Hub : Genes

PEX1

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Muscle Skeletal	0.0628	0.028	0.0006	0.033	NA	0.016	NA	0.022	3.0e-04	NA	0.0092	NA	0.0027
2	GTEx	Skin Sun Exposed Lower leg	0.1790	0.074	0.0038	0.058	NA	0.030	NA	0.023	1.5e-05	NA	0.0015	NA	0.0050
3	GTEx	Spleen	0.1810	0.079	0.0022	0.003	NA	0.047	NA	-0.004	2.7e-01	NA	0.0240	NA	0.4200

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3
Bipolar Disorder (2018)	0.6	0.9	1.3	-0.9	0.8	1.1
Bipolar Disorder or Schizophrenia	0.5	1.2	2.7	-1.6	0.4	0.9
Depressed Affect (Nagel 2018)	1.1	2.3	3.6	-1.1	1.4	1.9
Depression (Nagel 2018)	1.3	2.0	3.0	-0.8	-1.7	1.5
Intelligence (Savage-Jansen 2018)	0.2	0.5	0.6	0.6	0.8	-0.7
Neuroticism (Nagel 2018)	0.9	2.1	3.4	-1.8	1.2	1.2
Schizophrenia (2018)	0.3	0.6	1.8	-1.3	-0.2	0.1
Schizophrenia vs Biploar Disorder	1.3	1.7	2.7	-0.8	-1.6	-1.3
Worry (Nagel 2018)	0.9	2.0	3.0	-0.8	1.7	1.5
Alzheimer’s Disease (in mother)	0.6	0.7	1.4	0.5	0.7	1.2
Alzheimer’s Disease (in father)	0.4	0.5	1.4	1.2	-0.2	0.1
Alzheimer’s Disease (including proxy)	0.9	1.3	2.3	0.7	1.1	1.5
Crohns Disease (2017)	2.6	5.6	15.2	-1.2	0.4	3.9
Irritable Bowel Disease (IBD)	2.3	5.4	10.6	-1.3	2.0	3.3
Ulcerative Colitis (UC)	1.8	3.5	6.5	-1.6	2.5	1.2
Major Depression (MDD)	1.2	1.5	3.5	-1.9	0.1	1.0
Reaction Time	0.7	1.4	2.1	1.4	0.4	-1.4
Verbal and Numeric Reasoning (VNR)	0.3	0.8	1.6	-0.4	1.3	-0.8
Breast Cancer	3.5	8.4	18.0	-0.7	2.6	4.2
Ovarian Cancer	1.6	2.2	3.5	-1.6	1.9	-0.6
Prostate Cancer	0.4	0.6	1.0	0.7	0.5	-1.0
Age at First Birth	2.3	3.4	4.6	1.9	-1.4	-2.1
Bipolar Disorder (2011)	0.3	0.3	0.7	0.8	-0.3	-0.3
Body Mass Index (BMI) (2010)	0.2	0.3	0.8	-0.3	0.2	-0.9
Coronary Artery Disease (CAD)	1.8	2.1	2.8	-1.7	1.0	-1.6
Crohns Disease (2012)	0.7	1.1	2.3	-1.0	-0.0	1.5
Mean Putamen Volume	2.1	2.4	6.4	-0.4	-0.9	-2.5
Fasting Glucose	1.0	1.2	2.9	1.7	0.7	-0.5
HbA1C	0.7	0.7	1.3	1.1	0.8	0.4
HDL Cholesterol	0.1	0.1	0.4	-0.6	0.1	0.2
LDL Cholesterol	1.4	2.2	4.4	-2.1	0.7	1.3
Lupus	0.7	1.0	1.9	-1.0	-1.4	0.5
Neuroticism (2016)	2.6	3.8	7.4	-2.0	0.1	2.7
Primary Biliary Cirrhosis	0.4	0.5	1.2	-1.1	-0.5	0.3
Rheumatoid Arthritis	1.0	1.4	2.8	1.0	-1.7	-0.6
Schizophrenia (2014)	0.2	0.5	1.5	-1.2	-0.1	-0.3
Triglycerides	0.4	0.7	1.6	-0.3	1.3	0.5
Type 2 Diabetes (T2D) (2012)	3.1	3.6	8.7	3.0	-1.4	0.1
Ulcerative Colitis	1.2	1.7	2.9	0.6	1.3	1.7
Blood Eosinophil Count	3.6	27.7	39.9	5.4	-6.3	-3.7
Blood Platelet Count	1.6	18.6	23.4	-4.5	3.5	4.8
Blood Red Count	2.0	19.6	34.7	-2.1	4.4	5.9
Blood White Count	1.7	12.5	18.6	3.5	-4.3	2.6
Heel T-Score	6.4	51.2	56.2	-6.9	7.0	7.5
BMI	0.3	1.8	4.8	0.5	-0.6	-2.2
Height	12.9	247.8	313.3	15.3	-17.7	-14.0
Waist Hip Ratio (WHR)	0.3	1.5	4.5	-2.1	-0.2	-0.3
Systolic Blood Pressure	7.8	39.0	54.8	-6.2	4.8	7.4
Smoking Status	0.6	1.5	3.1	0.6	-1.8	-1.0
Allergy or Eczema	0.6	1.7	4.1	2.0	-0.8	0.6
Cardiovascular Disease	4.0	13.3	21.6	-4.7	2.8	3.2
Hypothyroidism (self reported)	1.5	3.5	6.8	1.1	-2.6	-1.6
Respiratory disease	0.9	2.1	5.4	0.9	-2.3	0.1
Type 2 Diabetes (T2D) (2018)	1.7	3.1	5.2	-0.8	1.9	2.3
Lung FEV1/FVC ratio	0.1	0.6	1.3	0.5	1.1	0.6
Lung FVC	0.6	3.0	6.7	-1.3	0.7	2.6
Neuroticism	1.0	2.3	3.2	-1.2	1.8	1.5
Chronotype (morning person)	0.5	1.2	1.8	-1.3	0.4	1.3
Hair Pigment	0.2	6.9	19.5	-0.7	0.8	4.4
Tanning	0.0	0.0	0.1	-0.1	-0.0	0.4
Hand grip strength (left)	0.3	0.9	2.6	0.2	-1.6	-0.2
Number of treatments/medications taken	0.9	1.5	3.6	-0.8	0.6	1.9
Average weekly spirits intake	0.7	0.9	1.7	-1.3	0.8	0.6
Sensitivity / hurt feelings	1.1	1.9	5.0	-2.2	0.9	0.1
Frequency of depressed mood in last 2 weeks	2.5	3.5	5.1	-0.4	-2.3	2.3
Hearing difficulty/problems: Yes	0.7	1.1	2.5	1.6	-0.9	-0.2
Relative age of first facial hair	0.3	0.7	1.4	0.2	0.7	-1.2
Other serious medical condition/disability diagnosed by doctor	0.7	1.0	2.3	0.7	0.3	1.5
Ever used hormone-replacement therapy (HRT)	4.0	5.1	7.9	0.8	2.6	2.8
Ever had hysterectomy (womb removed)	0.9	1.1	1.4	-1.2	0.7	1.2
Systolic blood pressure, automated reading	7.0	20.3	32.4	-5.7	2.9	4.5
Eye problems/disorders: Diabetes related eye disease	4.0	4.4	6.0	-1.6	2.5	2.1
Angina	0.4	0.6	1.5	-0.5	1.2	0.2
Medication for hormone replacement therapy	3.9	4.3	6.6	2.6	1.4	2.2
Vitamin and mineral supplements	0.2	0.3	0.5	0.6	0.7	-0.3
Supplements: Zinc	0.2	0.3	0.4	-0.6	0.3	0.5
Medication: Co-codamol	1.3	1.5	3.1	1.1	-1.8	0.1
Medication: Metformin	1.0	1.5	2.3	-0.9	1.2	1.5
Diabetes (father)	1.3	1.6	2.5	0.7	1.3	1.6
Diabetes (mother)	1.9	2.4	7.0	0.0	2.7	-0.4
Severe depression (siblings)	1.1	1.2	2.5	1.0	-0.4	1.6
Pack years adult smoking proportion	0.3	0.4	0.6	0.3	-0.7	0.8
Impedance of leg (right)	0.7	3.3	5.3	-2.3	0.8	2.0
Leg fat-free mass (left)	9.4	49.6	59.0	6.4	-7.7	-7.0
Trunk fat percentage	0.5	1.9	2.8	1.7	-1.6	-0.6
Hand grip strength (right)	0.1	0.3	0.8	0.1	-0.9	-0.3
Townsend deprivation index at recruitment	0.2	0.3	0.5	0.6	-0.1	-0.7
Current tobacco smoking	0.3	0.6	1.4	0.4	-1.2	-0.4
Average weekly fortified wine intake	0.6	0.7	2.0	0.1	0.1	1.4
Maternal smoking around birth	1.1	1.6	3.1	1.8	-1.3	-0.1
Fed-up feelings	0.3	0.6	1.4	-1.2	-0.1	0.5
Frequency of unenthusiasm / disinterest in last 2 weeks	1.4	1.9	4.9	-0.6	-2.2	-0.7
Relative age voice broke	0.0	0.1	0.2	-0.4	-0.1	-0.2
Taking other prescription medications	0.4	0.6	1.4	-0.1	-0.5	1.2
Age when periods started (menarche)	0.6	1.4	3.5	-0.4	-1.9	-0.6
Bilateral oophorectomy (both ovaries removed)	10.5	12.2	17.1	-2.1	3.9	4.1
Heel bone mineral density (BMD) T-score, automated (left)	4.5	10.3	13.8	-3.7	2.5	3.3
Tinnitus: Yes, but not now, but have in the past	0.5	0.5	1.0	0.7	-1.0	0.2
Qualifications: CSEs or equivalent	0.7	0.9	2.0	0.8	-1.4	-0.0
Serious illness, injury or assault to yourself	1.2	1.4	4.2	0.3	0.0	2.1
High blood pressure	1.8	5.1	6.5	-2.5	2.0	2.2
Hayfever, allergic rhinitis or eczema	0.8	1.7	3.4	1.8	-1.1	-0.8
Multivitamins +/- minerals	0.8	1.0	1.4	-0.9	-1.2	0.9
Stomach or abdominal pain in last month	4.3	5.3	13.4	-1.6	-0.2	3.7
Supplements: Glucosamine	0.9	1.2	3.2	0.4	-1.8	0.3
Diverticular disease/diverticulitis (self-reported)	1.5	1.8	2.7	-0.7	1.6	1.5
Medication: Atenolol	0.2	0.2	0.5	-0.3	-0.0	0.7
Medication: Levothyroxine sodium	1.2	2.0	3.7	0.7	-1.9	-1.4
Sitting height	8.5	60.3	72.6	7.4	-8.5	-7.3
Chronic bronchitis/emphysema (father)	1.0	1.2	1.5	1.0	-1.0	1.2
High blood pressure (mother)	1.0	1.4	2.3	-1.5	1.3	-0.5
Body mass index (BMI)	0.3	1.1	2.0	0.8	-0.8	-1.4
Impedance of leg (left)	0.9	4.4	7.3	-2.2	1.0	2.7
Leg predicted mass (left)	9.4	49.8	59.4	6.4	-7.7	-7.0
Trunk fat mass	2.9	12.5	15.6	3.6	-4.0	-3.0
Waist circumference	2.2	8.1	9.8	2.6	-3.1	-2.8
Number of incorrect matches in round	0.8	1.3	3.3	0.8	-0.3	1.8
Past tobacco smoking	0.5	0.9	1.7	-0.5	0.8	1.3
Alcohol usually taken with meals	0.6	1.0	2.7	-0.2	0.6	1.6
Nervous feelings	0.7	1.4	2.2	-1.4	1.5	0.1
Frequency of tenseness / restlessness in last 2 weeks	0.8	1.3	3.2	0.0	-1.8	0.8
Hearing difficulty/problems with background noise	2.4	3.8	9.2	3.0	-1.0	-1.1
Hair/balding pattern: Pattern 2	0.4	0.4	0.6	0.5	-0.8	-0.7
Had menopause	0.5	0.6	1.4	-0.5	1.2	0.2
Had other major operations	0.2	0.3	0.4	-0.6	0.3	0.6
Forced vital capacity (FVC)	3.1	11.8	19.3	3.6	-4.4	-1.8
Heel bone mineral density (BMD) T-score, automated (right)	5.2	11.9	16.3	-4.0	2.3	3.8
Ever unenthusiastic/disinterested for a whole week	2.0	2.4	5.3	0.5	1.3	2.3
Qualifications: None of the above	0.3	0.6	1.6	-0.0	-1.3	0.2
Financial difficulties in last 2 years	1.7	2.3	6.4	-0.6	-0.5	2.5
Mouth/teeth dental problems	1.0	1.6	3.9	-0.2	2.0	0.9
Heart attack	0.4	0.6	1.3	0.6	-1.1	0.3
Allergy	2.3	5.3	8.5	-2.6	2.9	0.6
Pain all over the body in last month	0.6	0.7	1.8	-0.5	1.4	0.1
Diabetes (self-reported)	2.0	3.1	6.6	-0.8	1.4	2.6
Hayfever/allergic rhinitis (self-reported)	0.3	0.4	0.6	-0.8	0.1	0.7
Medication: Ramipril	0.3	0.4	1.1	0.4	0.3	1.1
Medication: Simvastatin	1.0	1.4	1.9	-0.7	1.3	1.4
Fluid intelligence score	0.5	1.0	2.8	0.1	0.3	-1.7
Illnesses of siblings	2.3	3.2	5.6	1.7	-1.1	-2.4
Neuroticism score	0.8	1.8	2.8	-1.1	1.1	1.7
Weight	6.6	32.6	39.1	5.4	-6.2	-5.5
Impedance of arm (right)	0.4	1.7	3.3	-0.6	1.2	1.8
Arm fat percentage (right)	0.1	0.4	0.9	0.9	-0.2	-0.6
Trunk fat-free mass	12.9	74.2	90.2	7.5	-9.5	-8.7
Hip circumference	4.4	18.9	22.1	4.7	-4.7	-3.6
Time employed in main current job	0.3	0.4	1.1	0.3	0.1	-1.1
Alcohol intake versus 10 years previously	1.0	1.5	4.5	0.3	-0.1	2.1
Father’s age at death	0.2	0.2	0.5	0.3	0.2	0.7
Worrier / anxious feelings	0.5	0.9	2.1	-1.5	0.7	-0.0
Frequency of tiredness / lethargy in last 2 weeks	0.9	1.4	2.0	0.6	-1.4	1.4
Falls in the last year	1.6	2.1	6.1	2.5	-0.3	0.6
Hair/balding pattern: Pattern 3	0.1	0.1	0.1	0.3	-0.4	0.3
Number of live births	0.5	0.7	1.6	-0.6	1.3	0.3
Forced expiratory volume in 1-second (FEV1)	1.9	6.5	10.0	2.8	-3.2	-1.2
Pulse rate	0.3	0.5	1.1	0.5	0.3	-1.0
Happiness	0.9	1.0	3.1	0.0	-0.2	1.8
Noisy workplace	1.4	1.8	4.6	0.9	-0.2	2.1
Qualifications: A levels/AS levels or equivalent	0.4	1.0	2.2	-0.5	0.7	1.5
Serious illness, injury or assault of a close relative in last 2 years	1.0	1.2	2.6	-0.8	-0.6	1.6
Mouth/teeth dental problems: Dentures	0.3	0.5	0.7	-0.8	-0.7	0.6
Asthma	1.4	2.7	4.2	1.8	-2.0	0.8
Medication: Ibuprofen (e.g. Nurofen)	1.5	1.9	4.4	0.8	-2.1	-0.8
Medication: Cholesterol lowering	1.6	2.5	5.5	-1.4	0.3	2.3
Depression (self-reported)	0.9	1.1	1.8	-0.9	1.3	0.9
Medication: Lansoprazole	5.0	5.7	16.3	-0.4	0.8	4.0
Prospective memory result	0.2	0.2	0.5	0.2	-0.7	0.3
Lung cancer (father)	0.3	0.4	0.6	0.8	-0.7	-0.1
Illnesses of mother	1.4	1.8	5.2	0.2	-2.3	-0.1
Forced expiratory volume in 1-second (FEV1), Best measure	1.4	4.5	7.0	2.1	-2.6	-1.4
Pulse wave Arterial Stiffness index	2.5	2.9	3.4	1.8	-1.7	-1.6
Impedance of arm (left)	0.8	3.6	5.0	-1.0	2.2	2.2
Arm fat mass (right)	2.0	8.2	8.5	2.9	-2.9	-2.8
Trunk predicted mass	12.8	73.3	89.5	7.5	-9.5	-8.7
Standing height	11.3	112.2	146.4	10.2	-12.1	-9.3
Length of working week for main job	1.1	1.2	2.1	-1.5	0.9	0.8
Exposure to tobacco smoke at home	1.0	1.1	2.3	-1.1	1.5	0.3
Breastfed as a baby	0.4	0.5	1.0	0.1	-0.7	1.0
Tense / ‘highly strung’	0.8	1.4	3.2	0.9	0.3	1.8
Seen doctor (GP) for nerves, anxiety, tension or depression	0.4	0.6	1.2	-0.3	1.1	0.8
Hair/balding pattern: Pattern 4	0.5	1.1	1.9	-1.4	1.0	0.7
Birth weight of first child	1.4	2.6	7.1	0.6	0.6	-2.7
Peak expiratory flow (PEF)	1.1	2.6	7.0	0.4	-2.6	0.8
Pulse wave reflection index	0.6	0.8	1.4	1.2	-0.9	0.3
Ever highly irritable/argumentative for 2 days	0.9	1.1	1.7	1.1	-0.6	1.3
Loud music exposure frequency	1.1	1.2	2.9	0.7	-1.7	-0.2
Qualifications: O levels/GCSEs or equivalent	0.3	0.4	0.9	-0.2	0.9	-0.7
Mouth/teeth dental problems: Bleeding gums	3.2	4.2	9.7	1.3	-3.1	-1.1
Blood clot in the leg (DVT)	1.7	2.2	3.5	1.7	-0.6	-1.9
Medication: Paracetamol	0.9	1.5	2.9	1.2	-1.7	0.5
Headache pain in last month	0.9	1.5	4.3	0.5	-2.1	0.3
Medication for cholesterol, blood pressure or diabetes	1.2	2.0	3.4	1.9	-0.4	-1.6
Glaucoma (self-reported)	0.4	0.4	0.8	0.6	-0.9	0.1
Gout (self-reported)	0.7	0.9	1.7	-0.1	-1.3	-1.0
Hypothyroidism/myxoedema (self-reported)	1.4	2.8	4.2	0.6	-1.9	-2.0
Medication: Amlodipine	2.2	3.0	8.3	-2.9	0.8	0.4
Medication: Ventolin 100micrograms inhaler	0.1	0.2	0.2	0.5	-0.4	-0.3
Birth weight	0.6	1.3	2.4	1.2	-1.6	0.3
Chronic bronchitis/emphysema (mother)	0.2	0.2	0.2	0.4	-0.5	0.4
High blood pressure (siblings)	0.9	1.3	1.4	-1.2	1.0	1.2
Forced vital capacity (FVC), Best measure	2.6	9.5	15.6	3.0	-4.0	-1.9
Body fat percentage	0.2	0.7	1.0	1.0	-0.9	-0.4
Leg fat percentage (right)	0.0	0.1	0.1	-0.1	0.1	-0.4
Arm fat-free mass (right)	9.4	48.3	60.5	6.0	-7.8	-7.0
Exposure to tobacco smoke outside home	0.8	1.0	1.7	1.1	0.4	-1.3
Comparative body size at age 10	1.2	3.3	6.9	-0.6	-1.7	-2.6
Number of full brothers	1.7	2.2	4.6	-0.5	-2.1	-1.3
Worry too long after embarrassment	0.7	1.2	2.8	-0.8	-1.7	-0.3
Seen a psychiatrist for nerves, anxiety, tension or depression	4.0	5.2	12.8	-1.1	1.3	3.6
Wheeze or whistling in the chest in last year	0.5	0.9	2.6	0.4	-1.6	0.1
Number of children fathered	1.7	1.9	5.0	-0.5	-0.7	2.2
Reason for reducing amount of alcohol drunk: Health precaution	0.7	0.8	1.6	-1.3	-0.2	-1.0
Age at first live birth	1.0	1.8	4.9	-0.2	-0.6	-2.2
Pulse wave peak to peak time	0.8	0.9	1.5	-1.2	0.8	0.8
Health satisfaction	0.1	0.1	0.2	0.4	-0.1	0.2
Shortness of breath walking on level ground	1.3	1.5	2.8	1.7	-1.3	-0.5
Qualifications: College or University degree	0.1	0.3	0.5	-0.7	-0.5	-0.2
Eye problems/disorders: None of the above	0.5	0.5	1.2	-1.1	0.6	0.2
Mouth/teeth dental problems: Loose teeth	0.9	1.1	1.9	-0.6	-1.1	-1.4
Emphysema/chronic bronchitis	1.4	1.6	3.3	0.6	-1.8	-1.1
Medication for pain relief, constipation, heartburn	1.2	2.1	4.1	-0.7	1.4	-2.0
Neck or shoulder pain in last month	1.8	2.5	6.9	0.6	-2.6	-0.5
Medication: Blood pressure	0.6	1.1	3.1	-1.8	-0.3	0.4
Angina (self-reported)	0.5	0.6	1.5	-0.2	1.2	0.6
Migraine (self-reported)	0.6	0.7	1.4	0.9	-1.2	-0.3
Medication: Ibuprofen	0.7	0.9	2.3	0.6	-1.5	-0.1
Medication: Allopurinol	0.2	0.2	0.5	-0.4	-0.7	0.1
Medication: Omeprazole	3.0	3.6	10.4	-3.2	0.0	0.6
Medication: Seretide 50 evohaler	1.8	2.0	4.6	0.9	0.9	2.1
Mean time to correctly identify matches	0.7	1.3	1.8	1.1	0.8	-1.3
Heart disease (mother)	0.3	0.4	0.6	0.3	0.7	-0.7
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.2	0.2	0.7	-0.0	0.8	-0.1
Whole body fat mass	2.6	10.7	12.2	3.4	-3.5	-2.9
Leg fat mass (right)	1.9	7.5	8.6	2.4	-2.9	-2.9
Arm predicted mass (right)	10.0	51.0	63.8	6.2	-8.0	-7.2
Pulse rate, automated reading	0.3	0.9	1.5	0.7	-0.7	-1.2
Alcohol intake frequency.	0.2	0.4	1.2	-0.0	0.1	1.1
Comparative height size at age 10	7.4	40.5	53.1	7.3	-7.1	-4.3
Number of full sisters	1.2	1.5	2.9	-1.7	1.2	-0.5
Suffer from ‘nerves’	0.3	0.4	0.9	-1.0	-0.0	0.5
Overall health rating	1.5	3.2	9.3	0.6	0.1	3.0
Chest pain or discomfort	0.9	1.3	3.1	1.8	-0.3	0.7
Had major operations	1.0	1.2	3.0	0.7	0.3	1.7
Age at last live birth	0.2	0.3	0.7	-0.8	-0.3	-0.3
Family relationship satisfaction	0.8	0.9	2.4	-1.6	0.4	0.4
Leg pain on walking	0.9	1.2	2.3	0.7	0.8	1.5
Qualifications: NVQ or HND or HNC or equivalent	0.6	0.8	1.2	0.5	-1.1	-0.9
Commuting to job workplace: Car/motor vehicle	2.4	2.7	6.8	0.7	2.6	1.0
Illness, injury, bereavement, stress in last 2 years	1.4	1.8	3.8	-0.1	2.0	-1.2
Medication: Aspirin	3.5	4.6	8.3	-0.9	2.2	2.9
Supplements: Vitamin C	0.2	0.2	0.3	-0.6	-0.5	-0.1
Knee pain experienced in last month	0.2	0.3	0.5	0.4	0.3	0.7
Hypertension (Self-reported)	1.9	5.3	7.6	-2.7	1.8	2.2
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.4	0.5	0.7	-0.6	-0.6	0.9
Illnesses of father: Heart disease	1.2	1.6	4.5	-2.1	0.6	0.0
Illnesses of siblings: Diabetes	2.2	2.8	6.9	-0.3	1.2	2.6
Smoking status: Previous	0.0	0.0	0.1	-0.1	0.1	-0.3
Forced expiratory volume in 1-second (FEV1), predicted	5.3	11.1	16.5	1.8	-4.1	-3.7
Whole body fat-free mass	11.5	65.8	81.7	7.2	-9.0	-8.0
Leg fat-free mass (right)	9.1	48.4	57.8	6.5	-7.6	-6.7
Arm fat percentage (left)	0.1	0.3	0.4	0.6	0.3	-0.6
Average weekly red wine intake	0.6	1.0	1.3	-1.1	-0.9	-0.9
Handedness (chirality/laterality): Left-handed	1.4	1.6	4.1	-0.0	-0.9	-2.0
Mood swings	0.8	1.5	2.7	-1.6	-1.0	0.9
Loneliness, isolation	1.1	1.5	3.4	-0.8	0.7	1.9
Long-standing illness, disability or infirmity	1.4	2.1	5.6	-0.3	-0.8	2.4
Ever had bowel cancer screening	0.7	0.8	1.7	-0.8	-0.2	1.3
Diabetes diagnosed by doctor	2.0	3.3	5.5	-0.9	1.9	2.3
Ever had stillbirth, spontaneous miscarriage or termination	1.5	1.6	3.8	1.9	-0.8	-0.6
Friendships satisfaction	0.5	0.6	1.3	-1.2	-0.5	-0.2
Qualifications: nursing, teaching	0.6	0.9	1.5	0.8	1.2	-0.8
Commuting to job workplace: Walk	0.4	0.4	1.0	0.5	-1.0	-0.2
Eye problems/disorders: Cataract	0.0	0.0	0.1	0.3	0.0	-0.0
Mouth/teeth dental problems: Mouth ulcers	0.6	1.0	2.8	0.2	1.7	0.4
Medication for cholesterol	4.2	6.4	11.1	1.1	-3.3	-2.6
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.3	1.5	1.9	1.0	-1.3	-1.4
Back pain experienced in last month	1.0	1.4	3.3	0.9	-1.8	0.1
Mineral and other dietary supplements	0.2	0.3	0.6	0.8	0.4	-0.1
Breast cancer (self-reported)	1.1	1.4	3.3	-0.3	-0.9	-1.8
Asthma (self-reported)	1.1	2.2	3.6	1.7	-1.9	0.4
Osteoporosis (self-reported)	2.2	2.7	6.5	-2.5	0.9	0.9
Osteoarthritis (self-reported)	0.2	0.3	0.7	-0.4	0.8	0.2
Medication: Aspirin	3.6	4.7	7.6	-0.8	2.4	2.8
Medication: Gliclazide	2.9	3.3	6.6	-2.6	1.7	0.5
Illnesses of father: None of the above (group 1)	1.7	2.1	4.9	2.2	-1.1	-0.5
Smoking status: Current	0.8	1.2	2.3	0.5	-1.5	-1.1
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.3	0.6	1.3	-1.1	0.6	0.0
Whole body water mass	11.2	63.7	77.3	7.1	-8.8	-7.9
Leg predicted mass (right)	9.2	48.8	58.8	6.5	-7.7	-6.7
Arm fat mass (left)	1.9	8.0	8.5	2.9	-2.7	-2.9
Number of self-reported non-cancer illnesses	1.6	2.9	6.8	-0.8	-1.1	2.6
Average weekly champagne plus white wine intake	0.6	0.8	1.4	-0.1	1.0	-1.2
Miserableness	0.4	0.7	2.0	-1.4	-0.4	0.2
Guilty feelings	1.2	1.8	3.4	-1.4	-0.1	-1.8
Wears glasses or contact lenses	0.6	0.6	1.0	0.8	0.5	-1.0
Ever taken oral contraceptive pill	3.2	3.5	6.2	0.3	2.1	2.5
Hearing aid user	0.1	0.1	0.3	0.1	-0.5	-0.0
Mother’s age at death	0.4	0.6	1.3	1.2	-0.5	-0.3
Financial situation satisfaction	0.5	0.6	1.7	-0.1	-0.2	1.3
Tinnitus: Yes, now most or all of the time	1.3	1.5	4.4	0.4	0.2	2.1
Commuting to job workplace: Public transport	0.6	0.7	1.6	0.5	-0.5	-1.2
Eye problems/disorders: Glaucoma	0.3	0.3	0.7	0.9	0.1	0.5
Medication: Blood pressure	1.7	3.2	4.0	-1.7	2.0	1.6
Pain type(s) experienced in last month: Hip pain	1.5	1.9	4.5	-1.0	-0.3	2.1
Supplements: Fish oil (including cod liver oil)	0.6	0.8	1.4	-0.9	1.2	0.3
High cholesterol (Self-reported)	3.2	5.7	9.4	-3.1	2.4	1.5
Medication: Bendroflumethiazide	0.2	0.4	1.1	0.1	0.1	1.0
Medication: Paracetamol	0.5	0.7	1.8	0.1	-0.6	1.3
Medication: Lisinopril	0.5	0.7	1.6	-1.3	-0.0	-0.6
Medication: Atorvastatin	1.4	1.7	2.5	-1.2	1.6	1.1
Illnesses of father: High blood pressure	2.1	2.6	5.6	-2.4	1.3	0.8
Alcohol drinker status: Never	1.0	1.2	3.3	-0.3	-1.8	-0.3
Ever smoked	0.8	1.4	1.5	1.2	-1.1	-1.2
Basal metabolic rate	10.8	59.8	74.5	7.0	-8.6	-7.5
Leg fat percentage (left)	0.0	0.0	0.0	-0.0	-0.0	-0.1
Arm fat-free mass (left)	10.4	52.6	68.6	6.1	-8.3	-7.2
Number of operations (self-reported)	0.8	1.3	2.6	-0.3	1.0	1.6
Average weekly beer plus cider intake	0.3	0.4	1.1	-0.2	1.0	-0.2
Irritability	0.6	1.1	2.3	0.0	-1.5	1.0
Risk taking	0.7	1.1	2.4	0.8	-0.3	1.5
Ever had prostate specific antigen (PSA) test	1.5	1.8	4.2	-2.0	1.1	-0.1
Fractured/broken bones in last 5 years	2.5	3.3	4.0	1.6	-1.8	-2.0
Age started oral contraceptive pill	1.2	1.5	3.5	0.8	1.9	0.4
Diastolic blood pressure, automated reading	0.4	1.4	3.4	-1.8	-0.7	0.5
Ever depressed for a whole week	3.2	3.9	10.4	0.5	1.1	3.2
Unable to work because of sickness or disability	0.7	0.9	2.2	-0.4	-1.5	0.5
Commuting to job workplace: Cycle	1.5	1.8	4.7	-0.8	2.2	-0.0
Myopia	0.9	1.3	2.5	1.6	-1.0	-0.7
Vascular/heart problems diagnosed by doctor	2.0	5.4	6.0	2.1	-2.5	-2.4
Cholesterol lowering medication	5.4	7.9	17.1	-2.5	4.1	0.8
Medication: Omeprazole (e.g. Zanprol)	2.6	3.1	7.6	-2.8	-0.3	1.3
Pain experienced in last month	0.5	0.8	1.5	-0.7	1.2	-0.6
Supplements: Calcium	0.1	0.1	0.2	0.1	0.1	-0.5
Basal cell carcinoma (self-reported)	1.0	1.2	2.5	-0.0	-1.6	-1.0
Heart attack/myocardial infarction (self-reported)	0.4	0.5	1.2	0.5	-1.1	0.1
Deep venous thrombosis (DVT) (self-reported)	1.3	1.6	2.7	1.6	-0.2	-1.5
Heart disease (siblings)	1.4	1.7	2.9	-1.0	-1.7	1.1
Alcohol drinker status: Previous	1.4	1.6	3.9	0.4	2.0	0.8
Pack years of smoking	0.4	0.6	1.3	0.4	-0.5	1.1
Impedance of whole body	1.1	5.6	9.8	-1.7	2.0	3.1
Leg fat mass (left)	1.9	7.5	9.5	2.5	-3.1	-2.6
Arm predicted mass (left)	10.7	54.5	70.2	6.4	-8.4	-7.2