TWAS hub - LPA

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.1030	0.0370	3.4e-05	0.017	0.031	0.025	0.035	0.045	3.3e-03	9.1e-05	0.00047	3.6e-05	3.2e-06
2	TCGA	Prostate Adenocarcinoma	0.0901	0.0527	7.8e-04	0.039	0.032	0.025	NA	0.026	5.7e-05	2.3e-04	0.00110	NA	8.7e-04

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2
LDL Cholesterol	9.5	15.1	29.2	1.0	-5.4
Heart disease (mother)	8.2	10.0	13.1	3.6	-2.6
Reproduciblity of spirometry measurement using ERS/ATS criteria	7.7	9.2	18.4	4.3	-0.0
Cholesterol lowering medication	7.4	10.9	20.1	4.5	-1.3
High cholesterol (Self-reported)	6.2	11.1	15.1	3.9	-2.7
Heart attack/myocardial infarction (self-reported)	5.8	7.4	8.8	2.5	-3.0
Heart attack	5.4	6.9	8.4	2.3	-2.9
Angina (self-reported)	5.2	6.8	8.0	2.4	-2.8
Medication: Cholesterol lowering	4.6	7.1	12.1	1.4	-3.5
Waist Hip Ratio (WHR)	4.5	20.3	37.2	6.1	1.9
Heart disease (siblings)	4.5	5.5	7.6	1.8	-2.8
Angina	4.3	5.7	6.5	2.2	-2.6
Medication: Simvastatin	4.3	6.3	7.3	2.7	-2.3
Illnesses of father: Heart disease	4.3	6.0	8.0	2.8	-2.0
Arm predicted mass (right)	4.1	21.1	26.2	-5.1	-4.0
Arm fat-free mass (right)	4.0	20.3	24.6	-5.0	-4.0
Medication: Atorvastatin	3.8	4.6	4.9	2.2	-2.1
Comparative height size at age 10	3.7	20.5	33.8	-5.8	-2.7
Leg fat-free mass (right)	3.7	19.8	25.3	-5.0	-3.8
Leg predicted mass (right)	3.7	19.6	24.9	-5.0	-3.8
Arm fat-free mass (left)	3.7	18.9	22.8	-4.8	-3.9
Leg fat-free mass (left)	3.6	18.8	24.3	-4.9	-3.6
Leg predicted mass (left)	3.6	18.8	24.4	-4.9	-3.6
Arm predicted mass (left)	3.6	18.5	22.4	-4.7	-3.8
Eye problems/disorders: Diabetes related eye disease	3.5	3.8	6.9	-0.8	2.6
Whole body fat-free mass	3.5	20.0	24.9	-5.0	-3.9
Whole body water mass	3.5	20.1	23.8	-4.9	-4.1
Basal metabolic rate	3.4	18.7	23.5	-4.8	-3.7
Diabetes (father)	3.3	4.0	4.5	2.1	1.9
Diverticular disease/diverticulitis (self-reported)	3.2	3.7	5.5	2.4	-1.4
Trunk fat-free mass	3.2	18.3	22.5	-4.7	-3.8
Trunk predicted mass	3.2	18.4	22.7	-4.8	-3.8
Multivitamins +/- minerals	3.1	3.9	5.1	2.2	-1.6
Hip circumference	3.1	13.2	19.9	-4.5	-2.6
Noisy workplace	3.1	3.8	5.6	2.4	1.4
Maternal smoking around birth	3.0	4.3	7.0	1.3	-2.6
Hayfever/allergic rhinitis (self-reported)	3.0	4.0	4.4	1.9	2.1
Qualifications: NVQ or HND or HNC or equivalent	3.0	3.6	4.0	1.8	2.0
Gout (self-reported)	2.9	4.0	7.0	2.6	-1.0
Type 2 Diabetes (T2D) (2018)	2.8	5.3	10.3	3.2	0.5
Mouth/teeth dental problems: Bleeding gums	2.8	3.6	6.9	-0.5	2.6
Medication for cholesterol	2.8	4.2	8.3	-2.9	-0.1
HDL Cholesterol	2.7	4.4	8.1	-2.8	-0.9
Medication: Ramipril	2.7	3.5	4.6	2.1	-1.6
Weight	2.7	13.4	18.1	-4.2	-3.0
Triglycerides	2.6	4.3	8.5	2.9	0.1
Diabetes (mother)	2.6	3.3	5.6	2.4	1.0
Depression (Nagel 2018)	2.5	3.7	5.7	-1.3	-2.4
HbA1C	2.5	2.7	5.2	0.5	2.3
Ever unenthusiastic/disinterested for a whole week	2.5	3.0	6.0	2.5	-0.0
Supplements: Vitamin C	2.5	3.0	5.5	-0.6	2.4
Pain all over the body in last month	2.4	2.6	5.0	0.4	2.2
Prospective memory result	2.4	3.0	5.6	-0.6	-2.4
Whole body fat mass	2.4	9.8	14.7	-3.8	-2.2
Lupus	2.3	3.5	5.8	2.4	1.1
Ever had hysterectomy (womb removed)	2.2	2.5	4.5	2.1	-0.7
Mineral and other dietary supplements	2.2	3.0	3.8	-2.0	-1.4
Number of self-reported non-cancer illnesses	2.2	3.8	7.6	2.7	-0.1
Cardiovascular Disease	2.1	6.9	12.9	3.6	-0.9
Medication: Aspirin	2.1	2.8	5.1	2.3	-0.7
Medication: Metformin	2.0	2.9	4.9	2.2	0.9
Trunk fat mass	2.0	8.7	12.5	-3.5	-2.2
Father’s age at death	2.0	2.7	2.9	-1.7	1.6
Standing height	2.0	20.0	31.2	-5.6	-3.0
Myopia	2.0	2.8	5.6	0.2	2.4
Fed-up feelings	1.9	3.4	4.0	-2.0	-1.7
Stomach or abdominal pain in last month	1.8	2.2	4.3	0.2	2.1
Commuting to job workplace: Car/motor vehicle	1.8	2.0	3.3	1.8	-0.9
Pain type(s) experienced in last month: Hip pain	1.8	2.3	3.7	-0.9	-1.9
Frequency of unenthusiasm / disinterest in last 2 weeks	1.7	2.3	3.4	-1.8	-1.1
Sitting height	1.7	11.9	21.1	-4.6	-1.6
Lung cancer (father)	1.7	2.0	3.8	-2.0	0.5
Long-standing illness, disability or infirmity	1.7	2.6	4.6	0.7	2.1
Leg fat mass (left)	1.7	6.6	9.4	-3.1	-1.9
Bipolar Disorder (2011)	1.6	1.5	2.1	1.0	-1.4
Blood Platelet Count	1.6	18.7	22.7	4.8	3.8
Allergy or Eczema	1.6	4.1	8.2	0.1	2.9
Impedance of leg (right)	1.6	7.7	8.5	2.9	2.6
Frequency of tenseness / restlessness in last 2 weeks	1.6	2.5	4.4	-0.8	-2.1
Arm fat mass (right)	1.6	6.5	7.9	-2.8	-2.3
Comparative body size at age 10	1.6	4.4	7.8	-1.0	-2.8
Arm fat mass (left)	1.6	6.7	8.0	-2.8	-2.3
Pack years of smoking	1.6	2.4	3.1	1.2	-1.8
Alzheimer’s Disease (in mother)	1.5	1.7	3.5	1.9	-0.0
Pack years adult smoking proportion	1.5	2.3	2.5	1.4	-1.6
Bilateral oophorectomy (both ovaries removed)	1.5	1.7	3.3	1.8	-0.4
Hayfever, allergic rhinitis or eczema	1.5	3.3	6.3	0.4	2.5
Hair/balding pattern: Pattern 2	1.5	1.9	2.6	1.1	1.6
Medication: Ibuprofen (e.g. Nurofen)	1.5	1.8	2.2	-1.2	-1.5
Number of full sisters	1.5	1.8	3.4	1.9	0.4
Medication: Aspirin	1.5	1.9	2.9	1.7	-1.0
Supplements: Fish oil (including cod liver oil)	1.5	2.0	2.5	1.2	1.6
Height	1.4	27.2	46.2	-6.8	-2.9
Heel bone mineral density (BMD) T-score, automated (right)	1.4	3.3	3.7	-1.7	1.9
Number of children fathered	1.4	1.5	3.0	0.2	-1.7
Leg fat mass (right)	1.4	5.6	7.5	-2.7	-1.9
Neuroticism (2016)	1.3	1.8	3.6	-0.2	1.9
Average weekly spirits intake	1.3	1.6	3.2	-1.8	0.2
Hearing difficulty/problems: Yes	1.3	1.9	3.5	1.9	0.6
Heel bone mineral density (BMD) T-score, automated (left)	1.3	2.9	4.3	-1.2	2.1
Illnesses of siblings	1.3	1.8	3.0	-1.7	0.8
Number of live births	1.3	1.9	3.7	-0.1	1.9
Headache pain in last month	1.3	2.3	3.9	-2.0	-0.8
Loneliness, isolation	1.3	1.7	2.5	1.0	-1.6
Commuting to job workplace: Walk	1.3	1.4	2.8	1.7	0.1
Depressed Affect (Nagel 2018)	1.2	2.6	2.9	-1.7	-1.5
Ulcerative Colitis	1.2	1.7	2.1	1.5	-1.1
BMI	1.2	7.2	11.7	-3.4	-1.6
Supplements: Zinc	1.2	1.3	1.6	1.0	1.3
Severe depression (siblings)	1.2	1.3	1.6	1.0	1.3
Number of incorrect matches in round	1.2	2.0	3.3	0.9	-1.8
Pulse rate	1.2	2.1	4.2	2.0	-0.2
Age at last live birth	1.2	1.7	3.5	1.9	-0.1
Mother’s age at death	1.2	1.5	2.1	-1.5	0.9
Bipolar Disorder (2018)	1.1	1.7	3.4	1.8	-0.0
Medication: Co-codamol	1.1	1.3	2.2	-1.5	-0.6
Impedance of leg (left)	1.1	5.3	5.6	2.2	2.4
Hearing difficulty/problems with background noise	1.1	1.8	2.1	1.5	1.2
Qualifications: A levels/AS levels or equivalent	1.1	2.4	4.1	-0.8	2.0
Medication: Lansoprazole	1.1	1.2	2.4	1.6	0.1
Birth weight of first child	1.1	2.0	2.4	-1.5	-1.3
Emphysema/chronic bronchitis	1.1	1.3	1.5	1.2	-1.0
Medication: Ibuprofen	1.1	1.4	1.8	-1.0	-1.3
Mood swings	1.1	1.9	2.1	-1.4	-1.3
Smoking status: Current	1.1	1.7	2.6	-1.6	-1.0
Illnesses of father: High blood pressure	1.1	1.4	2.4	1.6	0.6
Impedance of whole body	1.1	5.8	6.9	2.2	2.6
Reaction Time	1.0	1.9	3.0	1.7	-0.9
Body Mass Index (BMI) (2010)	1.0	1.4	2.8	-1.7	0.2
Chronotype (morning person)	1.0	2.4	4.7	-0.2	-2.2
Frequency of depressed mood in last 2 weeks	1.0	1.4	2.7	-0.2	-1.7
Vitamin and mineral supplements	1.0	1.4	2.7	-1.6	-0.1
Qualifications: O levels/GCSEs or equivalent	1.0	1.6	1.7	-1.3	1.2
Shortness of breath walking on level ground	1.0	1.2	1.4	-1.0	-1.2
Migraine (self-reported)	1.0	1.2	1.2	-1.1	-1.1
Alcohol drinker status: Never	1.0	1.2	2.2	1.5	-0.3
Risk taking	1.0	1.4	2.7	-1.6	-0.3
Medication: Omeprazole (e.g. Zanprol)	1.0	1.2	2.4	1.5	-0.3
Schizophrenia vs Biploar Disorder	0.9	1.2	2.2	-0.5	-1.5
Systolic Blood Pressure	0.9	4.5	6.9	2.6	1.4
Trunk fat percentage	0.9	3.7	5.5	-2.3	-1.4
Glaucoma (self-reported)	0.9	1.0	2.1	-1.4	0.1
Pulse wave peak to peak time	0.9	1.1	1.6	-1.3	-0.8
Medication: Allopurinol	0.9	1.2	2.4	1.6	-0.1
Leg pain on walking	0.9	1.1	1.7	0.7	-1.3
Illnesses of father: None of the above (group 1)	0.9	1.1	1.8	-1.4	0.6
Average weekly champagne plus white wine intake	0.9	1.2	1.7	-1.3	-0.8
Miserableness	0.9	1.5	1.8	-1.1	-1.4
Medication: Blood pressure	0.9	1.6	2.5	1.6	0.9
Vascular/heart problems diagnosed by doctor	0.9	2.4	4.7	-2.2	0.2
Deep venous thrombosis (DVT) (self-reported)	0.9	1.1	1.3	-1.0	-1.1
Bipolar Disorder or Schizophrenia	0.8	2.0	3.9	2.0	-0.4
Breast Cancer	0.8	1.9	2.2	1.5	-1.3
Number of treatments/medications taken	0.8	1.4	2.9	1.7	0.2
Ever used hormone-replacement therapy (HRT)	0.8	1.1	1.2	1.0	1.1
Happiness	0.8	1.0	1.9	-0.1	1.4
Illnesses of mother	0.8	1.0	2.0	-1.4	0.2
Impedance of arm (left)	0.8	3.7	4.0	1.8	2.0
Blood clot in the leg (DVT)	0.8	1.0	1.0	-1.0	-1.0
Reason for reducing amount of alcohol drunk: Health precaution	0.8	0.9	1.2	1.1	-0.8
Neck or shoulder pain in last month	0.8	1.1	2.2	-0.0	-1.5
Mean time to correctly identify matches	0.8	1.5	2.4	1.6	-0.8
Back pain experienced in last month	0.8	1.2	2.4	-1.5	-0.2
Eye problems/disorders: Glaucoma	0.8	1.0	1.4	-1.2	0.8
Medication: Lisinopril	0.8	1.0	1.7	-0.5	1.3
Alzheimer’s Disease (in father)	0.7	0.8	1.3	-1.1	-0.5
Irritable Bowel Disease (IBD)	0.7	1.7	2.7	0.8	-1.6
Coronary Artery Disease (CAD)	0.7	0.8	1.4	0.4	-1.2
Hand grip strength (right)	0.7	1.8	3.4	-1.8	-0.5
Current tobacco smoking	0.7	1.1	1.8	-1.3	-0.6
Age when periods started (menarche)	0.7	1.8	2.2	-1.2	1.5
Supplements: Glucosamine	0.7	0.9	1.4	0.6	1.2
Chronic bronchitis/emphysema (father)	0.7	0.8	1.4	-1.2	0.4
Body mass index (BMI)	0.7	3.1	3.3	-1.8	-1.7
Allergy	0.7	1.6	2.9	-0.6	-1.7
Birth weight	0.7	1.6	2.7	-1.6	-0.7
High blood pressure (siblings)	0.7	1.0	2.1	1.4	0.0
Body fat percentage	0.7	2.9	4.3	-2.1	-1.2
Eye problems/disorders: None of the above	0.7	0.8	1.2	0.7	-1.1
Medication: Omeprazole	0.7	0.9	1.6	1.2	-0.5
Illness, injury, bereavement, stress in last 2 years	0.7	0.8	1.7	1.3	0.0
Hypertension (Self-reported)	0.7	1.9	3.1	1.8	0.8
Mouth/teeth dental problems: Mouth ulcers	0.7	1.1	2.0	1.4	0.4
Commuting to job workplace: Cycle	0.7	0.8	1.6	1.3	0.3
Mean Putamen Volume	0.6	0.7	0.8	0.8	-0.9
Lung FVC	0.6	2.9	4.2	2.0	1.3
Average weekly fortified wine intake	0.6	0.8	1.3	0.4	1.1
Relative age voice broke	0.6	0.9	1.6	-0.4	1.3
Fluid intelligence score	0.6	1.3	1.3	-1.2	-1.1
Impedance of arm (right)	0.6	2.9	3.3	1.6	1.8
Pulse wave Arterial Stiffness index	0.6	0.7	0.9	0.9	0.7
Health satisfaction	0.6	0.8	1.7	1.3	0.1
Alcohol intake frequency.	0.6	1.4	2.6	1.6	0.4
Family relationship satisfaction	0.6	0.8	1.1	0.7	1.1
Illnesses of siblings: Diabetes	0.6	0.7	0.9	1.0	-0.7
Diabetes diagnosed by doctor	0.6	1.0	1.7	1.3	0.6
Intelligence (Savage-Jansen 2018)	0.5	1.5	2.8	-1.7	0.4
Respiratory disease	0.5	1.1	2.2	-1.5	0.1
Lung FEV1/FVC ratio	0.5	2.3	3.9	2.0	0.8
Serious illness, injury or assault to yourself	0.5	0.6	1.0	-0.4	1.0
High blood pressure	0.5	1.5	2.2	1.5	0.8
Mouth/teeth dental problems	0.5	0.8	1.6	0.2	-1.3
Diabetes (self-reported)	0.5	0.8	0.9	0.9	0.9
Mouth/teeth dental problems: Dentures	0.5	0.9	1.1	-1.0	0.8
Breastfed as a baby	0.5	0.6	1.1	-1.1	0.3
Hair/balding pattern: Pattern 4	0.5	1.3	2.0	-1.4	-0.7
Average weekly red wine intake	0.5	0.7	1.4	-1.2	0.2
Ever had stillbirth, spontaneous miscarriage or termination	0.5	0.6	1.1	1.0	0.3
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.5	0.6	1.0	-1.0	-0.5
Tinnitus: Yes, now most or all of the time	0.5	0.6	1.1	1.0	0.4
Commuting to job workplace: Public transport	0.5	0.7	1.3	-1.1	-0.2
Crohns Disease (2017)	0.4	1.0	1.7	0.5	-1.3
Ulcerative Colitis (UC)	0.4	0.7	0.8	0.9	-0.8
Schizophrenia (2014)	0.4	0.9	0.9	1.0	-0.9
Tinnitus: Yes, but not now, but have in the past	0.4	0.5	0.5	-0.7	-0.6
Waist circumference	0.4	1.4	1.6	-1.1	-1.3
Had other major operations	0.4	0.5	0.6	-0.7	0.8
Arm fat percentage (right)	0.4	1.6	1.6	-1.3	-1.2
Frequency of tiredness / lethargy in last 2 weeks	0.4	0.6	0.8	-0.9	-0.6
Tense / ‘highly strung’	0.4	0.7	0.8	0.8	0.9
Ever highly irritable/argumentative for 2 days	0.4	0.5	0.7	-0.5	-0.8
Loud music exposure frequency	0.4	0.4	0.9	0.9	-0.1
Medication for cholesterol, blood pressure or diabetes	0.4	0.6	1.2	-0.3	1.1
Medication: Amlodipine	0.4	0.6	0.9	0.5	1.0
Chronic bronchitis/emphysema (mother)	0.4	0.5	0.9	-0.4	-0.9
Exposure to tobacco smoke outside home	0.4	0.6	0.7	-0.8	-0.7
Seen a psychiatrist for nerves, anxiety, tension or depression	0.4	0.6	1.1	1.1	0.0
Medication: Seretide 50 evohaler	0.4	0.4	0.8	-0.1	0.9
Smoking status: Previous	0.4	0.6	0.9	0.6	0.9
Forced expiratory volume in 1-second (FEV1), predicted	0.4	0.7	1.3	-1.2	0.4
Arm fat percentage (left)	0.4	1.7	1.7	-1.3	-1.3
Handedness (chirality/laterality): Left-handed	0.4	0.5	0.9	0.2	0.9
Osteoporosis (self-reported)	0.4	0.5	0.7	0.9	-0.5
Hearing aid user	0.4	0.5	0.8	-0.9	0.3
Unable to work because of sickness or disability	0.4	0.5	0.9	-1.0	0.4
Schizophrenia (2018)	0.3	0.7	1.1	1.1	-0.5
Rheumatoid Arthritis	0.3	0.4	0.8	-0.9	0.0
Heel T-Score	0.3	2.8	4.6	2.1	1.0
Systolic blood pressure, automated reading	0.3	0.8	1.6	-0.0	1.3
Taking other prescription medications	0.3	0.5	0.6	0.7	0.8
Medication: Atenolol	0.3	0.4	0.6	-0.7	-0.4
High blood pressure (mother)	0.3	0.4	0.7	-0.8	0.4
Time employed in main current job	0.3	0.3	0.6	-0.8	0.2
Depression (self-reported)	0.3	0.4	0.8	0.9	0.3
Forced expiratory volume in 1-second (FEV1), Best measure	0.3	1.1	2.1	0.1	1.4
Medication: Paracetamol	0.3	0.5	1.0	-1.0	0.3
Medication: Ventolin 100micrograms inhaler	0.3	0.3	0.6	0.3	0.8
Wheeze or whistling in the chest in last year	0.3	0.5	0.6	-0.7	-0.8
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.3	0.7	1.3	0.3	1.2
Ever taken oral contraceptive pill	0.3	0.3	0.6	-0.8	-0.1
Basal cell carcinoma (self-reported)	0.3	0.4	0.7	0.9	-0.0
Alcohol drinker status: Previous	0.3	0.4	0.4	-0.6	0.6
Major Depression (MDD)	0.2	0.3	0.5	-0.0	0.7
Verbal and Numeric Reasoning (VNR)	0.2	0.5	0.7	-0.8	0.5
Age at First Birth	0.2	0.3	0.5	0.4	0.7
Fasting Glucose	0.2	0.2	0.3	-0.6	-0.3
Blood Red Count	0.2	1.8	3.5	-0.4	1.9
Hypothyroidism (self reported)	0.2	0.5	0.6	-0.7	-0.8
Hand grip strength (left)	0.2	0.5	0.8	-0.9	-0.4
Medication for hormone replacement therapy	0.2	0.2	0.4	-0.2	-0.7
Alcohol usually taken with meals	0.2	0.3	0.5	-0.7	-0.3
Had menopause	0.2	0.2	0.4	-0.2	0.6
Alcohol intake versus 10 years previously	0.2	0.3	0.3	0.6	0.6
Forced expiratory volume in 1-second (FEV1)	0.2	0.8	1.3	0.5	1.1
Seen doctor (GP) for nerves, anxiety, tension or depression	0.2	0.3	0.6	0.2	0.8
Peak expiratory flow (PEF)	0.2	0.5	1.0	1.0	0.3
Pulse wave reflection index	0.2	0.3	0.5	-0.2	-0.7
Hypothyroidism/myxoedema (self-reported)	0.2	0.3	0.7	-0.0	-0.8
Forced vital capacity (FVC), Best measure	0.2	0.7	0.8	-0.7	0.9
Number of full brothers	0.2	0.2	0.5	0.7	0.1
Worry too long after embarrassment	0.2	0.3	0.5	-0.1	-0.7
Mouth/teeth dental problems: Loose teeth	0.2	0.2	0.2	-0.4	0.5
Friendships satisfaction	0.2	0.3	0.4	-0.6	-0.4
Breast cancer (self-reported)	0.2	0.2	0.3	-0.5	0.4
Wears glasses or contact lenses	0.2	0.2	0.5	0.1	-0.7
Medication: Paracetamol	0.2	0.4	0.4	-0.6	0.6
Leg fat percentage (left)	0.2	0.6	0.7	-0.8	-0.7
Ever had prostate specific antigen (PSA) test	0.2	0.2	0.4	0.2	0.6
Pain experienced in last month	0.2	0.3	0.6	0.1	0.8
Neuroticism (Nagel 2018)	0.1	0.2	0.2	-0.4	-0.5
Worry (Nagel 2018)	0.1	0.2	0.4	-0.1	0.6
Alzheimer’s Disease (including proxy)	0.1	0.1	0.3	0.5	0.1
Crohns Disease (2012)	0.1	0.2	0.3	-0.6	-0.3
Primary Biliary Cirrhosis	0.1	0.2	0.2	-0.4	-0.5
Type 2 Diabetes (T2D) (2012)	0.1	0.2	0.2	0.4	0.4
Blood Eosinophil Count	0.1	1.1	1.1	1.1	1.0
Neuroticism	0.1	0.2	0.2	-0.4	0.5
Tanning	0.1	1.2	2.0	-0.7	-1.4
Sensitivity / hurt feelings	0.1	0.3	0.5	-0.0	-0.7
Relative age of first facial hair	0.1	0.2	0.2	-0.5	0.4
Townsend deprivation index at recruitment	0.1	0.1	0.2	0.4	-0.2
Qualifications: CSEs or equivalent	0.1	0.1	0.2	0.4	0.3
Medication: Levothyroxine sodium	0.1	0.1	0.2	0.0	-0.5
Past tobacco smoking	0.1	0.3	0.5	0.7	-0.1
Forced vital capacity (FVC)	0.1	0.5	0.8	-0.4	0.9
Qualifications: None of the above	0.1	0.3	0.6	-0.1	-0.8
Financial difficulties in last 2 years	0.1	0.2	0.3	0.2	0.5
Neuroticism score	0.1	0.2	0.3	-0.4	-0.5
Worrier / anxious feelings	0.1	0.2	0.2	0.5	-0.5
Falls in the last year	0.1	0.2	0.3	-0.5	-0.3
Hair/balding pattern: Pattern 3	0.1	0.1	0.1	0.4	0.3
Age at first live birth	0.1	0.2	0.4	0.6	0.1
Qualifications: College or University degree	0.1	0.3	0.6	0.0	0.8
Medication for pain relief, constipation, heartburn	0.1	0.2	0.3	-0.1	0.6
Medication: Blood pressure	0.1	0.2	0.4	-0.6	-0.1
Pulse rate, automated reading	0.1	0.4	0.7	0.8	-0.3
Suffer from ‘nerves’	0.1	0.1	0.1	-0.4	0.1
Overall health rating	0.1	0.1	0.2	-0.2	-0.5
Chest pain or discomfort	0.1	0.2	0.2	0.3	-0.5
Had major operations	0.1	0.1	0.2	0.3	-0.4
Knee pain experienced in last month	0.1	0.1	0.2	0.5	0.1
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.1	0.1	0.2	0.3	-0.4
Ever had bowel cancer screening	0.1	0.2	0.3	-0.5	-0.2
Eye problems/disorders: Cataract	0.1	0.1	0.1	-0.3	-0.1
Osteoarthritis (self-reported)	0.1	0.2	0.3	0.4	-0.5
Financial situation satisfaction	0.1	0.1	0.1	-0.2	0.3
Medication: Bendroflumethiazide	0.1	0.1	0.1	0.3	-0.2
Ever smoked	0.1	0.1	0.2	-0.4	-0.1
Number of operations (self-reported)	0.1	0.2	0.3	-0.5	-0.4
Average weekly beer plus cider intake	0.1	0.2	0.3	-0.6	-0.1
Diastolic blood pressure, automated reading	0.1	0.2	0.3	-0.6	0.2
Ever depressed for a whole week	0.1	0.1	0.2	0.4	0.1
Supplements: Calcium	0.1	0.1	0.3	0.0	-0.5
Ovarian Cancer	0.0	0.1	0.1	0.3	-0.2
Prostate Cancer	0.0	0.0	0.0	0.0	0.0
Blood White Count	0.0	0.0	0.0	0.2	-0.1
Smoking Status	0.0	0.0	0.1	-0.3	-0.1
Hair Pigment	0.0	1.4	2.4	-0.6	-1.5
Other serious medical condition/disability diagnosed by doctor	0.0	0.0	0.1	-0.2	-0.2
Nervous feelings	0.0	0.1	0.1	0.4	-0.2
Serious illness, injury or assault of a close relative in last 2 years	0.0	0.0	0.1	0.2	-0.1
Asthma	0.0	0.0	0.0	-0.1	0.0
Length of working week for main job	0.0	0.0	0.0	0.1	0.1
Exposure to tobacco smoke at home	0.0	0.0	0.1	-0.2	-0.0
Leg fat percentage (right)	0.0	0.2	0.2	-0.3	-0.5
Qualifications: nursing, teaching	0.0	0.1	0.1	0.2	0.3
Asthma (self-reported)	0.0	0.0	0.0	-0.1	0.2
Medication: Gliclazide	0.0	0.0	0.0	-0.2	0.0
Guilty feelings	0.0	0.0	0.0	0.1	-0.2
Irritability	0.0	0.0	0.0	0.1	-0.1
Fractured/broken bones in last 5 years	0.0	0.0	0.0	-0.2	0.1
Age started oral contraceptive pill	0.0	0.1	0.1	0.2	0.2

Hub : Genes

LPA

Models

Trait associations