Best TWAS P=2.4e-10 · Best GWAS P=1.26e-14 conditioned to 1.8e-06
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | ELOVL1 | 0.04 | 0.01 | enet | 11 | 0.01 | 6.3e-03 | 5.1 | -5.3 | 9.2e-08 | -0.42 | 0.69 | 0.06 | FALSE |
| 2 | GTEx | Adipose Subcutaneous | MED8 | 0.07 | 0.00 | enet | 8 | 0.01 | 4.5e-02 | 5.0 | 5.3 | 1.3e-07 | 0.57 | 0.54 | 0.14 | FALSE |
| 3 | GTEx | Adipose Visceral Omentum | TIE1 | 0.13 | 0.09 | lasso | 4 | 0.06 | 7.5e-04 | 4.8 | -5.2 | 2.5e-07 | -0.45 | 0.56 | 0.06 | FALSE |
| 4 | GTEx | Artery Aorta | MED8 | 0.10 | 0.05 | enet | 13 | 0.08 | 4.6e-05 | 4.9 | 5.5 | 4.3e-08 | 0.48 | 0.88 | 0.02 | FALSE |
| 5 | GTEx | Breast Mammary Tissue | TIE1 | 0.08 | 0.06 | lasso | 5 | 0.08 | 7.1e-05 | 5.1 | -5.4 | 5.4e-08 | -0.51 | 0.61 | 0.14 | FALSE |
| 6 | GTEx | Breast Mammary Tissue (Female) | TIE1 | 0.10 | 0.07 | enet | 10 | 0.07 | 3.5e-03 | 5.5 | -6.2 | 6.5e-10 | -0.61 | 0.14 | 0.20 | FALSE |
| 7 | GTEx | Cells Transformed fibroblasts | RP1-92O14.6 | 0.12 | 0.02 | lasso | 5 | 0.03 | 3.6e-03 | 4.9 | -5.2 | 1.7e-07 | -0.47 | 0.84 | 0.01 | FALSE |
| 8 | GTEx | Heart Left Ventricle | TIE1 | 0.22 | 0.04 | lasso | 11 | 0.04 | 5.3e-03 | 4.9 | -6.0 | 1.5e-09 | -0.65 | 0.38 | 0.56 | FALSE |
| 9 | GTEx | Heart Left Ventricle | MED8 | 0.08 | 0.01 | lasso | 3 | 0.01 | 1.2e-01 | 6.0 | -6.2 | 6.0e-10 | -0.80 | 0.04 | 0.78 | FALSE |
| 10 | GTEx | Muscle Skeletal | RP11-7O11.3 | 0.05 | 0.02 | lasso | 3 | 0.02 | 7.2e-03 | -4.4 | 6.0 | 2.5e-09 | 0.44 | 0.11 | 0.31 | FALSE |
| 11 | GTEx | Nerve Tibial | MED8 | 0.13 | 0.07 | enet | 11 | 0.16 | 3.6e-11 | 5.0 | 6.3 | 2.4e-10 | 0.64 | 0.93 | 0.07 | TRUE |
| 12 | GTEx | Pancreas | HYI | 0.22 | 0.16 | enet | 9 | 0.20 | 9.7e-09 | -4.3 | -5.2 | 2.5e-07 | -0.40 | 0.97 | 0.00 | FALSE |
| 13 | GTEx | Testis | MED8 | 0.21 | 0.14 | lasso | 3 | 0.20 | 1.8e-09 | -4.7 | -5.5 | 2.9e-08 | -0.45 | 0.99 | 0.00 | FALSE |
| 14 | GTEx | Thyroid | TIE1 | 0.10 | 0.05 | lasso | 3 | 0.05 | 1.3e-04 | 4.8 | -5.1 | 3.1e-07 | -0.44 | 0.70 | 0.06 | FALSE |
| 15 | ROSMAP | Brain Pre-frontal Cortex | TMEM125 | 0.02 | 0.01 | lasso | 4 | 0.01 | 7.4e-03 | 4.8 | -6.3 | 3.0e-10 | -0.70 | 0.24 | 0.34 | FALSE |
| 16 | The Cancer Genome Atlas | Bladder Urothelial Carcinoma | C1orf84 | 0.02 | 0.02 | blup | 44 | 0.01 | 2.0e-02 | 5.0 | -5.2 | 1.9e-07 | -0.55 | 0.02 | 0.73 | FALSE |
| 17 | The Cancer Genome Atlas | Bladder Urothelial Carcinoma | MED8 | 0.03 | 0.00 | blup | 38 | 0.01 | 2.1e-02 | 5.0 | -5.3 | 9.3e-08 | -0.53 | 0.01 | 0.52 | FALSE |
| 18 | The Cancer Genome Atlas | Breast Invasive Carcinoma | C1orf84 | 0.02 | 0.03 | blup | 46 | 0.03 | 3.4e-07 | 5.0 | -5.2 | 2.1e-07 | -0.50 | 0.04 | 0.96 | FALSE |
| 19 | The Cancer Genome Atlas | Brain Lower Grade Glioma | TIE1 | 0.02 | 0.02 | blup | 46 | 0.02 | 9.0e-04 | 5.1 | -5.2 | 1.6e-07 | -0.44 | 0.01 | 0.87 | FALSE |
| 20 | The Cancer Genome Atlas | Lung Squamous Cell Carcinoma | MED8 | 0.03 | 0.01 | lasso | 4 | 0.02 | 6.2e-03 | -4.7 | -5.2 | 1.7e-07 | -0.46 | 0.02 | 0.59 | FALSE |
| 21 | The Cancer Genome Atlas | Rectum Adenocarcinoma | HYI | 0.23 | 0.08 | blup | 34 | 0.14 | 3.1e-04 | -4.3 | -5.2 | 2.5e-07 | -0.44 | 0.03 | 0.38 | FALSE |
| 22 | The Cancer Genome Atlas | Testicular Germ Cell Tumors | MED8 | 0.26 | 0.18 | blup | 39 | 0.24 | 3.5e-09 | 5.3 | -5.3 | 1.3e-07 | -0.48 | 0.02 | 0.98 | FALSE |
| 23 | The Cancer Genome Atlas | Thyroid Carcinoma | C1orf210 | 0.04 | 0.02 | lasso | 2 | 0.01 | 1.4e-02 | 5.3 | 5.3 | 1.4e-07 | 0.45 | 0.01 | 0.94 | FALSE |
| 24 | The Cancer Genome Atlas | Thyroid Carcinoma | TIE1 | 0.03 | 0.03 | blup | 46 | 0.03 | 6.1e-04 | 5.1 | -5.1 | 3.1e-07 | -0.43 | 0.02 | 0.96 | FALSE |