Hub : Genes

DEPTOR

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 CommonMind Brain Pre-frontal Cortex 0.151 0.0420 2.3e-08 0.029 0.088 0.083 0.086 0.050 1.7e-04 8.2e-11 2.5e-10 1.3e-10 9.5e-07
2 GTEx Adrenal Gland 0.157 0.0740 7.1e-03 -0.008 NA -0.002 NA -0.007 9.7e-01 NA 3.7e-01 NA 7.5e-01
3 GTEx Brain Cerebellar Hemisphere 0.316 0.0810 2.3e-06 0.152 NA 0.124 NA 0.291 1.0e-04 NA 4.6e-04 NA 3.4e-08
4 GTEx Brain Cerebellum 0.235 0.0800 1.7e-03 0.218 NA 0.124 NA 0.173 4.6e-07 NA 1.7e-04 NA 7.9e-06
5 GTEx Colon Sigmoid 0.283 0.0790 1.5e-05 0.225 NA 0.191 NA 0.226 1.8e-08 NA 2.5e-07 NA 1.7e-08
6 GTEx Colon Transverse 0.172 0.0600 5.8e-04 0.080 NA 0.040 NA 0.059 1.2e-04 NA 5.3e-03 NA 8.8e-04
7 GTEx Esophagus Gastroesophageal Junction 0.320 0.0720 8.7e-07 0.357 NA 0.306 NA 0.297 8.9e-14 NA 1.1e-11 NA 2.4e-11
8 GTEx Esophagus Mucosa 0.202 0.0550 2.1e-06 0.114 NA 0.085 NA 0.117 5.1e-08 NA 2.4e-06 NA 3.3e-08
9 GTEx Esophagus Muscularis 0.281 0.0550 8.5e-11 0.297 NA 0.268 NA 0.282 2.0e-18 NA 1.8e-16 NA 2.1e-17
10 GTEx Lung 0.157 0.0441 4.6e-07 0.124 NA 0.151 NA 0.077 9.5e-10 NA 1.3e-11 NA 1.5e-06
11 GTEx Pancreas 0.167 0.0580 7.9e-04 0.124 NA 0.136 NA 0.122 6.7e-06 NA 2.4e-06 NA 7.9e-06
12 GTEx Skin Sun Exposed Lower leg 0.069 0.0270 7.1e-04 0.028 NA 0.033 NA 0.023 2.1e-03 NA 8.9e-04 NA 4.9e-03
13 ROSMAP Brain Pre-frontal Cortex 0.198 0.0482 2.2e-07 0.048 0.069 0.043 0.072 0.043 7.1e-07 3.0e-09 2.6e-06 1.6e-09 3.2e-06

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12 13
Bipolar Disorder (2018) 0.7 1.1 3.8 0.0 1.0 0.7 1.4 -1.1 -1.2 -0.8 -1.3 -0.9 -1.1 -0.7 -1.9 -0.3
Bipolar Disorder or Schizophrenia 0.6 1.6 5.3 0.7 0.5 0.5 1.1 -1.0 -1.3 -1.4 -2.3 -1.4 -1.4 -1.3 -1.3 -0.8
Depressed Affect (Nagel 2018) 0.1 0.2 1.0 0.3 0.1 0.2 -0.1 0.1 -1.0 -0.6 -0.3 -0.6 -0.6 -0.6 0.6 -0.0
Depression (Nagel 2018) 0.6 0.9 2.3 -1.5 -0.1 1.5 1.3 -1.4 0.2 0.2 -0.5 0.2 -1.1 0.2 -1.1 0.4
Intelligence (Savage-Jansen 2018) 0.4 1.3 3.5 1.2 1.1 0.4 -0.7 0.7 1.4 1.5 1.0 1.5 0.4 1.5 0.6 1.9
Neuroticism (Nagel 2018) 0.3 0.8 5.3 1.2 0.4 -0.2 -1.2 1.3 -0.2 -0.4 -0.2 -0.2 0.1 -0.4 2.3 0.2
Schizophrenia (2018) 0.4 0.8 3.7 0.9 -0.0 0.1 0.3 -0.4 -0.7 -1.1 -1.9 -1.1 -0.9 -1.1 -0.1 -0.8
Schizophrenia vs Biploar Disorder 0.9 1.1 3.7 -0.4 1.3 -1.4 -0.7 0.8 1.9 1.1 1.0 1.0 1.2 1.0 0.5 -0.1
Worry (Nagel 2018) 1.4 3.0 11.8 1.5 1.1 -1.5 -2.7 2.5 1.2 0.8 0.9 1.1 1.6 0.8 3.4 0.8
Alzheimer’s Disease (in mother) 1.4 1.6 5.3 -2.1 -0.1 -1.6 -0.3 0.9 0.2 1.0 1.5 1.1 0.9 1.1 -1.0 -2.3
Alzheimer’s Disease (in father) 2.4 2.6 5.2 0.2 0.9 -2.0 -1.9 2.3 1.5 1.7 1.4 1.7 1.6 1.7 1.9 -0.5
Alzheimer’s Disease (including proxy) 1.5 2.2 4.2 -1.4 0.9 -2.0 -1.2 2.0 1.0 1.8 1.6 1.8 1.1 1.8 0.4 -1.6
Crohns Disease (2017) 0.4 0.9 2.5 0.2 0.8 0.1 0.0 0.1 1.4 1.6 0.9 1.5 -0.5 1.5 -0.1 0.6
Irritable Bowel Disease (IBD) 0.8 1.8 5.0 -1.3 -0.2 0.2 0.2 0.2 1.8 2.0 2.0 2.2 -0.3 2.2 -0.1 0.8
Ulcerative Colitis (UC) 1.6 3.0 8.1 -2.8 -0.8 -0.3 -0.3 0.8 1.9 2.2 2.9 2.5 0.4 2.6 0.4 0.1
Major Depression (MDD) 0.5 0.6 1.6 -0.3 -1.0 0.8 0.9 -0.9 -0.7 -0.9 -1.2 -0.7 -0.6 -0.7 -0.5 -0.2
Reaction Time 2.4 4.6 10.8 0.0 -0.4 2.0 1.3 -1.7 -3.0 -3.2 -2.8 -3.2 -0.6 -3.3 -1.4 0.3
Verbal and Numeric Reasoning (VNR) 0.4 0.9 4.9 1.6 0.5 1.1 0.4 -0.6 0.1 -0.1 0.0 -0.1 -1.2 -0.1 0.0 2.2
Breast Cancer 1.2 2.8 6.3 0.3 -1.8 2.5 2.4 -2.1 -0.5 -0.4 -2.5 -0.6 -0.9 -0.5 -2.4 1.5
Ovarian Cancer 0.4 0.5 1.1 0.1 -0.1 0.5 0.9 -0.7 -0.5 -0.7 -0.9 -1.0 -0.0 -1.0 -0.5 -0.7
Prostate Cancer 0.2 0.3 2.3 1.5 -0.1 0.2 0.0 0.4 -0.0 0.2 0.0 0.3 -0.9 0.2 0.3 1.0
Age at First Birth 1.0 1.5 4.2 -0.8 0.2 -1.0 -0.9 1.5 2.1 1.5 1.3 1.3 1.4 1.3 0.9 0.2
Bipolar Disorder (2011) 0.4 0.4 2.6 1.6 0.7 0.1 0.9 -0.1 -0.2 -0.1 -0.8 -0.1 -0.7 -0.2 -0.5 0.2
Body Mass Index (BMI) (2010) 0.4 0.5 1.8 0.1 -0.5 1.0 0.8 -1.3 -0.3 -0.4 -0.4 -0.4 -1.2 -0.4 -0.5 0.3
Coronary Artery Disease (CAD) 0.8 1.0 2.4 -1.5 -0.4 0.2 -0.3 -0.1 1.5 1.4 0.8 1.5 -0.3 1.5 0.7 -0.3
Crohns Disease (2012) 0.6 1.0 2.0 0.5 0.8 -0.7 -0.5 0.5 1.4 1.4 1.2 1.3 -0.6 1.3 0.9 0.9
Mean Putamen Volume 6.1 6.9 15.4 -1.3 0.8 -3.5 -2.0 1.9 3.3 3.3 3.9 3.5 1.9 3.6 0.7 -1.0
Fasting Glucose 0.4 0.4 1.3 -1.1 -0.8 -0.5 0.4 -0.1 0.3 0.2 0.3 1.1 -1.0 0.5 -0.6 -0.4
HbA1C 0.6 0.6 1.8 0.4 -0.6 -1.0 -1.3 1.0 1.1 0.5 0.7 0.7 0.4 0.7 0.9 0.1
HDL Cholesterol 0.5 0.8 1.8 1.4 -0.0 0.6 0.8 -0.1 -1.0 -1.2 -0.7 -1.1 0.2 -1.2 -0.7 1.3
LDL Cholesterol 0.7 1.1 2.5 -1.1 -0.6 -0.5 -1.4 0.8 -1.2 -1.3 -0.5 -1.1 0.2 -1.2 1.3 -1.6
Lupus 0.2 0.3 1.2 1.1 1.0 0.7 0.2 0.2 0.4 -0.3 -0.4 0.1 -0.3 0.0 -0.5 0.4
Neuroticism (2016) 0.4 0.6 2.8 0.6 -0.6 -0.7 -1.1 1.2 0.2 0.2 0.2 0.2 0.8 0.1 1.7 0.2
Primary Biliary Cirrhosis 0.6 0.9 3.1 -1.6 -0.5 1.2 0.7 -0.8 -0.9 -0.8 -0.5 -0.7 -0.6 -0.7 -1.8 0.1
Rheumatoid Arthritis 1.8 2.4 5.0 2.2 0.7 1.3 0.1 0.2 -1.5 -1.9 -2.2 -1.9 -0.8 -1.9 1.2 2.2
Schizophrenia (2014) 0.3 0.7 2.9 -0.1 -0.3 -0.3 0.1 -0.3 -0.2 -0.8 -1.6 -0.9 -0.8 -0.8 -0.3 -1.7
Triglycerides 0.2 0.3 0.8 -0.7 -0.1 -0.8 -0.4 0.4 0.3 0.8 0.9 0.8 -0.2 0.8 -0.2 -0.1
Type 2 Diabetes (T2D) (2012) 0.7 0.8 3.2 -0.3 -0.1 -0.6 -0.3 -0.0 1.6 1.0 0.7 1.0 0.4 1.0 0.0 1.8
Ulcerative Colitis 1.1 1.6 3.5 -1.7 -1.0 -0.2 -0.5 0.9 1.4 1.7 1.7 1.8 0.3 1.9 0.8 0.4
Blood Eosinophil Count 0.3 2.6 5.3 -0.5 0.5 -1.6 -1.4 1.4 1.8 2.2 2.0 2.3 1.0 2.3 1.4 1.1
Blood Platelet Count 2.0 23.5 40.2 -3.0 -1.9 6.3 5.4 -5.8 -5.2 -5.6 -4.1 -5.5 -4.6 -5.5 -5.7 1.0
Blood Red Count 0.5 5.2 20.6 -0.8 -3.9 1.9 3.0 -3.2 -0.3 -0.6 0.7 -0.4 -4.5 -0.3 -1.8 1.9
Blood White Count 1.1 8.5 16.6 -1.4 -2.8 4.0 4.1 -3.6 -2.8 -2.6 -2.3 -2.6 -3.1 -2.6 -3.5 -0.1
Heel T-Score 1.2 9.4 27.7 -5.3 1.0 3.4 2.9 -2.6 -3.1 -3.2 -3.3 -2.9 -0.0 -2.8 -3.8 -2.1
BMI 1.0 5.6 14.5 1.7 -1.5 2.3 3.8 -2.8 -1.9 -1.6 -2.5 -1.9 -3.8 -1.8 -2.6 -0.1
Height 3.5 68.4 151.3 0.5 10.7 -12.3 -10.9 10.1 6.1 7.7 7.2 7.6 9.6 7.3 6.5 -2.4
Waist Hip Ratio (WHR) 0.6 2.9 29.9 -5.5 0.1 0.3 -1.0 -0.4 0.8 0.2 0.7 0.6 1.5 0.6 -0.2 -1.4
Systolic Blood Pressure 2.0 9.8 14.3 3.6 2.1 -3.5 -3.2 2.8 3.8 3.4 3.7 3.5 1.7 3.4 2.3 2.9
Smoking Status 1.1 2.6 6.7 -1.2 2.6 -1.6 -1.0 0.9 1.7 1.5 2.1 1.8 2.0 1.8 -0.6 0.6
Allergy or Eczema 0.5 1.4 4.8 0.6 -0.4 -0.9 -0.2 -0.1 1.5 2.2 0.9 1.9 -0.4 2.1 0.4 0.5
Cardiovascular Disease 1.5 5.0 11.7 -1.0 0.6 -2.4 -1.4 1.3 3.2 3.0 3.4 3.2 1.5 3.2 0.5 -0.2
Hypothyroidism (self reported) 0.8 1.8 7.5 1.9 -0.3 -1.2 -2.0 1.6 0.1 0.3 1.3 0.4 0.1 0.3 2.7 1.6
Respiratory disease 1.1 2.4 8.3 -2.9 0.3 2.4 2.1 -1.7 -0.9 -0.3 -1.2 -0.5 -1.0 -0.4 -2.2 0.9
Type 2 Diabetes (T2D) (2018) 0.6 1.2 3.8 -0.1 -1.3 -0.4 0.6 0.3 1.3 1.3 1.9 1.4 -1.0 1.6 0.1 0.7
Lung FEV1/FVC ratio 3.6 18.3 40.0 -0.2 -4.3 5.6 5.0 -4.2 -4.2 -4.7 -4.2 -4.8 -6.3 -4.6 -1.9 -0.4
Lung FVC 0.5 2.7 9.9 0.6 1.1 -1.2 -2.5 2.0 -0.6 -0.7 -0.7 -1.0 3.1 -1.1 2.2 -2.1
Neuroticism 0.4 1.0 6.0 1.3 0.2 -0.0 -1.5 0.9 -0.2 -0.6 0.3 -0.4 -0.4 -0.5 2.5 0.8
Chronotype (morning person) 0.7 1.7 7.2 -1.8 -2.7 1.7 0.9 -1.3 -0.2 -0.9 -0.3 -0.6 -1.8 -0.6 -0.6 0.7
Hair Pigment 0.0 0.6 3.6 1.9 -0.2 -0.8 -0.4 0.2 0.7 0.5 0.6 0.4 0.2 0.4 0.9 -1.0
Tanning 0.3 3.6 11.4 -1.2 3.4 -1.5 -1.7 1.7 2.3 2.3 1.2 2.4 1.6 2.5 0.5 0.5
Hand grip strength (left) 0.5 1.2 2.9 -0.1 0.2 -1.4 -0.9 0.5 1.2 1.3 1.3 1.1 1.7 1.2 0.6 -1.3
Number of treatments/medications taken 1.1 2.0 4.5 0.6 1.5 -2.1 -1.3 1.5 1.0 1.5 1.4 1.6 1.7 1.5 0.7 1.2
Average weekly spirits intake 0.5 0.6 3.3 -0.8 0.2 0.7 1.1 -0.1 0.1 -0.5 -0.4 -0.4 -1.8 -0.5 -0.7 -0.3
Sensitivity / hurt feelings 0.2 0.3 1.5 1.1 -1.2 -0.3 -0.3 -0.2 -0.1 0.1 0.3 -0.0 -0.8 -0.1 0.8 0.1
Frequency of depressed mood in last 2 weeks 0.3 0.4 2.0 -1.4 0.7 0.3 0.6 -0.5 0.6 0.7 0.2 0.6 0.2 0.7 -0.9 -0.5
Hearing difficulty/problems: Yes 1.9 3.0 5.3 -2.2 -2.0 2.1 1.3 -1.4 -2.3 -1.5 -2.1 -1.9 -1.3 -1.9 -0.7 0.6
Relative age of first facial hair 0.4 0.8 4.4 0.1 1.2 0.2 -0.8 1.1 -0.4 -0.4 0.6 -0.3 0.4 -0.4 1.0 2.1
Other serious medical condition/disability diagnosed by doctor 0.8 1.0 2.5 -0.9 0.1 1.6 0.2 0.3 -1.0 -1.4 -1.6 -1.3 0.9 -1.5 0.2 0.3
Ever used hormone-replacement therapy (HRT) 0.6 0.8 2.5 -0.5 -0.9 1.1 1.1 -0.9 -0.5 -0.7 -1.2 -0.6 -0.1 -0.6 -1.6 0.3
Ever had hysterectomy (womb removed) 0.6 0.7 1.7 -1.3 0.6 0.0 -0.2 0.6 1.1 1.0 1.1 1.1 0.9 1.0 0.1 0.2
Systolic blood pressure, automated reading 3.1 9.0 24.0 4.9 3.1 -3.2 -3.4 3.1 3.1 2.8 2.4 2.6 1.9 2.5 3.0 1.8
Eye problems/disorders: Diabetes related eye disease 2.8 3.0 7.9 0.8 2.2 -1.6 -2.3 2.8 0.9 1.5 0.3 1.5 2.7 1.4 2.0 0.2
Angina 0.5 0.6 2.2 0.5 1.5 -0.6 -0.3 0.3 0.9 0.9 0.9 0.8 1.2 0.7 -0.0 0.7
Medication for hormone replacement therapy 0.8 0.9 5.8 0.1 0.1 -0.5 -1.4 1.4 -0.2 0.1 0.2 -0.1 2.4 -0.2 1.3 -0.8
Vitamin and mineral supplements 1.2 1.7 3.5 -0.8 0.1 -1.3 -1.8 1.3 1.4 1.2 1.9 1.5 0.9 1.5 1.2 0.9
Supplements: Zinc 0.2 0.2 1.3 0.8 -0.2 -0.5 -0.3 0.3 -0.2 -0.4 -0.2 -0.2 1.1 -0.3 0.1 -0.5
Medication: Co-codamol 0.9 1.0 2.4 0.7 0.1 1.5 1.0 -0.7 -0.9 -1.3 -1.3 -1.2 -0.2 -1.3 -0.8 1.0
Medication: Metformin 0.4 0.6 1.4 -0.2 -1.2 -0.4 0.2 0.2 0.9 1.1 0.7 1.0 -1.1 1.1 0.4 -0.5
Diabetes (father) 0.7 0.9 2.5 0.8 -1.1 -0.9 -0.8 1.0 0.7 0.6 1.4 0.9 0.1 0.9 1.6 0.5
Diabetes (mother) 1.3 1.7 5.4 2.3 0.4 -1.6 -1.2 1.1 1.3 1.1 1.0 1.0 0.4 0.9 1.7 1.7
Severe depression (siblings) 0.6 0.7 2.7 0.4 0.8 -1.2 -1.6 1.0 0.2 -0.1 0.9 -0.0 0.7 -0.1 1.5 0.1
Pack years adult smoking proportion 1.0 1.6 5.6 -2.4 -0.7 0.9 1.4 -1.7 -0.3 -0.1 -0.3 -0.1 -1.6 0.0 -2.0 -1.4
Impedance of leg (right) 0.3 1.5 5.9 -2.4 -1.7 0.9 0.8 -0.7 1.5 0.5 1.9 0.8 0.1 0.7 -0.6 0.8
Leg fat-free mass (left) 1.0 5.3 15.0 1.1 3.9 -3.9 -3.0 2.8 1.0 1.9 0.8 1.7 2.2 1.7 1.7 -1.3
Trunk fat percentage 0.5 2.1 10.2 1.2 -0.5 0.7 2.7 -1.9 0.1 -0.2 -0.6 -0.4 -3.2 -0.3 -2.0 -0.1
Hand grip strength (right) 1.0 2.8 7.6 0.3 1.1 -2.3 -1.9 1.5 1.7 1.7 1.4 1.4 2.8 1.5 1.2 -1.7
Townsend deprivation index at recruitment 2.5 3.5 6.2 -0.6 -1.8 2.2 2.3 -1.8 -2.1 -2.0 -2.5 -2.0 -1.9 -1.9 -1.5 -0.0
Current tobacco smoking 0.4 0.6 3.0 -1.4 0.7 -0.0 0.5 -0.8 0.1 0.3 0.6 0.5 -0.3 0.5 -1.7 0.1
Average weekly fortified wine intake 0.1 0.1 0.4 0.3 -0.2 0.1 0.1 -0.2 -0.2 -0.0 -0.6 -0.1 0.3 0.1 -0.3 -0.5
Maternal smoking around birth 0.3 0.4 1.4 -0.7 1.2 0.3 -0.1 -0.1 0.5 0.9 -0.0 0.7 0.6 0.8 0.2 0.9
Fed-up feelings 0.3 0.5 1.3 -0.2 0.8 -0.5 -1.0 1.1 -0.0 0.6 0.4 0.7 0.2 0.7 1.1 0.2
Frequency of unenthusiasm / disinterest in last 2 weeks 0.4 0.6 3.3 -1.8 -0.2 0.9 0.5 -0.7 0.7 0.6 0.4 0.6 0.5 0.6 -0.6 0.1
Relative age voice broke 1.0 1.5 5.7 1.9 2.4 -0.4 -1.1 1.2 -0.1 -0.3 0.2 -0.3 0.6 -0.4 1.4 2.1
Taking other prescription medications 0.2 0.3 0.9 0.5 0.2 -0.4 -0.6 0.8 0.1 0.0 0.1 0.1 0.4 0.1 1.0 0.8
Age when periods started (menarche) 1.9 4.6 12.6 0.5 1.4 -2.7 -3.2 3.0 1.6 1.6 2.0 1.6 3.5 1.5 1.9 -0.9
Bilateral oophorectomy (both ovaries removed) 0.4 0.4 2.0 0.3 -1.4 0.0 -0.3 0.2 0.4 0.0 0.7 0.1 0.1 -0.0 0.9 1.3
Heel bone mineral density (BMD) T-score, automated (left) 1.2 2.7 5.3 -2.3 1.4 0.6 1.2 -1.1 -2.1 -2.2 -0.5 -1.9 0.7 -2.0 -2.2 -1.5
Tinnitus: Yes, but not now, but have in the past 0.4 0.4 1.0 -0.1 0.3 0.6 -0.9 0.5 -0.2 0.3 -0.9 0.2 0.7 0.3 1.0 1.0
Qualifications: CSEs or equivalent 1.2 1.5 12.8 -3.6 -0.5 0.4 0.2 0.3 -0.7 -0.2 -0.9 -0.3 0.7 -0.3 -0.5 -2.1
Serious illness, injury or assault to yourself 0.8 0.9 2.7 0.8 1.0 -0.8 0.1 0.7 1.0 1.6 1.0 1.4 0.1 1.5 -0.4 0.7
High blood pressure 1.6 4.6 10.0 0.3 1.0 -2.9 -1.9 1.8 2.9 2.6 3.2 2.7 1.3 2.6 1.3 0.7
Hayfever, allergic rhinitis or eczema 0.6 1.2 4.6 0.3 -0.7 -0.5 0.2 0.0 1.7 2.1 0.3 1.8 -0.5 1.9 0.1 0.7
Multivitamins +/- minerals 2.4 3.1 6.4 0.3 -0.7 1.9 2.4 -2.4 -1.8 -1.5 -2.5 -1.9 -1.3 -1.8 -1.8 -0.8
Stomach or abdominal pain in last month 0.3 0.3 1.1 -1.1 0.1 -0.3 -0.5 -0.1 -0.8 -0.6 -0.4 -0.7 0.4 -0.7 0.6 -0.6
Supplements: Glucosamine 0.1 0.2 1.3 0.5 -0.4 -0.2 -0.2 0.0 0.1 -0.0 -0.4 -0.1 0.3 -0.1 -0.3 -1.1
Diverticular disease/diverticulitis (self-reported) 0.8 1.0 2.8 -0.3 -0.4 -0.8 -0.4 1.0 1.5 0.8 0.6 0.9 1.5 0.9 0.7 -1.7
Medication: Atenolol 0.7 0.9 2.2 1.5 0.7 -1.3 -0.8 0.9 1.0 1.0 0.9 1.0 0.4 0.9 0.4 0.4
Medication: Levothyroxine sodium 0.3 0.4 2.7 0.2 -0.5 0.3 -1.1 0.6 -0.6 -0.0 0.4 0.0 0.0 0.0 1.7 0.8
Sitting height 2.7 19.0 53.3 -1.3 7.3 -5.7 -5.7 5.2 2.5 3.5 3.0 3.5 6.1 3.3 3.5 -0.2
Chronic bronchitis/emphysema (father) 3.2 3.8 9.7 -0.9 1.0 -1.7 -1.4 1.1 2.5 2.9 2.4 3.0 1.3 3.1 0.3 -0.9
High blood pressure (mother) 0.6 0.8 2.1 1.4 0.3 -0.8 -0.7 1.4 0.9 0.6 0.6 0.8 0.5 0.7 1.0 1.3
Body mass index (BMI) 0.8 3.2 10.1 2.0 -1.0 1.2 2.7 -2.0 -1.2 -1.1 -1.9 -1.4 -3.2 -1.3 -1.9 -0.8
Impedance of leg (left) 0.2 0.9 2.2 -1.4 -1.5 0.9 0.9 -0.7 1.3 0.4 1.5 0.6 -0.2 0.6 -0.3 0.7
Leg predicted mass (left) 1.0 5.2 15.1 1.1 3.9 -3.8 -3.0 2.8 1.0 1.9 0.8 1.7 2.2 1.7 1.7 -1.3
Trunk fat mass 0.2 0.8 3.4 1.2 0.9 -0.5 1.3 -0.8 0.3 0.2 -0.4 0.1 -1.8 0.1 -1.1 -0.5
Waist circumference 0.3 1.0 3.7 -0.3 0.1 0.3 1.6 -1.5 -0.4 -0.2 -0.9 -0.3 -1.9 -0.2 -1.9 -0.6
Number of incorrect matches in round 0.3 0.4 2.3 -0.8 0.8 -0.4 -0.6 0.5 0.5 0.5 0.2 0.7 0.3 0.6 -0.2 1.5
Past tobacco smoking 0.4 0.8 3.2 1.8 -1.4 0.9 0.3 0.0 -0.6 -0.2 -1.2 -0.5 -0.6 -0.5 1.1 -0.3
Alcohol usually taken with meals 1.9 3.0 7.2 0.3 -1.6 2.6 2.3 -2.7 -0.3 -1.5 -1.2 -1.4 -2.1 -1.4 -1.8 1.3
Nervous feelings 0.2 0.4 1.0 0.0 0.7 -0.4 -1.0 0.6 0.6 -0.2 -0.2 -0.0 0.9 -0.1 0.9 0.8
Frequency of tenseness / restlessness in last 2 weeks 1.6 2.5 4.4 -1.7 1.4 -1.4 -0.9 1.4 2.0 1.8 1.6 1.9 2.1 1.9 0.0 -1.1
Hearing difficulty/problems with background noise 1.0 1.6 8.1 -2.8 -1.1 1.3 1.3 -1.4 -0.3 -0.2 -0.8 -0.4 -1.5 -0.3 -1.5 -1.1
Hair/balding pattern: Pattern 2 0.6 0.8 7.1 -2.7 -0.3 -0.1 0.5 -0.2 0.3 0.3 1.2 0.5 -0.7 0.6 -0.4 -0.6
Had menopause 0.6 0.7 2.0 0.8 -0.8 1.1 1.3 -1.4 0.4 -0.1 -0.9 -0.0 -0.9 0.1 -1.2 0.7
Had other major operations 2.2 2.7 8.5 -2.1 -0.9 2.2 2.5 -2.1 -0.5 -0.5 -0.1 -0.3 -2.1 -0.2 -2.9 0.5
Forced vital capacity (FVC) 2.4 9.1 22.0 -0.7 3.2 -3.9 -4.4 4.2 1.5 2.1 1.9 2.0 4.7 2.0 3.3 -2.0
Heel bone mineral density (BMD) T-score, automated (right) 1.1 2.5 5.7 -2.4 1.5 0.9 1.3 -0.9 -1.7 -2.0 -0.5 -1.6 1.1 -1.7 -2.4 -1.5
Ever unenthusiastic/disinterested for a whole week 0.9 1.1 3.2 -1.3 -0.1 -0.3 -0.2 -0.3 1.5 1.5 1.1 1.7 0.4 1.8 -0.3 -0.5
Qualifications: None of the above 0.2 0.5 2.8 -1.6 0.5 0.2 -0.4 0.1 -0.5 -0.4 -0.1 -0.2 0.3 -0.2 -0.2 -1.7
Financial difficulties in last 2 years 0.3 0.4 1.3 0.2 0.8 -0.9 -0.3 0.6 0.5 0.9 0.4 0.6 0.7 0.6 -0.1 -1.1
Mouth/teeth dental problems 0.2 0.3 2.1 0.7 -0.1 -0.2 0.3 0.0 0.6 0.5 0.3 0.5 -1.5 0.6 -0.2 -0.3
Heart attack 5.7 7.3 12.0 0.7 2.4 -3.5 -2.9 3.2 2.7 2.8 2.9 3.1 3.3 3.0 2.3 -0.4
Allergy 0.3 0.8 2.2 0.4 0.9 -0.3 -0.7 0.2 -1.0 -1.5 0.1 -1.2 0.8 -1.3 0.4 -1.1
Pain all over the body in last month 1.9 2.0 8.5 -0.3 0.1 1.5 2.4 -1.3 -0.2 -0.4 -1.1 -0.5 -2.1 -0.4 -2.9 -1.3
Diabetes (self-reported) 1.2 1.9 4.5 0.7 -1.4 -0.7 -0.0 0.8 1.8 1.8 2.1 2.0 -0.8 2.1 0.8 0.3
Hayfever/allergic rhinitis (self-reported) 0.4 0.5 3.0 -0.7 -0.6 0.4 0.7 -0.8 0.3 0.4 -0.5 0.5 -0.5 0.5 -0.2 -1.7
Medication: Ramipril 0.7 1.0 2.3 -0.2 -0.3 -1.3 -0.4 0.8 1.2 1.2 1.5 1.2 0.1 1.3 0.6 -1.0
Medication: Simvastatin 0.5 0.7 2.5 -0.8 0.8 -1.0 -0.6 0.3 0.9 0.9 1.6 1.0 0.2 1.0 0.3 0.4
Fluid intelligence score 0.5 1.1 2.6 1.3 -0.7 1.6 1.0 -1.4 -0.3 -0.7 -0.4 -0.7 -1.3 -0.6 -0.6 1.5
Illnesses of siblings 0.9 1.3 4.2 -1.5 -2.1 1.3 1.1 -1.5 -0.1 -0.3 0.1 -0.3 -1.9 -0.2 -1.0 0.6
Neuroticism score 0.2 0.4 1.5 0.4 1.0 -0.0 -0.8 0.4 -0.3 -0.3 -0.1 -0.2 0.2 -0.2 1.1 1.2
Weight 0.3 1.6 7.9 1.6 2.8 -2.2 -0.9 1.2 0.4 1.0 -0.0 0.7 0.1 0.7 0.3 -1.0
Impedance of arm (right) 0.4 1.7 9.9 -3.1 -0.9 0.3 0.6 -0.3 1.8 1.1 1.7 1.2 -0.2 1.3 -0.8 0.2
Arm fat percentage (right) 1.0 4.0 14.8 0.9 -1.5 1.6 3.5 -2.6 -0.5 -0.7 -1.6 -1.0 -3.8 -0.9 -2.5 -0.7
Trunk fat-free mass 1.8 10.5 33.2 1.4 5.8 -4.7 -4.8 4.0 1.1 2.1 1.1 1.9 3.9 1.9 3.0 -1.1
Hip circumference 0.3 1.3 5.3 2.3 1.0 -0.6 1.5 -0.5 -0.5 0.1 -1.1 -0.2 -1.9 -0.1 -1.7 -0.3
Time employed in main current job 2.3 2.7 7.0 0.5 1.5 -1.9 -2.2 2.0 1.2 1.3 1.6 1.3 2.6 1.3 1.7 -0.8
Alcohol intake versus 10 years previously 0.1 0.1 0.4 -0.2 0.3 -0.0 0.1 0.1 0.3 0.4 0.4 0.6 0.1 0.6 0.2 0.3
Father’s age at death 3.0 4.1 10.7 -1.9 -3.3 1.6 2.2 -2.9 -0.3 -1.1 -0.5 -1.0 -2.5 -0.8 -2.5 -2.6
Worrier / anxious feelings 0.5 0.9 4.0 1.0 0.2 -0.6 -1.8 1.2 0.2 -0.0 0.5 0.1 0.9 0.0 2.0 1.1
Frequency of tiredness / lethargy in last 2 weeks 1.0 1.6 2.7 -1.1 1.1 -1.4 -1.6 1.3 0.9 1.4 1.6 1.4 1.4 1.3 0.9 -0.8
Falls in the last year 0.5 0.7 2.1 -0.7 1.1 0.0 0.7 -0.6 0.9 0.6 0.5 0.8 0.1 0.8 -1.4 -1.3
Hair/balding pattern: Pattern 3 0.7 1.0 5.0 2.2 -0.7 0.5 0.9 -1.0 0.1 -0.7 -1.2 -0.6 -1.5 -0.6 -0.1 -0.8
Number of live births 0.5 0.8 3.2 -0.4 0.4 -1.0 -1.6 1.1 0.2 0.0 0.4 0.2 1.8 0.2 0.7 -1.1
Forced expiratory volume in 1-second (FEV1) 0.8 2.7 6.4 -1.2 1.4 -2.0 -2.0 2.3 0.3 0.7 0.7 0.6 2.5 0.6 1.8 -2.5
Pulse rate 1.2 2.0 4.7 -1.4 -1.5 2.2 0.8 -0.8 -1.6 -1.5 -1.8 -1.7 -1.4 -1.7 -0.1 -0.3
Happiness 0.3 0.4 1.2 -0.8 -0.1 -0.1 -0.5 0.1 1.1 0.5 0.1 0.7 1.1 0.7 0.3 -0.5
Noisy workplace 1.0 1.3 5.7 -2.4 0.2 -0.9 -0.8 0.8 0.5 1.1 1.0 0.9 1.0 0.9 0.4 -1.9
Qualifications: A levels/AS levels or equivalent 0.4 1.0 3.0 1.2 -1.7 -0.1 -0.3 -0.7 -0.9 -1.3 -0.7 -1.2 -0.3 -1.2 -0.0 -1.4
Serious illness, injury or assault of a close relative in last 2 years 0.9 1.0 2.2 -1.4 -0.6 0.5 0.8 -1.0 -1.3 -0.6 -1.2 -0.7 -1.5 -0.6 -1.4 -0.6
Mouth/teeth dental problems: Dentures 0.7 1.2 3.2 -0.3 -0.2 1.3 0.2 -0.8 -1.8 -1.7 -1.3 -1.5 -0.6 -1.6 -0.2 0.7
Asthma 1.0 2.0 11.3 -3.4 0.2 1.8 1.6 -1.4 -0.1 0.5 -0.2 0.4 -1.2 0.5 -2.1 0.6
Medication: Ibuprofen (e.g. Nurofen) 1.6 2.0 5.0 -0.2 0.9 -2.0 -0.9 0.7 1.6 1.7 2.2 1.7 1.8 1.7 0.2 -0.2
Medication: Cholesterol lowering 2.8 4.4 8.3 0.9 1.7 -2.2 -2.9 2.5 2.0 2.0 2.0 2.2 2.2 2.1 2.6 1.1
Depression (self-reported) 1.0 1.2 3.3 0.9 0.2 -1.2 -1.1 1.5 1.0 0.6 1.8 0.8 1.1 0.7 1.6 0.1
Medication: Lansoprazole 1.3 1.4 5.2 0.6 -1.3 0.8 0.3 -0.5 -1.2 -2.3 -0.9 -1.9 -0.4 -2.1 0.2 -0.1
Prospective memory result 0.3 0.4 2.1 0.5 -1.4 -0.5 0.4 -0.3 0.2 0.5 0.4 0.6 -0.8 0.6 -0.3 0.2
Lung cancer (father) 0.4 0.5 1.7 -0.9 -1.0 0.3 0.7 -0.5 -0.6 -0.4 0.5 -0.6 -1.3 -0.6 -0.4 -0.6
Illnesses of mother 0.3 0.3 0.7 -0.8 0.3 0.3 -0.2 -0.3 -0.7 -0.5 -0.8 -0.5 0.8 -0.4 0.0 -0.8
Forced expiratory volume in 1-second (FEV1), Best measure 1.2 3.7 7.5 -1.8 1.4 -2.3 -2.4 2.7 1.2 1.4 1.8 1.4 2.3 1.4 2.0 -2.2
Pulse wave Arterial Stiffness index 0.4 0.4 1.5 -1.2 -0.1 0.6 -0.1 -0.4 -0.8 -0.6 -0.5 -0.7 -0.5 -0.6 0.9 -0.5
Impedance of arm (left) 0.4 2.0 10.3 -3.2 -0.8 0.1 0.6 -0.0 2.0 1.3 2.1 1.5 0.0 1.5 -0.7 0.1
Arm fat mass (right) 0.3 1.1 4.2 1.0 0.3 -0.2 1.6 -1.0 -0.1 0.0 -1.0 -0.2 -2.1 -0.1 -1.3 -1.4
Trunk predicted mass 1.8 10.4 32.9 1.5 5.7 -4.8 -4.8 4.0 1.1 2.1 1.1 1.9 3.9 1.8 3.0 -1.1
Standing height 3.4 33.8 72.3 -0.5 8.5 -8.0 -8.1 7.2 4.1 4.9 4.4 4.9 7.3 4.8 5.0 -1.1
Length of working week for main job 0.5 0.5 2.6 -0.7 -1.2 -0.3 0.4 -0.3 0.1 0.4 0.4 0.2 -1.6 0.3 -0.1 -1.2
Exposure to tobacco smoke at home 0.1 0.1 0.5 -0.0 -0.2 0.4 0.7 -0.3 0.2 0.4 -0.6 0.2 -0.3 0.2 0.2 0.0
Breastfed as a baby 2.7 3.4 8.5 0.1 0.6 -2.9 -2.9 2.4 1.0 1.4 1.5 1.4 2.3 1.4 2.3 -1.1
Tense / ‘highly strung’ 1.9 3.1 6.2 -0.6 2.2 -1.7 -2.5 2.3 1.7 1.4 1.4 1.6 2.2 1.4 2.0 0.9
Seen doctor (GP) for nerves, anxiety, tension or depression 0.5 0.7 3.0 1.7 0.9 -0.7 -0.8 0.5 -0.1 0.4 -0.6 0.3 1.5 0.4 0.5 1.1
Hair/balding pattern: Pattern 4 0.0 0.1 0.3 0.0 0.5 -0.4 0.0 -0.3 0.1 0.4 0.3 0.0 0.3 0.1 -0.4 -0.1
Birth weight of first child 0.3 0.5 1.9 0.9 1.1 -0.7 -0.3 0.6 -0.5 -0.3 -0.5 -0.2 -0.7 -0.3 0.1 1.4
Peak expiratory flow (PEF) 0.9 2.1 5.9 -2.4 -1.5 1.3 2.0 -1.3 -0.7 -0.5 -1.0 -0.7 -0.9 -0.5 -1.8 -2.2
Pulse wave reflection index 0.5 0.7 2.9 -1.7 -0.6 -0.7 -0.8 0.3 0.4 0.6 1.1 0.8 0.7 0.9 0.7 -0.1
Ever highly irritable/argumentative for 2 days 1.4 1.7 6.7 1.7 2.0 1.4 0.1 -0.3 -0.6 -1.2 -1.5 -1.0 -0.1 -1.2 -0.0 2.6
Loud music exposure frequency 0.6 0.6 3.4 -0.1 0.7 0.4 -0.1 0.1 1.3 0.7 0.3 0.9 0.2 0.9 -0.5 1.8
Qualifications: O levels/GCSEs or equivalent 0.3 0.4 2.1 0.5 -0.5 -0.7 -0.9 0.9 -0.4 0.0 -0.0 -0.2 0.8 -0.1 1.5 0.1
Mouth/teeth dental problems: Bleeding gums 0.3 0.4 3.3 -0.3 -1.8 0.2 0.4 -1.0 0.4 0.1 -0.0 -0.0 0.7 -0.0 -0.0 -0.3
Blood clot in the leg (DVT) 0.8 1.1 9.7 3.1 -0.1 -0.3 -0.4 0.5 0.8 0.2 -0.7 0.1 -0.4 -0.1 0.6 1.4
Medication: Paracetamol 1.2 2.0 5.5 -0.8 2.3 -1.0 -1.6 0.8 1.4 1.3 1.9 1.4 1.8 1.3 0.7 1.1
Headache pain in last month 0.7 1.3 8.5 -2.9 0.2 -0.3 -1.5 0.2 0.7 0.7 0.6 0.8 1.5 0.9 0.8 0.0
Medication for cholesterol, blood pressure or diabetes 3.1 5.1 10.0 0.3 -0.7 2.6 2.3 -2.2 -2.8 -2.7 -3.2 -2.9 -1.7 -2.9 -1.9 0.0
Glaucoma (self-reported) 2.2 2.6 5.1 1.1 -0.9 1.9 0.4 -1.4 -2.3 -1.9 -2.0 -1.9 -1.1 -1.8 0.4 2.2
Gout (self-reported) 0.2 0.3 1.1 1.0 0.0 -0.1 -0.3 -0.0 0.6 0.6 0.4 0.7 -0.7 0.7 0.7 0.3
Hypothyroidism/myxoedema (self-reported) 0.3 0.7 3.6 0.7 -1.0 -0.3 -1.3 0.6 -0.3 -0.2 0.5 -0.0 -0.1 -0.1 1.9 1.0
Medication: Amlodipine 0.7 0.9 2.6 0.3 -0.6 -0.6 0.4 -0.2 1.6 1.2 1.5 1.5 0.2 1.4 -0.5 0.5
Medication: Ventolin 100micrograms inhaler 0.4 0.5 1.9 -1.4 -0.4 0.7 0.8 -0.3 0.2 0.7 0.9 0.8 -0.6 0.9 -0.6 0.6
Birth weight 0.6 1.4 4.5 -0.6 0.6 -1.2 -1.8 1.3 -1.1 -0.8 -0.6 -0.6 2.1 -0.6 0.8 -1.7
Chronic bronchitis/emphysema (mother) 0.2 0.3 1.3 -0.9 0.2 0.4 -0.1 -0.0 -0.4 -0.6 -0.3 -0.5 0.1 -0.5 -0.2 -1.2
High blood pressure (siblings) 2.5 3.6 7.5 -0.4 2.7 -1.9 -2.1 2.4 1.8 1.8 1.7 2.0 2.4 1.9 1.7 0.3
Forced vital capacity (FVC), Best measure 2.5 9.0 17.1 -1.6 3.1 -3.7 -4.0 4.1 2.3 2.4 2.7 2.5 3.9 2.4 3.0 -1.8
Body fat percentage 0.8 3.2 13.2 1.2 -1.4 1.3 3.2 -2.4 -0.2 -0.5 -1.0 -0.7 -3.6 -0.6 -2.3 0.0
Leg fat percentage (right) 1.3 4.7 13.7 1.2 -2.4 2.2 3.5 -2.8 -1.0 -1.2 -1.6 -1.5 -3.7 -1.4 -2.3 0.2
Arm fat-free mass (right) 1.6 8.1 23.3 2.0 4.8 -4.4 -3.9 3.4 1.1 2.1 1.2 2.0 2.9 1.9 2.8 -0.8
Exposure to tobacco smoke outside home 1.2 1.5 3.8 -1.1 -0.2 1.2 1.7 -1.9 -0.8 -1.0 -0.7 -1.1 -1.9 -1.0 -1.2 -1.1
Comparative body size at age 10 0.9 2.4 4.7 -0.5 -1.3 1.3 1.0 -0.8 -1.9 -2.1 -1.4 -2.1 -1.2 -2.2 -0.9 -2.2
Number of full brothers 0.6 0.7 4.6 -1.7 -0.3 -0.2 0.5 -0.1 0.3 0.1 0.7 0.1 -0.9 0.1 -0.7 -2.1
Worry too long after embarrassment 0.9 1.5 3.2 0.5 -1.3 1.4 0.7 -0.7 -1.3 -1.8 -1.1 -1.5 -1.6 -1.5 0.4 1.2
Seen a psychiatrist for nerves, anxiety, tension or depression 1.7 2.1 6.1 1.0 0.7 -2.5 -1.3 1.0 1.3 1.5 2.0 1.7 1.7 1.8 0.5 -0.5
Wheeze or whistling in the chest in last year 1.3 2.2 15.7 -4.0 -0.3 1.8 1.3 -1.7 -0.1 0.4 0.2 0.3 -0.1 0.4 -2.1 -0.7
Number of children fathered 0.5 0.6 2.7 1.6 1.4 -0.5 -0.6 0.4 -0.5 -0.3 -0.3 -0.3 0.6 -0.4 0.8 -0.4
Reason for reducing amount of alcohol drunk: Health precaution 5.7 6.7 10.5 1.2 1.3 -3.2 -3.0 3.1 3.1 2.6 2.7 2.9 2.4 2.7 3.0 0.2
Age at first live birth 0.2 0.3 1.2 -0.1 -0.8 -0.3 0.3 -0.2 1.1 0.7 0.8 0.6 0.2 0.6 -0.4 0.4
Pulse wave peak to peak time 0.6 0.7 1.8 1.3 0.7 -1.0 -0.4 0.8 1.0 0.8 0.6 0.9 0.9 0.8 -0.4 0.7
Health satisfaction 0.2 0.3 0.9 -1.0 -0.7 0.0 -0.2 -0.2 -0.6 -0.4 -0.7 -0.6 0.0 -0.5 -0.5 -0.1
Shortness of breath walking on level ground 0.7 0.8 3.8 0.8 1.7 -0.7 -0.3 1.0 0.3 0.6 -0.2 0.5 -0.6 0.5 -0.3 2.0
Qualifications: College or University degree 0.1 0.3 2.0 0.4 -1.4 0.1 0.7 -0.4 -0.5 -0.1 -0.5 -0.4 0.0 -0.3 -0.5 -0.2
Eye problems/disorders: None of the above 1.0 1.2 2.6 -1.0 -0.7 -1.3 -1.1 0.3 1.6 1.2 1.1 1.1 0.3 1.1 0.9 -1.6
Mouth/teeth dental problems: Loose teeth 2.0 2.3 8.5 0.3 1.6 -1.5 -1.9 1.8 1.5 1.5 0.4 1.4 2.9 1.3 0.9 -0.8
Emphysema/chronic bronchitis 0.3 0.3 1.4 -0.6 1.2 -0.1 -0.0 -0.3 -0.6 -0.6 -0.1 -0.4 -0.0 -0.5 -0.6 0.9
Medication for pain relief, constipation, heartburn 4.2 7.2 11.7 -0.2 -3.4 3.4 2.3 -1.9 -3.0 -3.3 -3.3 -3.4 -3.0 -3.2 -0.8 -0.2
Neck or shoulder pain in last month 0.8 1.1 2.7 -0.8 0.4 -1.3 -1.2 0.5 0.5 1.1 1.6 1.1 1.2 1.2 1.1 0.6
Medication: Blood pressure 1.9 3.4 8.9 -1.3 0.6 -2.1 -1.3 1.3 2.5 2.4 3.0 2.5 1.2 2.4 0.7 -0.7
Angina (self-reported) 0.5 0.6 1.6 0.1 1.3 -0.5 -0.0 0.2 1.1 1.0 1.1 1.0 0.9 0.9 -0.4 0.7
Migraine (self-reported) 0.8 0.9 2.6 -1.4 0.4 -1.6 -1.1 0.9 0.9 0.6 1.4 0.8 0.6 0.8 0.7 -0.5
Medication: Ibuprofen 1.8 2.2 5.7 -0.6 1.0 -2.2 -1.6 1.4 1.0 1.4 1.8 1.2 2.4 1.2 1.0 -1.3
Medication: Allopurinol 0.7 0.9 2.0 1.0 -0.6 0.8 0.6 -1.3 -1.0 -1.1 -1.0 -0.9 -1.4 -0.9 -0.4 0.8
Medication: Omeprazole 0.8 0.9 2.5 -0.2 -1.5 -0.5 1.3 -1.1 0.8 0.6 1.3 0.7 -0.3 0.8 -1.6 0.3
Medication: Seretide 50 evohaler 0.6 0.7 3.7 0.6 1.9 -0.5 -0.6 0.7 1.1 0.9 0.1 1.0 0.4 0.9 0.3 0.5
Mean time to correctly identify matches 1.6 3.1 8.4 1.3 -0.1 1.5 0.5 -1.2 -2.3 -2.7 -2.3 -2.8 -0.4 -2.9 -0.7 0.5
Heart disease (mother) 0.9 1.1 2.8 -0.6 -0.9 1.0 1.5 -1.6 -0.7 -0.6 -1.3 -0.7 -1.1 -0.6 -1.7 0.4
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.4 0.5 1.8 -0.4 -0.7 -0.2 -0.0 -0.6 0.6 1.0 1.0 0.8 0.6 0.8 -0.2 1.3
Whole body fat mass 0.2 0.9 4.0 1.3 0.5 -0.3 1.5 -1.0 0.2 0.2 -0.6 -0.0 -2.0 0.1 -1.2 -0.5
Leg fat mass (right) 0.3 1.1 4.1 1.0 -0.8 0.2 1.8 -1.2 -0.2 -0.2 -0.9 -0.5 -2.0 -0.4 -1.3 -0.7
Arm predicted mass (right) 1.3 6.6 20.2 1.8 4.5 -4.1 -3.6 2.9 0.8 1.8 1.0 1.7 2.8 1.6 2.3 -0.9
Pulse rate, automated reading 0.2 0.5 4.0 -2.0 -0.0 0.7 -0.2 0.4 -0.6 -0.2 -0.1 -0.4 0.5 -0.3 -0.2 -1.1
Alcohol intake frequency. 0.4 0.9 3.0 -0.2 -0.0 1.1 0.9 -0.7 -1.2 -0.8 -0.7 -0.7 -1.4 -0.7 -0.7 1.7
Comparative height size at age 10 2.0 11.1 29.7 -1.6 3.8 -5.5 -4.0 3.5 2.6 3.1 3.3 3.2 3.4 3.2 2.0 -2.6
Number of full sisters 0.9 1.1 2.3 -1.5 0.4 0.3 -1.2 0.7 -1.3 -0.9 -1.2 -1.2 1.2 -1.3 1.0 -0.6
Suffer from ‘nerves’ 1.4 2.2 6.8 1.1 1.7 -1.1 -2.3 2.1 0.9 0.8 0.8 0.9 1.8 0.9 2.6 0.5
Overall health rating 0.7 1.5 2.5 -1.4 0.7 -1.6 -1.3 1.4 0.9 1.1 1.5 1.3 1.4 1.3 0.6 -0.7
Chest pain or discomfort 0.8 1.2 2.2 -1.4 0.2 -0.9 -0.6 1.1 1.2 1.5 1.1 1.2 1.3 1.3 0.6 -0.8
Had major operations 0.2 0.3 1.2 -0.1 -0.2 0.6 -0.2 -0.3 -0.3 -0.6 -1.1 -0.8 0.5 -0.7 0.3 -0.2
Age at last live birth 1.0 1.5 3.8 -0.2 -0.1 -1.3 -1.1 0.9 1.6 1.5 2.0 1.5 1.3 1.5 0.2 0.7
Family relationship satisfaction 1.6 2.0 6.1 -1.0 -1.9 1.7 2.0 -2.5 0.2 -0.6 -0.9 -0.6 -1.1 -0.5 -2.0 1.0
Leg pain on walking 0.0 0.1 0.2 -0.0 -0.3 0.1 0.3 -0.4 0.2 0.2 0.1 0.1 -0.3 0.1 -0.3 0.3
Qualifications: NVQ or HND or HNC or equivalent 0.6 0.8 2.1 -0.5 -0.5 1.4 1.1 -0.9 -0.6 -0.8 -1.0 -0.9 -1.2 -0.8 -0.7 0.3
Commuting to job workplace: Car/motor vehicle 3.7 4.2 9.7 0.5 1.8 -2.7 -1.0 1.2 2.4 2.8 3.1 2.9 1.0 3.0 0.1 -0.7
Illness, injury, bereavement, stress in last 2 years 1.7 2.1 5.4 0.4 -1.5 1.6 1.3 -1.4 -1.5 -2.3 -1.2 -1.9 -0.6 -2.1 -0.9 -0.0
Medication: Aspirin 9.5 12.5 19.7 0.9 3.7 -4.4 -4.0 3.8 3.6 4.1 3.5 4.2 3.6 4.1 2.8 0.8
Supplements: Vitamin C 0.5 0.6 3.1 1.8 0.9 -0.6 -0.6 0.6 -0.2 -0.3 -0.2 -0.4 0.9 -0.5 1.1 -0.7
Knee pain experienced in last month 0.3 0.4 2.5 -0.1 -0.7 0.2 -0.7 -0.3 -0.9 -0.2 -0.0 -0.2 0.3 -0.3 0.9 1.6
Hypertension (Self-reported) 2.1 5.8 12.6 0.3 0.9 -3.4 -2.2 2.1 3.1 2.9 3.6 3.0 1.6 3.0 1.5 0.6
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.6 0.7 1.7 -1.1 -1.3 1.0 1.2 -1.2 -0.2 -0.5 0.2 -0.5 -0.6 -0.5 -1.2 -0.4
Illnesses of father: Heart disease 0.6 0.9 2.6 0.7 0.3 0.3 0.5 -0.5 -1.1 -1.4 -0.7 -1.5 0.3 -1.6 -0.8 0.9
Illnesses of siblings: Diabetes 0.1 0.1 0.3 0.0 0.2 -0.0 0.2 0.2 -0.5 -0.3 -0.3 -0.5 0.5 -0.4 0.0 -0.4
Smoking status: Previous 0.9 1.3 3.0 -0.7 1.7 -1.7 -0.9 0.5 1.2 0.8 1.6 1.1 1.5 1.2 -0.5 0.4
Forced expiratory volume in 1-second (FEV1), predicted 2.7 5.6 8.2 -1.3 2.5 -2.8 -2.9 2.7 2.7 2.4 2.5 2.6 2.3 2.6 1.8 -0.6
Whole body fat-free mass 1.5 8.5 26.3 1.6 5.1 -4.5 -4.1 3.6 1.0 2.1 0.9 1.9 3.2 1.9 2.5 -1.2
Leg fat-free mass (right) 1.2 6.3 19.0 1.5 4.4 -4.1 -3.3 3.1 1.0 2.0 0.7 1.8 2.4 1.8 2.1 -1.3
Arm fat percentage (left) 1.0 3.8 14.1 0.5 -1.5 1.6 3.6 -2.5 -0.5 -0.7 -1.4 -0.9 -3.8 -0.8 -2.6 -0.8
Average weekly red wine intake 0.3 0.4 1.7 0.2 -0.4 -0.5 -1.3 1.0 0.3 -0.1 0.3 -0.2 1.1 -0.3 1.1 -0.0
Handedness (chirality/laterality): Left-handed 0.4 0.5 4.2 -0.5 2.1 -0.5 -0.7 1.0 -0.1 0.1 -0.1 -0.0 0.2 -0.1 0.3 0.5
Mood swings 0.4 0.8 1.7 -1.1 -0.4 1.1 0.6 -0.5 -1.3 -1.2 -0.7 -1.0 -0.7 -1.0 -0.6 0.2
Loneliness, isolation 0.5 0.6 2.1 -1.4 0.1 1.1 0.9 -0.7 -1.0 -0.5 -0.9 -0.7 -0.4 -0.5 -0.8 -0.1
Long-standing illness, disability or infirmity 0.4 0.6 3.3 0.8 1.8 0.5 0.1 0.8 -0.7 -0.7 -0.5 -0.5 0.4 -0.5 -0.3 1.1
Ever had bowel cancer screening 0.9 1.0 1.7 -0.1 -1.1 1.1 1.0 -1.3 -1.3 -1.3 -0.8 -1.1 -0.4 -1.1 -0.7 1.0
Diabetes diagnosed by doctor 1.3 2.1 4.8 0.8 -1.0 -1.2 -0.7 1.3 1.6 1.8 2.2 2.1 -0.3 2.2 1.3 0.8
Ever had stillbirth, spontaneous miscarriage or termination 1.6 1.7 3.9 -2.0 0.5 1.8 0.7 -1.3 -2.0 -1.1 -1.4 -1.1 -1.2 -1.0 -1.5 0.1
Friendships satisfaction 0.1 0.1 0.4 -0.3 0.0 0.0 -0.4 -0.0 -0.0 -0.4 -0.6 -0.4 0.4 -0.5 0.1 0.0
Qualifications: nursing, teaching 1.9 3.0 7.8 1.4 -2.8 1.7 1.7 -2.0 -1.6 -1.5 -1.4 -1.6 -1.9 -1.5 -1.2 1.6
Commuting to job workplace: Walk 0.4 0.4 0.9 -0.9 -0.9 1.0 -0.3 -0.0 -0.3 -0.8 -0.6 -0.6 -0.5 -0.6 0.5 -0.4
Eye problems/disorders: Cataract 0.9 1.0 5.5 2.3 1.4 -0.4 -0.3 1.1 0.7 0.3 -0.0 0.4 1.2 0.3 0.0 1.4
Mouth/teeth dental problems: Mouth ulcers 0.5 0.8 1.8 -0.5 0.1 0.9 0.9 -0.7 -1.1 -1.3 -0.4 -1.3 -0.1 -1.3 -1.3 -0.2
Medication for cholesterol 0.4 0.7 1.7 -1.3 -0.8 1.1 0.8 -0.9 -0.4 -0.8 -0.6 -0.6 -1.1 -0.6 -0.7 0.1
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.3 0.3 1.2 0.7 -1.1 0.6 0.6 -1.0 -0.3 -0.5 -0.2 -0.5 -0.3 -0.5 -0.4 0.1
Back pain experienced in last month 1.6 2.3 5.1 1.3 0.2 2.3 1.4 -1.4 -1.6 -1.8 -2.2 -1.8 -0.8 -1.8 -1.0 0.6
Mineral and other dietary supplements 1.8 2.4 5.0 0.5 2.2 -1.1 -1.1 1.4 1.8 2.1 1.5 1.9 0.4 1.9 1.6 1.2
Breast cancer (self-reported) 0.5 0.6 1.9 1.4 -0.0 -1.1 0.2 -0.1 0.7 0.5 1.2 0.7 -1.0 0.6 0.2 0.7
Asthma (self-reported) 1.0 2.1 11.1 -3.3 0.2 1.8 1.7 -1.5 -0.1 0.5 -0.3 0.4 -1.2 0.4 -2.3 0.7
Osteoporosis (self-reported) 1.4 1.8 7.1 0.8 0.3 -1.3 -2.2 2.0 0.2 0.6 0.8 0.7 1.6 0.5 2.7 0.7
Osteoarthritis (self-reported) 1.9 2.5 5.3 1.8 -1.1 1.4 0.5 -0.7 -1.9 -2.2 -2.0 -2.2 -1.1 -2.3 0.3 0.8
Medication: Aspirin 8.8 11.5 19.2 0.9 3.2 -4.4 -4.0 3.8 3.2 3.8 3.3 3.9 3.6 3.8 3.1 0.6
Medication: Gliclazide 0.7 0.8 1.9 -0.9 -1.4 -0.6 0.5 -0.3 0.7 0.9 1.2 0.9 -1.3 1.0 -0.4 -1.0
Illnesses of father: None of the above (group 1) 0.5 0.6 2.0 0.5 0.2 0.6 -0.2 -0.2 -1.0 -1.1 -1.4 -1.1 -0.4 -1.1 0.6 0.2
Smoking status: Current 0.3 0.4 1.7 -1.3 0.9 0.0 0.2 -0.4 0.1 0.2 0.6 0.4 -0.1 0.4 -1.2 0.4
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.4 0.9 2.7 -0.5 -1.2 0.9 -0.8 0.8 -0.5 -0.5 -1.0 -0.8 0.4 -0.8 1.6 -1.6
Whole body water mass 1.5 8.3 25.6 1.7 5.1 -4.5 -4.1 3.5 0.9 2.0 0.8 1.8 3.2 1.8 2.6 -1.1
Leg predicted mass (right) 1.1 6.1 19.1 1.5 4.4 -4.0 -3.3 3.1 0.9 1.9 0.7 1.7 2.3 1.7 2.0 -1.3
Arm fat mass (left) 0.2 1.0 4.4 0.7 0.1 -0.1 1.7 -1.0 -0.0 0.1 -0.8 -0.2 -2.1 -0.1 -1.3 -1.3
Number of self-reported non-cancer illnesses 0.6 1.1 2.2 -0.3 0.9 -1.4 -0.6 0.8 1.1 1.4 1.3 1.4 1.0 1.5 0.3 0.3
Average weekly champagne plus white wine intake 2.3 3.2 6.4 -0.9 0.8 -2.0 -1.9 0.9 2.5 2.3 2.2 2.1 2.0 2.2 1.3 -0.5
Miserableness 0.6 1.1 2.5 -0.3 1.5 -1.6 -1.6 1.4 0.0 0.2 1.0 0.2 1.4 0.2 1.3 -0.5
Guilty feelings 0.5 0.7 2.3 1.3 0.1 0.9 -0.5 0.7 -0.4 -0.8 -1.2 -0.7 -0.3 -0.8 1.5 0.5
Wears glasses or contact lenses 0.3 0.4 2.2 1.3 0.2 0.5 0.1 -0.5 0.2 0.0 -0.3 0.0 -0.6 -0.1 -0.3 1.5
Ever taken oral contraceptive pill 1.0 1.1 7.6 -1.3 -0.1 -1.3 -0.3 0.7 0.5 0.4 0.6 0.3 1.3 0.3 -0.2 -2.8
Hearing aid user 1.5 1.6 2.2 1.3 0.2 1.1 0.8 -1.5 -1.4 -1.4 -1.5 -1.4 -1.5 -1.3 -1.3 1.5
Mother’s age at death 1.0 1.3 5.3 -0.3 -2.3 1.5 0.6 -1.3 -0.6 -0.6 -0.9 -0.7 -2.2 -0.7 -0.2 0.4
Financial situation satisfaction 0.4 0.5 2.2 -1.5 -0.2 0.8 0.2 -0.9 0.2 0.2 -0.3 0.3 0.5 0.4 -1.2 -0.2
Tinnitus: Yes, now most or all of the time 0.3 0.3 1.5 -0.2 -0.2 0.4 0.4 -0.3 -0.7 -0.7 -0.5 -0.6 0.4 -0.6 -0.3 -1.2
Commuting to job workplace: Public transport 0.1 0.1 0.6 -0.8 -0.3 0.2 -0.5 0.3 -0.0 0.3 -0.3 0.1 0.5 0.1 0.6 -0.0
Eye problems/disorders: Glaucoma 2.1 2.5 4.6 0.4 -0.8 2.1 0.8 -1.8 -2.2 -2.0 -2.0 -1.9 -1.7 -1.8 -0.5 1.3
Medication: Blood pressure 0.5 1.0 5.8 2.4 0.8 -1.8 -0.4 0.8 0.5 0.5 0.7 0.5 0.5 0.5 -0.1 0.5
Pain type(s) experienced in last month: Hip pain 4.3 5.4 12.0 1.5 -1.3 3.5 3.4 -3.1 -1.4 -2.3 -2.2 -2.2 -1.5 -2.3 -2.7 1.2
Supplements: Fish oil (including cod liver oil) 2.5 3.2 7.3 -0.2 -1.7 1.9 2.0 -2.2 -1.7 -2.0 -2.1 -1.9 -1.0 -1.8 -2.7 -0.0
High cholesterol (Self-reported) 0.2 0.3 2.4 0.6 0.3 -0.3 -0.4 0.3 -0.0 0.0 0.4 0.3 0.0 0.3 0.6 1.5
Medication: Bendroflumethiazide 0.5 0.7 1.9 1.3 0.4 -0.8 0.0 0.9 1.4 0.9 0.8 1.0 0.4 0.9 -0.1 0.8
Medication: Paracetamol 0.9 1.3 3.2 -0.5 1.5 -1.1 -1.8 0.9 0.7 0.9 1.3 0.9 1.8 0.7 1.0 1.1
Medication: Lisinopril 0.8 1.1 3.4 -1.2 0.3 0.4 0.7 -0.6 -1.8 -1.1 -1.5 -1.2 0.3 -1.2 -1.3 0.1
Medication: Atorvastatin 0.8 1.0 4.2 1.4 0.4 0.6 -0.8 1.0 -0.8 -0.5 -0.8 -0.5 0.7 -0.6 1.7 2.0
Illnesses of father: High blood pressure 0.6 0.8 1.5 -1.0 -0.6 -0.6 -0.1 0.3 1.1 1.2 1.1 1.2 0.5 1.2 -0.1 -1.0
Alcohol drinker status: Never 0.4 0.5 2.7 0.7 0.2 -0.2 0.6 -0.2 0.5 0.7 0.6 0.8 -0.8 0.7 -0.6 1.6
Ever smoked 0.8 1.4 8.4 -2.9 0.4 0.1 1.1 -1.0 -0.0 -0.3 0.7 -0.0 -0.7 0.1 -2.3 -0.9
Basal metabolic rate 1.2 6.6 22.0 1.5 4.7 -4.2 -3.5 3.1 0.9 1.9 0.8 1.7 2.5 1.7 2.0 -1.2
Leg fat percentage (left) 1.4 5.1 15.3 2.1 -2.2 2.2 3.6 -2.8 -1.2 -1.3 -1.9 -1.7 -3.9 -1.6 -2.1 0.3
Arm fat-free mass (left) 1.4 7.1 22.6 2.3 4.7 -4.2 -3.6 3.1 0.9 1.9 0.6 1.7 2.8 1.7 2.4 -0.9
Number of operations (self-reported) 1.6 2.4 5.8 -1.5 -0.3 2.4 2.1 -1.9 -0.9 -1.1 -1.7 -1.1 -1.5 -1.0 -2.2 0.4
Average weekly beer plus cider intake 0.7 1.1 3.6 0.3 1.5 -0.8 -1.0 1.9 0.1 0.9 0.9 0.8 1.4 0.7 1.2 0.2
Irritability 0.2 0.4 4.5 -0.5 2.1 -0.3 0.2 0.2 0.2 0.1 -0.1 -0.0 0.5 -0.0 -0.2 0.3
Risk taking 0.6 0.9 3.1 0.4 0.3 -1.1 -0.5 0.2 0.9 1.8 1.2 1.4 0.4 1.5 -0.1 0.5
Ever had prostate specific antigen (PSA) test 0.3 0.3 0.7 -0.2 -0.0 0.5 -0.3 0.0 -0.6 -0.8 -0.8 -0.8 0.9 -0.8 -0.1 0.2
Fractured/broken bones in last 5 years 0.4 0.6 2.8 -1.1 -0.4 0.1 1.0 -0.8 -0.4 -0.0 -0.4 -0.2 -0.2 -0.1 -1.7 -1.1
Age started oral contraceptive pill 0.4 0.5 4.7 2.2 -0.5 -0.9 -0.3 0.3 0.5 0.0 0.4 0.4 0.0 0.3 0.1 -0.6
Diastolic blood pressure, automated reading 1.1 3.4 15.5 -0.1 3.9 -1.7 -3.0 2.7 0.6 0.8 0.3 0.6 2.0 0.5 1.9 -0.4
Ever depressed for a whole week 0.5 0.6 2.0 0.8 -0.4 1.4 1.1 -1.1 -0.3 -0.1 -0.9 -0.1 -1.1 -0.0 -0.4 0.3
Unable to work because of sickness or disability 0.8 1.0 3.3 -1.0 1.3 1.1 0.8 -0.8 -1.1 -1.1 -1.0 -0.9 -0.1 -0.9 -1.8 0.1
Commuting to job workplace: Cycle 0.4 0.5 1.2 0.1 -1.0 -0.2 -0.1 -0.5 -0.9 -1.1 -0.5 -1.0 -0.4 -1.0 -0.0 -0.5
Myopia 0.5 0.7 6.2 2.5 0.3 -0.3 -0.7 0.4 -0.5 -0.4 0.0 -0.4 0.4 -0.5 0.7 0.6
Vascular/heart problems diagnosed by doctor 2.6 7.1 13.6 -0.2 -1.7 3.6 2.1 -2.2 -3.6 -3.4 -3.7 -3.5 -1.8 -3.4 -1.3 -0.5
Cholesterol lowering medication 0.3 0.4 1.5 1.2 0.7 0.3 0.6 -0.1 0.1 0.6 0.3 0.8 -0.2 0.8 -0.2 1.2
Medication: Omeprazole (e.g. Zanprol) 1.1 1.3 3.1 -1.1 -1.3 -0.5 1.4 -0.7 1.3 1.1 1.7 1.2 0.2 1.3 -1.8 -0.4
Pain experienced in last month 0.3 0.6 1.4 0.4 -0.0 -1.0 -0.4 1.1 0.9 1.2 0.5 1.1 -0.0 1.0 0.5 0.2
Supplements: Calcium 0.4 0.4 3.1 -1.8 0.7 -0.0 -0.0 -0.0 -0.8 -0.6 -0.4 -0.6 0.1 -0.6 -0.4 -0.4
Basal cell carcinoma (self-reported) 1.2 1.4 8.6 -2.9 -0.6 -0.9 -0.2 -0.2 0.0 0.2 0.2 0.3 1.2 0.4 -0.7 -2.4
Heart attack/myocardial infarction (self-reported) 5.2 6.7 10.1 0.5 2.4 -3.2 -2.8 3.1 2.7 2.7 2.8 3.0 3.1 2.9 2.2 -0.4
Deep venous thrombosis (DVT) (self-reported) 0.8 1.1 10.1 3.2 -0.1 -0.3 -0.3 0.5 0.7 0.2 -0.7 0.1 -0.5 -0.1 0.6 1.4
Heart disease (siblings) 0.5 0.6 1.3 0.3 1.1 0.7 0.7 -1.2 -0.9 -0.9 -0.9 -1.0 -0.2 -0.9 -0.6 0.1
Alcohol drinker status: Previous 0.1 0.1 0.3 -0.3 0.4 -0.3 -0.4 0.5 -0.3 0.2 0.5 0.2 -0.1 0.1 0.5 0.6
Pack years of smoking 1.2 1.8 5.4 -2.3 -0.8 1.2 1.5 -1.9 -0.3 -0.4 -0.6 -0.2 -1.8 -0.2 -2.0 -1.3
Impedance of whole body 0.3 1.5 4.8 -2.2 -0.9 0.3 0.7 -0.3 1.9 1.1 2.1 1.3 -0.0 1.3 -0.3 0.9
Leg fat mass (left) 0.3 1.2 4.5 1.5 -0.6 0.2 1.7 -1.2 -0.3 -0.2 -1.1 -0.5 -2.1 -0.4 -1.2 -0.7
Arm predicted mass (left) 1.4 7.2 22.2 2.2 4.7 -4.2 -3.6 3.1 1.0 1.9 0.6 1.7 2.9 1.7 2.5 -0.9