Best TWAS P=1.76e-08 · Best GWAS P=2.68e-07 conditioned to 0.777
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Artery Tibial | NPC1 | 0.26 | 0.07 | enet | 31 | 0.11 | 3.7e-09 | 4.3 | -5.4 | 6.4e-08 | 0.80 | 0.06 | 0.92 | FALSE |
| 2 | GTEx | Nerve Tibial | C18orf8 | 0.16 | 0.07 | enet | 21 | 0.09 | 3.9e-07 | -4.5 | -5.6 | 1.8e-08 | 0.89 | 0.02 | 0.97 | TRUE |
| 3 | GTEx | Thyroid | NPC1 | 0.20 | 0.10 | enet | 25 | 0.13 | 2.3e-10 | -5.1 | -5.5 | 3.2e-08 | 0.90 | 0.01 | 0.98 | FALSE |
| 4 | The Cancer Genome Atlas | Thyroid Carcinoma | NPC1 | 0.04 | 0.03 | blup | 70 | 0.05 | 9.4e-06 | -4.9 | -5.1 | 2.9e-07 | 0.88 | 0.03 | 0.96 | FALSE |