Best TWAS P=8.08e-16 · Best GWAS P=2.44e-14 conditioned to 0.0278
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | CommonMind | Brain Pre-frontal Cortex | NOV | 0.06 | 0.02 | enet | 8 | 0.05 | 1.5e-06 | -3.6 | -5.7 | 1.3e-08 | 0.76 | 0.02 | 0.98 | FALSE |
2 | GTEx | Artery Aorta | NOV | 0.12 | 0.05 | enet | 18 | 0.04 | 3.7e-03 | -6.0 | -6.8 | 9.3e-12 | 0.68 | 0.07 | 0.68 | FALSE |
3 | GTEx | Brain Cerebellar Hemisphere | DEPTOR | 0.32 | 0.15 | lasso | 8 | 0.29 | 3.4e-08 | 4.0 | -5.5 | 4.9e-08 | 0.12 | 0.61 | 0.02 | TRUE |
4 | GTEx | Cells Transformed fibroblasts | NOV | 0.10 | 0.04 | enet | 30 | 0.03 | 3.7e-03 | -7.6 | -6.2 | 4.3e-10 | 0.77 | 0.01 | 0.99 | FALSE |
5 | GTEx | Colon Sigmoid | NOV | 0.15 | 0.16 | lasso | 4 | 0.15 | 6.6e-06 | -7.4 | -7.4 | 1.6e-13 | 0.87 | 0.01 | 0.98 | FALSE |
6 | GTEx | Esophagus Muscularis | NOV | 0.11 | 0.03 | enet | 19 | 0.05 | 3.9e-04 | -7.4 | -5.5 | 4.5e-08 | 0.71 | 0.02 | 0.95 | FALSE |
7 | GTEx | Lung | NOV | 0.06 | 0.02 | enet | 23 | 0.03 | 2.5e-03 | -5.3 | -8.1 | 8.1e-16 | 0.67 | 0.15 | 0.57 | TRUE |
8 | GTEx | Skin Sun Exposed Lower leg | NOV | 0.11 | 0.03 | lasso | 7 | 0.04 | 1.4e-04 | -6.8 | -6.4 | 1.5e-10 | 0.83 | 0.06 | 0.94 | FALSE |
9 | GTEx | Thyroid | COL14A1 | 0.10 | 0.02 | enet | 14 | 0.02 | 2.3e-02 | 4.8 | -5.3 | 8.8e-08 | 0.18 | 0.19 | 0.05 | FALSE |
10 | NTR | Blood | NOV | 0.02 | 0.01 | bslmm | 481 | 0.01 | 1.7e-04 | -7.5 | -5.8 | 8.3e-09 | 0.68 | 0.01 | 0.98 | FALSE |
11 | The Cancer Genome Atlas | Bladder Urothelial Carcinoma | NOV | 0.03 | 0.00 | blup | 42 | 0.01 | 5.3e-02 | -6.8 | -6.9 | 6.5e-12 | 0.85 | 0.02 | 0.74 | FALSE |
12 | The Cancer Genome Atlas | Colon Adenocarcinoma | NOV | 0.31 | 0.10 | blup | 42 | 0.10 | 1.2e-06 | -6.9 | -6.3 | 3.6e-10 | 0.69 | 0.02 | 0.97 | FALSE |
13 | The Cancer Genome Atlas | Pancreatic Adenocarcinoma | NOV | 0.11 | 0.02 | enet | 15 | 0.05 | 2.9e-03 | -6.9 | -6.6 | 3.6e-11 | 0.74 | 0.02 | 0.56 | FALSE |
14 | The Cancer Genome Atlas | Prostate Adenocarcinoma | NOV | 0.04 | 0.05 | blup | 42 | 0.05 | 8.7e-06 | -7.5 | -7.0 | 2.1e-12 | 0.85 | 0.01 | 0.99 | FALSE |