Best TWAS P=5.21e-09 · Best GWAS P=9.33e-13 conditioned to 0.805
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | LPA | 0.10 | 0.02 | lasso | 5 | 0.04 | 3.2e-06 | 2.7 | -5.8 | 6.2e-09 | -0.62 | 0.04 | 0.91 | TRUE |
| 2 | GTEx | Adipose Visceral Omentum | SLC22A3 | 0.13 | 0.06 | enet | 7 | 0.09 | 1.3e-05 | -4.9 | -5.2 | 2.3e-07 | -0.63 | 0.53 | 0.46 | FALSE |
| 3 | GTEx | Brain Caudate basal ganglia | SLC22A3 | 0.15 | 0.10 | enet | 39 | 0.11 | 5.6e-04 | -6.2 | -5.7 | 1.6e-08 | -0.71 | 0.04 | 0.89 | FALSE |
| 4 | GTEx | Esophagus Mucosa | SLC22A3 | 0.19 | 0.08 | enet | 47 | 0.12 | 1.7e-08 | 4.1 | -5.8 | 5.2e-09 | -0.58 | 0.64 | 0.35 | TRUE |
| 5 | ROSMAP | Brain Pre-frontal Cortex | SLC22A3 | 0.14 | 0.20 | lasso | 10 | 0.19 | 2.4e-24 | -5.4 | -5.5 | 4.1e-08 | -0.67 | 1.00 | 0.00 | FALSE |