Best TWAS P=1.17e-08 · Best GWAS P=1.17e-08 conditioned to 1
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | GTEx | Cells Transformed fibroblasts | IPP | 0.04 | 0.08 | lasso | 1 | 0.08 | 2.3e-06 | 5.7 | -5.7 | 1.2e-08 | -1.00 | 0.03 | 0.97 | TRUE |
2 | GTEx | Colon Transverse | GPBP1L1 | 0.06 | 0.01 | lasso | 6 | 0.01 | 8.3e-02 | 5.4 | -5.4 | 8.5e-08 | -0.88 | 0.08 | 0.78 | FALSE |
3 | GTEx | Esophagus Mucosa | GPBP1L1 | 0.04 | 0.02 | lasso | 3 | 0.02 | 1.5e-02 | 5.5 | -5.5 | 3.3e-08 | -0.97 | 0.05 | 0.79 | FALSE |
4 | GTEx | Esophagus Muscularis | CCDC17 | 0.04 | 0.04 | lasso | 6 | 0.01 | 9.1e-02 | 5.7 | -5.7 | 1.6e-08 | -1.00 | 0.04 | 0.91 | FALSE |
5 | GTEx | Lung | GPBP1L1 | 0.04 | 0.02 | enet | 14 | 0.02 | 5.8e-03 | 5.5 | -5.5 | 3.7e-08 | -0.89 | 0.07 | 0.88 | FALSE |
6 | GTEx | Muscle Skeletal | GPBP1L1 | 0.03 | 0.02 | enet | 19 | 0.03 | 7.2e-04 | 5.1 | -5.2 | 2.4e-07 | -0.84 | 0.07 | 0.88 | FALSE |
7 | GTEx | Skin Not Sun Exposed Suprapubic | CCDC17 | 0.10 | 0.13 | lasso | 6 | 0.13 | 9.6e-08 | 5.5 | -5.7 | 1.3e-08 | -0.98 | 0.03 | 0.97 | FALSE |
8 | GTEx | Skin Not Sun Exposed Suprapubic | GPBP1L1 | 0.09 | 0.02 | enet | 11 | 0.02 | 3.5e-02 | 5.4 | -5.2 | 2.0e-07 | -0.93 | 0.05 | 0.94 | FALSE |
9 | GTEx | Skin Sun Exposed Lower leg | GPBP1L1 | 0.03 | 0.00 | lasso | 5 | 0.00 | 4.8e-01 | 2.9 | -5.2 | 1.9e-07 | -0.78 | 0.07 | 0.57 | FALSE |
10 | GTEx | Testis | PIK3R3 | 0.08 | 0.05 | enet | 7 | 0.06 | 1.5e-03 | 5.5 | -5.3 | 9.4e-08 | -0.99 | 0.07 | 0.88 | FALSE |
11 | GTEx | Testis | IPP | 0.05 | 0.06 | enet | 8 | 0.03 | 1.4e-02 | 5.5 | 5.5 | 3.0e-08 | 0.97 | 0.05 | 0.84 | FALSE |
12 | GTEx | Testis | RP11-767N6.2 | 0.05 | 0.00 | enet | 14 | 0.01 | 1.1e-01 | 5.5 | 5.1 | 2.9e-07 | 0.86 | 0.07 | 0.72 | FALSE |
13 | ROSMAP | Brain Pre-frontal Cortex | IPP | 0.08 | 0.15 | lasso | 9 | 0.14 | 5.0e-18 | 5.3 | -5.2 | 1.6e-07 | -0.98 | 0.04 | 0.96 | FALSE |
14 | YFS | Blood | CCDC17 | 0.04 | 0.02 | lasso | 8 | 0.02 | 6.8e-08 | 5.5 | -5.4 | 8.1e-08 | -0.95 | 0.04 | 0.96 | FALSE |
15 | The Cancer Genome Atlas | Breast Invasive Carcinoma | GPBP1L1 | 0.01 | 0.02 | lasso | 2 | 0.02 | 1.2e-04 | 5.5 | -5.5 | 4.5e-08 | -0.98 | 0.03 | 0.93 | FALSE |
16 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | GPBP1L1 | 0.03 | 0.04 | lasso | 1 | 0.03 | 8.0e-05 | 5.7 | -5.7 | 1.2e-08 | -1.00 | 0.02 | 0.96 | FALSE |
17 | The Cancer Genome Atlas | Kidney Renal Papillary Cell Carcinoma | GPBP1L1 | 0.07 | 0.10 | lasso | 3 | 0.09 | 6.3e-06 | 5.5 | -5.5 | 4.6e-08 | -0.98 | 0.04 | 0.96 | FALSE |
18 | The Cancer Genome Atlas | Prostate Adenocarcinoma | GPBP1L1 | 0.04 | 0.04 | blup | 50 | 0.04 | 2.9e-05 | 5.5 | -5.5 | 3.3e-08 | -0.97 | 0.03 | 0.96 | FALSE |
19 | The Cancer Genome Atlas | Stomach Adenocarcinoma | IPP | 0.04 | 0.04 | blup | 47 | 0.04 | 1.4e-03 | 4.7 | -5.2 | 1.6e-07 | -0.95 | 0.03 | 0.77 | FALSE |
20 | The Cancer Genome Atlas | Thyroid Carcinoma | GPBP1L1 | 0.11 | 0.06 | lasso | 3 | 0.06 | 1.6e-06 | 5.5 | -5.7 | 1.5e-08 | -0.98 | 0.02 | 0.98 | FALSE |