TWAS hub - RGP1

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	NTR	Blood	0.0275	0.0093	2.9e-05	0.032	0.014	0.021	0.021	0.024	1.5e-10	1.5e-05	2.2e-07	1.4e-07	2.1e-08
2	TCGA	Bladder Urothelial Carcinoma	0.0730	0.0470	4.6e-03	0.005	0.023	0.033	NA	0.033	1.2e-01	4.6e-03	8.2e-04	NA	8.1e-04

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2
Current tobacco smoking	4.7	7.6	12.6	-3.5	-1.7
Qualifications: CSEs or equivalent	4.6	6.1	6.4	2.5	-2.4
Gout (self-reported)	4.4	6.1	8.3	-2.9	-2.0
Tense / ‘highly strung’	4.1	6.7	8.5	-2.2	-2.9
Headache pain in last month	4.0	6.8	13.2	3.6	0.6
Smoking status: Current	4.0	6.4	10.7	-3.3	-1.4
Diabetes (mother)	3.9	5.0	7.5	2.7	1.6
Emphysema/chronic bronchitis	3.8	4.2	5.9	2.4	1.6
Arm fat percentage (right)	3.7	14.6	25.2	5.0	2.0
Forced expiratory volume in 1-second (FEV1), predicted	3.7	7.7	15.4	-0.2	-3.9
Leg fat percentage (left)	3.7	13.2	13.5	3.6	3.7
Comparative height size at age 10	3.6	19.8	38.5	-1.1	-6.2
Supplements: Vitamin C	3.5	4.2	8.0	-2.8	-0.7
Alcohol usually taken with meals	3.4	5.5	9.6	3.1	1.2
Leg fat percentage (right)	3.4	12.5	13.8	3.7	3.3
Reason for reducing amount of alcohol drunk: Health precaution	3.4	3.9	7.7	0.4	2.8
Wears glasses or contact lenses	3.3	3.8	5.1	2.3	1.6
HbA1C	3.2	3.5	4.1	-1.7	-2.0
Arm fat percentage (left)	3.2	12.8	22.3	4.7	1.8
Migraine (self-reported)	2.8	3.5	6.6	2.6	-0.6
Blood Platelet Count	2.7	31.8	60.1	7.8	1.9
Body fat percentage	2.7	10.6	15.6	4.0	2.4
Medication: Allopurinol	2.6	3.4	4.8	-1.4	-2.2
Hip circumference	2.5	10.7	19.9	4.5	-1.2
Pack years adult smoking proportion	2.4	3.6	7.2	-2.7	-0.0
Hair/balding pattern: Pattern 2	2.4	3.1	6.2	0.3	2.5
Hayfever/allergic rhinitis (self-reported)	2.4	3.2	6.1	-2.5	-0.5
Standing height	2.4	24.0	48.0	0.2	-6.9
Ever had stillbirth, spontaneous miscarriage or termination	2.4	2.5	3.4	1.3	1.8
Arm fat mass (left)	2.4	10.0	19.9	4.5	0.3
Lupus	2.3	3.5	4.0	-2.0	1.7
Height	2.3	44.0	87.0	-1.0	-9.3
Lung FEV1/FVC ratio	2.3	11.8	21.8	-4.7	1.3
Leg fat-free mass (left)	2.3	12.1	15.8	2.9	-4.0
Trunk fat-free mass	2.3	13.3	24.3	1.5	-4.9
Trunk predicted mass	2.3	13.1	23.7	1.6	-4.9
Mouth/teeth dental problems: Loose teeth	2.3	2.7	4.5	-2.1	-1.0
Osteoarthritis (self-reported)	2.3	2.9	5.5	-2.4	-0.5
Age started oral contraceptive pill	2.3	2.9	5.1	0.9	2.3
Trunk fat percentage	2.2	8.9	14.7	3.8	1.8
Leg predicted mass (left)	2.2	11.7	15.6	2.8	-3.9
Arm fat mass (right)	2.2	9.2	18.4	4.3	0.2
Breastfed as a baby	2.2	2.8	4.8	2.2	-0.9
Birth weight of first child	2.2	3.9	7.4	-0.7	-2.7
Alcohol intake frequency.	2.2	5.2	9.2	3.0	-1.1
Pack years of smoking	2.2	3.2	6.0	-2.4	0.6
Hand grip strength (right)	2.1	5.6	7.8	-2.8	-1.9
Trunk fat mass	2.1	8.9	17.6	4.2	0.3
Whole body fat-free mass	2.1	12.2	20.6	1.9	-4.5
Leg fat-free mass (right)	2.1	11.1	16.9	2.3	-4.1
Whole body water mass	2.1	12.2	20.5	2.0	-4.5
Leg predicted mass (right)	2.1	11.1	17.1	2.3	-4.1
Type 2 Diabetes (T2D) (2012)	2.0	2.3	4.3	2.1	-0.5
Smoking Status	2.0	4.9	9.4	-3.1	-0.6
Hand grip strength (left)	2.0	5.3	8.2	-2.9	-1.6
Forced vital capacity (FVC)	2.0	7.7	15.3	-0.4	-3.9
Hair/balding pattern: Pattern 3	2.0	3.0	3.1	-1.7	1.8
Forced expiratory volume in 1-second (FEV1)	2.0	6.7	12.9	-0.7	-3.6
Peak expiratory flow (PEF)	2.0	4.5	6.2	-1.7	-2.5
Whole body fat mass	2.0	8.4	16.6	4.1	0.5
Basal cell carcinoma (self-reported)	2.0	2.4	4.0	0.9	2.0
LDL Cholesterol	1.9	3.0	5.6	-0.6	2.4
Triglycerides	1.9	3.2	3.3	-1.7	1.8
Blood White Count	1.9	13.9	27.9	5.3	-0.0
BMI	1.9	11.2	19.3	4.4	1.8
Type 2 Diabetes (T2D) (2018)	1.9	3.5	6.4	2.5	0.9
Medication for hormone replacement therapy	1.9	2.1	3.4	-0.9	-1.9
Forced vital capacity (FVC), Best measure	1.9	7.0	13.9	0.0	-3.7
Handedness (chirality/laterality): Left-handed	1.9	2.3	4.4	-0.5	2.1
Basal metabolic rate	1.9	10.7	15.9	2.3	-4.0
Leg fat mass (left)	1.9	7.2	13.1	3.6	1.2
Alzheimer’s Disease (in mother)	1.8	2.1	4.0	-2.0	-0.4
Relative age voice broke	1.8	2.7	3.2	1.5	1.8
Sitting height	1.8	12.6	24.5	0.8	-5.0
Leg fat mass (right)	1.8	7.0	13.3	3.6	0.8
Chest pain or discomfort	1.8	2.6	4.9	-0.6	-2.2
Coronary Artery Disease (CAD)	1.7	2.1	3.6	-1.9	0.7
Heel bone mineral density (BMD) T-score, automated (left)	1.7	3.8	6.8	-2.6	-1.0
Stomach or abdominal pain in last month	1.7	2.1	4.2	2.0	-0.2
Body mass index (BMI)	1.7	7.3	12.4	3.5	1.5
Pulse rate	1.7	2.9	5.3	-0.8	2.3
Illnesses of father: Heart disease	1.7	2.4	4.8	-2.2	-0.2
Fractured/broken bones in last 5 years	1.7	2.2	3.0	-1.7	-1.2
Diabetes (father)	1.6	1.9	2.4	1.5	1.2
Diverticular disease/diverticulitis (self-reported)	1.6	2.0	3.5	0.6	-1.9
Weight	1.6	7.6	12.5	3.5	-1.7
Asthma	1.6	3.1	5.9	-0.5	-2.4
Forced expiratory volume in 1-second (FEV1), Best measure	1.6	5.1	9.9	-0.5	-3.1
Average weekly beer plus cider intake	1.6	2.3	4.4	-2.1	0.5
Depression (Nagel 2018)	1.5	2.3	4.6	-2.1	0.0
Alzheimer’s Disease (in father)	1.5	1.6	3.2	1.8	0.2
Bipolar Disorder (2011)	1.5	1.4	2.3	0.8	-1.5
Severe depression (siblings)	1.5	1.7	2.1	-1.5	-1.1
Arm fat-free mass (right)	1.5	7.7	14.8	0.7	-3.9
Qualifications: nursing, teaching	1.5	2.3	4.5	2.1	-0.1
Asthma (self-reported)	1.5	3.0	5.8	-0.5	-2.4
Fasting Glucose	1.4	1.7	2.0	1.4	-1.2
Frequency of unenthusiasm / disinterest in last 2 weeks	1.4	1.8	3.2	-1.8	0.7
Supplements: Glucosamine	1.4	1.8	2.1	1.3	1.4
Impedance of leg (left)	1.4	6.7	7.6	-2.8	2.4
Pain all over the body in last month	1.4	1.5	1.7	-1.3	-1.2
Medication: Ibuprofen (e.g. Nurofen)	1.4	1.7	2.9	-0.8	-1.7
Glaucoma (self-reported)	1.4	1.7	1.9	-1.4	-1.2
Birth weight	1.4	3.1	4.8	-2.2	-1.2
Arm predicted mass (right)	1.4	7.4	14.2	0.7	-3.8
Diabetes diagnosed by doctor	1.4	2.2	4.5	2.1	0.1
Arm fat-free mass (left)	1.4	7.2	13.4	1.0	-3.7
Alcohol drinker status: Previous	1.4	1.6	3.1	0.1	-1.8
Arm predicted mass (left)	1.4	7.3	13.1	1.2	-3.6
Bipolar Disorder (2018)	1.3	2.0	2.6	-1.6	-1.2
Financial difficulties in last 2 years	1.3	1.7	3.2	0.4	-1.8
Length of working week for main job	1.3	1.5	2.8	0.3	-1.7
Loud music exposure frequency	1.3	1.5	2.0	-1.0	-1.4
Health satisfaction	1.3	1.6	2.4	-1.0	-1.5
Medication: Seretide 50 evohaler	1.3	1.4	2.4	-1.6	-0.7
Commuting to job workplace: Public transport	1.3	1.5	2.7	1.6	-0.6
Illnesses of father: High blood pressure	1.3	1.6	2.1	1.4	1.1
Chronotype (morning person)	1.2	2.7	4.5	-2.1	-0.9
Tinnitus: Yes, but not now, but have in the past	1.2	1.3	2.4	1.6	-0.4
Waist circumference	1.2	4.5	8.6	2.9	0.7
Qualifications: A levels/AS levels or equivalent	1.2	2.6	4.6	2.1	-0.8
Medication: Ibuprofen	1.2	1.4	2.5	-0.5	-1.6
Illnesses of siblings: Diabetes	1.2	1.5	3.0	1.7	0.0
Crohns Disease (2017)	1.1	2.4	4.8	2.2	0.2
Age when periods started (menarche)	1.1	2.6	2.9	1.5	1.7
Heel bone mineral density (BMD) T-score, automated (right)	1.1	2.6	5.0	-2.2	-0.4
Mouth/teeth dental problems	1.1	1.8	2.1	-1.2	1.4
Heart attack	1.1	1.4	2.6	-1.6	0.4
Long-standing illness, disability or infirmity	1.1	1.7	2.9	0.7	-1.7
Commuting to job workplace: Walk	1.1	1.2	2.1	0.5	-1.4
Osteoporosis (self-reported)	1.1	1.4	2.5	0.5	1.6
Guilty feelings	1.1	1.7	3.2	-1.8	0.4
Financial situation satisfaction	1.1	1.3	2.7	-0.1	-1.6
Medication: Atorvastatin	1.1	1.3	2.5	-1.6	-0.3
Major Depression (MDD)	1.0	1.2	1.9	1.4	-0.6
Crohns Disease (2012)	1.0	1.5	2.9	1.7	-0.4
Other serious medical condition/disability diagnosed by doctor	1.0	1.3	2.7	0.0	-1.6
Fluid intelligence score	1.0	2.0	2.8	1.1	1.7
Frequency of tiredness / lethargy in last 2 weeks	1.0	1.6	2.8	-0.6	-1.7
Qualifications: College or University degree	1.0	3.0	4.8	2.2	1.1
Ever had bowel cancer screening	1.0	1.1	1.9	-0.5	1.4
Medication: Aspirin	1.0	1.3	2.2	-0.6	1.5
Age at First Birth	0.9	1.3	2.2	-1.5	-0.7
Body Mass Index (BMI) (2010)	0.9	1.2	2.4	1.5	0.1
Blood Eosinophil Count	0.9	7.0	14.0	3.7	0.2
Waist Hip Ratio (WHR)	0.9	4.0	4.6	-1.8	2.1
Average weekly spirits intake	0.9	1.1	1.6	0.8	1.3
Medication: Co-codamol	0.9	1.1	2.1	1.4	-0.1
Frequency of tenseness / restlessness in last 2 weeks	0.9	1.5	2.9	-1.7	-0.2
Had menopause	0.9	1.1	1.8	0.7	1.3
Qualifications: None of the above	0.9	1.9	3.5	-1.9	0.4
Medication: Blood pressure	0.9	1.5	2.8	1.7	0.4
Family relationship satisfaction	0.9	1.2	2.3	-1.5	0.1
Mother’s age at death	0.9	1.2	2.0	1.4	-0.6
Medication: Omeprazole (e.g. Zanprol)	0.9	1.1	1.3	0.9	1.1
Heart attack/myocardial infarction (self-reported)	0.9	1.2	2.2	-1.5	0.5
Impedance of leg (right)	0.8	3.9	4.0	-1.9	2.0
Serious illness, injury or assault to yourself	0.8	1.0	2.0	-0.1	1.4
Number of live births	0.8	1.2	2.1	-0.5	1.5
Happiness	0.8	1.0	1.0	-1.0	-1.0
Medication: Amlodipine	0.8	1.1	2.0	1.4	0.5
Seen a psychiatrist for nerves, anxiety, tension or depression	0.8	1.1	1.2	1.0	1.1
Had major operations	0.8	0.9	1.1	1.1	-0.8
Qualifications: NVQ or HND or HNC or equivalent	0.8	0.9	1.8	1.3	0.3
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.8	0.9	1.1	-1.1	0.8
Back pain experienced in last month	0.8	1.2	2.4	0.3	-1.5
Intelligence (Savage-Jansen 2018)	0.7	2.3	3.4	1.1	1.8
Reaction Time	0.7	1.3	1.4	1.1	-1.2
Heel T-Score	0.7	5.4	10.4	-3.2	0.7
Average weekly fortified wine intake	0.7	0.8	1.1	0.7	1.1
Chronic bronchitis/emphysema (father)	0.7	0.9	1.7	1.3	-0.0
Illnesses of siblings	0.7	0.9	1.0	-0.9	-1.0
Neuroticism score	0.7	1.5	1.8	-1.1	-1.3
Medication: Cholesterol lowering	0.7	1.2	2.3	-0.2	-1.5
Depression (self-reported)	0.7	0.8	1.6	-1.3	-0.2
Pulse wave reflection index	0.7	0.8	1.1	0.8	-1.0
Ever highly irritable/argumentative for 2 days	0.7	0.8	1.2	-0.6	-1.1
Suffer from ‘nerves’	0.7	1.1	1.6	-1.3	-0.8
Leg pain on walking	0.7	0.8	1.2	-0.7	-1.1
Medication: Blood pressure	0.7	1.3	2.3	1.5	0.6
Medication: Lisinopril	0.7	0.9	1.0	0.9	1.0
Irritability	0.7	1.2	1.9	-0.7	-1.4
Alzheimer’s Disease (including proxy)	0.6	0.9	1.5	-1.2	-0.5
Cardiovascular Disease	0.6	1.9	2.3	1.3	-1.5
Medication: Metformin	0.6	0.9	1.1	0.8	-1.1
Worrier / anxious feelings	0.6	1.2	2.4	-1.5	0.0
Pulse wave Arterial Stiffness index	0.6	0.8	1.0	0.7	-1.0
Commuting to job workplace: Car/motor vehicle	0.6	0.7	1.3	-0.0	1.2
Number of self-reported non-cancer illnesses	0.6	1.1	1.5	0.8	-1.2
Supplements: Fish oil (including cod liver oil)	0.6	0.8	1.1	-0.7	-1.1
Unable to work because of sickness or disability	0.6	0.8	0.9	-0.8	-1.0
Irritable Bowel Disease (IBD)	0.5	1.3	2.5	1.6	-0.2
Neuroticism (2016)	0.5	0.8	1.5	-0.2	-1.2
Taking other prescription medications	0.5	0.8	1.6	1.3	0.2
Diabetes (self-reported)	0.5	0.8	1.5	1.2	0.2
Medication: Simvastatin	0.5	0.7	1.0	1.0	-0.6
Father’s age at death	0.5	0.6	1.2	1.1	0.1
Falls in the last year	0.5	0.7	1.3	-1.2	0.1
Mouth/teeth dental problems: Dentures	0.5	0.9	1.8	0.0	-1.3
Exposure to tobacco smoke at home	0.5	0.6	1.2	1.1	-0.0
Seen doctor (GP) for nerves, anxiety, tension or depression	0.5	0.7	1.1	0.6	1.0
Hypothyroidism/myxoedema (self-reported)	0.5	0.9	1.1	1.1	-0.8
Mean time to correctly identify matches	0.5	0.9	1.8	1.3	0.2
Overall health rating	0.5	1.2	1.3	-1.2	-1.0
Medication: Aspirin	0.5	0.7	1.2	-0.4	1.1
Loneliness, isolation	0.5	0.7	1.3	-1.1	-0.1
Breast cancer (self-reported)	0.5	0.6	0.7	0.8	0.7
Ever taken oral contraceptive pill	0.5	0.6	1.1	-0.1	1.1
Ever had prostate specific antigen (PSA) test	0.5	0.6	1.0	0.3	1.0
Commuting to job workplace: Cycle	0.5	0.6	1.0	1.0	0.3
Worry (Nagel 2018)	0.4	0.9	1.5	-1.2	-0.4
Verbal and Numeric Reasoning (VNR)	0.4	1.0	2.0	0.1	1.4
Breast Cancer	0.4	1.0	1.8	1.4	-0.3
Ovarian Cancer	0.4	0.6	1.0	1.0	0.4
Prostate Cancer	0.4	0.6	0.9	0.9	-0.5
Ever had hysterectomy (womb removed)	0.4	0.4	0.7	-0.9	-0.4
Angina	0.4	0.6	1.1	-1.1	0.1
Vitamin and mineral supplements	0.4	0.5	1.0	1.0	0.2
Fed-up feelings	0.4	0.8	0.9	0.8	-1.0
High blood pressure	0.4	1.2	2.4	1.6	-0.0
Hayfever, allergic rhinitis or eczema	0.4	1.0	1.1	-1.0	-0.9
Allergy	0.4	1.0	2.0	0.1	1.4
Illnesses of mother	0.4	0.5	0.6	-0.6	-0.8
Mouth/teeth dental problems: Bleeding gums	0.4	0.5	0.6	0.7	0.8
Wheeze or whistling in the chest in last year	0.4	0.8	1.3	0.6	-1.1
Number of children fathered	0.4	0.4	0.4	-0.7	-0.6
Medication for pain relief, constipation, heartburn	0.4	0.7	1.4	1.2	-0.1
Angina (self-reported)	0.4	0.5	1.0	-1.0	-0.1
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.4	0.4	0.8	-0.9	0.4
Hypertension (Self-reported)	0.4	1.1	2.1	1.5	0.2
Friendships satisfaction	0.4	0.5	1.0	0.1	1.0
Mouth/teeth dental problems: Mouth ulcers	0.4	0.7	1.4	1.2	0.1
Pain type(s) experienced in last month: Hip pain	0.4	0.5	1.1	1.0	0.1
Ever depressed for a whole week	0.4	0.5	0.7	-0.6	0.8
Deep venous thrombosis (DVT) (self-reported)	0.4	0.6	0.7	0.6	0.9
Schizophrenia (2018)	0.3	0.6	1.1	0.3	1.0
Schizophrenia vs Biploar Disorder	0.3	0.4	0.6	0.8	0.4
Blood Red Count	0.3	2.7	5.4	-2.3	-0.2
Respiratory disease	0.3	0.7	1.3	-0.2	-1.1
Neuroticism	0.3	0.7	1.2	-1.1	-0.4
Number of treatments/medications taken	0.3	0.5	0.7	0.6	-0.8
Sensitivity / hurt feelings	0.3	0.5	0.8	-0.9	-0.4
Hearing difficulty/problems: Yes	0.3	0.5	0.7	0.9	-0.5
Relative age of first facial hair	0.3	0.6	1.1	-0.4	1.1
Nervous feelings	0.3	0.6	1.0	-1.0	-0.5
Serious illness, injury or assault of a close relative in last 2 years	0.3	0.4	0.4	0.6	0.7
Prospective memory result	0.3	0.4	0.4	-0.6	-0.6
Blood clot in the leg (DVT)	0.3	0.3	0.3	0.6	0.6
Medication for cholesterol, blood pressure or diabetes	0.3	0.6	0.8	-0.9	0.6
Medication: Ventolin 100micrograms inhaler	0.3	0.4	0.6	0.3	-0.8
Exposure to tobacco smoke outside home	0.3	0.4	0.8	0.3	0.9
Comparative body size at age 10	0.3	0.7	1.5	1.2	0.1
Worry too long after embarrassment	0.3	0.6	1.1	-1.1	-0.2
Shortness of breath walking on level ground	0.3	0.4	0.7	-0.8	-0.0
Medication: Omeprazole	0.3	0.3	0.6	0.8	0.0
Pulse rate, automated reading	0.3	0.8	1.7	0.1	1.3
Knee pain experienced in last month	0.3	0.5	0.9	0.0	1.0
Medication for cholesterol	0.3	0.5	0.8	-0.4	0.9
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.3	0.7	1.4	-0.3	-1.2
Medication: Bendroflumethiazide	0.3	0.4	0.4	0.6	0.6
Alcohol drinker status: Never	0.3	0.3	0.7	0.8	0.1
Heart disease (siblings)	0.3	0.4	0.6	-0.8	-0.4
Impedance of whole body	0.3	1.7	1.9	-1.2	1.4
Depressed Affect (Nagel 2018)	0.2	0.3	0.4	-0.6	-0.5
Neuroticism (Nagel 2018)	0.2	0.5	0.9	-0.9	-0.3
Ulcerative Colitis (UC)	0.2	0.4	0.7	0.8	-0.1
Ulcerative Colitis	0.2	0.3	0.7	0.8	-0.0
Allergy or Eczema	0.2	0.4	0.5	-0.6	0.7
Hypothyroidism (self reported)	0.2	0.5	0.6	0.6	-0.8
Lung FVC	0.2	1.1	1.4	0.9	-1.2
Townsend deprivation index at recruitment	0.2	0.4	0.4	-0.6	0.6
Medication: Atenolol	0.2	0.2	0.4	0.6	0.0
Medication: Levothyroxine sodium	0.2	0.3	0.4	0.6	-0.4
Ever unenthusiastic/disinterested for a whole week	0.2	0.2	0.4	-0.2	0.7
Medication: Ramipril	0.2	0.3	0.6	-0.8	0.1
Time employed in main current job	0.2	0.2	0.5	-0.1	-0.7
Lung cancer (father)	0.2	0.2	0.4	-0.2	-0.6
Qualifications: O levels/GCSEs or equivalent	0.2	0.4	0.7	0.9	-0.2
High blood pressure (siblings)	0.2	0.2	0.3	0.5	0.5
Number of full brothers	0.2	0.2	0.4	-0.7	-0.2
Age at first live birth	0.2	0.4	0.8	-0.0	-0.9
Pulse wave peak to peak time	0.2	0.2	0.3	-0.5	0.5
Eye problems/disorders: None of the above	0.2	0.3	0.6	0.8	0.1
Neck or shoulder pain in last month	0.2	0.3	0.6	0.8	-0.3
Age at last live birth	0.2	0.3	0.5	0.0	-0.7
Average weekly red wine intake	0.2	0.3	0.6	0.0	-0.8
Eye problems/disorders: Cataract	0.2	0.2	0.3	-0.3	0.5
Mineral and other dietary supplements	0.2	0.2	0.3	-0.3	-0.6
Illnesses of father: None of the above (group 1)	0.2	0.3	0.6	-0.8	0.0
Average weekly champagne plus white wine intake	0.2	0.3	0.4	-0.5	0.6
Hearing aid user	0.2	0.2	0.2	0.4	-0.5
Ever smoked	0.2	0.3	0.6	-0.7	0.2
Number of operations (self-reported)	0.2	0.3	0.4	0.5	-0.6
Myopia	0.2	0.3	0.3	0.6	-0.5
Vascular/heart problems diagnosed by doctor	0.2	0.4	0.5	-0.7	-0.6
Bipolar Disorder or Schizophrenia	0.1	0.3	0.6	-0.8	0.0
HDL Cholesterol	0.1	0.1	0.1	0.3	-0.3
Primary Biliary Cirrhosis	0.1	0.1	0.2	0.2	0.5
Rheumatoid Arthritis	0.1	0.1	0.2	-0.5	0.1
Systolic Blood Pressure	0.1	0.5	0.8	0.5	-0.9
Hair Pigment	0.1	2.3	3.2	-1.2	1.8
Tanning	0.1	1.8	3.5	-1.9	-0.2
Ever used hormone-replacement therapy (HRT)	0.1	0.1	0.2	-0.0	-0.5
Eye problems/disorders: Diabetes related eye disease	0.1	0.1	0.1	-0.2	-0.4
Supplements: Zinc	0.1	0.1	0.2	0.5	0.2
Maternal smoking around birth	0.1	0.2	0.4	-0.0	0.6
Bilateral oophorectomy (both ovaries removed)	0.1	0.1	0.2	-0.2	-0.4
Past tobacco smoking	0.1	0.1	0.2	0.2	-0.5
Had other major operations	0.1	0.2	0.2	-0.3	0.5
Impedance of arm (right)	0.1	0.6	1.0	1.0	0.5
Alcohol intake versus 10 years previously	0.1	0.2	0.4	0.2	0.6
Noisy workplace	0.1	0.1	0.2	-0.4	-0.2
Medication: Lansoprazole	0.1	0.1	0.2	-0.2	-0.4
Hair/balding pattern: Pattern 4	0.1	0.3	0.6	0.2	-0.8
Chronic bronchitis/emphysema (mother)	0.1	0.1	0.2	0.4	-0.1
Heart disease (mother)	0.1	0.1	0.2	0.0	0.5
Illness, injury, bereavement, stress in last 2 years	0.1	0.2	0.2	-0.5	-0.3
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.1	0.1	0.1	0.4	0.2
Smoking status: Previous	0.1	0.1	0.1	0.4	0.3
Medication: Gliclazide	0.1	0.2	0.3	0.6	-0.1
Miserableness	0.1	0.1	0.2	-0.4	-0.1
Eye problems/disorders: Glaucoma	0.1	0.1	0.2	-0.4	-0.2
Risk taking	0.1	0.1	0.2	0.1	-0.5
Diastolic blood pressure, automated reading	0.1	0.4	0.7	-0.9	0.2
Pain experienced in last month	0.1	0.2	0.2	-0.4	-0.5
Supplements: Calcium	0.1	0.1	0.2	-0.5	0.0
Mean Putamen Volume	0.0	0.0	0.0	-0.0	-0.0
Schizophrenia (2014)	0.0	0.1	0.1	0.0	0.3
Frequency of depressed mood in last 2 weeks	0.0	0.1	0.1	-0.3	0.0
Systolic blood pressure, automated reading	0.0	0.0	0.1	-0.1	0.3
Multivitamins +/- minerals	0.0	0.0	0.0	-0.2	-0.2
High blood pressure (mother)	0.0	0.0	0.1	-0.3	-0.1
Number of incorrect matches in round	0.0	0.0	0.1	-0.1	0.3
Hearing difficulty/problems with background noise	0.0	0.1	0.1	-0.3	-0.2
Impedance of arm (left)	0.0	0.2	0.2	0.4	0.5
Medication: Paracetamol	0.0	0.0	0.1	0.3	-0.2
Number of full sisters	0.0	0.1	0.1	-0.0	0.3
Mood swings	0.0	0.0	0.1	0.3	0.0
Tinnitus: Yes, now most or all of the time	0.0	0.0	0.0	0.0	-0.2
High cholesterol (Self-reported)	0.0	0.0	0.0	-0.1	-0.0
Medication: Paracetamol	0.0	0.0	0.0	-0.2	0.1
Cholesterol lowering medication	0.0	0.0	0.0	-0.1	0.2

Hub : Genes

RGP1

Models

Trait associations