Best TWAS P=5.1e-57 · Best GWAS P=1.5e-58 conditioned to 9.91e-05
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | CDK6 | 0.12 | 0.10 | lasso | 2 | 0.10 | 1.9e-12 | 15.398 | 15.4 | 1.1e-53 | 0.90 | 0.07 | 0.93 | FALSE |
| 2 | GTEx | Adipose Subcutaneous | GATAD1 | 0.21 | 0.14 | enet | 10 | 0.16 | 3.4e-13 | 8.264 | -6.2 | 4.1e-10 | -0.42 | 1.00 | 0.00 | FALSE |
| 3 | GTEx | Adipose Visceral Omentum | GATAD1 | 0.12 | 0.08 | lasso | 5 | 0.06 | 7.5e-04 | 8.264 | -8.5 | 1.7e-17 | -0.53 | 0.68 | 0.21 | FALSE |
| 4 | GTEx | Adrenal Gland | GATAD1 | 0.40 | 0.22 | lasso | 7 | 0.25 | 2.0e-09 | 8.264 | -8.9 | 7.5e-19 | -0.52 | 0.68 | 0.07 | FALSE |
| 5 | GTEx | Artery Aorta | KRIT1 | 0.15 | 0.00 | enet | 24 | 0.03 | 1.3e-02 | -0.544 | -7.9 | 2.3e-15 | -0.35 | 0.12 | 0.09 | FALSE |
| 6 | GTEx | Artery Aorta | GATAD1 | 0.09 | 0.08 | enet | 4 | 0.07 | 7.4e-05 | 8.264 | -8.4 | 5.8e-17 | -0.48 | 0.54 | 0.03 | FALSE |
| 7 | GTEx | Artery Coronary | GATAD1 | 0.12 | 0.15 | lasso | 3 | 0.12 | 8.0e-05 | 8.297 | -8.5 | 1.5e-17 | -0.48 | 0.21 | 0.12 | FALSE |
| 8 | GTEx | Artery Tibial | GATAD1 | 0.14 | 0.04 | enet | 17 | 0.04 | 4.1e-04 | 8.264 | -7.3 | 3.7e-13 | -0.45 | 0.72 | 0.09 | FALSE |
| 9 | GTEx | Artery Tibial | AC007566.10 | 0.13 | 0.04 | lasso | 5 | 0.00 | 3.1e-01 | 4.400 | -5.7 | 1.2e-08 | -0.21 | 0.08 | 0.03 | FALSE |
| 10 | GTEx | Brain Caudate basal ganglia | GATAD1 | 0.21 | 0.09 | lasso | 4 | 0.08 | 2.3e-03 | 6.725 | -9.5 | 2.9e-21 | -0.48 | 0.08 | 0.23 | FALSE |
| 11 | GTEx | Brain Cortex | AC000120.7 | 0.12 | 0.08 | enet | 16 | 0.07 | 7.0e-03 | 3.383 | -6.6 | 5.1e-11 | -0.45 | 0.14 | 0.05 | FALSE |
| 12 | GTEx | Breast Mammary Tissue (Female) | AC007566.10 | 0.04 | -0.01 | lasso | 2 | 0.01 | 2.0e-01 | 0.005 | -6.4 | 1.9e-10 | -0.35 | 0.03 | 0.17 | FALSE |
| 13 | GTEx | Cells Transformed fibroblasts | GATAD1 | 0.23 | 0.20 | lasso | 4 | 0.22 | 1.4e-16 | 8.264 | -10.8 | 5.8e-27 | -0.60 | 1.00 | 0.00 | FALSE |
| 14 | GTEx | Colon Transverse | GATAD1 | 0.13 | 0.00 | enet | 16 | 0.05 | 3.0e-03 | 8.264 | -8.0 | 9.1e-16 | -0.44 | 0.23 | 0.06 | FALSE |
| 15 | GTEx | Esophagus Mucosa | GATAD1 | 0.16 | 0.05 | enet | 16 | 0.08 | 7.3e-06 | 8.264 | -9.2 | 4.8e-20 | -0.51 | 0.82 | 0.05 | FALSE |
| 16 | GTEx | Esophagus Muscularis | GATAD1 | 0.18 | 0.10 | enet | 33 | 0.13 | 1.6e-08 | 8.264 | -6.6 | 5.5e-11 | -0.40 | 0.98 | 0.00 | FALSE |
| 17 | GTEx | Esophagus Muscularis | FAM133B | 0.07 | 0.01 | enet | 2 | 0.01 | 1.2e-01 | -9.307 | -9.4 | 3.8e-21 | -0.56 | 0.05 | 0.51 | FALSE |
| 18 | GTEx | Lung | GATAD1 | 0.15 | 0.12 | lasso | 2 | 0.11 | 1.1e-08 | 8.264 | -8.4 | 5.8e-17 | -0.48 | 0.99 | 0.00 | FALSE |
| 19 | GTEx | Muscle Skeletal | PEX1 | 0.06 | 0.03 | lasso | 5 | 0.02 | 2.7e-03 | 6.835 | 7.3 | 3.1e-13 | 0.34 | 0.49 | 0.20 | FALSE |
| 20 | GTEx | Muscle Skeletal | GATAD1 | 0.05 | 0.00 | enet | 13 | 0.01 | 2.4e-02 | 3.956 | -7.5 | 8.6e-14 | -0.45 | 0.48 | 0.02 | FALSE |
| 21 | GTEx | Nerve Tibial | GATAD1 | 0.30 | 0.19 | lasso | 5 | 0.23 | 1.8e-16 | 8.264 | -6.2 | 4.8e-10 | -0.41 | 1.00 | 0.00 | FALSE |
| 22 | GTEx | Pancreas | GATAD1 | 0.12 | 0.13 | lasso | 2 | 0.14 | 2.0e-06 | 8.264 | -7.7 | 2.0e-14 | -0.46 | 0.26 | 0.20 | FALSE |
| 23 | GTEx | Pituitary | KRIT1 | 0.21 | -0.01 | enet | 14 | 0.20 | 1.1e-05 | -0.389 | -5.3 | 1.1e-07 | -0.15 | 0.27 | 0.10 | TRUE |
| 24 | GTEx | Skin Not Sun Exposed Suprapubic | GATAD1 | 0.22 | 0.27 | lasso | 4 | 0.26 | 1.1e-14 | 8.264 | -8.7 | 4.4e-18 | -0.48 | 1.00 | 0.00 | FALSE |
| 25 | GTEx | Skin Sun Exposed Lower leg | PEX1 | 0.18 | 0.06 | enet | 41 | 0.03 | 1.5e-03 | -6.684 | -7.1 | 1.7e-12 | -0.49 | 0.21 | 0.14 | FALSE |
| 26 | GTEx | Skin Sun Exposed Lower leg | GATAD1 | 0.30 | 0.10 | enet | 14 | 0.16 | 7.0e-13 | 8.264 | -8.6 | 6.0e-18 | -0.45 | 1.00 | 0.00 | FALSE |
| 27 | GTEx | Stomach | GATAD1 | 0.30 | 0.13 | lasso | 5 | 0.15 | 8.6e-08 | 8.264 | -9.0 | 2.0e-19 | -0.53 | 0.98 | 0.00 | FALSE |
| 28 | GTEx | Testis | CDK6 | 0.10 | 0.10 | lasso | 3 | 0.09 | 8.0e-05 | 14.883 | -15.9 | 5.1e-57 | -0.84 | 0.05 | 0.91 | TRUE |
| 29 | GTEx | Thyroid | GATAD1 | 0.18 | 0.06 | lasso | 4 | 0.06 | 3.3e-05 | 8.264 | -8.3 | 7.9e-17 | -0.49 | 0.96 | 0.02 | FALSE |
| 30 | METSIM | Adipose | GATAD1 | 0.10 | 0.05 | lasso | 7 | 0.06 | 9.4e-10 | 3.956 | -7.0 | 3.0e-12 | -0.47 | 0.97 | 0.03 | FALSE |
| 31 | ROSMAP | Brain Pre-frontal Cortex | KRIT1 | 0.04 | 0.03 | bslmm | 311 | 0.01 | 9.0e-03 | 2.907 | 6.6 | 4.6e-11 | 0.44 | 0.77 | 0.02 | FALSE |
| 32 | ROSMAP | Brain Pre-frontal Cortex | GATAD1 | 0.17 | 0.15 | lasso | 4 | 0.16 | 6.0e-20 | 9.026 | -9.4 | 6.1e-21 | -0.49 | 1.00 | 0.00 | FALSE |
| 33 | YFS | Blood | GATAD1 | 0.01 | 0.01 | blup | 297 | 0.01 | 5.1e-04 | 8.264 | -10.6 | 1.9e-26 | -0.59 | 0.74 | 0.09 | FALSE |
| 34 | The Cancer Genome Atlas | Breast Invasive Carcinoma | GATAD1 | 0.06 | 0.04 | lasso | 6 | 0.04 | 2.2e-09 | 8.763 | -8.4 | 4.8e-17 | -0.35 | 0.04 | 0.96 | FALSE |
| 35 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | GATAD1 | 0.04 | 0.04 | lasso | 2 | 0.03 | 2.8e-04 | 8.763 | -8.5 | 1.9e-17 | -0.41 | 0.03 | 0.81 | FALSE |
| 36 | The Cancer Genome Atlas | Pheochromocytoma and Paraganglioma | C7orf64 | 0.06 | 0.02 | blup | 36 | 0.02 | 6.0e-02 | 7.259 | 5.5 | 5.1e-08 | 0.25 | 0.02 | 0.53 | FALSE |