Hub : Genes

PIK3R3

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 GTEx Adipose Visceral Omentum 0.0670 0.0350 0.00220 0.024 NA 0.005 NA 0.038 1.9e-02 NA 1.6e-01 NA 4.6e-03
2 GTEx Testis 0.0850 0.0420 0.00100 0.054 NA 0.057 NA 0.053 2.1e-03 NA 1.6e-03 NA 2.3e-03
3 NTR Blood 0.0126 0.0060 0.00040 0.019 0.010 0.015 0.010 0.016 8.1e-07 1.8e-04 7.2e-06 0.00028 4.5e-06
4 ROSMAP Brain Pre-frontal Cortex 0.0505 0.0292 0.00110 0.019 0.014 0.028 0.018 0.032 1.4e-03 5.8e-03 1.5e-04 0.00200 4.4e-05
5 TCGA Thyroid Carcinoma 0.0480 0.0270 0.00015 0.009 0.043 0.035 NA 0.021 4.1e-02 4.4e-05 2.3e-04 NA 3.3e-03

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5
Bipolar Disorder (2018) 0.9 1.4 4.6 1.0 -0.3 1.1 2.2 -0.1
Bipolar Disorder or Schizophrenia 0.4 0.9 1.9 1.1 -0.6 1.0 1.4 -0.1
Depressed Affect (Nagel 2018) 0.7 1.4 2.2 1.3 -1.1 -1.4 -0.5 -1.5
Depression (Nagel 2018) 1.2 1.7 2.6 1.5 -0.8 -1.2 -1.3 -1.6
Intelligence (Savage-Jansen 2018) 0.3 1.1 3.3 1.1 -0.8 0.2 1.8 0.1
Neuroticism (Nagel 2018) 1.3 3.1 5.4 2.2 -1.8 -1.2 0.2 -2.3
Schizophrenia (2018) 0.1 0.2 0.4 0.6 -0.5 0.4 0.1 -0.0
Schizophrenia vs Biploar Disorder 1.6 2.1 4.8 0.1 -0.6 -2.2 -2.1 -1.0
Worry (Nagel 2018) 0.7 1.4 2.4 1.2 -1.1 -1.3 -0.5 -1.5
Alzheimer’s Disease (in mother) 0.6 0.7 1.3 -0.9 0.9 1.2 -0.2 0.7
Alzheimer’s Disease (in father) 0.7 0.8 1.5 -0.4 1.0 1.2 1.1 -0.1
Alzheimer’s Disease (including proxy) 1.2 1.8 5.3 -1.1 1.2 2.3 0.8 0.7
Crohns Disease (2017) 0.5 1.1 1.6 0.7 -1.3 -1.2 -1.0 -0.9
Irritable Bowel Disease (IBD) 1.8 4.3 6.9 2.0 -2.6 -2.1 -0.5 -2.4
Ulcerative Colitis (UC) 3.0 5.6 8.5 2.5 -2.8 -2.4 -0.0 -2.9
Major Depression (MDD) 0.7 0.8 1.4 -0.9 0.9 0.8 1.2 0.6
Reaction Time 1.0 1.8 3.6 1.2 -1.4 -1.9 0.1 -1.6
Verbal and Numeric Reasoning (VNR) 0.2 0.6 1.3 0.6 -0.8 -0.6 1.1 0.4
Breast Cancer 5.4 12.9 24.4 4.9 -4.2 -2.2 1.1 -4.0
Ovarian Cancer 0.5 0.6 1.3 -0.5 1.1 0.6 1.0 0.6
Prostate Cancer 1.3 1.8 4.1 -1.5 1.1 -1.2 -2.0 0.4
Age at First Birth 2.9 4.2 9.2 3.0 -2.6 -1.1 -0.7 -1.9
Bipolar Disorder (2011) 1.4 1.3 2.8 1.7 -1.4 -0.9 0.0 -1.1
Body Mass Index (BMI) (2010) 3.2 4.4 5.8 -2.3 2.3 2.4 1.0 2.2
Coronary Artery Disease (CAD) 0.9 1.0 1.9 -1.3 1.4 0.8 0.0 0.9
Crohns Disease (2012) 0.8 1.3 2.5 1.1 -1.6 -0.8 0.0 -1.5
Mean Putamen Volume 0.1 0.1 0.2 0.3 0.0 -0.5 0.1 -0.4
Fasting Glucose 2.4 2.8 4.9 -2.2 1.3 1.8 -0.6 1.9
HbA1C 1.0 1.1 3.1 -0.8 1.8 0.3 -1.2 0.4
HDL Cholesterol 1.9 3.2 9.0 -0.7 0.9 3.0 2.3 0.8
LDL Cholesterol 0.4 0.7 1.3 -1.1 0.7 -0.4 0.6 1.1
Lupus 0.3 0.4 0.9 0.6 -0.0 0.9 0.8 -0.3
Neuroticism (2016) 2.7 3.9 8.0 2.8 -2.1 0.0 1.4 -2.3
Primary Biliary Cirrhosis 0.3 0.4 1.0 -0.6 0.6 1.0 0.0 0.7
Rheumatoid Arthritis 3.4 4.7 7.6 -2.8 2.2 1.8 0.0 2.8
Schizophrenia (2014) 0.3 0.7 1.8 1.3 -1.0 0.2 -0.1 -0.8
Triglycerides 0.3 0.4 1.1 -0.4 -0.0 -1.0 -1.0 0.1
Type 2 Diabetes (T2D) (2012) 2.9 3.4 6.9 -2.6 2.0 1.6 -0.1 1.9
Ulcerative Colitis 3.1 4.5 7.7 2.3 -2.8 -2.2 -0.6 -2.1
Blood Eosinophil Count 0.8 5.8 11.6 -1.3 1.7 -3.0 -3.4 -1.9
Blood Platelet Count 7.6 88.0 139.2 -11.6 11.8 9.6 -1.0 8.6
Blood Red Count 20.6 199.3 306.2 13.9 -13.5 -17.5 -9.0 -15.3
Blood White Count 2.8 20.9 63.8 0.1 -0.1 -8.0 -6.0 -2.3
Heel T-Score 0.5 4.1 5.8 2.4 -2.4 -2.3 0.1 -1.9
BMI 3.4 19.6 28.3 -5.3 5.0 4.4 1.5 4.8
Height 3.8 72.6 110.2 9.4 -10.5 -8.0 -5.1 -8.6
Waist Hip Ratio (WHR) 0.1 0.3 1.0 0.0 -0.3 -1.0 -0.3 0.3
Systolic Blood Pressure 0.9 4.7 8.8 -1.4 1.9 3.0 2.0 2.3
Smoking Status 3.9 9.3 15.5 -3.5 3.9 2.2 0.8 3.6
Allergy or Eczema 3.3 8.7 16.3 -2.2 2.0 4.0 3.0 3.0
Cardiovascular Disease 0.2 0.8 2.3 0.9 -0.2 0.7 -1.5 -0.6
Hypothyroidism (self reported) 3.0 6.9 10.5 -3.2 3.2 2.0 1.3 2.8
Respiratory disease 0.8 1.9 4.6 -0.6 0.5 2.1 1.8 0.8
Type 2 Diabetes (T2D) (2018) 0.9 1.6 3.4 -1.8 1.6 0.4 -0.2 1.4
Lung FEV1/FVC ratio 5.2 26.6 53.9 -4.3 5.2 7.3 4.0 4.3
Lung FVC 0.3 1.3 2.8 -1.2 1.7 -1.2 -0.9 0.1
Neuroticism 3.2 7.7 13.0 3.6 -2.8 -2.0 -0.9 -3.5
Chronotype (morning person) 0.0 0.1 0.2 0.1 -0.5 0.4 -0.0 -0.1
Hair Pigment 0.0 0.8 1.8 -0.6 0.8 -0.6 -0.7 1.3
Tanning 0.1 1.1 2.6 -0.3 1.1 1.6 1.3 -0.1
Hand grip strength (left) 1.0 2.7 6.0 2.1 -1.8 -0.5 -0.0 -2.4
Number of treatments/medications taken 2.2 3.9 8.2 -2.0 1.6 2.9 1.2 1.7
Average weekly spirits intake 1.9 2.3 4.2 -2.0 1.9 1.1 0.7 1.4
Sensitivity / hurt feelings 0.5 0.8 1.7 1.3 -0.2 0.3 0.9 -1.1
Frequency of depressed mood in last 2 weeks 0.3 0.4 1.4 0.1 0.2 -0.6 -1.2 0.0
Hearing difficulty/problems: Yes 10.7 16.4 22.7 4.7 -4.4 -4.1 -1.1 -4.8
Relative age of first facial hair 0.8 1.7 2.7 1.4 -0.9 -1.3 -1.1 -1.6
Other serious medical condition/disability diagnosed by doctor 0.9 1.1 3.4 -1.4 1.8 0.4 0.1 0.1
Ever used hormone-replacement therapy (HRT) 0.5 0.6 1.5 -0.7 0.7 1.2 0.4 0.6
Ever had hysterectomy (womb removed) 2.0 2.2 4.6 -1.9 2.1 1.1 -0.8 0.8
Systolic blood pressure, automated reading 2.7 7.8 13.4 -2.2 2.2 3.7 2.6 3.1
Eye problems/disorders: Diabetes related eye disease 1.0 1.1 2.8 1.1 -1.0 -1.7 -0.6 -0.4
Angina 1.1 1.4 4.3 -0.9 1.4 -0.2 -2.1 0.1
Medication for hormone replacement therapy 0.5 0.5 1.8 -0.1 0.3 -0.7 -1.4 -0.3
Vitamin and mineral supplements 1.6 2.2 7.5 0.8 -0.9 -2.7 -0.9 -1.1
Supplements: Zinc 3.2 3.4 5.2 -2.3 1.6 2.0 0.9 2.2
Medication: Co-codamol 0.4 0.4 1.2 -1.1 0.7 -0.0 -0.7 0.3
Medication: Metformin 1.1 1.6 3.2 -1.8 1.4 0.8 0.4 1.4
Diabetes (father) 2.1 2.6 5.4 -2.1 2.3 0.3 -0.4 1.7
Diabetes (mother) 2.9 3.7 6.5 -2.0 2.6 1.5 1.4 2.0
Severe depression (siblings) 1.9 2.2 4.9 1.6 -2.2 1.4 0.9 -0.8
Pack years adult smoking proportion 0.3 0.5 1.6 -0.5 0.3 0.2 -1.3 0.8
Impedance of leg (right) 0.2 0.9 1.5 -0.6 1.2 -1.2 -1.0 -0.3
Leg fat-free mass (left) 0.2 1.3 3.6 1.6 -1.9 -0.0 -0.4 -0.5
Trunk fat percentage 1.7 7.0 11.6 -3.4 3.1 1.8 -0.5 3.2
Hand grip strength (right) 0.6 1.6 3.1 1.7 -1.1 0.3 0.7 -1.8
Townsend deprivation index at recruitment 1.7 2.5 5.5 -1.9 1.4 1.0 -0.1 2.4
Current tobacco smoking 3.0 4.8 7.5 -2.5 2.7 1.9 0.4 2.6
Average weekly fortified wine intake 1.6 1.9 4.7 1.4 -1.6 -0.5 0.1 -2.2
Maternal smoking around birth 5.0 7.2 11.4 -3.4 3.3 1.8 0.3 3.2
Fed-up feelings 0.0 0.0 0.1 0.1 0.1 -0.3 -0.2 -0.1
Frequency of unenthusiasm / disinterest in last 2 weeks 0.4 0.5 1.3 0.6 0.1 -0.4 -1.1 -0.9
Relative age voice broke 1.2 1.9 4.1 0.5 0.5 -2.0 -1.8 -1.3
Taking other prescription medications 2.8 4.4 8.2 -2.9 2.9 1.8 -0.0 1.5
Age when periods started (menarche) 0.2 0.4 1.4 -0.3 0.2 -0.5 -1.2 0.3
Bilateral oophorectomy (both ovaries removed) 1.7 2.0 6.9 -0.4 1.0 -1.4 -2.6 -0.2
Heel bone mineral density (BMD) T-score, automated (left) 0.2 0.4 1.4 0.4 -0.6 -0.1 1.2 -0.5
Tinnitus: Yes, but not now, but have in the past 1.4 1.4 3.6 -1.9 1.7 0.5 -0.7 0.3
Qualifications: CSEs or equivalent 2.0 2.6 5.2 -1.7 2.3 1.5 -0.0 1.7
Serious illness, injury or assault to yourself 1.1 1.3 2.4 0.4 -0.4 -1.5 -1.2 -1.5
High blood pressure 0.3 0.8 1.8 0.8 -0.9 0.8 -1.3 -0.4
Hayfever, allergic rhinitis or eczema 2.6 5.6 13.3 -1.5 1.5 3.6 2.4 2.2
Multivitamins +/- minerals 3.5 4.4 9.0 -1.5 1.6 3.0 2.0 2.1
Stomach or abdominal pain in last month 0.3 0.4 1.0 -0.9 1.0 0.1 0.4 -0.5
Supplements: Glucosamine 6.8 8.8 13.5 -2.9 3.2 3.7 2.3 2.6
Diverticular disease/diverticulitis (self-reported) 0.3 0.4 1.2 1.1 -0.0 0.3 0.2 -0.7
Medication: Atenolol 0.7 0.8 1.3 0.8 -0.9 -0.7 -1.1 -0.9
Medication: Levothyroxine sodium 2.3 4.0 6.7 -2.6 2.5 1.7 0.6 1.9
Sitting height 8.3 59.2 75.3 8.4 -8.7 -7.7 -5.6 -7.7
Chronic bronchitis/emphysema (father) 0.4 0.5 1.7 0.1 -0.1 1.3 0.8 -0.2
High blood pressure (mother) 0.4 0.5 1.7 -0.3 0.4 1.3 0.3 0.8
Body mass index (BMI) 3.4 14.4 19.2 -4.4 4.2 3.8 1.4 4.3
Impedance of leg (left) 0.2 1.0 2.2 -0.4 0.8 -1.5 -1.2 -0.4
Leg predicted mass (left) 0.2 1.3 3.7 1.6 -1.9 -0.1 -0.4 -0.5
Trunk fat mass 1.1 4.8 7.6 -2.7 2.4 1.8 -0.5 2.8
Waist circumference 1.7 6.3 11.0 -2.6 2.1 2.7 1.2 3.3
Number of incorrect matches in round 1.8 3.0 5.1 1.9 -1.6 -1.2 -1.6 -2.3
Past tobacco smoking 3.3 6.1 9.5 3.1 -2.9 -2.0 -0.6 -2.9
Alcohol usually taken with meals 0.8 1.3 1.8 0.9 -1.4 -1.1 -1.3 -1.0
Nervous feelings 1.2 2.3 4.6 2.1 -1.9 -0.3 0.5 -1.7
Frequency of tenseness / restlessness in last 2 weeks 0.3 0.5 0.7 0.9 -0.3 0.7 0.7 -0.8
Hearing difficulty/problems with background noise 7.1 11.3 14.9 3.8 -3.6 -3.1 -2.1 -3.9
Hair/balding pattern: Pattern 2 0.3 0.4 1.2 -0.7 0.3 1.1 0.4 0.0
Had menopause 2.0 2.4 3.9 2.0 -1.9 -0.4 1.1 -1.8
Had other major operations 0.7 0.9 1.5 -1.2 1.1 0.7 0.4 0.9
Forced vital capacity (FVC) 1.2 4.5 5.9 1.8 -1.9 -2.4 -2.4 -1.9
Heel bone mineral density (BMD) T-score, automated (right) 0.2 0.5 1.5 -0.7 0.3 0.4 1.2 0.5
Ever unenthusiastic/disinterested for a whole week 0.5 0.6 1.4 1.2 -0.9 0.0 0.1 -0.9
Qualifications: None of the above 1.1 2.3 4.1 -1.9 2.0 -0.1 -1.3 1.5
Financial difficulties in last 2 years 1.8 2.4 4.5 -1.2 1.9 1.5 0.4 2.1
Mouth/teeth dental problems 3.9 6.0 8.9 2.8 -2.9 -2.2 0.6 -3.0
Heart attack 0.6 0.8 1.6 0.4 -0.2 -1.1 -1.3 -1.0
Allergy 3.1 7.2 17.6 1.8 -2.1 -4.2 -2.5 -2.1
Pain all over the body in last month 0.2 0.2 0.7 0.3 -0.0 -0.0 -0.3 -0.8
Diabetes (self-reported) 1.4 2.2 5.5 -2.3 1.7 -0.1 0.0 1.6
Hayfever/allergic rhinitis (self-reported) 1.8 2.4 5.1 -1.0 1.4 2.3 1.5 1.3
Medication: Ramipril 2.0 2.6 6.6 2.6 -2.1 -0.1 -0.6 -1.2
Medication: Simvastatin 0.3 0.5 1.4 -0.8 1.2 -0.1 0.1 0.6
Fluid intelligence score 0.2 0.4 0.9 0.2 -0.6 0.1 0.9 0.8
Illnesses of siblings 0.5 0.7 1.6 -1.0 1.2 -0.4 0.9 0.0
Neuroticism score 1.1 2.2 4.4 2.0 -1.5 -0.6 -0.2 -2.1
Weight 0.2 1.2 2.3 -1.1 0.9 1.2 -0.4 1.5
Impedance of arm (right) 1.1 4.9 10.6 1.3 -1.7 -3.2 -2.7 -1.5
Arm fat percentage (right) 2.7 10.6 15.7 -4.0 3.7 2.8 0.3 4.0
Trunk fat-free mass 0.2 1.2 2.9 1.6 -1.7 0.3 -0.1 -0.7
Hip circumference 0.7 3.0 5.1 -1.8 1.5 2.0 0.7 2.3
Time employed in main current job 2.0 2.3 4.5 1.0 -1.0 -2.1 -2.1 -0.7
Alcohol intake versus 10 years previously 0.2 0.3 0.6 0.7 -0.8 0.1 0.6 0.2
Father’s age at death 1.7 2.3 4.7 1.7 -1.6 -1.1 -0.4 -2.2
Worrier / anxious feelings 0.5 0.9 2.1 1.1 -1.0 0.0 0.4 -1.5
Frequency of tiredness / lethargy in last 2 weeks 0.3 0.6 1.2 -0.7 1.1 0.6 -0.0 0.9
Falls in the last year 0.1 0.1 0.3 -0.5 -0.2 0.3 0.1 0.2
Hair/balding pattern: Pattern 3 1.2 1.8 4.0 -1.9 2.0 -0.4 -0.5 0.8
Number of live births 0.7 1.0 1.4 -1.1 0.7 1.2 1.1 0.7
Forced expiratory volume in 1-second (FEV1) 0.2 0.6 1.2 0.8 -0.5 -0.0 -1.1 -0.9
Pulse rate 2.6 4.4 6.4 1.9 -2.2 -2.5 -1.9 -1.8
Happiness 0.6 0.7 1.3 0.9 -1.1 0.8 -0.3 -0.9
Noisy workplace 1.0 1.2 2.4 -0.8 1.5 1.2 1.2 0.5
Qualifications: A levels/AS levels or equivalent 2.0 4.5 7.3 2.2 -2.3 -1.9 -0.9 -2.7
Serious illness, injury or assault of a close relative in last 2 years 2.4 2.7 7.2 -0.8 1.2 2.7 2.0 0.8
Mouth/teeth dental problems: Dentures 2.3 3.9 6.5 -2.4 2.6 -0.3 -2.2 1.6
Asthma 3.2 6.3 12.8 -1.7 1.9 3.6 3.0 1.8
Medication: Ibuprofen (e.g. Nurofen) 0.6 0.7 1.3 0.6 -0.7 -1.0 -1.1 -0.8
Medication: Cholesterol lowering 0.3 0.5 1.6 -0.3 0.5 -1.2 -0.5 -0.6
Depression (self-reported) 0.1 0.2 0.4 0.5 -0.4 -0.1 -0.1 -0.7
Medication: Lansoprazole 0.4 0.5 0.7 0.5 -0.6 0.9 0.7 0.7
Prospective memory result 0.5 0.7 2.4 1.6 -0.7 0.0 -0.6 -0.2
Lung cancer (father) 2.4 2.8 4.5 -1.8 2.1 1.7 0.9 1.7
Illnesses of mother 2.0 2.5 4.4 1.4 -1.5 -2.1 -0.7 -1.9
Forced expiratory volume in 1-second (FEV1), Best measure 0.2 0.5 0.9 0.9 -0.5 -0.2 -1.0 -0.8
Pulse wave Arterial Stiffness index 0.4 0.5 1.0 0.8 -0.2 -0.5 -1.0 -0.8
Impedance of arm (left) 1.5 6.8 10.0 2.1 -2.6 -3.2 -2.9 -2.2
Arm fat mass (right) 1.9 8.0 11.9 -3.3 3.1 2.8 0.4 3.5
Trunk predicted mass 0.2 1.2 3.0 1.6 -1.7 0.2 -0.3 -0.8
Standing height 3.3 32.9 47.6 6.6 -6.9 -5.2 -3.7 -5.7
Length of working week for main job 1.8 2.0 5.2 -1.5 2.3 0.5 -1.2 1.1
Exposure to tobacco smoke at home 4.1 4.6 8.6 -2.2 2.2 1.9 1.1 2.9
Breastfed as a baby 0.1 0.1 0.3 0.0 -0.5 0.2 -0.1 -0.1
Tense / ‘highly strung’ 0.9 1.4 3.6 1.4 -0.9 -0.7 -0.6 -1.9
Seen doctor (GP) for nerves, anxiety, tension or depression 0.6 0.9 2.0 -0.3 0.4 1.3 1.4 0.7
Hair/balding pattern: Pattern 4 0.5 1.3 2.8 0.5 -0.1 -1.6 -1.7 -0.8
Birth weight of first child 1.5 2.7 4.2 0.9 -1.9 -2.1 -1.8 -1.3
Peak expiratory flow (PEF) 1.4 3.2 9.5 -0.7 1.1 3.1 1.7 1.3
Pulse wave reflection index 0.1 0.1 0.3 -0.3 0.3 0.6 0.2 0.0
Ever highly irritable/argumentative for 2 days 0.7 0.8 1.6 -0.7 1.1 0.8 0.2 1.3
Loud music exposure frequency 0.4 0.5 1.4 0.2 0.3 1.2 0.8 -0.2
Qualifications: O levels/GCSEs or equivalent 0.9 1.5 2.9 1.2 -1.6 -0.3 0.4 -1.7
Mouth/teeth dental problems: Bleeding gums 3.4 4.3 7.7 -2.1 2.8 1.9 -0.3 2.5
Blood clot in the leg (DVT) 0.1 0.1 0.3 -0.1 0.2 0.4 0.3 -0.5
Medication: Paracetamol 0.9 1.4 2.5 -1.2 0.9 1.6 1.5 0.4
Headache pain in last month 0.3 0.5 1.7 -0.4 0.4 1.3 0.6 0.3
Medication for cholesterol, blood pressure or diabetes 0.1 0.1 0.3 -0.2 0.2 0.3 0.3 0.6
Glaucoma (self-reported) 0.9 1.0 1.5 -1.1 1.2 1.2 -0.9 0.4
Gout (self-reported) 0.5 0.6 1.1 -1.1 0.7 -0.9 -0.9 0.2
Hypothyroidism/myxoedema (self-reported) 4.0 7.8 11.8 -3.4 3.4 2.3 1.8 2.7
Medication: Amlodipine 0.7 1.0 3.2 0.6 -0.3 -1.2 -1.8 -0.4
Medication: Ventolin 100micrograms inhaler 3.5 4.4 5.9 -2.4 2.0 2.2 1.6 2.2
Birth weight 0.1 0.3 0.6 0.3 -0.4 -0.8 -0.8 0.1
Chronic bronchitis/emphysema (mother) 0.3 0.4 0.9 -0.9 1.0 0.1 -0.4 -0.2
High blood pressure (siblings) 0.5 0.7 2.7 0.2 -0.5 1.6 -0.1 0.8
Forced vital capacity (FVC), Best measure 1.1 4.1 5.0 2.0 -1.9 -2.2 -2.1 -1.9
Body fat percentage 2.7 10.6 17.1 -4.1 3.9 2.5 -0.0 3.9
Leg fat percentage (right) 5.0 18.2 30.1 -5.2 5.5 3.5 1.0 4.5
Arm fat-free mass (right) 0.2 0.8 1.8 1.2 -1.4 0.8 0.2 -0.3
Exposure to tobacco smoke outside home 5.1 6.8 12.5 -3.5 3.4 2.1 0.0 2.4
Comparative body size at age 10 2.5 6.8 15.1 -2.4 2.2 3.9 1.6 2.5
Number of full brothers 0.1 0.1 0.2 -0.1 -0.1 -0.5 -0.3 -0.2
Worry too long after embarrassment 4.7 7.9 14.2 3.8 -3.6 -1.3 0.1 -3.2
Seen a psychiatrist for nerves, anxiety, tension or depression 1.8 2.4 3.8 -1.5 1.8 1.9 1.1 1.2
Wheeze or whistling in the chest in last year 4.8 8.6 12.8 -3.3 3.4 3.6 0.8 2.6
Number of children fathered 0.3 0.4 1.2 -0.1 0.4 -0.6 -0.5 -1.1
Reason for reducing amount of alcohol drunk: Health precaution 3.3 3.9 7.2 1.8 -2.3 -1.9 -0.6 -2.7
Age at first live birth 0.7 1.2 1.6 0.9 -1.3 -1.1 -1.1 -0.9
Pulse wave peak to peak time 0.2 0.2 0.6 -0.3 -0.2 0.3 0.8 0.5
Health satisfaction 0.1 0.2 0.4 -0.2 0.4 0.3 -0.3 0.6
Shortness of breath walking on level ground 1.7 2.1 3.1 1.3 -1.2 -1.8 -1.6 -1.3
Qualifications: College or University degree 3.3 10.4 16.7 3.6 -4.1 -3.1 -0.4 -3.6
Eye problems/disorders: None of the above 0.2 0.3 0.4 -0.6 0.7 -0.4 -0.7 -0.0
Mouth/teeth dental problems: Loose teeth 1.2 1.4 2.5 -1.2 1.6 0.9 0.7 1.4
Emphysema/chronic bronchitis 0.3 0.3 0.5 -0.7 0.7 0.0 -0.6 0.4
Medication for pain relief, constipation, heartburn 0.4 0.6 2.1 0.5 -0.5 -1.4 -0.5 -0.4
Neck or shoulder pain in last month 0.6 0.8 1.9 -0.8 1.4 0.6 0.4 0.9
Medication: Blood pressure 0.2 0.3 0.7 0.5 -0.6 -0.1 -0.8 -0.5
Angina (self-reported) 1.3 1.7 5.6 -0.9 1.4 -0.5 -2.4 -0.1
Migraine (self-reported) 0.2 0.3 1.0 1.0 -0.5 -0.2 -0.0 -0.4
Medication: Ibuprofen 0.3 0.4 0.6 0.6 -0.8 -0.4 -0.6 -0.6
Medication: Allopurinol 0.6 0.8 1.4 -1.2 1.0 -1.0 -0.8 0.5
Medication: Omeprazole 0.8 1.0 2.2 -1.3 1.5 0.9 -0.0 0.3
Medication: Seretide 50 evohaler 1.5 1.7 4.1 -2.0 1.5 0.4 0.5 1.4
Mean time to correctly identify matches 2.2 4.1 8.3 1.8 -1.8 -2.9 -0.1 -2.4
Heart disease (mother) 0.4 0.5 0.9 0.7 -0.8 0.9 0.8 -0.2
Reproduciblity of spirometry measurement using ERS/ATS criteria 2.6 3.1 4.9 -2.0 2.1 1.4 0.4 2.2
Whole body fat mass 1.4 6.0 9.4 -3.0 2.7 2.1 0.0 3.1
Leg fat mass (right) 2.5 9.7 13.8 -3.7 3.7 2.9 0.7 3.5
Arm predicted mass (right) 0.2 1.1 2.9 1.5 -1.7 0.4 -0.1 -0.4
Pulse rate, automated reading 3.9 12.6 14.4 3.3 -3.5 -3.8 -3.4 -3.7
Alcohol intake frequency. 0.2 0.5 1.5 0.9 -1.2 -0.6 0.2 0.2
Comparative height size at age 10 2.9 15.7 28.5 4.4 -5.3 -3.7 -2.5 -3.2
Number of full sisters 2.0 2.5 7.2 -1.6 1.2 1.2 -0.0 2.7
Suffer from ‘nerves’ 2.1 3.2 6.4 -2.1 2.5 1.6 0.5 1.5
Overall health rating 1.3 2.9 5.4 -2.2 2.3 0.3 -0.7 1.9
Chest pain or discomfort 0.8 1.1 2.2 -0.8 1.3 1.5 -0.2 1.1
Had major operations 6.4 7.5 11.1 -3.3 3.2 2.8 0.0 2.8
Age at last live birth 0.1 0.2 0.3 0.4 -0.5 -0.2 -0.6 -0.0
Family relationship satisfaction 0.5 0.7 1.8 0.9 -0.8 -0.1 0.1 -1.3
Leg pain on walking 2.9 3.7 7.1 -1.9 2.2 1.7 -0.2 2.7
Qualifications: NVQ or HND or HNC or equivalent 2.2 2.6 5.6 -1.9 2.4 0.8 0.9 1.5
Commuting to job workplace: Car/motor vehicle 0.8 0.9 1.9 1.4 -0.4 -0.5 -1.2 -0.8
Illness, injury, bereavement, stress in last 2 years 0.1 0.1 0.4 -0.2 0.1 0.0 0.3 0.7
Medication: Aspirin 1.2 1.6 3.3 1.4 -1.8 -0.6 -1.0 -1.1
Supplements: Vitamin C 0.3 0.4 1.8 -0.4 0.0 1.4 0.0 -0.1
Knee pain experienced in last month 2.4 3.7 6.2 -2.4 2.5 2.0 0.7 1.5
Hypertension (Self-reported) 0.2 0.6 1.4 0.5 -0.5 1.1 -1.2 -0.1
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.8 0.9 2.2 0.7 -0.9 1.1 1.5 -0.3
Illnesses of father: Heart disease 0.4 0.5 1.0 0.4 -0.5 -0.8 -1.0 -0.8
Illnesses of siblings: Diabetes 0.7 0.8 2.2 -1.5 1.1 0.0 -0.3 0.9
Smoking status: Previous 0.7 1.1 1.6 -1.3 1.0 1.1 0.5 1.1
Forced expiratory volume in 1-second (FEV1), predicted 1.8 3.8 5.0 2.2 -2.1 -1.8 -1.2 -2.2
Whole body fat-free mass 0.2 1.2 3.4 1.6 -1.9 0.1 -0.2 -0.6
Leg fat-free mass (right) 0.5 2.4 6.5 2.1 -2.5 -0.4 -0.7 -0.8
Arm fat percentage (left) 2.5 9.9 14.4 -3.8 3.4 2.9 0.2 3.8
Average weekly red wine intake 0.7 1.0 1.7 -1.3 1.2 1.0 0.7 0.7
Handedness (chirality/laterality): Left-handed 1.2 1.4 2.5 0.7 -1.0 -1.5 -1.6 -1.0
Mood swings 0.2 0.3 0.6 -0.6 0.5 0.7 0.1 0.6
Loneliness, isolation 0.9 1.2 2.2 1.2 -0.9 -1.1 -0.3 -1.5
Long-standing illness, disability or infirmity 0.5 0.7 1.4 -1.0 1.2 1.1 0.1 0.3
Ever had bowel cancer screening 2.6 3.1 5.7 1.0 -1.1 -2.1 -1.8 -2.4
Diabetes diagnosed by doctor 1.6 2.6 5.8 -2.4 2.0 -0.2 -0.0 1.8
Ever had stillbirth, spontaneous miscarriage or termination 0.4 0.4 0.9 0.6 -1.0 0.4 0.5 -0.7
Friendships satisfaction 2.3 2.8 4.5 2.1 -2.0 -0.7 1.1 -1.9
Qualifications: nursing, teaching 0.8 1.3 2.4 1.1 -1.3 -0.0 0.9 -1.6
Commuting to job workplace: Walk 1.8 1.9 3.8 1.2 -1.7 1.1 1.9 -0.4
Eye problems/disorders: Cataract 2.8 3.2 6.1 2.0 -2.5 -1.9 0.5 -1.4
Mouth/teeth dental problems: Mouth ulcers 0.4 0.6 1.7 0.4 -0.7 0.9 1.3 -0.2
Medication for cholesterol 0.7 1.0 2.0 1.0 -1.0 -0.4 1.4 -0.9
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.2 0.3 1.0 -0.0 0.4 1.0 -0.4 -0.0
Back pain experienced in last month 2.4 3.5 6.2 -1.3 1.7 2.1 2.5 1.5
Mineral and other dietary supplements 2.4 3.2 7.7 1.4 -1.5 -2.8 -1.5 -1.4
Breast cancer (self-reported) 1.6 1.9 3.3 -1.6 1.8 0.6 -0.4 1.7
Asthma (self-reported) 2.9 5.8 11.5 -1.8 1.9 3.4 2.8 1.8
Osteoporosis (self-reported) 1.0 1.3 2.4 1.1 -0.6 -1.5 -0.9 -1.3
Osteoarthritis (self-reported) 5.9 7.7 12.0 -3.5 3.4 2.4 1.0 2.8
Medication: Aspirin 1.5 2.0 4.4 1.6 -2.1 -0.9 -0.9 -1.3
Medication: Gliclazide 0.2 0.2 0.6 -0.4 0.3 -0.3 0.8 -0.2
Illnesses of father: None of the above (group 1) 0.7 0.9 1.3 -0.8 1.2 0.5 1.0 1.1
Smoking status: Current 3.2 5.1 8.2 -2.7 2.9 1.7 0.5 2.6
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.2 0.4 1.3 -0.6 1.1 0.5 0.5 0.3
Whole body water mass 0.3 1.5 4.0 1.7 -2.0 0.1 -0.2 -0.7
Leg predicted mass (right) 0.5 2.5 6.6 2.1 -2.6 -0.5 -0.7 -0.9
Arm fat mass (left) 1.3 5.5 8.7 -2.7 2.3 2.5 0.3 2.9
Number of self-reported non-cancer illnesses 3.2 5.6 8.7 -2.6 2.7 3.0 1.0 2.0
Average weekly champagne plus white wine intake 1.6 2.1 4.1 1.4 -1.2 -2.0 -0.5 -1.7
Miserableness 0.1 0.2 0.5 0.0 0.1 0.7 0.6 0.4
Guilty feelings 3.7 5.5 12.8 3.1 -2.2 -0.6 -0.0 -3.6
Wears glasses or contact lenses 2.5 2.9 3.8 -1.5 1.7 1.8 1.6 1.9
Ever taken oral contraceptive pill 1.3 1.5 2.8 1.1 -0.6 -1.3 -1.2 -1.7
Hearing aid user 0.3 0.4 0.8 0.4 -0.6 -0.0 0.9 -0.7
Mother’s age at death 0.6 0.7 2.2 1.0 -1.5 -0.0 0.1 -0.5
Financial situation satisfaction 3.4 4.2 6.3 -1.9 2.4 2.3 0.5 2.5
Tinnitus: Yes, now most or all of the time 1.9 2.2 3.5 1.3 -1.0 -1.7 -1.9 -1.4
Commuting to job workplace: Public transport 1.2 1.4 4.2 0.4 -0.4 -2.1 -1.4 -0.7
Eye problems/disorders: Glaucoma 1.6 1.9 3.7 -1.5 1.9 1.6 -0.6 0.8
Medication: Blood pressure 0.7 1.3 2.4 1.3 -1.6 0.0 -1.1 -1.2
Pain type(s) experienced in last month: Hip pain 0.1 0.1 0.6 0.1 0.2 0.2 0.2 -0.8
Supplements: Fish oil (including cod liver oil) 2.7 3.6 9.4 -1.1 1.8 3.1 1.5 1.3
High cholesterol (Self-reported) 0.7 1.3 4.6 -1.2 2.1 0.5 -0.2 0.5
Medication: Bendroflumethiazide 0.6 0.9 1.7 1.2 -1.3 -0.2 -0.8 -0.9
Medication: Paracetamol 1.4 2.1 3.9 -1.3 0.8 1.9 2.0 0.9
Medication: Lisinopril 0.6 0.8 1.8 0.2 -1.0 -1.4 -0.8 -0.7
Medication: Atorvastatin 0.2 0.3 0.4 0.3 0.7 -0.5 -0.5 -0.5
Illnesses of father: High blood pressure 0.3 0.4 1.7 0.3 -0.5 0.1 -1.3 -0.2
Alcohol drinker status: Never 0.1 0.2 0.5 -0.2 0.1 -0.5 -0.7 0.3
Ever smoked 4.6 8.1 12.3 -3.5 3.5 2.2 0.2 3.3
Basal metabolic rate 0.1 0.5 1.6 1.0 -1.2 0.4 -0.1 -0.0
Leg fat percentage (left) 4.9 17.7 28.3 -5.2 5.3 3.4 0.9 4.5
Arm fat-free mass (left) 0.1 0.4 1.0 0.9 -1.0 0.6 0.1 -0.1
Number of operations (self-reported) 3.0 4.4 8.5 -2.9 2.8 1.8 -0.9 1.3
Average weekly beer plus cider intake 0.2 0.3 0.6 -0.3 0.4 0.5 0.8 0.7
Irritability 0.0 0.1 0.2 0.3 -0.2 -0.2 0.0 -0.4
Risk taking 0.6 0.8 2.4 0.9 -0.7 0.6 -0.1 -1.5
Ever had prostate specific antigen (PSA) test 0.3 0.4 0.9 -0.1 0.3 -0.9 -0.4 -0.8
Fractured/broken bones in last 5 years 0.4 0.5 1.4 0.2 -0.4 1.2 1.0 -0.1
Age started oral contraceptive pill 4.5 5.6 9.3 2.3 -2.5 -2.5 -1.0 -3.0
Diastolic blood pressure, automated reading 0.2 0.5 1.8 -0.1 0.4 1.3 0.3 0.7
Ever depressed for a whole week 1.4 1.7 3.5 1.9 -1.2 0.5 1.3 -1.3
Unable to work because of sickness or disability 1.6 2.1 4.4 -1.6 1.2 2.1 0.7 1.1
Commuting to job workplace: Cycle 2.3 2.8 5.8 -1.3 0.7 2.1 2.4 1.3
Myopia 2.1 3.1 4.7 -2.1 2.2 -0.4 -1.9 1.5
Vascular/heart problems diagnosed by doctor 0.4 1.1 1.9 -1.1 1.2 -0.6 1.4 0.8
Cholesterol lowering medication 0.3 0.4 0.6 -0.7 0.8 0.3 -0.4 0.7
Medication: Omeprazole (e.g. Zanprol) 0.7 0.9 1.6 -1.1 1.3 0.9 0.8 0.4
Pain experienced in last month 2.7 4.5 6.7 2.3 -2.6 -2.6 -1.3 -1.7
Supplements: Calcium 0.2 0.3 0.6 0.6 0.3 0.8 -0.4 -0.4
Basal cell carcinoma (self-reported) 1.6 1.9 4.0 1.4 -2.0 -0.7 -0.6 -1.6
Heart attack/myocardial infarction (self-reported) 1.0 1.3 2.3 0.7 -0.5 -1.4 -1.5 -1.3
Deep venous thrombosis (DVT) (self-reported) 0.1 0.1 0.2 0.1 0.0 0.5 0.4 -0.5
Heart disease (siblings) 2.4 2.9 4.8 2.2 -2.1 -0.8 -1.5 -1.6
Alcohol drinker status: Previous 0.2 0.2 0.5 0.5 -0.7 0.6 0.0 -0.1
Pack years of smoking 0.4 0.5 1.2 -0.7 0.5 0.3 -1.1 0.8
Impedance of whole body 0.6 3.0 6.8 0.8 -0.8 -2.6 -2.1 -1.4
Leg fat mass (left) 2.4 9.2 13.3 -3.7 3.5 2.8 0.6 3.5
Arm predicted mass (left) 0.1 0.4 1.0 0.5 -0.6 1.0 0.3 0.4