TWAS hub - DEPTOR

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.151	0.0420	2.3e-08	0.029	0.088	0.083	0.086	0.050	1.7e-04	8.2e-11	2.5e-10	1.3e-10	9.5e-07
2	GTEx	Adrenal Gland	0.157	0.0740	7.1e-03	-0.008	NA	-0.002	NA	-0.007	9.7e-01	NA	3.7e-01	NA	7.5e-01
3	GTEx	Brain Cerebellar Hemisphere	0.316	0.0810	2.3e-06	0.152	NA	0.124	NA	0.291	1.0e-04	NA	4.6e-04	NA	3.4e-08
4	GTEx	Brain Cerebellum	0.235	0.0800	1.7e-03	0.218	NA	0.124	NA	0.173	4.6e-07	NA	1.7e-04	NA	7.9e-06
5	GTEx	Colon Sigmoid	0.283	0.0790	1.5e-05	0.225	NA	0.191	NA	0.226	1.8e-08	NA	2.5e-07	NA	1.7e-08
6	GTEx	Colon Transverse	0.172	0.0600	5.8e-04	0.080	NA	0.040	NA	0.059	1.2e-04	NA	5.3e-03	NA	8.8e-04
7	GTEx	Esophagus Gastroesophageal Junction	0.320	0.0720	8.7e-07	0.357	NA	0.306	NA	0.297	8.9e-14	NA	1.1e-11	NA	2.4e-11
8	GTEx	Esophagus Mucosa	0.202	0.0550	2.1e-06	0.114	NA	0.085	NA	0.117	5.1e-08	NA	2.4e-06	NA	3.3e-08
9	GTEx	Esophagus Muscularis	0.281	0.0550	8.5e-11	0.297	NA	0.268	NA	0.282	2.0e-18	NA	1.8e-16	NA	2.1e-17
10	GTEx	Lung	0.157	0.0441	4.6e-07	0.124	NA	0.151	NA	0.077	9.5e-10	NA	1.3e-11	NA	1.5e-06
11	GTEx	Pancreas	0.167	0.0580	7.9e-04	0.124	NA	0.136	NA	0.122	6.7e-06	NA	2.4e-06	NA	7.9e-06
12	GTEx	Skin Sun Exposed Lower leg	0.069	0.0270	7.1e-04	0.028	NA	0.033	NA	0.023	2.1e-03	NA	8.9e-04	NA	4.9e-03
13	ROSMAP	Brain Pre-frontal Cortex	0.198	0.0482	2.2e-07	0.048	0.069	0.043	0.072	0.043	7.1e-07	3.0e-09	2.6e-06	1.6e-09	3.2e-06

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7	8	9	10	11	12	13
Medication: Aspirin	9.5	12.5	19.7	0.9	3.7	-4.4	-4.0	3.8	3.6	4.1	3.5	4.2	3.6	4.1	2.8	0.8
Medication: Aspirin	8.8	11.5	19.2	0.9	3.2	-4.4	-4.0	3.8	3.2	3.8	3.3	3.9	3.6	3.8	3.1	0.6
Mean Putamen Volume	6.1	6.9	15.4	-1.3	0.8	-3.5	-2.0	1.9	3.3	3.3	3.9	3.5	1.9	3.6	0.7	-1.0
Heart attack	5.7	7.3	12.0	0.7	2.4	-3.5	-2.9	3.2	2.7	2.8	2.9	3.1	3.3	3.0	2.3	-0.4
Reason for reducing amount of alcohol drunk: Health precaution	5.7	6.7	10.5	1.2	1.3	-3.2	-3.0	3.1	3.1	2.6	2.7	2.9	2.4	2.7	3.0	0.2
Heart attack/myocardial infarction (self-reported)	5.2	6.7	10.1	0.5	2.4	-3.2	-2.8	3.1	2.7	2.7	2.8	3.0	3.1	2.9	2.2	-0.4
Pain type(s) experienced in last month: Hip pain	4.3	5.4	12.0	1.5	-1.3	3.5	3.4	-3.1	-1.4	-2.3	-2.2	-2.2	-1.5	-2.3	-2.7	1.2
Medication for pain relief, constipation, heartburn	4.2	7.2	11.7	-0.2	-3.4	3.4	2.3	-1.9	-3.0	-3.3	-3.3	-3.4	-3.0	-3.2	-0.8	-0.2
Commuting to job workplace: Car/motor vehicle	3.7	4.2	9.7	0.5	1.8	-2.7	-1.0	1.2	2.4	2.8	3.1	2.9	1.0	3.0	0.1	-0.7
Lung FEV1/FVC ratio	3.6	18.3	40.0	-0.2	-4.3	5.6	5.0	-4.2	-4.2	-4.7	-4.2	-4.8	-6.3	-4.6	-1.9	-0.4
Height	3.5	68.4	151.3	0.5	10.7	-12.3	-10.9	10.1	6.1	7.7	7.2	7.6	9.6	7.3	6.5	-2.4
Standing height	3.4	33.8	72.3	-0.5	8.5	-8.0	-8.1	7.2	4.1	4.9	4.4	4.9	7.3	4.8	5.0	-1.1
Chronic bronchitis/emphysema (father)	3.2	3.8	9.7	-0.9	1.0	-1.7	-1.4	1.1	2.5	2.9	2.4	3.0	1.3	3.1	0.3	-0.9
Systolic blood pressure, automated reading	3.1	9.0	24.0	4.9	3.1	-3.2	-3.4	3.1	3.1	2.8	2.4	2.6	1.9	2.5	3.0	1.8
Medication for cholesterol, blood pressure or diabetes	3.1	5.1	10.0	0.3	-0.7	2.6	2.3	-2.2	-2.8	-2.7	-3.2	-2.9	-1.7	-2.9	-1.9	0.0
Father’s age at death	3.0	4.1	10.7	-1.9	-3.3	1.6	2.2	-2.9	-0.3	-1.1	-0.5	-1.0	-2.5	-0.8	-2.5	-2.6
Eye problems/disorders: Diabetes related eye disease	2.8	3.0	7.9	0.8	2.2	-1.6	-2.3	2.8	0.9	1.5	0.3	1.5	2.7	1.4	2.0	0.2
Medication: Cholesterol lowering	2.8	4.4	8.3	0.9	1.7	-2.2	-2.9	2.5	2.0	2.0	2.0	2.2	2.2	2.1	2.6	1.1
Sitting height	2.7	19.0	53.3	-1.3	7.3	-5.7	-5.7	5.2	2.5	3.5	3.0	3.5	6.1	3.3	3.5	-0.2
Breastfed as a baby	2.7	3.4	8.5	0.1	0.6	-2.9	-2.9	2.4	1.0	1.4	1.5	1.4	2.3	1.4	2.3	-1.1
Forced expiratory volume in 1-second (FEV1), predicted	2.7	5.6	8.2	-1.3	2.5	-2.8	-2.9	2.7	2.7	2.4	2.5	2.6	2.3	2.6	1.8	-0.6
Vascular/heart problems diagnosed by doctor	2.6	7.1	13.6	-0.2	-1.7	3.6	2.1	-2.2	-3.6	-3.4	-3.7	-3.5	-1.8	-3.4	-1.3	-0.5
Townsend deprivation index at recruitment	2.5	3.5	6.2	-0.6	-1.8	2.2	2.3	-1.8	-2.1	-2.0	-2.5	-2.0	-1.9	-1.9	-1.5	-0.0
High blood pressure (siblings)	2.5	3.6	7.5	-0.4	2.7	-1.9	-2.1	2.4	1.8	1.8	1.7	2.0	2.4	1.9	1.7	0.3
Forced vital capacity (FVC), Best measure	2.5	9.0	17.1	-1.6	3.1	-3.7	-4.0	4.1	2.3	2.4	2.7	2.5	3.9	2.4	3.0	-1.8
Supplements: Fish oil (including cod liver oil)	2.5	3.2	7.3	-0.2	-1.7	1.9	2.0	-2.2	-1.7	-2.0	-2.1	-1.9	-1.0	-1.8	-2.7	-0.0
Alzheimer’s Disease (in father)	2.4	2.6	5.2	0.2	0.9	-2.0	-1.9	2.3	1.5	1.7	1.4	1.7	1.6	1.7	1.9	-0.5
Reaction Time	2.4	4.6	10.8	0.0	-0.4	2.0	1.3	-1.7	-3.0	-3.2	-2.8	-3.2	-0.6	-3.3	-1.4	0.3
Multivitamins +/- minerals	2.4	3.1	6.4	0.3	-0.7	1.9	2.4	-2.4	-1.8	-1.5	-2.5	-1.9	-1.3	-1.8	-1.8	-0.8
Forced vital capacity (FVC)	2.4	9.1	22.0	-0.7	3.2	-3.9	-4.4	4.2	1.5	2.1	1.9	2.0	4.7	2.0	3.3	-2.0
Time employed in main current job	2.3	2.7	7.0	0.5	1.5	-1.9	-2.2	2.0	1.2	1.3	1.6	1.3	2.6	1.3	1.7	-0.8
Average weekly champagne plus white wine intake	2.3	3.2	6.4	-0.9	0.8	-2.0	-1.9	0.9	2.5	2.3	2.2	2.1	2.0	2.2	1.3	-0.5
Had other major operations	2.2	2.7	8.5	-2.1	-0.9	2.2	2.5	-2.1	-0.5	-0.5	-0.1	-0.3	-2.1	-0.2	-2.9	0.5
Glaucoma (self-reported)	2.2	2.6	5.1	1.1	-0.9	1.9	0.4	-1.4	-2.3	-1.9	-2.0	-1.9	-1.1	-1.8	0.4	2.2
Hypertension (Self-reported)	2.1	5.8	12.6	0.3	0.9	-3.4	-2.2	2.1	3.1	2.9	3.6	3.0	1.6	3.0	1.5	0.6
Eye problems/disorders: Glaucoma	2.1	2.5	4.6	0.4	-0.8	2.1	0.8	-1.8	-2.2	-2.0	-2.0	-1.9	-1.7	-1.8	-0.5	1.3
Blood Platelet Count	2.0	23.5	40.2	-3.0	-1.9	6.3	5.4	-5.8	-5.2	-5.6	-4.1	-5.5	-4.6	-5.5	-5.7	1.0
Systolic Blood Pressure	2.0	9.8	14.3	3.6	2.1	-3.5	-3.2	2.8	3.8	3.4	3.7	3.5	1.7	3.4	2.3	2.9
Mouth/teeth dental problems: Loose teeth	2.0	2.3	8.5	0.3	1.6	-1.5	-1.9	1.8	1.5	1.5	0.4	1.4	2.9	1.3	0.9	-0.8
Comparative height size at age 10	2.0	11.1	29.7	-1.6	3.8	-5.5	-4.0	3.5	2.6	3.1	3.3	3.2	3.4	3.2	2.0	-2.6
Hearing difficulty/problems: Yes	1.9	3.0	5.3	-2.2	-2.0	2.1	1.3	-1.4	-2.3	-1.5	-2.1	-1.9	-1.3	-1.9	-0.7	0.6
Age when periods started (menarche)	1.9	4.6	12.6	0.5	1.4	-2.7	-3.2	3.0	1.6	1.6	2.0	1.6	3.5	1.5	1.9	-0.9
Alcohol usually taken with meals	1.9	3.0	7.2	0.3	-1.6	2.6	2.3	-2.7	-0.3	-1.5	-1.2	-1.4	-2.1	-1.4	-1.8	1.3
Pain all over the body in last month	1.9	2.0	8.5	-0.3	0.1	1.5	2.4	-1.3	-0.2	-0.4	-1.1	-0.5	-2.1	-0.4	-2.9	-1.3
Tense / ‘highly strung’	1.9	3.1	6.2	-0.6	2.2	-1.7	-2.5	2.3	1.7	1.4	1.4	1.6	2.2	1.4	2.0	0.9
Medication: Blood pressure	1.9	3.4	8.9	-1.3	0.6	-2.1	-1.3	1.3	2.5	2.4	3.0	2.5	1.2	2.4	0.7	-0.7
Qualifications: nursing, teaching	1.9	3.0	7.8	1.4	-2.8	1.7	1.7	-2.0	-1.6	-1.5	-1.4	-1.6	-1.9	-1.5	-1.2	1.6
Osteoarthritis (self-reported)	1.9	2.5	5.3	1.8	-1.1	1.4	0.5	-0.7	-1.9	-2.2	-2.0	-2.2	-1.1	-2.3	0.3	0.8
Rheumatoid Arthritis	1.8	2.4	5.0	2.2	0.7	1.3	0.1	0.2	-1.5	-1.9	-2.2	-1.9	-0.8	-1.9	1.2	2.2
Trunk fat-free mass	1.8	10.5	33.2	1.4	5.8	-4.7	-4.8	4.0	1.1	2.1	1.1	1.9	3.9	1.9	3.0	-1.1
Trunk predicted mass	1.8	10.4	32.9	1.5	5.7	-4.8	-4.8	4.0	1.1	2.1	1.1	1.9	3.9	1.8	3.0	-1.1
Medication: Ibuprofen	1.8	2.2	5.7	-0.6	1.0	-2.2	-1.6	1.4	1.0	1.4	1.8	1.2	2.4	1.2	1.0	-1.3
Mineral and other dietary supplements	1.8	2.4	5.0	0.5	2.2	-1.1	-1.1	1.4	1.8	2.1	1.5	1.9	0.4	1.9	1.6	1.2
Seen a psychiatrist for nerves, anxiety, tension or depression	1.7	2.1	6.1	1.0	0.7	-2.5	-1.3	1.0	1.3	1.5	2.0	1.7	1.7	1.8	0.5	-0.5
Illness, injury, bereavement, stress in last 2 years	1.7	2.1	5.4	0.4	-1.5	1.6	1.3	-1.4	-1.5	-2.3	-1.2	-1.9	-0.6	-2.1	-0.9	-0.0
Ulcerative Colitis (UC)	1.6	3.0	8.1	-2.8	-0.8	-0.3	-0.3	0.8	1.9	2.2	2.9	2.5	0.4	2.6	0.4	0.1
High blood pressure	1.6	4.6	10.0	0.3	1.0	-2.9	-1.9	1.8	2.9	2.6	3.2	2.7	1.3	2.6	1.3	0.7
Frequency of tenseness / restlessness in last 2 weeks	1.6	2.5	4.4	-1.7	1.4	-1.4	-0.9	1.4	2.0	1.8	1.6	1.9	2.1	1.9	0.0	-1.1
Medication: Ibuprofen (e.g. Nurofen)	1.6	2.0	5.0	-0.2	0.9	-2.0	-0.9	0.7	1.6	1.7	2.2	1.7	1.8	1.7	0.2	-0.2
Arm fat-free mass (right)	1.6	8.1	23.3	2.0	4.8	-4.4	-3.9	3.4	1.1	2.1	1.2	2.0	2.9	1.9	2.8	-0.8
Mean time to correctly identify matches	1.6	3.1	8.4	1.3	-0.1	1.5	0.5	-1.2	-2.3	-2.7	-2.3	-2.8	-0.4	-2.9	-0.7	0.5
Family relationship satisfaction	1.6	2.0	6.1	-1.0	-1.9	1.7	2.0	-2.5	0.2	-0.6	-0.9	-0.6	-1.1	-0.5	-2.0	1.0
Ever had stillbirth, spontaneous miscarriage or termination	1.6	1.7	3.9	-2.0	0.5	1.8	0.7	-1.3	-2.0	-1.1	-1.4	-1.1	-1.2	-1.0	-1.5	0.1
Back pain experienced in last month	1.6	2.3	5.1	1.3	0.2	2.3	1.4	-1.4	-1.6	-1.8	-2.2	-1.8	-0.8	-1.8	-1.0	0.6
Number of operations (self-reported)	1.6	2.4	5.8	-1.5	-0.3	2.4	2.1	-1.9	-0.9	-1.1	-1.7	-1.1	-1.5	-1.0	-2.2	0.4
Alzheimer’s Disease (including proxy)	1.5	2.2	4.2	-1.4	0.9	-2.0	-1.2	2.0	1.0	1.8	1.6	1.8	1.1	1.8	0.4	-1.6
Cardiovascular Disease	1.5	5.0	11.7	-1.0	0.6	-2.4	-1.4	1.3	3.2	3.0	3.4	3.2	1.5	3.2	0.5	-0.2
Whole body fat-free mass	1.5	8.5	26.3	1.6	5.1	-4.5	-4.1	3.6	1.0	2.1	0.9	1.9	3.2	1.9	2.5	-1.2
Whole body water mass	1.5	8.3	25.6	1.7	5.1	-4.5	-4.1	3.5	0.9	2.0	0.8	1.8	3.2	1.8	2.6	-1.1
Hearing aid user	1.5	1.6	2.2	1.3	0.2	1.1	0.8	-1.5	-1.4	-1.4	-1.5	-1.4	-1.5	-1.3	-1.3	1.5
Worry (Nagel 2018)	1.4	3.0	11.8	1.5	1.1	-1.5	-2.7	2.5	1.2	0.8	0.9	1.1	1.6	0.8	3.4	0.8
Alzheimer’s Disease (in mother)	1.4	1.6	5.3	-2.1	-0.1	-1.6	-0.3	0.9	0.2	1.0	1.5	1.1	0.9	1.1	-1.0	-2.3
Ever highly irritable/argumentative for 2 days	1.4	1.7	6.7	1.7	2.0	1.4	0.1	-0.3	-0.6	-1.2	-1.5	-1.0	-0.1	-1.2	-0.0	2.6
Suffer from ‘nerves’	1.4	2.2	6.8	1.1	1.7	-1.1	-2.3	2.1	0.9	0.8	0.8	0.9	1.8	0.9	2.6	0.5
Osteoporosis (self-reported)	1.4	1.8	7.1	0.8	0.3	-1.3	-2.2	2.0	0.2	0.6	0.8	0.7	1.6	0.5	2.7	0.7
Leg fat percentage (left)	1.4	5.1	15.3	2.1	-2.2	2.2	3.6	-2.8	-1.2	-1.3	-1.9	-1.7	-3.9	-1.6	-2.1	0.3
Arm fat-free mass (left)	1.4	7.1	22.6	2.3	4.7	-4.2	-3.6	3.1	0.9	1.9	0.6	1.7	2.8	1.7	2.4	-0.9
Arm predicted mass (left)	1.4	7.2	22.2	2.2	4.7	-4.2	-3.6	3.1	1.0	1.9	0.6	1.7	2.9	1.7	2.5	-0.9
Diabetes (mother)	1.3	1.7	5.4	2.3	0.4	-1.6	-1.2	1.1	1.3	1.1	1.0	1.0	0.4	0.9	1.7	1.7
Medication: Lansoprazole	1.3	1.4	5.2	0.6	-1.3	0.8	0.3	-0.5	-1.2	-2.3	-0.9	-1.9	-0.4	-2.1	0.2	-0.1
Leg fat percentage (right)	1.3	4.7	13.7	1.2	-2.4	2.2	3.5	-2.8	-1.0	-1.2	-1.6	-1.5	-3.7	-1.4	-2.3	0.2
Wheeze or whistling in the chest in last year	1.3	2.2	15.7	-4.0	-0.3	1.8	1.3	-1.7	-0.1	0.4	0.2	0.3	-0.1	0.4	-2.1	-0.7
Arm predicted mass (right)	1.3	6.6	20.2	1.8	4.5	-4.1	-3.6	2.9	0.8	1.8	1.0	1.7	2.8	1.6	2.3	-0.9
Diabetes diagnosed by doctor	1.3	2.1	4.8	0.8	-1.0	-1.2	-0.7	1.3	1.6	1.8	2.2	2.1	-0.3	2.2	1.3	0.8
Breast Cancer	1.2	2.8	6.3	0.3	-1.8	2.5	2.4	-2.1	-0.5	-0.4	-2.5	-0.6	-0.9	-0.5	-2.4	1.5
Heel T-Score	1.2	9.4	27.7	-5.3	1.0	3.4	2.9	-2.6	-3.1	-3.2	-3.3	-2.9	-0.0	-2.8	-3.8	-2.1
Vitamin and mineral supplements	1.2	1.7	3.5	-0.8	0.1	-1.3	-1.8	1.3	1.4	1.2	1.9	1.5	0.9	1.5	1.2	0.9
Heel bone mineral density (BMD) T-score, automated (left)	1.2	2.7	5.3	-2.3	1.4	0.6	1.2	-1.1	-2.1	-2.2	-0.5	-1.9	0.7	-2.0	-2.2	-1.5
Qualifications: CSEs or equivalent	1.2	1.5	12.8	-3.6	-0.5	0.4	0.2	0.3	-0.7	-0.2	-0.9	-0.3	0.7	-0.3	-0.5	-2.1
Diabetes (self-reported)	1.2	1.9	4.5	0.7	-1.4	-0.7	-0.0	0.8	1.8	1.8	2.1	2.0	-0.8	2.1	0.8	0.3
Pulse rate	1.2	2.0	4.7	-1.4	-1.5	2.2	0.8	-0.8	-1.6	-1.5	-1.8	-1.7	-1.4	-1.7	-0.1	-0.3
Forced expiratory volume in 1-second (FEV1), Best measure	1.2	3.7	7.5	-1.8	1.4	-2.3	-2.4	2.7	1.2	1.4	1.8	1.4	2.3	1.4	2.0	-2.2
Medication: Paracetamol	1.2	2.0	5.5	-0.8	2.3	-1.0	-1.6	0.8	1.4	1.3	1.9	1.4	1.8	1.3	0.7	1.1
Exposure to tobacco smoke outside home	1.2	1.5	3.8	-1.1	-0.2	1.2	1.7	-1.9	-0.8	-1.0	-0.7	-1.1	-1.9	-1.0	-1.2	-1.1
Leg fat-free mass (right)	1.2	6.3	19.0	1.5	4.4	-4.1	-3.3	3.1	1.0	2.0	0.7	1.8	2.4	1.8	2.1	-1.3
Basal metabolic rate	1.2	6.6	22.0	1.5	4.7	-4.2	-3.5	3.1	0.9	1.9	0.8	1.7	2.5	1.7	2.0	-1.2
Basal cell carcinoma (self-reported)	1.2	1.4	8.6	-2.9	-0.6	-0.9	-0.2	-0.2	0.0	0.2	0.2	0.3	1.2	0.4	-0.7	-2.4
Pack years of smoking	1.2	1.8	5.4	-2.3	-0.8	1.2	1.5	-1.9	-0.3	-0.4	-0.6	-0.2	-1.8	-0.2	-2.0	-1.3
Ulcerative Colitis	1.1	1.6	3.5	-1.7	-1.0	-0.2	-0.5	0.9	1.4	1.7	1.7	1.8	0.3	1.9	0.8	0.4
Blood White Count	1.1	8.5	16.6	-1.4	-2.8	4.0	4.1	-3.6	-2.8	-2.6	-2.3	-2.6	-3.1	-2.6	-3.5	-0.1
Smoking Status	1.1	2.6	6.7	-1.2	2.6	-1.6	-1.0	0.9	1.7	1.5	2.1	1.8	2.0	1.8	-0.6	0.6
Respiratory disease	1.1	2.4	8.3	-2.9	0.3	2.4	2.1	-1.7	-0.9	-0.3	-1.2	-0.5	-1.0	-0.4	-2.2	0.9
Number of treatments/medications taken	1.1	2.0	4.5	0.6	1.5	-2.1	-1.3	1.5	1.0	1.5	1.4	1.6	1.7	1.5	0.7	1.2
Heel bone mineral density (BMD) T-score, automated (right)	1.1	2.5	5.7	-2.4	1.5	0.9	1.3	-0.9	-1.7	-2.0	-0.5	-1.6	1.1	-1.7	-2.4	-1.5
Leg predicted mass (right)	1.1	6.1	19.1	1.5	4.4	-4.0	-3.3	3.1	0.9	1.9	0.7	1.7	2.3	1.7	2.0	-1.3
Diastolic blood pressure, automated reading	1.1	3.4	15.5	-0.1	3.9	-1.7	-3.0	2.7	0.6	0.8	0.3	0.6	2.0	0.5	1.9	-0.4
Medication: Omeprazole (e.g. Zanprol)	1.1	1.3	3.1	-1.1	-1.3	-0.5	1.4	-0.7	1.3	1.1	1.7	1.2	0.2	1.3	-1.8	-0.4
Age at First Birth	1.0	1.5	4.2	-0.8	0.2	-1.0	-0.9	1.5	2.1	1.5	1.3	1.3	1.4	1.3	0.9	0.2
BMI	1.0	5.6	14.5	1.7	-1.5	2.3	3.8	-2.8	-1.9	-1.6	-2.5	-1.9	-3.8	-1.8	-2.6	-0.1
Pack years adult smoking proportion	1.0	1.6	5.6	-2.4	-0.7	0.9	1.4	-1.7	-0.3	-0.1	-0.3	-0.1	-1.6	0.0	-2.0	-1.4
Leg fat-free mass (left)	1.0	5.3	15.0	1.1	3.9	-3.9	-3.0	2.8	1.0	1.9	0.8	1.7	2.2	1.7	1.7	-1.3
Hand grip strength (right)	1.0	2.8	7.6	0.3	1.1	-2.3	-1.9	1.5	1.7	1.7	1.4	1.4	2.8	1.5	1.2	-1.7
Relative age voice broke	1.0	1.5	5.7	1.9	2.4	-0.4	-1.1	1.2	-0.1	-0.3	0.2	-0.3	0.6	-0.4	1.4	2.1
Leg predicted mass (left)	1.0	5.2	15.1	1.1	3.9	-3.8	-3.0	2.8	1.0	1.9	0.8	1.7	2.2	1.7	1.7	-1.3
Hearing difficulty/problems with background noise	1.0	1.6	8.1	-2.8	-1.1	1.3	1.3	-1.4	-0.3	-0.2	-0.8	-0.4	-1.5	-0.3	-1.5	-1.1
Arm fat percentage (right)	1.0	4.0	14.8	0.9	-1.5	1.6	3.5	-2.6	-0.5	-0.7	-1.6	-1.0	-3.8	-0.9	-2.5	-0.7
Frequency of tiredness / lethargy in last 2 weeks	1.0	1.6	2.7	-1.1	1.1	-1.4	-1.6	1.3	0.9	1.4	1.6	1.4	1.4	1.3	0.9	-0.8
Noisy workplace	1.0	1.3	5.7	-2.4	0.2	-0.9	-0.8	0.8	0.5	1.1	1.0	0.9	1.0	0.9	0.4	-1.9
Asthma	1.0	2.0	11.3	-3.4	0.2	1.8	1.6	-1.4	-0.1	0.5	-0.2	0.4	-1.2	0.5	-2.1	0.6
Depression (self-reported)	1.0	1.2	3.3	0.9	0.2	-1.2	-1.1	1.5	1.0	0.6	1.8	0.8	1.1	0.7	1.6	0.1
Eye problems/disorders: None of the above	1.0	1.2	2.6	-1.0	-0.7	-1.3	-1.1	0.3	1.6	1.2	1.1	1.1	0.3	1.1	0.9	-1.6
Age at last live birth	1.0	1.5	3.8	-0.2	-0.1	-1.3	-1.1	0.9	1.6	1.5	2.0	1.5	1.3	1.5	0.2	0.7
Arm fat percentage (left)	1.0	3.8	14.1	0.5	-1.5	1.6	3.6	-2.5	-0.5	-0.7	-1.4	-0.9	-3.8	-0.8	-2.6	-0.8
Asthma (self-reported)	1.0	2.1	11.1	-3.3	0.2	1.8	1.7	-1.5	-0.1	0.5	-0.3	0.4	-1.2	0.4	-2.3	0.7
Ever taken oral contraceptive pill	1.0	1.1	7.6	-1.3	-0.1	-1.3	-0.3	0.7	0.5	0.4	0.6	0.3	1.3	0.3	-0.2	-2.8
Mother’s age at death	1.0	1.3	5.3	-0.3	-2.3	1.5	0.6	-1.3	-0.6	-0.6	-0.9	-0.7	-2.2	-0.7	-0.2	0.4
Schizophrenia vs Biploar Disorder	0.9	1.1	3.7	-0.4	1.3	-1.4	-0.7	0.8	1.9	1.1	1.0	1.0	1.2	1.0	0.5	-0.1
Medication: Co-codamol	0.9	1.0	2.4	0.7	0.1	1.5	1.0	-0.7	-0.9	-1.3	-1.3	-1.2	-0.2	-1.3	-0.8	1.0
Ever unenthusiastic/disinterested for a whole week	0.9	1.1	3.2	-1.3	-0.1	-0.3	-0.2	-0.3	1.5	1.5	1.1	1.7	0.4	1.8	-0.3	-0.5
Illnesses of siblings	0.9	1.3	4.2	-1.5	-2.1	1.3	1.1	-1.5	-0.1	-0.3	0.1	-0.3	-1.9	-0.2	-1.0	0.6
Serious illness, injury or assault of a close relative in last 2 years	0.9	1.0	2.2	-1.4	-0.6	0.5	0.8	-1.0	-1.3	-0.6	-1.2	-0.7	-1.5	-0.6	-1.4	-0.6
Peak expiratory flow (PEF)	0.9	2.1	5.9	-2.4	-1.5	1.3	2.0	-1.3	-0.7	-0.5	-1.0	-0.7	-0.9	-0.5	-1.8	-2.2
Comparative body size at age 10	0.9	2.4	4.7	-0.5	-1.3	1.3	1.0	-0.8	-1.9	-2.1	-1.4	-2.1	-1.2	-2.2	-0.9	-2.2
Worry too long after embarrassment	0.9	1.5	3.2	0.5	-1.3	1.4	0.7	-0.7	-1.3	-1.8	-1.1	-1.5	-1.6	-1.5	0.4	1.2
Heart disease (mother)	0.9	1.1	2.8	-0.6	-0.9	1.0	1.5	-1.6	-0.7	-0.6	-1.3	-0.7	-1.1	-0.6	-1.7	0.4
Number of full sisters	0.9	1.1	2.3	-1.5	0.4	0.3	-1.2	0.7	-1.3	-0.9	-1.2	-1.2	1.2	-1.3	1.0	-0.6
Smoking status: Previous	0.9	1.3	3.0	-0.7	1.7	-1.7	-0.9	0.5	1.2	0.8	1.6	1.1	1.5	1.2	-0.5	0.4
Ever had bowel cancer screening	0.9	1.0	1.7	-0.1	-1.1	1.1	1.0	-1.3	-1.3	-1.3	-0.8	-1.1	-0.4	-1.1	-0.7	1.0
Eye problems/disorders: Cataract	0.9	1.0	5.5	2.3	1.4	-0.4	-0.3	1.1	0.7	0.3	-0.0	0.4	1.2	0.3	0.0	1.4
Medication: Paracetamol	0.9	1.3	3.2	-0.5	1.5	-1.1	-1.8	0.9	0.7	0.9	1.3	0.9	1.8	0.7	1.0	1.1
Irritable Bowel Disease (IBD)	0.8	1.8	5.0	-1.3	-0.2	0.2	0.2	0.2	1.8	2.0	2.0	2.2	-0.3	2.2	-0.1	0.8
Coronary Artery Disease (CAD)	0.8	1.0	2.4	-1.5	-0.4	0.2	-0.3	-0.1	1.5	1.4	0.8	1.5	-0.3	1.5	0.7	-0.3
Hypothyroidism (self reported)	0.8	1.8	7.5	1.9	-0.3	-1.2	-2.0	1.6	0.1	0.3	1.3	0.4	0.1	0.3	2.7	1.6
Other serious medical condition/disability diagnosed by doctor	0.8	1.0	2.5	-0.9	0.1	1.6	0.2	0.3	-1.0	-1.4	-1.6	-1.3	0.9	-1.5	0.2	0.3
Medication for hormone replacement therapy	0.8	0.9	5.8	0.1	0.1	-0.5	-1.4	1.4	-0.2	0.1	0.2	-0.1	2.4	-0.2	1.3	-0.8
Serious illness, injury or assault to yourself	0.8	0.9	2.7	0.8	1.0	-0.8	0.1	0.7	1.0	1.6	1.0	1.4	0.1	1.5	-0.4	0.7
Diverticular disease/diverticulitis (self-reported)	0.8	1.0	2.8	-0.3	-0.4	-0.8	-0.4	1.0	1.5	0.8	0.6	0.9	1.5	0.9	0.7	-1.7
Body mass index (BMI)	0.8	3.2	10.1	2.0	-1.0	1.2	2.7	-2.0	-1.2	-1.1	-1.9	-1.4	-3.2	-1.3	-1.9	-0.8
Forced expiratory volume in 1-second (FEV1)	0.8	2.7	6.4	-1.2	1.4	-2.0	-2.0	2.3	0.3	0.7	0.7	0.6	2.5	0.6	1.8	-2.5
Blood clot in the leg (DVT)	0.8	1.1	9.7	3.1	-0.1	-0.3	-0.4	0.5	0.8	0.2	-0.7	0.1	-0.4	-0.1	0.6	1.4
Body fat percentage	0.8	3.2	13.2	1.2	-1.4	1.3	3.2	-2.4	-0.2	-0.5	-1.0	-0.7	-3.6	-0.6	-2.3	0.0
Neck or shoulder pain in last month	0.8	1.1	2.7	-0.8	0.4	-1.3	-1.2	0.5	0.5	1.1	1.6	1.1	1.2	1.2	1.1	0.6
Migraine (self-reported)	0.8	0.9	2.6	-1.4	0.4	-1.6	-1.1	0.9	0.9	0.6	1.4	0.8	0.6	0.8	0.7	-0.5
Medication: Omeprazole	0.8	0.9	2.5	-0.2	-1.5	-0.5	1.3	-1.1	0.8	0.6	1.3	0.7	-0.3	0.8	-1.6	0.3
Chest pain or discomfort	0.8	1.2	2.2	-1.4	0.2	-0.9	-0.6	1.1	1.2	1.5	1.1	1.2	1.3	1.3	0.6	-0.8
Medication: Lisinopril	0.8	1.1	3.4	-1.2	0.3	0.4	0.7	-0.6	-1.8	-1.1	-1.5	-1.2	0.3	-1.2	-1.3	0.1
Medication: Atorvastatin	0.8	1.0	4.2	1.4	0.4	0.6	-0.8	1.0	-0.8	-0.5	-0.8	-0.5	0.7	-0.6	1.7	2.0
Ever smoked	0.8	1.4	8.4	-2.9	0.4	0.1	1.1	-1.0	-0.0	-0.3	0.7	-0.0	-0.7	0.1	-2.3	-0.9
Unable to work because of sickness or disability	0.8	1.0	3.3	-1.0	1.3	1.1	0.8	-0.8	-1.1	-1.1	-1.0	-0.9	-0.1	-0.9	-1.8	0.1
Deep venous thrombosis (DVT) (self-reported)	0.8	1.1	10.1	3.2	-0.1	-0.3	-0.3	0.5	0.7	0.2	-0.7	0.1	-0.5	-0.1	0.6	1.4
Bipolar Disorder (2018)	0.7	1.1	3.8	0.0	1.0	0.7	1.4	-1.1	-1.2	-0.8	-1.3	-0.9	-1.1	-0.7	-1.9	-0.3
LDL Cholesterol	0.7	1.1	2.5	-1.1	-0.6	-0.5	-1.4	0.8	-1.2	-1.3	-0.5	-1.1	0.2	-1.2	1.3	-1.6
Type 2 Diabetes (T2D) (2012)	0.7	0.8	3.2	-0.3	-0.1	-0.6	-0.3	-0.0	1.6	1.0	0.7	1.0	0.4	1.0	0.0	1.8
Chronotype (morning person)	0.7	1.7	7.2	-1.8	-2.7	1.7	0.9	-1.3	-0.2	-0.9	-0.3	-0.6	-1.8	-0.6	-0.6	0.7
Diabetes (father)	0.7	0.9	2.5	0.8	-1.1	-0.9	-0.8	1.0	0.7	0.6	1.4	0.9	0.1	0.9	1.6	0.5
Medication: Atenolol	0.7	0.9	2.2	1.5	0.7	-1.3	-0.8	0.9	1.0	1.0	0.9	1.0	0.4	0.9	0.4	0.4
Medication: Ramipril	0.7	1.0	2.3	-0.2	-0.3	-1.3	-0.4	0.8	1.2	1.2	1.5	1.2	0.1	1.3	0.6	-1.0
Hair/balding pattern: Pattern 3	0.7	1.0	5.0	2.2	-0.7	0.5	0.9	-1.0	0.1	-0.7	-1.2	-0.6	-1.5	-0.6	-0.1	-0.8
Mouth/teeth dental problems: Dentures	0.7	1.2	3.2	-0.3	-0.2	1.3	0.2	-0.8	-1.8	-1.7	-1.3	-1.5	-0.6	-1.6	-0.2	0.7
Headache pain in last month	0.7	1.3	8.5	-2.9	0.2	-0.3	-1.5	0.2	0.7	0.7	0.6	0.8	1.5	0.9	0.8	0.0
Medication: Amlodipine	0.7	0.9	2.6	0.3	-0.6	-0.6	0.4	-0.2	1.6	1.2	1.5	1.5	0.2	1.4	-0.5	0.5
Shortness of breath walking on level ground	0.7	0.8	3.8	0.8	1.7	-0.7	-0.3	1.0	0.3	0.6	-0.2	0.5	-0.6	0.5	-0.3	2.0
Medication: Allopurinol	0.7	0.9	2.0	1.0	-0.6	0.8	0.6	-1.3	-1.0	-1.1	-1.0	-0.9	-1.4	-0.9	-0.4	0.8
Overall health rating	0.7	1.5	2.5	-1.4	0.7	-1.6	-1.3	1.4	0.9	1.1	1.5	1.3	1.4	1.3	0.6	-0.7
Medication: Gliclazide	0.7	0.8	1.9	-0.9	-1.4	-0.6	0.5	-0.3	0.7	0.9	1.2	0.9	-1.3	1.0	-0.4	-1.0
Average weekly beer plus cider intake	0.7	1.1	3.6	0.3	1.5	-0.8	-1.0	1.9	0.1	0.9	0.9	0.8	1.4	0.7	1.2	0.2
Bipolar Disorder or Schizophrenia	0.6	1.6	5.3	0.7	0.5	0.5	1.1	-1.0	-1.3	-1.4	-2.3	-1.4	-1.4	-1.3	-1.3	-0.8
Depression (Nagel 2018)	0.6	0.9	2.3	-1.5	-0.1	1.5	1.3	-1.4	0.2	0.2	-0.5	0.2	-1.1	0.2	-1.1	0.4
Crohns Disease (2012)	0.6	1.0	2.0	0.5	0.8	-0.7	-0.5	0.5	1.4	1.4	1.2	1.3	-0.6	1.3	0.9	0.9
HbA1C	0.6	0.6	1.8	0.4	-0.6	-1.0	-1.3	1.0	1.1	0.5	0.7	0.7	0.4	0.7	0.9	0.1
Primary Biliary Cirrhosis	0.6	0.9	3.1	-1.6	-0.5	1.2	0.7	-0.8	-0.9	-0.8	-0.5	-0.7	-0.6	-0.7	-1.8	0.1
Waist Hip Ratio (WHR)	0.6	2.9	29.9	-5.5	0.1	0.3	-1.0	-0.4	0.8	0.2	0.7	0.6	1.5	0.6	-0.2	-1.4
Type 2 Diabetes (T2D) (2018)	0.6	1.2	3.8	-0.1	-1.3	-0.4	0.6	0.3	1.3	1.3	1.9	1.4	-1.0	1.6	0.1	0.7
Ever used hormone-replacement therapy (HRT)	0.6	0.8	2.5	-0.5	-0.9	1.1	1.1	-0.9	-0.5	-0.7	-1.2	-0.6	-0.1	-0.6	-1.6	0.3
Ever had hysterectomy (womb removed)	0.6	0.7	1.7	-1.3	0.6	0.0	-0.2	0.6	1.1	1.0	1.1	1.1	0.9	1.0	0.1	0.2
Severe depression (siblings)	0.6	0.7	2.7	0.4	0.8	-1.2	-1.6	1.0	0.2	-0.1	0.9	-0.0	0.7	-0.1	1.5	0.1
Hayfever, allergic rhinitis or eczema	0.6	1.2	4.6	0.3	-0.7	-0.5	0.2	0.0	1.7	2.1	0.3	1.8	-0.5	1.9	0.1	0.7
High blood pressure (mother)	0.6	0.8	2.1	1.4	0.3	-0.8	-0.7	1.4	0.9	0.6	0.6	0.8	0.5	0.7	1.0	1.3
Hair/balding pattern: Pattern 2	0.6	0.8	7.1	-2.7	-0.3	-0.1	0.5	-0.2	0.3	0.3	1.2	0.5	-0.7	0.6	-0.4	-0.6
Had menopause	0.6	0.7	2.0	0.8	-0.8	1.1	1.3	-1.4	0.4	-0.1	-0.9	-0.0	-0.9	0.1	-1.2	0.7
Loud music exposure frequency	0.6	0.6	3.4	-0.1	0.7	0.4	-0.1	0.1	1.3	0.7	0.3	0.9	0.2	0.9	-0.5	1.8
Birth weight	0.6	1.4	4.5	-0.6	0.6	-1.2	-1.8	1.3	-1.1	-0.8	-0.6	-0.6	2.1	-0.6	0.8	-1.7
Number of full brothers	0.6	0.7	4.6	-1.7	-0.3	-0.2	0.5	-0.1	0.3	0.1	0.7	0.1	-0.9	0.1	-0.7	-2.1
Pulse wave peak to peak time	0.6	0.7	1.8	1.3	0.7	-1.0	-0.4	0.8	1.0	0.8	0.6	0.9	0.9	0.8	-0.4	0.7
Medication: Seretide 50 evohaler	0.6	0.7	3.7	0.6	1.9	-0.5	-0.6	0.7	1.1	0.9	0.1	1.0	0.4	0.9	0.3	0.5
Qualifications: NVQ or HND or HNC or equivalent	0.6	0.8	2.1	-0.5	-0.5	1.4	1.1	-0.9	-0.6	-0.8	-1.0	-0.9	-1.2	-0.8	-0.7	0.3
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.6	0.7	1.7	-1.1	-1.3	1.0	1.2	-1.2	-0.2	-0.5	0.2	-0.5	-0.6	-0.5	-1.2	-0.4
Illnesses of father: Heart disease	0.6	0.9	2.6	0.7	0.3	0.3	0.5	-0.5	-1.1	-1.4	-0.7	-1.5	0.3	-1.6	-0.8	0.9
Number of self-reported non-cancer illnesses	0.6	1.1	2.2	-0.3	0.9	-1.4	-0.6	0.8	1.1	1.4	1.3	1.4	1.0	1.5	0.3	0.3
Miserableness	0.6	1.1	2.5	-0.3	1.5	-1.6	-1.6	1.4	0.0	0.2	1.0	0.2	1.4	0.2	1.3	-0.5
Illnesses of father: High blood pressure	0.6	0.8	1.5	-1.0	-0.6	-0.6	-0.1	0.3	1.1	1.2	1.1	1.2	0.5	1.2	-0.1	-1.0
Risk taking	0.6	0.9	3.1	0.4	0.3	-1.1	-0.5	0.2	0.9	1.8	1.2	1.4	0.4	1.5	-0.1	0.5
Major Depression (MDD)	0.5	0.6	1.6	-0.3	-1.0	0.8	0.9	-0.9	-0.7	-0.9	-1.2	-0.7	-0.6	-0.7	-0.5	-0.2
HDL Cholesterol	0.5	0.8	1.8	1.4	-0.0	0.6	0.8	-0.1	-1.0	-1.2	-0.7	-1.1	0.2	-1.2	-0.7	1.3
Blood Red Count	0.5	5.2	20.6	-0.8	-3.9	1.9	3.0	-3.2	-0.3	-0.6	0.7	-0.4	-4.5	-0.3	-1.8	1.9
Allergy or Eczema	0.5	1.4	4.8	0.6	-0.4	-0.9	-0.2	-0.1	1.5	2.2	0.9	1.9	-0.4	2.1	0.4	0.5
Lung FVC	0.5	2.7	9.9	0.6	1.1	-1.2	-2.5	2.0	-0.6	-0.7	-0.7	-1.0	3.1	-1.1	2.2	-2.1
Hand grip strength (left)	0.5	1.2	2.9	-0.1	0.2	-1.4	-0.9	0.5	1.2	1.3	1.3	1.1	1.7	1.2	0.6	-1.3
Average weekly spirits intake	0.5	0.6	3.3	-0.8	0.2	0.7	1.1	-0.1	0.1	-0.5	-0.4	-0.4	-1.8	-0.5	-0.7	-0.3
Angina	0.5	0.6	2.2	0.5	1.5	-0.6	-0.3	0.3	0.9	0.9	0.9	0.8	1.2	0.7	-0.0	0.7
Trunk fat percentage	0.5	2.1	10.2	1.2	-0.5	0.7	2.7	-1.9	0.1	-0.2	-0.6	-0.4	-3.2	-0.3	-2.0	-0.1
Medication: Simvastatin	0.5	0.7	2.5	-0.8	0.8	-1.0	-0.6	0.3	0.9	0.9	1.6	1.0	0.2	1.0	0.3	0.4
Fluid intelligence score	0.5	1.1	2.6	1.3	-0.7	1.6	1.0	-1.4	-0.3	-0.7	-0.4	-0.7	-1.3	-0.6	-0.6	1.5
Worrier / anxious feelings	0.5	0.9	4.0	1.0	0.2	-0.6	-1.8	1.2	0.2	-0.0	0.5	0.1	0.9	0.0	2.0	1.1
Falls in the last year	0.5	0.7	2.1	-0.7	1.1	0.0	0.7	-0.6	0.9	0.6	0.5	0.8	0.1	0.8	-1.4	-1.3
Number of live births	0.5	0.8	3.2	-0.4	0.4	-1.0	-1.6	1.1	0.2	0.0	0.4	0.2	1.8	0.2	0.7	-1.1
Length of working week for main job	0.5	0.5	2.6	-0.7	-1.2	-0.3	0.4	-0.3	0.1	0.4	0.4	0.2	-1.6	0.3	-0.1	-1.2
Seen doctor (GP) for nerves, anxiety, tension or depression	0.5	0.7	3.0	1.7	0.9	-0.7	-0.8	0.5	-0.1	0.4	-0.6	0.3	1.5	0.4	0.5	1.1
Pulse wave reflection index	0.5	0.7	2.9	-1.7	-0.6	-0.7	-0.8	0.3	0.4	0.6	1.1	0.8	0.7	0.9	0.7	-0.1
Number of children fathered	0.5	0.6	2.7	1.6	1.4	-0.5	-0.6	0.4	-0.5	-0.3	-0.3	-0.3	0.6	-0.4	0.8	-0.4
Angina (self-reported)	0.5	0.6	1.6	0.1	1.3	-0.5	-0.0	0.2	1.1	1.0	1.1	1.0	0.9	0.9	-0.4	0.7
Supplements: Vitamin C	0.5	0.6	3.1	1.8	0.9	-0.6	-0.6	0.6	-0.2	-0.3	-0.2	-0.4	0.9	-0.5	1.1	-0.7
Loneliness, isolation	0.5	0.6	2.1	-1.4	0.1	1.1	0.9	-0.7	-1.0	-0.5	-0.9	-0.7	-0.4	-0.5	-0.8	-0.1
Mouth/teeth dental problems: Mouth ulcers	0.5	0.8	1.8	-0.5	0.1	0.9	0.9	-0.7	-1.1	-1.3	-0.4	-1.3	-0.1	-1.3	-1.3	-0.2
Breast cancer (self-reported)	0.5	0.6	1.9	1.4	-0.0	-1.1	0.2	-0.1	0.7	0.5	1.2	0.7	-1.0	0.6	0.2	0.7
Illnesses of father: None of the above (group 1)	0.5	0.6	2.0	0.5	0.2	0.6	-0.2	-0.2	-1.0	-1.1	-1.4	-1.1	-0.4	-1.1	0.6	0.2
Guilty feelings	0.5	0.7	2.3	1.3	0.1	0.9	-0.5	0.7	-0.4	-0.8	-1.2	-0.7	-0.3	-0.8	1.5	0.5
Medication: Blood pressure	0.5	1.0	5.8	2.4	0.8	-1.8	-0.4	0.8	0.5	0.5	0.7	0.5	0.5	0.5	-0.1	0.5
Medication: Bendroflumethiazide	0.5	0.7	1.9	1.3	0.4	-0.8	0.0	0.9	1.4	0.9	0.8	1.0	0.4	0.9	-0.1	0.8
Ever depressed for a whole week	0.5	0.6	2.0	0.8	-0.4	1.4	1.1	-1.1	-0.3	-0.1	-0.9	-0.1	-1.1	-0.0	-0.4	0.3
Myopia	0.5	0.7	6.2	2.5	0.3	-0.3	-0.7	0.4	-0.5	-0.4	0.0	-0.4	0.4	-0.5	0.7	0.6
Heart disease (siblings)	0.5	0.6	1.3	0.3	1.1	0.7	0.7	-1.2	-0.9	-0.9	-0.9	-1.0	-0.2	-0.9	-0.6	0.1
Intelligence (Savage-Jansen 2018)	0.4	1.3	3.5	1.2	1.1	0.4	-0.7	0.7	1.4	1.5	1.0	1.5	0.4	1.5	0.6	1.9
Schizophrenia (2018)	0.4	0.8	3.7	0.9	-0.0	0.1	0.3	-0.4	-0.7	-1.1	-1.9	-1.1	-0.9	-1.1	-0.1	-0.8
Crohns Disease (2017)	0.4	0.9	2.5	0.2	0.8	0.1	0.0	0.1	1.4	1.6	0.9	1.5	-0.5	1.5	-0.1	0.6
Verbal and Numeric Reasoning (VNR)	0.4	0.9	4.9	1.6	0.5	1.1	0.4	-0.6	0.1	-0.1	0.0	-0.1	-1.2	-0.1	0.0	2.2
Ovarian Cancer	0.4	0.5	1.1	0.1	-0.1	0.5	0.9	-0.7	-0.5	-0.7	-0.9	-1.0	-0.0	-1.0	-0.5	-0.7
Bipolar Disorder (2011)	0.4	0.4	2.6	1.6	0.7	0.1	0.9	-0.1	-0.2	-0.1	-0.8	-0.1	-0.7	-0.2	-0.5	0.2
Body Mass Index (BMI) (2010)	0.4	0.5	1.8	0.1	-0.5	1.0	0.8	-1.3	-0.3	-0.4	-0.4	-0.4	-1.2	-0.4	-0.5	0.3
Fasting Glucose	0.4	0.4	1.3	-1.1	-0.8	-0.5	0.4	-0.1	0.3	0.2	0.3	1.1	-1.0	0.5	-0.6	-0.4
Neuroticism (2016)	0.4	0.6	2.8	0.6	-0.6	-0.7	-1.1	1.2	0.2	0.2	0.2	0.2	0.8	0.1	1.7	0.2
Neuroticism	0.4	1.0	6.0	1.3	0.2	-0.0	-1.5	0.9	-0.2	-0.6	0.3	-0.4	-0.4	-0.5	2.5	0.8
Relative age of first facial hair	0.4	0.8	4.4	0.1	1.2	0.2	-0.8	1.1	-0.4	-0.4	0.6	-0.3	0.4	-0.4	1.0	2.1
Medication: Metformin	0.4	0.6	1.4	-0.2	-1.2	-0.4	0.2	0.2	0.9	1.1	0.7	1.0	-1.1	1.1	0.4	-0.5
Current tobacco smoking	0.4	0.6	3.0	-1.4	0.7	-0.0	0.5	-0.8	0.1	0.3	0.6	0.5	-0.3	0.5	-1.7	0.1
Frequency of unenthusiasm / disinterest in last 2 weeks	0.4	0.6	3.3	-1.8	-0.2	0.9	0.5	-0.7	0.7	0.6	0.4	0.6	0.5	0.6	-0.6	0.1
Bilateral oophorectomy (both ovaries removed)	0.4	0.4	2.0	0.3	-1.4	0.0	-0.3	0.2	0.4	0.0	0.7	0.1	0.1	-0.0	0.9	1.3
Tinnitus: Yes, but not now, but have in the past	0.4	0.4	1.0	-0.1	0.3	0.6	-0.9	0.5	-0.2	0.3	-0.9	0.2	0.7	0.3	1.0	1.0
Past tobacco smoking	0.4	0.8	3.2	1.8	-1.4	0.9	0.3	0.0	-0.6	-0.2	-1.2	-0.5	-0.6	-0.5	1.1	-0.3
Hayfever/allergic rhinitis (self-reported)	0.4	0.5	3.0	-0.7	-0.6	0.4	0.7	-0.8	0.3	0.4	-0.5	0.5	-0.5	0.5	-0.2	-1.7
Impedance of arm (right)	0.4	1.7	9.9	-3.1	-0.9	0.3	0.6	-0.3	1.8	1.1	1.7	1.2	-0.2	1.3	-0.8	0.2
Qualifications: A levels/AS levels or equivalent	0.4	1.0	3.0	1.2	-1.7	-0.1	-0.3	-0.7	-0.9	-1.3	-0.7	-1.2	-0.3	-1.2	-0.0	-1.4
Lung cancer (father)	0.4	0.5	1.7	-0.9	-1.0	0.3	0.7	-0.5	-0.6	-0.4	0.5	-0.6	-1.3	-0.6	-0.4	-0.6
Pulse wave Arterial Stiffness index	0.4	0.4	1.5	-1.2	-0.1	0.6	-0.1	-0.4	-0.8	-0.6	-0.5	-0.7	-0.5	-0.6	0.9	-0.5
Impedance of arm (left)	0.4	2.0	10.3	-3.2	-0.8	0.1	0.6	-0.0	2.0	1.3	2.1	1.5	0.0	1.5	-0.7	0.1
Medication: Ventolin 100micrograms inhaler	0.4	0.5	1.9	-1.4	-0.4	0.7	0.8	-0.3	0.2	0.7	0.9	0.8	-0.6	0.9	-0.6	0.6
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.4	0.5	1.8	-0.4	-0.7	-0.2	-0.0	-0.6	0.6	1.0	1.0	0.8	0.6	0.8	-0.2	1.3
Alcohol intake frequency.	0.4	0.9	3.0	-0.2	-0.0	1.1	0.9	-0.7	-1.2	-0.8	-0.7	-0.7	-1.4	-0.7	-0.7	1.7
Handedness (chirality/laterality): Left-handed	0.4	0.5	4.2	-0.5	2.1	-0.5	-0.7	1.0	-0.1	0.1	-0.1	-0.0	0.2	-0.1	0.3	0.5
Mood swings	0.4	0.8	1.7	-1.1	-0.4	1.1	0.6	-0.5	-1.3	-1.2	-0.7	-1.0	-0.7	-1.0	-0.6	0.2
Long-standing illness, disability or infirmity	0.4	0.6	3.3	0.8	1.8	0.5	0.1	0.8	-0.7	-0.7	-0.5	-0.5	0.4	-0.5	-0.3	1.1
Commuting to job workplace: Walk	0.4	0.4	0.9	-0.9	-0.9	1.0	-0.3	-0.0	-0.3	-0.8	-0.6	-0.6	-0.5	-0.6	0.5	-0.4
Medication for cholesterol	0.4	0.7	1.7	-1.3	-0.8	1.1	0.8	-0.9	-0.4	-0.8	-0.6	-0.6	-1.1	-0.6	-0.7	0.1
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.4	0.9	2.7	-0.5	-1.2	0.9	-0.8	0.8	-0.5	-0.5	-1.0	-0.8	0.4	-0.8	1.6	-1.6
Financial situation satisfaction	0.4	0.5	2.2	-1.5	-0.2	0.8	0.2	-0.9	0.2	0.2	-0.3	0.3	0.5	0.4	-1.2	-0.2
Alcohol drinker status: Never	0.4	0.5	2.7	0.7	0.2	-0.2	0.6	-0.2	0.5	0.7	0.6	0.8	-0.8	0.7	-0.6	1.6
Fractured/broken bones in last 5 years	0.4	0.6	2.8	-1.1	-0.4	0.1	1.0	-0.8	-0.4	-0.0	-0.4	-0.2	-0.2	-0.1	-1.7	-1.1
Age started oral contraceptive pill	0.4	0.5	4.7	2.2	-0.5	-0.9	-0.3	0.3	0.5	0.0	0.4	0.4	0.0	0.3	0.1	-0.6
Commuting to job workplace: Cycle	0.4	0.5	1.2	0.1	-1.0	-0.2	-0.1	-0.5	-0.9	-1.1	-0.5	-1.0	-0.4	-1.0	-0.0	-0.5
Supplements: Calcium	0.4	0.4	3.1	-1.8	0.7	-0.0	-0.0	-0.0	-0.8	-0.6	-0.4	-0.6	0.1	-0.6	-0.4	-0.4
Neuroticism (Nagel 2018)	0.3	0.8	5.3	1.2	0.4	-0.2	-1.2	1.3	-0.2	-0.4	-0.2	-0.2	0.1	-0.4	2.3	0.2
Schizophrenia (2014)	0.3	0.7	2.9	-0.1	-0.3	-0.3	0.1	-0.3	-0.2	-0.8	-1.6	-0.9	-0.8	-0.8	-0.3	-1.7
Blood Eosinophil Count	0.3	2.6	5.3	-0.5	0.5	-1.6	-1.4	1.4	1.8	2.2	2.0	2.3	1.0	2.3	1.4	1.1
Tanning	0.3	3.6	11.4	-1.2	3.4	-1.5	-1.7	1.7	2.3	2.3	1.2	2.4	1.6	2.5	0.5	0.5
Frequency of depressed mood in last 2 weeks	0.3	0.4	2.0	-1.4	0.7	0.3	0.6	-0.5	0.6	0.7	0.2	0.6	0.2	0.7	-0.9	-0.5
Impedance of leg (right)	0.3	1.5	5.9	-2.4	-1.7	0.9	0.8	-0.7	1.5	0.5	1.9	0.8	0.1	0.7	-0.6	0.8
Maternal smoking around birth	0.3	0.4	1.4	-0.7	1.2	0.3	-0.1	-0.1	0.5	0.9	-0.0	0.7	0.6	0.8	0.2	0.9
Fed-up feelings	0.3	0.5	1.3	-0.2	0.8	-0.5	-1.0	1.1	-0.0	0.6	0.4	0.7	0.2	0.7	1.1	0.2
Stomach or abdominal pain in last month	0.3	0.3	1.1	-1.1	0.1	-0.3	-0.5	-0.1	-0.8	-0.6	-0.4	-0.7	0.4	-0.7	0.6	-0.6
Medication: Levothyroxine sodium	0.3	0.4	2.7	0.2	-0.5	0.3	-1.1	0.6	-0.6	-0.0	0.4	0.0	0.0	0.0	1.7	0.8
Waist circumference	0.3	1.0	3.7	-0.3	0.1	0.3	1.6	-1.5	-0.4	-0.2	-0.9	-0.3	-1.9	-0.2	-1.9	-0.6
Number of incorrect matches in round	0.3	0.4	2.3	-0.8	0.8	-0.4	-0.6	0.5	0.5	0.5	0.2	0.7	0.3	0.6	-0.2	1.5
Financial difficulties in last 2 years	0.3	0.4	1.3	0.2	0.8	-0.9	-0.3	0.6	0.5	0.9	0.4	0.6	0.7	0.6	-0.1	-1.1
Allergy	0.3	0.8	2.2	0.4	0.9	-0.3	-0.7	0.2	-1.0	-1.5	0.1	-1.2	0.8	-1.3	0.4	-1.1
Weight	0.3	1.6	7.9	1.6	2.8	-2.2	-0.9	1.2	0.4	1.0	-0.0	0.7	0.1	0.7	0.3	-1.0
Hip circumference	0.3	1.3	5.3	2.3	1.0	-0.6	1.5	-0.5	-0.5	0.1	-1.1	-0.2	-1.9	-0.1	-1.7	-0.3
Happiness	0.3	0.4	1.2	-0.8	-0.1	-0.1	-0.5	0.1	1.1	0.5	0.1	0.7	1.1	0.7	0.3	-0.5
Prospective memory result	0.3	0.4	2.1	0.5	-1.4	-0.5	0.4	-0.3	0.2	0.5	0.4	0.6	-0.8	0.6	-0.3	0.2
Illnesses of mother	0.3	0.3	0.7	-0.8	0.3	0.3	-0.2	-0.3	-0.7	-0.5	-0.8	-0.5	0.8	-0.4	0.0	-0.8
Arm fat mass (right)	0.3	1.1	4.2	1.0	0.3	-0.2	1.6	-1.0	-0.1	0.0	-1.0	-0.2	-2.1	-0.1	-1.3	-1.4
Birth weight of first child	0.3	0.5	1.9	0.9	1.1	-0.7	-0.3	0.6	-0.5	-0.3	-0.5	-0.2	-0.7	-0.3	0.1	1.4
Qualifications: O levels/GCSEs or equivalent	0.3	0.4	2.1	0.5	-0.5	-0.7	-0.9	0.9	-0.4	0.0	-0.0	-0.2	0.8	-0.1	1.5	0.1
Mouth/teeth dental problems: Bleeding gums	0.3	0.4	3.3	-0.3	-1.8	0.2	0.4	-1.0	0.4	0.1	-0.0	-0.0	0.7	-0.0	-0.0	-0.3
Hypothyroidism/myxoedema (self-reported)	0.3	0.7	3.6	0.7	-1.0	-0.3	-1.3	0.6	-0.3	-0.2	0.5	-0.0	-0.1	-0.1	1.9	1.0
Emphysema/chronic bronchitis	0.3	0.3	1.4	-0.6	1.2	-0.1	-0.0	-0.3	-0.6	-0.6	-0.1	-0.4	-0.0	-0.5	-0.6	0.9
Leg fat mass (right)	0.3	1.1	4.1	1.0	-0.8	0.2	1.8	-1.2	-0.2	-0.2	-0.9	-0.5	-2.0	-0.4	-1.3	-0.7
Knee pain experienced in last month	0.3	0.4	2.5	-0.1	-0.7	0.2	-0.7	-0.3	-0.9	-0.2	-0.0	-0.2	0.3	-0.3	0.9	1.6
Average weekly red wine intake	0.3	0.4	1.7	0.2	-0.4	-0.5	-1.3	1.0	0.3	-0.1	0.3	-0.2	1.1	-0.3	1.1	-0.0
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.3	0.3	1.2	0.7	-1.1	0.6	0.6	-1.0	-0.3	-0.5	-0.2	-0.5	-0.3	-0.5	-0.4	0.1
Smoking status: Current	0.3	0.4	1.7	-1.3	0.9	0.0	0.2	-0.4	0.1	0.2	0.6	0.4	-0.1	0.4	-1.2	0.4
Wears glasses or contact lenses	0.3	0.4	2.2	1.3	0.2	0.5	0.1	-0.5	0.2	0.0	-0.3	0.0	-0.6	-0.1	-0.3	1.5
Tinnitus: Yes, now most or all of the time	0.3	0.3	1.5	-0.2	-0.2	0.4	0.4	-0.3	-0.7	-0.7	-0.5	-0.6	0.4	-0.6	-0.3	-1.2
Ever had prostate specific antigen (PSA) test	0.3	0.3	0.7	-0.2	-0.0	0.5	-0.3	0.0	-0.6	-0.8	-0.8	-0.8	0.9	-0.8	-0.1	0.2
Cholesterol lowering medication	0.3	0.4	1.5	1.2	0.7	0.3	0.6	-0.1	0.1	0.6	0.3	0.8	-0.2	0.8	-0.2	1.2
Pain experienced in last month	0.3	0.6	1.4	0.4	-0.0	-1.0	-0.4	1.1	0.9	1.2	0.5	1.1	-0.0	1.0	0.5	0.2
Impedance of whole body	0.3	1.5	4.8	-2.2	-0.9	0.3	0.7	-0.3	1.9	1.1	2.1	1.3	-0.0	1.3	-0.3	0.9
Leg fat mass (left)	0.3	1.2	4.5	1.5	-0.6	0.2	1.7	-1.2	-0.3	-0.2	-1.1	-0.5	-2.1	-0.4	-1.2	-0.7
Prostate Cancer	0.2	0.3	2.3	1.5	-0.1	0.2	0.0	0.4	-0.0	0.2	0.0	0.3	-0.9	0.2	0.3	1.0
Lupus	0.2	0.3	1.2	1.1	1.0	0.7	0.2	0.2	0.4	-0.3	-0.4	0.1	-0.3	0.0	-0.5	0.4
Triglycerides	0.2	0.3	0.8	-0.7	-0.1	-0.8	-0.4	0.4	0.3	0.8	0.9	0.8	-0.2	0.8	-0.2	-0.1
Sensitivity / hurt feelings	0.2	0.3	1.5	1.1	-1.2	-0.3	-0.3	-0.2	-0.1	0.1	0.3	-0.0	-0.8	-0.1	0.8	0.1
Supplements: Zinc	0.2	0.2	1.3	0.8	-0.2	-0.5	-0.3	0.3	-0.2	-0.4	-0.2	-0.2	1.1	-0.3	0.1	-0.5
Taking other prescription medications	0.2	0.3	0.9	0.5	0.2	-0.4	-0.6	0.8	0.1	0.0	0.1	0.1	0.4	0.1	1.0	0.8
Impedance of leg (left)	0.2	0.9	2.2	-1.4	-1.5	0.9	0.9	-0.7	1.3	0.4	1.5	0.6	-0.2	0.6	-0.3	0.7
Trunk fat mass	0.2	0.8	3.4	1.2	0.9	-0.5	1.3	-0.8	0.3	0.2	-0.4	0.1	-1.8	0.1	-1.1	-0.5
Nervous feelings	0.2	0.4	1.0	0.0	0.7	-0.4	-1.0	0.6	0.6	-0.2	-0.2	-0.0	0.9	-0.1	0.9	0.8
Qualifications: None of the above	0.2	0.5	2.8	-1.6	0.5	0.2	-0.4	0.1	-0.5	-0.4	-0.1	-0.2	0.3	-0.2	-0.2	-1.7
Mouth/teeth dental problems	0.2	0.3	2.1	0.7	-0.1	-0.2	0.3	0.0	0.6	0.5	0.3	0.5	-1.5	0.6	-0.2	-0.3
Neuroticism score	0.2	0.4	1.5	0.4	1.0	-0.0	-0.8	0.4	-0.3	-0.3	-0.1	-0.2	0.2	-0.2	1.1	1.2
Gout (self-reported)	0.2	0.3	1.1	1.0	0.0	-0.1	-0.3	-0.0	0.6	0.6	0.4	0.7	-0.7	0.7	0.7	0.3
Chronic bronchitis/emphysema (mother)	0.2	0.3	1.3	-0.9	0.2	0.4	-0.1	-0.0	-0.4	-0.6	-0.3	-0.5	0.1	-0.5	-0.2	-1.2
Age at first live birth	0.2	0.3	1.2	-0.1	-0.8	-0.3	0.3	-0.2	1.1	0.7	0.8	0.6	0.2	0.6	-0.4	0.4
Health satisfaction	0.2	0.3	0.9	-1.0	-0.7	0.0	-0.2	-0.2	-0.6	-0.4	-0.7	-0.6	0.0	-0.5	-0.5	-0.1
Whole body fat mass	0.2	0.9	4.0	1.3	0.5	-0.3	1.5	-1.0	0.2	0.2	-0.6	-0.0	-2.0	0.1	-1.2	-0.5
Pulse rate, automated reading	0.2	0.5	4.0	-2.0	-0.0	0.7	-0.2	0.4	-0.6	-0.2	-0.1	-0.4	0.5	-0.3	-0.2	-1.1
Had major operations	0.2	0.3	1.2	-0.1	-0.2	0.6	-0.2	-0.3	-0.3	-0.6	-1.1	-0.8	0.5	-0.7	0.3	-0.2
Arm fat mass (left)	0.2	1.0	4.4	0.7	0.1	-0.1	1.7	-1.0	-0.0	0.1	-0.8	-0.2	-2.1	-0.1	-1.3	-1.3
High cholesterol (Self-reported)	0.2	0.3	2.4	0.6	0.3	-0.3	-0.4	0.3	-0.0	0.0	0.4	0.3	0.0	0.3	0.6	1.5
Irritability	0.2	0.4	4.5	-0.5	2.1	-0.3	0.2	0.2	0.2	0.1	-0.1	-0.0	0.5	-0.0	-0.2	0.3
Depressed Affect (Nagel 2018)	0.1	0.2	1.0	0.3	0.1	0.2	-0.1	0.1	-1.0	-0.6	-0.3	-0.6	-0.6	-0.6	0.6	-0.0
Average weekly fortified wine intake	0.1	0.1	0.4	0.3	-0.2	0.1	0.1	-0.2	-0.2	-0.0	-0.6	-0.1	0.3	0.1	-0.3	-0.5
Supplements: Glucosamine	0.1	0.2	1.3	0.5	-0.4	-0.2	-0.2	0.0	0.1	-0.0	-0.4	-0.1	0.3	-0.1	-0.3	-1.1
Alcohol intake versus 10 years previously	0.1	0.1	0.4	-0.2	0.3	-0.0	0.1	0.1	0.3	0.4	0.4	0.6	0.1	0.6	0.2	0.3
Exposure to tobacco smoke at home	0.1	0.1	0.5	-0.0	-0.2	0.4	0.7	-0.3	0.2	0.4	-0.6	0.2	-0.3	0.2	0.2	0.0
Qualifications: College or University degree	0.1	0.3	2.0	0.4	-1.4	0.1	0.7	-0.4	-0.5	-0.1	-0.5	-0.4	0.0	-0.3	-0.5	-0.2
Illnesses of siblings: Diabetes	0.1	0.1	0.3	0.0	0.2	-0.0	0.2	0.2	-0.5	-0.3	-0.3	-0.5	0.5	-0.4	0.0	-0.4
Friendships satisfaction	0.1	0.1	0.4	-0.3	0.0	0.0	-0.4	-0.0	-0.0	-0.4	-0.6	-0.4	0.4	-0.5	0.1	0.0
Commuting to job workplace: Public transport	0.1	0.1	0.6	-0.8	-0.3	0.2	-0.5	0.3	-0.0	0.3	-0.3	0.1	0.5	0.1	0.6	-0.0
Alcohol drinker status: Previous	0.1	0.1	0.3	-0.3	0.4	-0.3	-0.4	0.5	-0.3	0.2	0.5	0.2	-0.1	0.1	0.5	0.6
Hair Pigment	0.0	0.6	3.6	1.9	-0.2	-0.8	-0.4	0.2	0.7	0.5	0.6	0.4	0.2	0.4	0.9	-1.0
Hair/balding pattern: Pattern 4	0.0	0.1	0.3	0.0	0.5	-0.4	0.0	-0.3	0.1	0.4	0.3	0.0	0.3	0.1	-0.4	-0.1
Leg pain on walking	0.0	0.1	0.2	-0.0	-0.3	0.1	0.3	-0.4	0.2	0.2	0.1	0.1	-0.3	0.1	-0.3	0.3

Hub : Genes

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Models

Trait associations