.4	0.1	0.1
Osteoarthritis (self-reported)	0.1	0.1	0.4	0.3	-0.6	0.3	-0.3	0.3	0.1
Hearing aid user	0.1	0.1	0.4	-0.1	0.6	-0.2	-0.1	-0.3	-0.1
High cholesterol (Self-reported)	0.1	0.2	0.6	-0.1	0.8	0.5	0.5	0.4	0.0
Number of operations (self-reported)	0.1	0.2	0.6	0.4	0.3	-0.5	-0.3	-0.3	0.7
Commuting to job workplace: Cycle	0.1	0.1	0.7	0.0	-0.0	-0.3	-0.2	-0.8	-0.1
Heart attack/myocardial infarction (self-reported)	0.1	0.1	0.5	0.7	0.2	0.1	0.3	-0.1	0.0
Bipolar Disorder (2011)	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Hair Pigment	0.0	1.1	4.3	0.4	1.2	0.1	-0.2	-0.8	2.1
Forced expiratory volume in 1-second (FEV1)	0.0	0.2	0.4	0.0	0.6	0.4	0.3	0.1	-0.6
Forced expiratory volume in 1-second (FEV1), Best measure	0.0	0.1	0.2	0.1	0.5	0.0	0.1	-0.4	-0.4
Age started oral contraceptive pill	0.0	0.0	0.1	0.2	0.3	-0.1	-0.1	-0.1	0.2

Hub : Genes

FHOD1

Models

Trait associations