Best TWAS P=3.07e-10 · Best GWAS P=8.46e-08 conditioned to 0.3
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | GTEx | Adipose Subcutaneous | SPAG8 | 0.13 | 0.04 | enet | 14 | 0.06 | 8.7e-06 | -5.3 | -5.4 | 6.6e-08 | 0.28 | 0.01 | 0.99 | FALSE |
2 | GTEx | Adrenal Gland | HRCT1 | 0.23 | 0.19 | lasso | 3 | 0.15 | 6.4e-06 | -4.5 | -5.3 | 1.1e-07 | 0.42 | 0.06 | 0.89 | TRUE |
3 | GTEx | Artery Aorta | RP11-112J3.16 | 0.20 | 0.09 | lasso | 5 | 0.11 | 1.6e-06 | -5.0 | -5.2 | 1.7e-07 | 0.33 | 0.03 | 0.96 | FALSE |
4 | GTEx | Artery Tibial | RP11-112J3.16 | 0.07 | 0.05 | lasso | 3 | 0.05 | 9.1e-05 | -4.2 | -5.1 | 2.8e-07 | 0.33 | 0.04 | 0.95 | FALSE |
5 | GTEx | Heart Atrial Appendage | RP11-112J3.16 | 0.15 | 0.02 | lasso | 5 | 0.05 | 1.9e-03 | -5.0 | -6.2 | 4.9e-10 | 0.51 | 0.04 | 0.64 | FALSE |
6 | GTEx | Lung | HRCT1 | 0.08 | 0.01 | enet | 14 | 0.02 | 5.5e-03 | -5.1 | -5.9 | 3.7e-09 | 0.42 | 0.04 | 0.59 | TRUE |
7 | GTEx | Muscle Skeletal | RP11-112J3.16 | 0.06 | 0.07 | lasso | 3 | 0.05 | 2.7e-05 | -5.0 | -5.1 | 3.1e-07 | 0.35 | 0.04 | 0.96 | FALSE |
8 | GTEx | Nerve Tibial | SPAG8 | 0.13 | 0.09 | lasso | 4 | 0.08 | 5.2e-06 | -5.3 | -5.6 | 2.5e-08 | 0.33 | 0.01 | 0.99 | FALSE |
9 | GTEx | Skin Sun Exposed Lower leg | TMEM8B | 0.19 | 0.16 | enet | 29 | 0.19 | 6.5e-16 | -4.7 | -5.5 | 3.5e-08 | 0.38 | 0.14 | 0.85 | FALSE |
10 | GTEx | Testis | TMEM8B | 0.16 | 0.19 | lasso | 2 | 0.16 | 1.2e-07 | -5.3 | -5.3 | 1.2e-07 | 0.33 | 0.01 | 0.99 | FALSE |
11 | YFS | Blood | SPAG8 | 0.04 | 0.03 | lasso | 7 | 0.02 | 2.6e-08 | -5.1 | -5.2 | 1.8e-07 | 0.32 | 0.02 | 0.98 | FALSE |
12 | The Cancer Genome Atlas | Bladder Urothelial Carcinoma | RGP1 | 0.07 | 0.00 | lasso | 5 | 0.03 | 8.1e-04 | -2.5 | -6.2 | 5.6e-10 | 0.19 | 0.01 | 0.27 | TRUE |
13 | The Cancer Genome Atlas | Rectum Adenocarcinoma | HRCT1 | 0.26 | 0.03 | blup | 49 | 0.11 | 1.5e-03 | -4.9 | -6.3 | 3.1e-10 | 0.59 | 0.01 | 0.15 | TRUE |