Hub : Genes

IPP

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Cells Transformed fibroblasts	0.0440	0.0220	1.8e-04	0.080	NA	0.052	NA	0.076	1.3e-06	NA	8.7e-05	NA	2.3e-06
2	GTEx	Muscle Skeletal	0.1547	0.1053	6.9e-04	0.009	NA	0.041	NA	0.031	3.6e-02	NA	6.4e-05	NA	4.6e-04
3	GTEx	Nerve Tibial	0.0674	0.0396	5.7e-04	0.040	NA	0.050	NA	0.048	8.3e-04	NA	1.9e-04	NA	2.5e-04
4	GTEx	Testis	0.0540	0.0330	4.5e-03	0.060	NA	0.032	NA	0.029	1.2e-03	NA	1.4e-02	NA	1.9e-02
5	GTEx	Thyroid	0.0850	0.0450	6.7e-05	0.074	NA	0.073	NA	0.082	2.7e-06	NA	3.0e-06	NA	7.1e-07
6	ROSMAP	Brain Pre-frontal Cortex	0.0826	0.0302	3.9e-16	0.150	0.139	0.140	0.139	0.144	8.2e-19	1.6e-17	1.5e-17	1.8e-17	5.0e-18
7	YFS	Blood	0.0971	0.0285	0.0e+00	0.114	0.110	0.116	0.106	0.117	2.7e-35	4.6e-34	5.8e-36	9.5e-33	4.6e-36
8	TCGA	Stomach Adenocarcinoma	0.0370	0.0330	3.3e-03	0.035	0.035	0.017	NA	0.032	1.3e-03	1.4e-03	2.1e-02	NA	2.1e-03

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7	8
Bipolar Disorder (2018)	0.2	0.3	0.8	-0.2	-0.7	0.8	0.5	0.9	-0.4	-0.2	-0.2
Bipolar Disorder or Schizophrenia	0.2	0.5	1.7	-0.4	-1.3	0.3	0.5	1.0	-0.5	-0.5	-0.4
Depressed Affect (Nagel 2018)	0.8	1.7	3.1	-1.1	-1.0	-1.7	0.6	-1.8	-1.1	-1.1	-1.4
Depression (Nagel 2018)	0.5	0.8	1.9	-0.7	0.5	-0.9	0.4	-1.4	-0.9	-0.9	-1.0
Intelligence (Savage-Jansen 2018)	0.2	0.6	1.7	-0.6	-0.8	0.3	1.3	0.4	-0.5	-1.0	-0.7
Neuroticism (Nagel 2018)	1.4	3.3	4.5	-1.7	-1.9	-1.7	1.5	-1.6	-1.9	-2.0	-2.1
Schizophrenia (2018)	0.1	0.3	1.2	-0.3	-1.1	-0.3	0.3	0.6	-0.4	-0.5	-0.3
Schizophrenia vs Biploar Disorder	1.0	1.4	4.5	-0.5	0.7	-1.9	0.5	-2.1	-0.7	-0.6	-0.9
Worry (Nagel 2018)	0.7	1.4	2.6	-1.0	-0.2	-1.4	0.7	-1.6	-1.2	-1.2	-1.5
Alzheimer’s Disease (in mother)	0.7	0.8	1.3	1.1	0.6	0.5	-1.0	1.1	1.0	0.8	1.0
Alzheimer’s Disease (in father)	1.0	1.1	2.0	1.0	-0.1	0.8	-1.3	1.0	1.1	1.4	1.0
Alzheimer’s Disease (including proxy)	1.2	1.8	3.2	1.4	0.1	0.9	-1.5	1.8	1.4	1.5	1.4
Crohns Disease (2017)	0.7	1.5	3.2	-1.6	-0.8	-1.8	0.9	-1.3	-1.2	-0.8	-1.1
Irritable Bowel Disease (IBD)	2.6	6.1	9.2	-3.0	-2.1	-3.0	2.4	-2.0	-2.6	-2.0	-2.5
Ulcerative Colitis (UC)	3.8	7.1	10.0	-3.2	-2.2	-2.8	2.8	-2.1	-2.8	-2.4	-2.9
Major Depression (MDD)	0.9	1.1	1.5	1.2	-1.2	0.1	-1.0	0.8	1.1	1.2	1.0
Reaction Time	1.3	2.4	4.6	-1.6	-0.7	-2.1	1.2	-2.0	-1.5	-1.3	-1.5
Verbal and Numeric Reasoning (VNR)	0.3	0.7	1.9	-0.6	-0.9	-0.5	1.4	-0.5	-0.5	-1.1	-0.7
Breast Cancer	6.6	16.0	25.8	-4.4	-3.6	-3.5	5.1	-2.2	-4.6	-3.9	-4.1
Ovarian Cancer	0.6	0.8	1.1	0.8	0.5	0.9	-0.8	0.8	1.1	1.0	1.0
Prostate Cancer	0.8	1.1	1.7	1.1	0.9	-0.2	-1.3	-1.2	1.1	1.3	0.9
Age at First Birth	3.4	5.0	7.7	-2.5	-1.8	-1.4	2.7	-0.9	-2.6	-2.8	-2.5
Bipolar Disorder (2011)	1.6	1.6	2.3	-1.5	-0.9	-1.0	1.4	-0.9	-1.5	-1.3	-1.3
Body Mass Index (BMI) (2010)	3.2	4.4	6.2	2.2	0.8	1.8	-2.3	2.2	2.1	2.4	2.5
Coronary Artery Disease (CAD)	1.1	1.3	2.2	1.1	0.2	0.9	-1.3	0.8	1.4	1.5	1.4
Crohns Disease (2012)	1.0	1.7	3.1	-1.8	-0.3	-1.3	1.1	-0.9	-1.8	-1.2	-1.4
Mean Putamen Volume	0.3	0.3	1.5	0.2	-1.2	-0.7	-0.1	-0.7	-0.0	-0.1	-0.2
Fasting Glucose	3.0	3.6	8.3	0.8	2.2	2.0	-2.9	1.6	1.8	1.7	1.6
HbA1C	1.7	1.8	5.8	2.4	0.9	0.1	-1.2	0.3	1.8	1.3	1.1
HDL Cholesterol	2.3	3.8	12.1	0.8	1.7	3.5	-0.9	3.0	1.0	1.3	1.5
LDL Cholesterol	0.2	0.3	0.6	0.5	-0.7	-0.4	-0.3	-0.4	0.4	0.8	0.7
Lupus	0.1	0.1	0.6	0.3	-0.4	-0.1	0.5	0.8	-0.2	-0.3	-0.0
Neuroticism (2016)	2.1	3.0	5.1	-1.9	-1.8	-0.8	1.9	-0.1	-2.3	-2.0	-1.9
Primary Biliary Cirrhosis	0.3	0.5	1.0	0.5	0.6	0.6	-0.7	1.0	0.6	0.6	0.7
Rheumatoid Arthritis	3.2	4.4	5.9	1.9	1.7	2.0	-2.1	1.8	2.2	2.4	2.4
Schizophrenia (2014)	0.3	0.6	1.0	-0.7	-0.8	-1.0	0.5	-0.0	-0.9	-1.0	-0.9
Triglycerides	0.2	0.3	1.1	0.1	0.1	-1.0	0.0	-1.0	0.1	-0.3	-0.4
Type 2 Diabetes (T2D) (2012)	4.0	4.6	6.8	2.0	2.3	1.9	-2.3	1.7	1.9	2.6	2.3
Ulcerative Colitis	4.5	6.5	8.9	-3.0	-2.5	-2.2	2.7	-1.8	-2.7	-2.6	-2.8
Blood Eosinophil Count	0.5	3.6	9.5	1.6	0.8	-3.1	-1.6	-3.0	1.4	1.4	0.8
Blood Platelet Count	12.4	143.9	219.0	12.0	13.0	9.7	-14.8	9.3	11.8	12.2	12.3
Blood Red Count	22.0	212.2	306.2	-13.4	-9.2	-16.6	14.3	-17.5	-14.2	-14.2	-15.6
Blood White Count	1.9	13.8	63.7	-0.1	0.5	-6.4	-0.1	-8.0	-0.7	-0.8	-2.1
Heel T-Score	0.9	7.1	14.5	-2.5	-3.8	-1.6	3.1	-2.1	-2.6	-2.6	-2.4
BMI	4.1	23.6	29.9	5.2	3.0	4.4	-5.4	4.4	5.3	5.2	5.5
Height	4.4	85.4	116.6	-10.8	-4.6	-8.0	10.1	-8.1	-10.5	-9.6	-10.6
Waist Hip Ratio (WHR)	0.3	1.2	5.2	-0.7	-2.3	-1.2	0.8	-1.0	-0.5	-0.6	-0.5
Systolic Blood Pressure	1.6	8.0	16.0	2.0	3.6	4.0	-2.9	3.0	2.2	2.0	2.3
Smoking Status	5.2	12.5	18.3	3.9	3.1	2.6	-4.3	2.0	3.9	4.0	3.9
Allergy or Eczema	2.7	7.2	17.3	1.8	1.3	3.4	-1.8	4.2	2.3	2.6	3.0
Cardiovascular Disease	0.3	1.1	5.3	-0.1	2.3	1.7	-0.4	0.7	-0.1	-0.3	-0.1
Hypothyroidism (self reported)	3.4	7.8	10.7	3.0	1.9	2.5	-3.3	1.9	3.2	3.0	3.1
Respiratory disease	0.6	1.3	4.5	0.4	-0.1	1.9	-0.2	2.1	0.6	0.9	1.1
Type 2 Diabetes (T2D) (2018)	1.1	2.1	3.3	1.6	1.4	0.9	-1.8	0.5	1.7	1.4	1.6
Lung FEV1/FVC ratio	7.9	40.2	65.4	5.0	6.6	8.1	-6.3	7.2	5.2	5.6	6.1
Lung FVC	0.4	2.0	3.6	1.8	1.3	-0.8	-1.9	-1.2	1.5	1.4	1.1
Neuroticism	3.2	7.6	9.5	-2.7	-2.4	-2.7	2.8	-2.3	-3.0	-3.1	-3.0
Chronotype (morning person)	0.2	0.5	1.6	-0.6	-1.3	-0.5	1.0	0.4	-0.3	-0.3	-0.3
Hair Pigment	0.0	0.9	2.5	0.8	1.6	0.0	-1.1	0.1	0.9	1.3	0.6
Tanning	0.1	1.1	2.2	0.8	0.5	1.4	-0.8	1.5	0.8	1.1	1.2
Hand grip strength (left)	1.0	2.5	3.8	-1.9	-1.3	-0.9	1.9	-0.5	-1.9	-1.9	-1.7
Number of treatments/medications taken	2.5	4.5	9.5	1.4	1.1	3.1	-2.0	2.9	1.9	1.6	2.3
Average weekly spirits intake	2.7	3.4	4.4	2.0	1.4	1.8	-2.0	1.2	2.1	2.1	1.9
Sensitivity / hurt feelings	0.2	0.3	1.8	-0.5	-1.4	-0.0	0.6	0.3	-0.4	-0.3	-0.2
Frequency of depressed mood in last 2 weeks	0.1	0.1	0.3	0.2	0.4	0.0	-0.3	-0.5	0.1	0.2	0.1
Hearing difficulty/problems: Yes	12.9	19.6	23.1	-4.5	-3.5	-4.7	4.8	-4.2	-4.7	-4.2	-4.7
Relative age of first facial hair	0.6	1.2	1.9	-0.8	-0.5	-1.4	0.7	-1.4	-1.2	-1.1	-1.3
Other serious medical condition/disability diagnosed by doctor	2.3	3.0	6.9	2.0	2.6	1.2	-1.9	0.4	1.9	1.3	1.6
Ever used hormone-replacement therapy (HRT)	0.6	0.8	1.6	0.8	0.5	1.0	-0.8	1.2	0.9	1.0	0.9
Ever had hysterectomy (womb removed)	3.1	3.6	6.6	2.0	0.9	1.4	-2.6	1.2	2.3	2.0	2.0
Systolic blood pressure, automated reading	2.9	8.5	16.1	2.1	2.4	4.0	-2.8	3.7	2.5	2.3	2.9
Eye problems/disorders: Diabetes related eye disease	1.3	1.4	2.3	-1.0	-1.0	-1.0	1.4	-1.5	-1.1	-1.1	-1.2
Angina	0.7	0.9	1.8	1.3	0.8	0.2	-1.3	-0.1	1.4	0.9	0.9
Medication for hormone replacement therapy	0.2	0.2	0.5	0.5	0.2	-0.6	-0.2	-0.7	0.4	0.4	-0.0
Vitamin and mineral supplements	2.6	3.6	11.5	-1.2	-1.3	-3.4	1.3	-2.7	-1.4	-0.9	-1.4
Supplements: Zinc	2.8	3.1	4.5	1.7	0.4	2.0	-2.0	2.1	1.9	1.5	1.8
Medication: Co-codamol	0.2	0.2	0.5	0.7	-0.1	0.5	-0.7	-0.0	0.7	0.3	0.4
Medication: Metformin	0.9	1.2	2.2	1.5	-0.7	0.7	-0.9	0.9	1.3	1.1	1.5
Diabetes (father)	2.8	3.4	4.9	2.2	1.7	1.1	-2.1	0.4	2.1	2.1	2.2
Diabetes (mother)	4.1	5.2	7.4	2.6	1.3	1.9	-2.7	1.6	2.5	2.6	2.6
Severe depression (siblings)	2.6	2.9	5.3	-2.3	-1.1	0.3	1.8	1.2	-2.1	-2.3	-1.5
Pack years adult smoking proportion	0.0	0.1	0.2	0.3	-0.4	0.1	-0.3	0.1	0.2	0.1	0.1
Impedance of leg (right)	0.2	0.9	1.9	1.1	-0.1	-1.4	-1.0	-1.2	1.0	0.7	0.4
Leg fat-free mass (left)	0.3	1.6	3.6	-1.9	-0.3	0.1	1.7	0.0	-1.7	-1.3	-1.3
Trunk fat percentage	2.0	8.0	11.3	2.8	1.9	2.4	-3.2	2.0	3.1	3.4	3.3
Hand grip strength (right)	0.4	1.1	2.1	-1.1	-1.3	-0.5	1.4	0.3	-1.3	-1.0	-0.8
Townsend deprivation index at recruitment	1.5	2.1	3.5	1.3	1.9	1.6	-1.3	1.0	1.5	1.6	1.4
Current tobacco smoking	4.0	6.6	10.4	2.9	2.1	1.8	-3.2	1.8	2.8	2.8	2.8
Average weekly fortified wine intake	1.5	1.8	2.6	-1.6	-1.3	-0.5	1.6	-0.4	-1.5	-1.6	-1.6
Maternal smoking around birth	6.1	8.9	11.8	3.3	2.7	2.8	-3.2	1.9	3.4	2.9	3.2
Fed-up feelings	0.1	0.1	0.5	-0.2	0.3	-0.7	-0.3	-0.5	-0.2	0.1	0.0
Frequency of unenthusiasm / disinterest in last 2 weeks	0.4	0.5	3.6	0.2	1.9	0.2	-0.4	-0.6	0.0	0.1	0.1
Relative age voice broke	0.5	0.8	4.1	0.7	0.4	-1.1	-0.5	-2.0	0.1	0.1	-0.3
Taking other prescription medications	4.0	6.1	8.7	2.7	1.2	2.1	-3.0	1.9	2.9	2.7	2.9
Age when periods started (menarche)	0.1	0.2	0.5	0.3	0.3	-0.7	-0.6	-0.4	0.2	0.4	0.2
Bilateral oophorectomy (both ovaries removed)	0.9	1.1	2.0	1.1	1.4	-0.0	-1.4	-1.2	1.1	0.8	0.4
Heel bone mineral density (BMD) T-score, automated (left)	0.5	1.1	5.5	-0.7	-2.3	0.0	1.0	0.1	-0.6	-0.9	-0.3
Tinnitus: Yes, but not now, but have in the past	2.7	2.9	5.1	1.7	2.3	1.5	-2.0	0.5	1.6	1.9	1.6
Qualifications: CSEs or equivalent	3.6	4.8	6.0	2.5	2.4	2.1	-2.2	1.5	2.2	2.2	2.1
Serious illness, injury or assault to yourself	0.6	0.8	2.6	-0.2	0.1	-1.6	0.2	-1.5	-0.5	-0.7	-0.7
High blood pressure	0.3	0.7	1.7	-0.9	1.2	1.3	0.1	0.7	-0.8	-0.6	-0.4
Hayfever, allergic rhinitis or eczema	2.3	4.9	14.8	1.3	1.2	2.8	-1.5	3.9	1.7	1.8	2.3
Multivitamins +/- minerals	4.3	5.4	14.5	1.7	1.3	3.8	-1.7	3.2	2.0	1.6	2.1
Stomach or abdominal pain in last month	0.5	0.7	1.1	1.1	-0.5	-0.5	-1.1	-0.0	1.0	0.9	0.9
Supplements: Glucosamine	8.7	11.4	15.6	3.1	1.9	4.0	-3.5	3.8	3.5	3.3	3.6
Diverticular disease/diverticulitis (self-reported)	0.1	0.2	0.7	0.1	-0.8	-0.3	0.2	0.2	-0.1	-0.6	-0.3
Medication: Atenolol	0.6	0.7	1.5	-1.2	0.5	-0.4	0.6	-0.8	-0.9	-0.9	-1.0
Medication: Levothyroxine sodium	2.8	4.8	6.4	2.4	1.4	2.1	-2.4	1.6	2.4	2.4	2.5
Sitting height	8.8	62.5	81.0	-8.7	-3.0	-8.0	8.2	-7.9	-8.8	-7.9	-9.0
Chronic bronchitis/emphysema (father)	0.3	0.4	1.3	-0.3	-1.1	0.4	0.2	1.1	-0.1	-0.3	0.2
High blood pressure (mother)	0.7	1.0	3.1	0.6	1.1	1.8	-0.8	1.4	0.5	0.3	0.7
Body mass index (BMI)	4.2	18.0	22.8	4.1	2.7	4.4	-4.4	4.0	4.4	4.7	4.8
Impedance of leg (left)	0.2	0.9	3.4	0.7	-0.7	-1.8	-0.6	-1.5	0.6	0.4	0.1
Leg predicted mass (left)	0.3	1.6	3.6	-1.9	-0.3	0.1	1.7	-0.0	-1.7	-1.3	-1.4
Trunk fat mass	1.3	5.7	8.2	2.2	1.8	2.3	-2.6	1.9	2.5	2.9	2.7
Waist circumference	1.5	5.7	8.5	1.9	0.7	2.9	-2.0	2.9	2.3	2.6	2.8
Number of incorrect matches in round	1.2	1.9	3.4	-1.7	-0.2	-1.0	1.4	-1.4	-1.6	-1.3	-1.8
Past tobacco smoking	4.1	7.5	9.9	-2.7	-2.2	-2.3	3.1	-2.0	-3.0	-3.1	-3.1
Alcohol usually taken with meals	1.0	1.6	2.2	-1.5	-0.2	-1.3	1.2	-1.2	-1.4	-1.4	-1.4
Nervous feelings	1.1	2.1	3.9	-1.9	0.8	0.2	1.7	-0.6	-2.0	-1.6	-1.7
Frequency of tenseness / restlessness in last 2 weeks	0.1	0.1	0.4	-0.4	0.0	0.6	0.2	0.6	-0.2	-0.1	0.0
Hearing difficulty/problems with background noise	7.0	11.1	15.0	-3.8	-1.0	-3.0	3.5	-3.2	-3.8	-3.5	-3.9
Hair/balding pattern: Pattern 2	0.4	0.5	1.7	0.0	0.8	1.3	0.1	1.1	0.1	0.2	0.6
Had menopause	2.1	2.7	4.8	-2.1	-1.0	-0.9	2.2	-0.5	-2.0	-1.8	-1.7
Had other major operations	0.8	1.0	1.7	1.3	-0.9	0.2	-1.1	0.7	1.1	0.9	1.2
Forced vital capacity (FVC)	1.0	4.0	7.9	-1.6	-0.5	-2.8	1.5	-2.5	-2.0	-1.9	-2.1
Heel bone mineral density (BMD) T-score, automated (right)	0.1	0.3	0.7	0.2	-0.8	0.8	-0.1	0.6	0.4	-0.0	0.6
Ever unenthusiastic/disinterested for a whole week	0.9	1.0	3.6	-0.8	-1.9	-0.5	1.1	-0.2	-1.1	-0.9	-0.8
Qualifications: None of the above	1.1	2.3	3.8	1.9	0.9	0.4	-1.9	0.0	1.8	1.9	1.7
Financial difficulties in last 2 years	2.3	3.1	4.3	2.1	1.7	1.5	-1.9	1.5	1.8	1.7	1.8
Mouth/teeth dental problems	5.2	8.0	11.8	-2.7	-3.4	-2.4	3.1	-2.2	-2.9	-2.9	-2.8
Heart attack	0.4	0.5	1.4	-0.3	-1.2	-1.1	0.3	-1.0	-0.1	-0.6	-0.4
Allergy	3.4	7.7	18.5	-2.0	-1.6	-3.6	1.9	-4.3	-2.4	-2.4	-2.9
Pain all over the body in last month	0.1	0.1	0.3	0.1	0.6	0.3	-0.2	-0.1	-0.1	0.1	0.1
Diabetes (self-reported)	1.1	1.7	3.0	1.7	0.3	0.6	-1.6	0.1	1.7	1.4	1.7
Hayfever/allergic rhinitis (self-reported)	1.6	2.2	5.1	1.3	-0.1	1.5	-1.2	2.3	1.3	1.4	1.8
Medication: Ramipril	1.7	2.2	4.2	-2.1	-0.3	0.1	1.7	-0.2	-1.9	-1.9	-1.9
Medication: Simvastatin	0.8	1.1	1.7	1.1	1.2	1.1	-1.3	0.1	1.2	1.0	0.9
Fluid intelligence score	0.3	0.5	1.2	-0.6	-1.1	-0.3	1.1	0.2	-0.4	-1.1	-0.4
Illnesses of siblings	0.5	0.7	2.4	1.5	-0.2	-0.6	-0.6	-0.4	1.1	0.8	0.8
Neuroticism score	0.8	1.7	2.7	-1.5	-1.1	-0.8	1.4	-0.8	-1.6	-1.5	-1.5
Weight	0.4	1.7	2.9	0.7	1.5	1.7	-1.1	1.3	1.1	1.5	1.4
Impedance of arm (right)	1.0	4.6	10.4	-1.9	-0.1	-2.4	1.9	-3.2	-1.9	-2.2	-2.4
Arm fat percentage (right)	3.3	13.1	16.4	3.5	2.7	3.6	-4.0	3.0	3.9	4.0	4.0
Trunk fat-free mass	0.2	1.2	2.9	-1.7	-0.4	-0.1	1.5	0.3	-1.5	-1.0	-1.1
Hip circumference	0.8	3.6	6.2	1.5	1.1	2.5	-1.5	2.2	1.8	2.0	2.0
Time employed in main current job	1.7	1.9	4.7	-1.0	-0.1	-1.9	1.1	-2.2	-1.1	-1.3	-1.5
Alcohol intake versus 10 years previously	0.3	0.5	0.9	-1.0	0.8	0.6	0.8	0.2	-0.7	-0.8	-0.6
Father’s age at death	1.7	2.2	3.6	-1.4	-0.9	-1.9	1.4	-1.2	-1.6	-1.7	-1.7
Worrier / anxious feelings	0.3	0.5	1.1	-1.1	-0.3	-0.1	0.4	-0.1	-1.1	-0.7	-0.9
Frequency of tiredness / lethargy in last 2 weeks	0.8	1.3	2.0	1.3	1.4	1.4	-1.1	0.7	1.1	0.9	1.1
Falls in the last year	0.1	0.1	0.4	-0.2	-0.6	0.2	0.1	0.3	-0.0	-0.4	-0.1
Hair/balding pattern: Pattern 3	1.9	2.8	5.6	2.2	0.0	-0.4	-2.4	-0.4	2.1	2.0	1.7
Number of live births	0.5	0.8	1.7	0.8	-0.2	0.6	-1.0	1.0	0.6	1.3	1.0
Forced expiratory volume in 1-second (FEV1)	0.2	0.6	4.0	-0.2	2.0	-0.1	-0.3	-0.2	-0.6	-0.3	-0.4
Pulse rate	3.4	5.8	11.0	-2.1	-1.3	-3.3	2.4	-2.6	-2.4	-2.3	-2.4
Happiness	0.6	0.8	1.6	-1.3	-0.3	-0.2	1.0	0.7	-1.0	-1.2	-0.7
Noisy workplace	1.6	2.0	2.7	1.6	0.3	1.6	-1.4	1.2	1.4	1.7	1.6
Qualifications: A levels/AS levels or equivalent	2.5	5.5	7.6	-2.3	-2.0	-2.4	2.8	-1.9	-2.4	-2.6	-2.5
Serious illness, injury or assault of a close relative in last 2 years	2.1	2.4	7.2	1.1	0.3	1.8	-1.1	2.7	1.2	1.4	1.7
Mouth/teeth dental problems: Dentures	3.1	5.3	10.7	2.4	3.3	1.1	-2.9	-0.1	2.5	2.6	2.0
Asthma	3.6	7.1	16.1	1.8	2.2	4.0	-1.8	3.6	2.2	2.4	2.5
Medication: Ibuprofen (e.g. Nurofen)	0.6	0.8	2.4	-0.6	-0.7	-1.6	0.3	-1.1	-0.7	-0.7	-0.8
Medication: Cholesterol lowering	0.3	0.4	1.1	0.6	0.8	-0.7	-0.8	-1.1	0.6	0.1	0.3
Depression (self-reported)	0.2	0.2	0.9	-0.5	-1.0	-0.4	0.3	-0.0	-0.4	-0.3	-0.3
Medication: Lansoprazole	0.3	0.4	0.6	-0.7	-0.5	0.6	0.6	0.8	-0.6	-0.6	-0.3
Prospective memory result	0.8	1.0	3.3	-0.8	-1.8	-0.6	1.2	0.0	-1.0	-0.6	-0.8
Lung cancer (father)	2.6	3.0	4.5	2.0	0.6	0.9	-2.0	1.6	2.0	1.9	2.1
Illnesses of mother	2.3	2.9	5.1	-1.6	-1.2	-2.2	1.6	-2.2	-1.5	-1.0	-1.7
Forced expiratory volume in 1-second (FEV1), Best measure	0.1	0.4	1.7	-0.4	1.3	-0.2	0.0	-0.4	-0.6	-0.3	-0.6
Pulse wave Arterial Stiffness index	0.2	0.2	0.6	-0.2	0.8	0.1	-0.0	-0.6	-0.3	-0.5	-0.4
Impedance of arm (left)	1.5	7.1	9.9	-2.6	-0.4	-2.6	2.6	-3.1	-2.7	-3.1	-3.1
Arm fat mass (right)	2.5	10.2	12.6	2.9	2.4	3.5	-3.3	3.0	3.3	3.5	3.5
Trunk predicted mass	0.2	1.3	3.0	-1.7	-0.3	-0.1	1.5	0.2	-1.5	-1.1	-1.1
Standing height	3.7	37.0	49.0	-7.0	-2.5	-5.5	6.8	-5.3	-6.9	-6.4	-6.9
Length of working week for main job	3.5	3.9	7.2	2.2	2.7	0.8	-2.3	0.3	2.1	2.1	2.0
Exposure to tobacco smoke at home	3.5	4.0	5.8	2.4	-0.7	2.1	-2.1	1.8	2.3	2.0	2.0
Breastfed as a baby	0.1	0.2	0.3	-0.4	0.4	0.5	0.5	0.3	-0.3	-0.6	-0.3
Tense / ‘highly strung’	0.4	0.7	1.3	-0.9	-0.1	-0.8	0.5	-0.9	-0.9	-1.0	-1.2
Seen doctor (GP) for nerves, anxiety, tension or depression	0.3	0.5	1.5	0.2	-0.2	0.2	-0.4	1.2	0.4	1.2	0.8
Hair/balding pattern: Pattern 4	0.4	0.9	3.0	0.2	1.7	-0.9	-0.1	-1.7	-0.3	-0.4	-0.7
Birth weight of first child	1.7	3.1	4.3	-1.9	-0.2	-2.1	1.8	-2.0	-1.9	-1.6	-1.9
Peak expiratory flow (PEF)	1.7	4.0	9.0	1.3	2.2	3.0	-1.4	3.0	1.3	1.1	1.7
Pulse wave reflection index	0.3	0.4	1.0	0.2	1.0	0.9	-0.7	0.6	0.4	0.2	0.4
Ever highly irritable/argumentative for 2 days	0.5	0.7	1.0	0.9	-0.5	0.4	-0.6	0.9	1.0	0.9	1.0
Loud music exposure frequency	0.5	0.5	2.2	0.2	-1.5	0.5	-0.0	1.1	0.4	0.6	0.4
Qualifications: O levels/GCSEs or equivalent	1.1	1.7	3.2	-1.8	-0.6	-0.4	1.7	-0.3	-1.6	-1.5	-1.5
Mouth/teeth dental problems: Bleeding gums	5.5	7.1	13.0	2.9	3.6	2.1	-2.8	1.8	2.7	2.5	2.6
Blood clot in the leg (DVT)	0.1	0.1	0.4	0.2	-0.4	0.6	-0.1	0.5	0.2	0.0	0.3
Medication: Paracetamol	0.8	1.4	3.0	0.8	-0.4	1.7	-1.0	1.6	0.9	1.0	1.4
Headache pain in last month	0.6	1.0	3.3	0.8	1.8	1.3	-0.9	1.1	0.5	0.7	0.5
Medication for cholesterol, blood pressure or diabetes	0.1	0.2	0.9	0.4	-1.0	-0.3	0.4	0.2	0.1	0.3	0.3
Glaucoma (self-reported)	1.3	1.6	2.6	1.0	1.6	0.6	-1.5	1.1	1.3	1.3	1.2
Gout (self-reported)	0.2	0.3	0.6	0.7	0.6	-0.4	-0.4	-0.8	0.6	0.3	0.4
Hypothyroidism/myxoedema (self-reported)	4.4	8.5	11.4	3.2	1.7	2.5	-3.3	2.2	3.3	3.2	3.4
Medication: Amlodipine	0.2	0.2	1.3	-0.1	0.2	-0.4	0.1	-1.1	-0.3	-0.4	-0.5
Medication: Ventolin 100micrograms inhaler	3.5	4.4	5.3	2.2	2.0	2.2	-2.0	2.2	2.0	2.1	2.3
Birth weight	0.2	0.4	1.0	-0.5	0.8	-1.0	0.7	-0.8	-0.4	-0.1	-0.5
Chronic bronchitis/emphysema (mother)	0.5	0.6	1.2	1.1	0.5	-0.2	-1.1	0.2	0.9	0.7	0.8
High blood pressure (siblings)	0.6	0.9	3.1	-0.8	0.5	1.8	-0.2	1.7	-0.4	-0.1	0.1
Forced vital capacity (FVC), Best measure	1.0	3.8	6.2	-1.8	-0.7	-2.5	1.7	-2.4	-1.9	-1.8	-2.2
Body fat percentage	3.3	12.8	17.4	3.6	2.5	3.2	-4.0	2.6	4.0	4.2	4.1
Leg fat percentage (right)	6.9	24.9	33.3	5.3	3.2	4.3	-5.7	3.7	5.6	5.8	5.6
Arm fat-free mass (right)	0.1	0.8	1.6	-1.3	-0.4	0.3	1.2	0.8	-1.1	-0.7	-0.7
Exposure to tobacco smoke outside home	7.0	9.3	13.5	3.6	2.1	2.8	-3.7	2.0	3.2	3.3	3.2
Comparative body size at age 10	2.7	7.5	15.1	2.2	1.0	3.6	-2.5	3.9	2.4	2.5	2.8
Number of full brothers	0.1	0.1	0.4	-0.1	-0.3	-0.3	-0.1	-0.6	-0.2	-0.2	-0.2
Worry too long after embarrassment	6.2	10.3	13.9	-3.7	-3.5	-2.0	3.7	-1.5	-3.7	-3.4	-3.4
Seen a psychiatrist for nerves, anxiety, tension or depression	2.6	3.4	4.6	1.5	1.5	1.9	-1.8	1.9	1.7	2.1	2.0
Wheeze or whistling in the chest in last year	6.2	11.0	14.7	3.5	1.8	3.2	-3.2	3.7	3.6	3.3	3.8
Number of children fathered	0.2	0.3	0.8	0.6	-0.0	-0.8	-0.9	-0.5	0.3	0.2	0.2
Reason for reducing amount of alcohol drunk: Health precaution	3.4	3.9	5.3	-2.3	-0.9	-2.0	2.0	-1.9	-2.1	-2.0	-2.2
Age at first live birth	0.7	1.3	2.1	-1.0	0.7	-0.5	1.2	-1.2	-1.3	-1.4	-1.4
Pulse wave peak to peak time	0.2	0.2	1.0	-0.2	-1.0	-0.4	0.4	0.4	-0.1	0.1	0.1
Health satisfaction	0.3	0.3	1.0	0.6	0.4	1.0	-0.6	0.4	0.6	0.3	0.5
Shortness of breath walking on level ground	1.7	2.0	2.6	-1.1	-1.3	-1.5	1.5	-1.6	-1.3	-1.5	-1.5
Qualifications: College or University degree	4.9	15.4	21.3	-4.0	-3.4	-3.9	4.6	-3.1	-4.1	-4.1	-4.1
Eye problems/disorders: None of the above	0.2	0.3	0.5	0.6	-0.1	-0.4	-0.7	-0.3	0.6	0.7	0.4
Mouth/teeth dental problems: Loose teeth	1.6	1.9	3.1	1.7	1.2	0.5	-1.8	0.9	1.5	1.5	1.3
Emphysema/chronic bronchitis	0.3	0.4	0.8	0.7	0.3	0.1	-0.9	0.1	0.9	0.7	0.6
Medication for pain relief, constipation, heartburn	0.4	0.8	2.0	-0.3	0.7	-1.3	0.7	-1.4	-0.7	-0.4	-0.8
Neck or shoulder pain in last month	1.2	1.6	3.0	1.7	0.1	0.3	-1.7	0.7	1.5	1.6	1.4
Medication: Blood pressure	0.2	0.3	1.1	-0.7	1.0	0.3	-0.2	-0.2	-0.5	-0.5	-0.5
Angina (self-reported)	0.7	1.0	1.8	1.3	0.9	-0.1	-1.3	-0.4	1.4	0.9	0.9
Migraine (self-reported)	0.1	0.2	0.4	-0.4	0.0	-0.6	-0.1	-0.4	-0.4	-0.3	-0.6
Medication: Ibuprofen	0.4	0.4	1.1	-0.7	-0.3	-1.0	0.3	-0.6	-0.7	-0.6	-0.6
Medication: Allopurinol	0.3	0.4	0.9	0.8	0.4	-0.5	-0.4	-1.0	0.8	0.6	0.6
Medication: Omeprazole	1.3	1.6	2.3	1.5	0.9	1.1	-1.5	0.9	1.4	1.3	1.4
Medication: Seretide 50 evohaler	1.0	1.1	2.4	1.2	-0.1	0.4	-0.9	0.3	1.3	1.6	1.5
Mean time to correctly identify matches	2.5	4.9	9.1	-2.2	-1.2	-3.0	1.6	-3.0	-2.0	-1.8	-2.1
Heart disease (mother)	0.4	0.5	0.7	-0.6	-0.4	0.8	0.6	0.8	-0.6	-0.8	-0.5
Reproduciblity of spirometry measurement using ERS/ATS criteria	3.4	4.0	4.9	1.9	2.0	2.0	-2.0	1.6	2.2	2.1	2.2
Whole body fat mass	1.7	7.3	9.9	2.5	1.9	2.8	-2.9	2.2	2.9	3.1	3.1
Leg fat mass (right)	3.3	12.8	17.2	3.5	2.2	3.4	-3.9	3.0	3.9	4.2	4.0
Arm predicted mass (right)	0.3	1.3	2.8	-1.7	-0.7	-0.1	1.6	0.4	-1.5	-1.0	-1.0
Pulse rate, automated reading	4.1	13.2	20.5	-3.4	-1.5	-4.5	3.5	-4.0	-3.9	-3.6	-3.8
Alcohol intake frequency.	0.3	0.7	1.3	-1.1	-0.2	0.0	1.1	-0.5	-1.0	-1.1	-1.0
Comparative height size at age 10	4.1	22.5	32.5	-5.7	-2.6	-4.1	5.5	-3.7	-5.2	-5.0	-5.2
Number of full sisters	1.3	1.6	3.2	1.2	1.0	1.8	-1.1	1.2	1.3	1.0	1.4
Suffer from ‘nerves’	3.4	5.3	7.2	2.4	2.5	1.9	-2.7	1.4	2.5	2.5	2.2
Overall health rating	2.2	4.6	6.7	2.4	2.3	1.4	-2.6	0.4	2.4	2.5	2.3
Chest pain or discomfort	1.4	2.1	4.0	1.4	0.4	2.0	-1.5	1.6	1.4	1.3	1.5
Had major operations	9.1	10.6	14.3	3.5	3.2	2.9	-3.8	2.8	3.3	3.1	3.4
Age at last live birth	0.3	0.4	1.9	-0.3	1.4	0.5	0.4	-0.4	-0.5	-0.5	-0.6
Family relationship satisfaction	0.5	0.7	1.7	-1.0	-0.7	-1.3	0.6	-0.1	-0.8	-0.9	-0.7
Leg pain on walking	3.3	4.1	5.4	2.3	0.8	1.9	-1.9	1.9	2.3	2.3	2.2
Qualifications: NVQ or HND or HNC or equivalent	3.1	3.8	6.3	2.4	1.4	1.0	-2.5	0.9	2.3	2.2	2.1
Commuting to job workplace: Car/motor vehicle	0.1	0.2	0.4	-0.4	0.2	-0.4	0.4	-0.5	-0.4	-0.2	-0.6
Illness, injury, bereavement, stress in last 2 years	0.1	0.1	0.6	-0.2	-0.1	0.8	0.2	0.1	0.2	0.3	0.1
Medication: Aspirin	1.5	2.0	3.9	-1.9	-0.7	-0.4	1.4	-0.7	-1.6	-2.0	-1.7
Supplements: Vitamin C	0.3	0.3	1.4	0.3	-0.2	1.0	-0.4	1.2	0.2	-0.1	0.3
Knee pain experienced in last month	3.5	5.4	7.4	2.3	0.7	2.4	-2.5	2.2	2.6	2.7	2.5
Hypertension (Self-reported)	0.3	0.7	2.6	-0.7	1.2	1.6	-0.1	1.0	-0.5	-0.2	-0.1
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.5	0.6	1.0	-0.8	-0.8	0.8	0.7	0.9	-0.7	-1.0	-0.5
Illnesses of father: Heart disease	0.2	0.3	0.6	-0.3	0.8	-0.1	0.2	-0.7	-0.3	-0.5	-0.6
Illnesses of siblings: Diabetes	1.5	1.8	4.7	1.2	2.2	1.2	-1.5	0.2	1.4	1.3	1.1
Smoking status: Previous	0.9	1.4	1.9	0.9	1.0	1.1	-1.3	1.1	1.3	1.4	1.3
Forced expiratory volume in 1-second (FEV1), predicted	2.0	4.1	4.9	-2.0	-1.3	-2.1	2.2	-1.9	-2.2	-2.2	-2.2
Whole body fat-free mass	0.3	1.5	3.5	-1.9	-0.5	-0.1	1.7	0.2	-1.6	-1.2	-1.2
Leg fat-free mass (right)	0.6	3.3	6.5	-2.5	-0.8	-0.5	2.4	-0.4	-2.4	-2.0	-2.0
Arm fat percentage (left)	3.0	12.0	14.5	3.3	2.6	3.7	-3.7	3.1	3.6	3.7	3.8
Average weekly red wine intake	0.8	1.2	2.2	1.2	-0.2	0.6	-1.5	1.0	1.3	1.3	1.3
Handedness (chirality/laterality): Left-handed	1.0	1.3	2.0	-1.1	0.7	-1.2	0.8	-1.4	-1.2	-1.2	-1.2
Mood swings	0.2	0.3	0.6	0.4	-0.1	0.6	-0.7	0.6	0.5	0.5	0.6
Loneliness, isolation	1.0	1.4	2.6	-1.1	-1.1	-1.6	1.2	-1.4	-1.2	-0.9	-1.1
Long-standing illness, disability or infirmity	0.9	1.4	2.0	1.1	0.9	1.4	-1.2	1.1	1.3	1.1	1.3
Ever had bowel cancer screening	1.8	2.1	4.4	-1.1	-0.9	-1.9	0.8	-2.1	-1.2	-1.5	-1.7
Diabetes diagnosed by doctor	1.5	2.4	4.0	1.9	0.9	0.9	-1.9	0.0	2.0	1.7	1.9
Ever had stillbirth, spontaneous miscarriage or termination	0.6	0.6	1.5	-1.1	0.1	0.2	1.2	0.2	-0.9	-0.8	-0.8
Friendships satisfaction	3.8	4.7	11.6	-2.1	-3.4	-2.0	2.3	-0.7	-1.9	-2.1	-1.8
Qualifications: nursing, teaching	0.6	1.0	1.5	-1.2	-1.2	-0.8	1.1	-0.2	-1.1	-0.9	-1.0
Commuting to job workplace: Walk	1.5	1.6	3.0	-1.7	-0.9	0.3	1.5	1.1	-1.5	-1.5	-1.1
Eye problems/disorders: Cataract	4.5	5.2	6.5	-2.5	-1.9	-2.2	2.5	-2.0	-2.5	-2.2	-2.4
Mouth/teeth dental problems: Mouth ulcers	0.3	0.4	1.0	-0.8	-1.0	0.2	0.6	0.7	-0.6	-0.5	-0.4
Medication for cholesterol	0.9	1.4	2.3	-1.1	-1.5	-1.5	1.1	-0.5	-1.1	-1.2	-1.0
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.5	0.6	2.0	0.5	1.4	0.7	-0.8	1.0	0.5	0.1	0.3
Back pain experienced in last month	2.0	2.9	4.3	1.9	-0.1	1.5	-1.8	2.1	1.8	1.8	1.8
Mineral and other dietary supplements	3.2	4.3	8.2	-1.4	-1.4	-2.8	2.0	-2.9	-1.9	-1.9	-2.0
Breast cancer (self-reported)	2.1	2.5	4.2	2.1	1.2	0.8	-2.0	0.8	1.9	1.6	1.7
Asthma (self-reported)	3.3	6.6	14.6	1.8	2.0	3.8	-1.7	3.4	2.1	2.4	2.5
Osteoporosis (self-reported)	0.7	0.9	2.6	-0.3	-0.1	-1.1	0.6	-1.6	-0.6	-1.0	-1.2
Osteoarthritis (self-reported)	8.7	11.3	13.6	3.3	3.3	3.5	-3.3	2.7	3.4	3.6	3.7
Medication: Aspirin	2.0	2.6	5.1	-2.0	-0.7	-0.6	1.6	-1.0	-1.8	-2.3	-2.0
Medication: Gliclazide	0.1	0.1	0.4	0.4	0.6	0.2	-0.5	-0.3	0.1	0.4	0.3
Illnesses of father: None of the above (group 1)	0.7	0.9	1.7	1.3	0.5	0.4	-0.9	0.5	1.2	1.2	1.1
Smoking status: Current	4.3	6.8	10.7	3.0	2.0	1.8	-3.3	1.7	2.8	2.9	2.9
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.6	1.2	2.2	1.2	1.4	0.8	-1.5	0.5	1.1	0.9	1.0
Whole body water mass	0.3	1.8	3.9	-2.0	-0.6	-0.2	1.8	0.2	-1.8	-1.3	-1.4
Leg predicted mass (right)	0.6	3.4	6.6	-2.6	-0.8	-0.5	2.5	-0.4	-2.4	-2.0	-2.0
Arm fat mass (left)	1.7	6.9	9.5	2.2	2.1	3.1	-2.6	2.6	2.5	2.8	2.9
Number of self-reported non-cancer illnesses	5.0	8.7	11.0	2.6	2.8	3.3	-3.2	3.0	2.9	2.6	3.1
Average weekly champagne plus white wine intake	1.6	2.3	4.8	-1.5	-0.0	-1.4	1.6	-2.2	-1.4	-1.5	-1.6
Miserableness	0.1	0.2	0.3	0.3	-0.4	0.6	-0.5	0.5	0.1	0.3	0.2
Guilty feelings	2.2	3.4	5.1	-2.1	-1.1	-1.2	2.2	-0.7	-2.3	-2.1	-2.2
Wears glasses or contact lenses	2.6	3.0	4.6	1.6	0.6	2.1	-1.6	1.9	1.6	1.9	2.1
Ever taken oral contraceptive pill	0.7	0.7	2.3	-0.5	0.3	-1.5	0.6	-1.3	-0.7	-0.3	-0.8
Hearing aid user	0.7	0.8	3.2	-0.9	-1.8	-0.5	1.1	0.1	-0.6	-0.6	-0.5
Mother’s age at death	0.8	1.0	2.0	-1.4	-0.3	-0.1	1.2	-0.1	-1.3	-1.2	-1.1
Financial situation satisfaction	4.0	5.0	7.0	2.5	1.4	1.6	-2.6	2.2	2.6	2.2	2.3
Tinnitus: Yes, now most or all of the time	1.3	1.5	2.9	-1.0	-0.5	-1.7	1.2	-1.6	-1.0	-1.1	-1.3
Commuting to job workplace: Public transport	1.1	1.3	4.5	-0.6	-0.2	-2.0	0.4	-2.1	-0.7	-0.7	-0.9
Eye problems/disorders: Glaucoma	3.0	3.6	4.7	1.7	2.2	1.7	-2.0	1.6	2.0	1.9	1.9
Medication: Blood pressure	0.6	1.1	2.7	-1.6	-0.1	0.4	1.3	0.0	-1.5	-1.1	-1.1
Pain type(s) experienced in last month: Hip pain	0.2	0.2	0.8	0.4	0.9	0.4	-0.4	0.3	0.3	0.1	0.3
Supplements: Fish oil (including cod liver oil)	4.0	5.2	9.7	1.7	1.5	3.0	-2.1	3.1	2.0	2.0	2.2
High cholesterol (Self-reported)	2.4	4.3	8.8	2.3	3.0	1.5	-2.4	0.7	2.1	2.0	1.9
Medication: Bendroflumethiazide	0.5	0.8	2.0	-1.4	0.0	-0.0	0.8	-0.3	-1.4	-0.9	-1.0
Medication: Paracetamol	1.1	1.8	4.5	0.8	-0.3	2.1	-1.0	1.9	1.0	1.1	1.5
Medication: Lisinopril	0.9	1.2	2.2	-1.1	-0.2	-1.5	1.0	-1.3	-1.1	-1.0	-0.9
Medication: Atorvastatin	0.5	0.6	2.0	0.9	1.4	-0.0	-0.8	-0.4	0.9	0.5	0.4
Illnesses of father: High blood pressure	0.1	0.1	0.3	-0.3	0.1	0.2	0.1	0.0	-0.4	-0.6	-0.4
Alcohol drinker status: Never	0.3	0.4	2.3	-0.0	-1.5	-0.2	0.3	-0.5	0.3	-0.3	-0.1
Ever smoked	6.1	10.8	15.9	3.3	3.0	2.5	-4.0	2.2	3.6	3.6	3.6
Basal metabolic rate	0.1	0.6	1.6	-1.3	-0.1	0.4	1.1	0.5	-1.0	-0.6	-0.6
Leg fat percentage (left)	6.3	23.0	31.9	5.1	2.8	4.0	-5.5	3.6	5.4	5.7	5.5
Arm fat-free mass (left)	0.1	0.4	1.1	-1.1	-0.0	0.2	0.9	0.6	-0.8	-0.3	-0.4
Number of operations (self-reported)	4.7	7.0	11.6	3.0	2.6	1.8	-3.4	1.8	2.8	2.6	2.8
Average weekly beer plus cider intake	0.2	0.2	0.4	0.4	0.3	0.5	-0.5	0.5	0.5	0.6	0.4
Irritability	0.1	0.1	0.3	-0.0	0.2	0.0	0.2	-0.3	-0.1	-0.6	-0.4
Risk taking	0.2	0.3	0.5	-0.6	-0.7	0.1	0.7	0.5	-0.6	-0.7	-0.4
Ever had prostate specific antigen (PSA) test	0.4	0.4	1.1	0.3	0.7	-1.0	-0.8	-0.9	0.4	0.3	0.0
Fractured/broken bones in last 5 years	0.6	0.7	2.9	-0.5	-1.7	0.8	0.6	1.2	-0.5	-0.3	-0.0
Age started oral contraceptive pill	4.8	6.0	8.0	-2.7	-1.3	-1.9	2.7	-2.5	-2.5	-2.7	-2.8
Diastolic blood pressure, automated reading	0.2	0.7	1.7	0.4	1.0	1.1	-0.7	1.3	0.4	0.5	0.8
Ever depressed for a whole week	1.2	1.5	4.1	-1.2	-2.0	-0.4	1.5	0.4	-1.4	-1.0	-0.9
Unable to work because of sickness or disability	1.7	2.2	4.2	1.4	0.4	1.8	-1.3	2.0	1.3	1.4	1.6
Commuting to job workplace: Cycle	1.3	1.5	5.1	0.6	0.6	1.8	-0.3	2.3	0.8	1.0	1.2
Myopia	2.4	3.5	6.6	2.3	2.3	0.3	-2.6	-0.2	2.2	1.8	1.7
Vascular/heart problems diagnosed by doctor	0.3	0.8	1.6	1.3	-0.8	-1.0	-0.4	-0.5	1.1	1.0	0.8
Cholesterol lowering medication	0.5	0.7	1.3	1.0	0.2	1.2	-0.8	0.5	1.0	0.8	0.7
Medication: Omeprazole (e.g. Zanprol)	1.0	1.3	1.7	1.3	0.5	1.1	-1.3	0.9	1.2	1.2	1.3
Pain experienced in last month	3.8	6.3	7.9	-2.7	-1.1	-2.2	2.8	-2.6	-2.7	-2.7	-2.7
Supplements: Calcium	0.9	1.0	4.4	0.7	2.1	1.2	-1.0	0.7	0.4	0.2	0.2
Basal cell carcinoma (self-reported)	2.1	2.5	5.1	-2.2	-0.7	-0.9	2.0	-0.7	-1.9	-1.7	-1.8
Heart attack/myocardial infarction (self-reported)	0.7	1.0	1.9	-0.6	-1.4	-1.4	0.6	-1.3	-0.4	-0.9	-0.8
Deep venous thrombosis (DVT) (self-reported)	0.1	0.1	0.5	0.0	-0.7	0.6	0.1	0.4	0.0	-0.1	0.2
Heart disease (siblings)	2.2	2.7	5.3	-2.3	-0.2	-0.6	1.9	-0.7	-2.0	-2.0	-2.0
Alcohol drinker status: Previous	0.2	0.2	0.6	-0.8	-0.3	0.1	0.6	0.5	-0.7	-0.3	-0.1
Pack years of smoking	0.1	0.2	0.3	0.5	-0.4	0.2	-0.6	0.3	0.4	0.4	0.4
Impedance of whole body	0.5	2.6	7.0	-0.9	-0.5	-2.5	1.0	-2.6	-1.1	-1.3	-1.6
Leg fat mass (left)	2.9	11.5	15.9	3.3	1.9	3.2	-3.7	2.9	3.7	4.0	3.9
Arm predicted mass (left)	0.1	0.3	1.1	-0.7	0.2	0.6	0.5	1.0	-0.4	0.1	0.1