Hub : Genes

SPAG8

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Adipose Subcutaneous	0.1290	0.0380	7.0e-06	0.044	NA	0.062	NA	0.055	1.5e-04	NA	8.7e-06	NA	2.6e-05
2	GTEx	Artery Aorta	0.1140	0.0410	7.9e-04	0.097	NA	0.029	NA	0.064	5.2e-06	NA	9.8e-03	NA	2.0e-04
3	GTEx	Brain Cerebellum	0.1870	0.0720	3.4e-03	0.110	NA	0.053	NA	0.114	3.9e-04	NA	1.2e-02	NA	3.0e-04
4	GTEx	Nerve Tibial	0.1328	0.0416	4.4e-05	0.087	NA	0.069	NA	0.075	9.1e-07	NA	1.3e-05	NA	5.2e-06
5	GTEx	Thyroid	0.1550	0.0450	4.6e-05	0.001	NA	0.025	NA	0.011	2.7e-01	NA	5.0e-03	NA	4.4e-02
6	YFS	Blood	0.0381	0.0122	1.1e-05	0.029	0.016	0.019	0.02	0.024	6.6e-10	3.1e-06	4.9e-07	2.9e-07	2.6e-08
7	TCGA	Bladder Urothelial Carcinoma	0.0400	0.0270	6.3e-03	0.011	0.009	0.002	NA	0.004	3.8e-02	5.3e-02	2.0e-01	NA	1.3e-01
8	TCGA	Breast Invasive Carcinoma	0.0560	0.0291	2.0e-05	0.023	0.025	0.023	NA	0.024	1.4e-05	6.7e-06	1.4e-05	NA	8.1e-06
9	TCGA	Kidney Renal Clear Cell Carcinoma	0.0663	0.0292	9.3e-06	0.060	0.041	0.055	NA	0.057	2.5e-07	2.1e-05	7.7e-07	NA	5.5e-07
10	TCGA	Thyroid Carcinoma	0.0790	0.0390	2.5e-04	0.017	0.014	0.017	NA	0.021	7.5e-03	1.4e-02	7.9e-03	NA	3.5e-03
11	TCGA	Uterine Corpus Endometrial Carcinoma	0.1820	0.1080	4.0e-03	0.071	0.091	0.077	NA	0.072	4.9e-03	1.7e-03	3.6e-03	NA	4.8e-03

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7	8	9	10	11
Bipolar Disorder (2018)	1.2	2.0	5.3	-1.1	1.2	-0.5	-1.2	0.2	-1.4	1.7	1.6	1.5	1.5	2.3
Bipolar Disorder or Schizophrenia	1.2	2.9	5.0	-1.7	1.1	-1.0	-2.0	-0.5	-1.9	2.2	1.3	2.1	2.1	2.0
Depressed Affect (Nagel 2018)	0.5	1.1	2.6	-0.0	0.9	0.1	-0.8	-1.3	-1.1	0.8	1.6	1.2	1.1	1.3
Depression (Nagel 2018)	1.6	2.4	5.8	-0.6	2.0	0.4	-0.9	-1.5	-1.4	1.6	1.8	1.6	1.4	2.4
Intelligence (Savage-Jansen 2018)	1.5	4.7	10.3	3.2	2.3	3.1	2.8	2.6	1.8	-1.5	0.3	-1.6	-1.9	0.9
Neuroticism (Nagel 2018)	0.7	1.7	5.5	1.1	2.0	0.3	-0.1	-0.9	-0.8	0.8	1.8	1.1	0.9	2.3
Schizophrenia (2018)	0.7	1.4	2.5	-1.5	0.4	-0.9	-1.6	-0.8	-1.4	1.5	0.4	1.5	1.4	0.8
Schizophrenia vs Biploar Disorder	1.6	2.1	4.2	0.8	-0.0	0.7	1.6	0.8	2.0	-0.9	-1.8	-2.0	-2.0	-1.4
Worry (Nagel 2018)	0.8	1.6	6.4	1.5	2.1	0.5	0.2	-0.6	-0.5	0.8	1.6	0.8	0.6	2.5
Alzheimer’s Disease (in mother)	1.0	1.2	5.4	-0.4	2.3	0.6	-0.2	-0.2	-0.2	1.8	-0.5	0.2	0.3	1.8
Alzheimer’s Disease (in father)	0.8	0.9	2.9	-0.5	-1.7	-0.2	-0.3	-1.1	-0.5	-1.5	1.2	0.6	0.6	-0.8
Alzheimer’s Disease (including proxy)	0.5	0.7	1.9	-0.5	0.9	0.4	-0.4	-1.1	-0.6	1.0	0.7	0.7	0.7	1.4
Crohns Disease (2017)	0.9	1.9	5.8	0.6	-1.2	0.7	1.0	-0.6	1.3	-2.0	-1.4	-1.6	-1.5	-2.4
Irritable Bowel Disease (IBD)	0.7	1.7	3.5	0.7	-0.8	0.5	1.0	-0.8	1.3	-1.7	-1.5	-1.6	-1.5	-1.9
Ulcerative Colitis (UC)	0.7	1.3	3.4	0.7	-0.5	0.1	0.8	-0.7	1.2	-1.2	-1.8	-1.5	-1.3	-1.6
Major Depression (MDD)	0.3	0.3	1.1	-0.1	-0.6	-0.3	0.2	0.7	0.3	-0.9	-0.2	-0.4	-0.5	-1.0
Reaction Time	0.4	0.8	2.1	0.9	-1.0	0.2	0.8	1.0	0.9	-1.4	-0.6	-0.9	-0.8	-0.8
Verbal and Numeric Reasoning (VNR)	1.1	2.6	6.9	2.1	2.4	2.1	1.4	2.6	0.7	0.4	0.6	-0.4	-0.7	1.9
Breast Cancer	0.3	0.7	2.4	0.3	-1.3	-0.6	0.3	-0.0	0.4	-1.5	-0.4	-0.4	-0.4	-1.6
Ovarian Cancer	0.3	0.4	1.3	0.0	-0.9	-1.1	-0.6	-0.0	-0.2	0.2	-1.2	-0.1	0.2	-0.7
Prostate Cancer	0.3	0.4	1.4	0.4	-0.5	0.7	0.6	1.2	0.5	-0.9	0.0	-0.4	-0.5	-0.5
Age at First Birth	2.6	3.8	9.2	-0.6	1.4	-0.3	-1.4	-0.9	-2.2	1.9	2.5	2.5	2.4	3.0
Bipolar Disorder (2011)	0.3	0.3	1.7	-1.3	0.4	-0.3	-0.2	-0.6	-0.3	-0.3	0.7	0.6	0.4	0.5
Body Mass Index (BMI) (2010)	0.8	1.1	4.5	-0.8	-2.1	-1.1	-0.6	-0.4	-0.3	-1.3	0.0	0.3	0.3	-2.0
Coronary Artery Disease (CAD)	1.0	1.2	4.2	0.2	2.1	0.3	0.5	1.4	0.9	1.3	-1.2	-0.9	-0.8	1.0
Crohns Disease (2012)	0.9	1.5	5.0	0.2	-1.3	0.1	0.7	-0.2	1.4	-1.6	-1.2	-1.2	-1.3	-2.2
Mean Putamen Volume	0.2	0.2	0.6	-0.2	-0.8	-0.3	-0.6	-0.5	-0.4	0.1	-0.3	0.3	0.5	-0.8
Fasting Glucose	2.1	2.5	4.4	0.8	-0.9	-0.2	1.4	1.2	2.0	-2.0	-1.5	-2.0	-2.0	-2.1
HbA1C	0.8	0.8	2.8	0.1	1.1	-0.7	-0.5	1.3	0.0	1.7	-0.1	0.1	-0.0	1.6
HDL Cholesterol	0.1	0.1	0.6	0.8	0.1	0.1	0.2	0.3	-0.2	-0.8	0.1	0.2	0.2	-0.1
LDL Cholesterol	0.9	1.4	4.4	0.2	1.5	1.4	0.3	-0.4	-0.2	1.4	1.9	0.4	0.1	2.1
Lupus	0.8	1.2	3.9	0.3	2.0	1.3	0.6	0.9	0.2	1.6	0.5	-0.2	-0.2	1.8
Neuroticism (2016)	0.3	0.5	1.3	1.1	0.8	-0.8	0.4	0.7	0.6	0.3	-0.8	-0.5	-0.4	0.6
Primary Biliary Cirrhosis	2.2	3.2	7.3	2.7	1.3	2.0	2.1	2.4	2.0	-0.6	-0.2	-1.8	-2.0	0.6
Rheumatoid Arthritis	0.9	1.2	4.8	-0.6	-0.5	-0.3	-0.8	-1.5	-1.2	-0.3	2.2	1.4	1.2	0.2
Schizophrenia (2014)	0.2	0.4	1.3	-0.8	0.7	-0.5	-0.7	0.1	-0.3	1.1	-0.2	0.5	0.5	0.5
Triglycerides	2.2	3.7	8.0	-2.2	-0.5	-1.1	-2.1	-2.8	-2.1	2.6	1.6	2.0	2.0	0.7
Type 2 Diabetes (T2D) (2012)	1.5	1.8	3.7	-1.9	-1.9	0.1	-1.2	-1.7	-1.1	-1.4	0.9	1.2	1.2	-1.1
Ulcerative Colitis	0.9	1.3	2.2	1.4	0.2	0.9	1.4	0.1	1.5	-1.2	-1.1	-1.4	-1.4	-0.6
Blood Eosinophil Count	0.3	2.6	10.6	0.1	-2.7	-0.2	0.5	-0.6	0.8	-2.8	-0.7	-0.8	-0.9	-3.3
Blood Platelet Count	0.9	10.7	40.6	-1.4	-5.7	-1.6	-0.1	-2.9	0.4	-5.6	-0.8	-0.3	-0.4	-6.4
Blood Red Count	0.2	1.6	4.9	-1.9	-0.7	-2.2	-1.4	-1.3	-0.8	1.3	-0.7	0.7	0.9	-0.8
Blood White Count	1.8	13.3	47.3	-2.1	-6.8	-3.6	-1.1	-3.4	0.0	-4.5	-1.2	-0.2	-0.0	-6.9
Heel T-Score	1.3	10.5	33.8	1.9	5.8	5.1	2.4	1.7	1.4	3.0	0.6	-1.2	-1.3	5.4
BMI	0.8	4.8	20.6	-0.7	-3.6	-1.4	0.2	-1.2	0.9	-3.0	-1.9	-1.1	-0.8	-4.5
Height	3.0	58.0	89.7	-8.2	-8.5	-8.6	-9.5	-7.2	-9.1	1.5	6.5	8.9	8.8	-0.5
Waist Hip Ratio (WHR)	0.9	4.1	14.4	1.2	3.3	2.2	0.4	1.4	0.0	3.3	1.0	0.0	-0.1	3.8
Systolic Blood Pressure	0.4	1.8	5.0	1.2	1.8	2.2	1.5	-0.1	0.6	-0.8	1.1	-0.4	-0.5	2.2
Smoking Status	0.7	1.7	2.7	1.1	1.5	-0.5	1.1	1.0	1.6	1.4	-1.6	-1.6	-1.5	0.6
Allergy or Eczema	0.3	0.9	3.6	-0.4	1.3	1.1	0.2	-0.7	-0.5	0.8	1.2	0.6	0.5	1.9
Cardiovascular Disease	0.5	1.6	4.6	1.7	1.3	2.1	1.4	0.3	0.9	-0.5	0.8	-0.8	-0.8	1.9
Hypothyroidism (self reported)	0.1	0.3	1.4	-0.6	-1.2	-0.6	-0.4	-0.4	-0.3	-0.6	-0.1	0.2	0.3	-0.7
Respiratory disease	0.2	0.4	2.3	-1.2	-0.1	-0.7	-0.1	-1.5	-0.1	0.1	-0.3	-0.1	0.0	0.0
Type 2 Diabetes (T2D) (2018)	0.4	0.8	2.9	0.1	-1.5	0.1	0.4	-0.4	0.5	-1.5	-0.3	-0.4	-0.4	-1.7
Lung FEV1/FVC ratio	0.8	4.2	12.8	-2.0	1.7	-1.4	-1.8	-1.3	-1.9	3.6	1.1	1.9	2.0	2.7
Lung FVC	0.3	1.4	3.3	0.8	-0.5	0.6	0.9	1.8	1.4	-1.2	-1.3	-1.4	-1.3	-1.1
Neuroticism	0.6	1.5	6.0	1.3	2.0	0.5	0.1	-0.4	-0.6	0.7	1.7	0.9	0.7	2.5
Chronotype (morning person)	0.9	2.1	7.8	-2.2	-1.1	-2.8	-1.4	-0.7	-0.5	1.4	-1.6	0.2	0.4	-1.3
Hair Pigment	0.0	0.5	2.3	0.0	1.0	0.9	-0.2	0.6	0.2	1.5	-0.3	-0.3	-0.2	0.6
Tanning	0.1	1.4	2.4	0.9	1.4	0.2	1.2	0.3	1.5	1.1	-1.5	-1.6	-1.4	0.7
Hand grip strength (left)	1.3	3.5	11.8	-1.3	0.9	-1.1	-1.9	-0.1	-1.9	3.4	1.0	1.8	1.9	2.8
Number of treatments/medications taken	0.2	0.3	0.9	0.2	0.9	0.8	0.4	-0.4	0.2	-0.4	-0.4	-0.2	-0.2	0.8
Average weekly spirits intake	0.3	0.4	3.2	0.0	0.4	1.8	0.4	-0.1	0.1	-0.2	0.7	0.1	-0.1	0.5
Sensitivity / hurt feelings	2.6	4.4	8.7	-0.9	1.1	-0.7	-1.9	-2.1	-2.5	1.5	3.0	2.8	2.6	2.5
Frequency of depressed mood in last 2 weeks	1.1	1.5	6.2	1.1	2.5	1.7	0.7	-0.7	0.2	0.7	0.7	-0.0	-0.1	2.1
Hearing difficulty/problems: Yes	0.9	1.4	5.0	-0.6	-1.6	-0.5	0.2	-1.2	0.8	-1.0	-1.4	-1.0	-0.8	-2.2
Relative age of first facial hair	1.0	2.1	6.9	1.0	2.6	1.7	0.9	1.9	0.9	1.3	-1.2	-1.1	-1.0	1.3
Other serious medical condition/disability diagnosed by doctor	0.4	0.5	1.9	-0.7	-0.7	-0.3	-0.0	-1.4	-0.3	-1.3	0.4	0.3	0.3	-0.5
Ever used hormone-replacement therapy (HRT)	0.2	0.3	1.1	-1.1	-0.7	-0.1	-0.6	0.2	-0.3	-0.4	0.1	0.3	0.3	-0.7
Ever had hysterectomy (womb removed)	0.5	0.6	1.1	-0.3	0.4	-0.7	-0.4	-0.9	-0.9	-0.1	1.0	1.1	1.1	0.8
Systolic blood pressure, automated reading	0.1	0.4	1.0	0.4	0.5	1.0	1.0	0.1	0.7	-0.6	-0.3	-0.7	-0.7	0.3
Eye problems/disorders: Diabetes related eye disease	0.2	0.2	0.7	-0.2	0.6	-0.7	-0.2	-0.2	-0.3	0.8	-0.1	0.3	0.2	0.7
Angina	0.8	1.0	3.7	0.4	1.9	0.8	0.1	0.6	0.1	1.5	-0.0	-0.1	-0.0	1.9
Medication for hormone replacement therapy	0.4	0.4	1.6	-0.9	-0.1	-1.3	-0.8	-0.4	-0.6	0.0	-0.4	0.7	0.7	-0.2
Vitamin and mineral supplements	1.1	1.5	2.6	0.9	0.3	1.4	1.2	0.9	1.6	-0.7	-1.5	-1.6	-1.6	-1.0
Supplements: Zinc	0.6	0.6	1.6	0.5	0.7	0.9	1.2	1.0	0.8	-0.7	0.1	-0.7	-1.0	0.3
Medication: Co-codamol	0.6	0.7	3.4	-0.3	-1.8	-1.0	-0.3	0.3	-0.1	-0.7	0.1	0.0	0.0	-1.6
Medication: Metformin	3.3	4.7	13.6	-1.7	-3.4	-3.7	-1.9	-1.8	-1.7	-1.3	1.0	1.7	1.7	-2.2
Diabetes (father)	0.5	0.6	1.2	-0.4	-0.4	0.9	-0.7	-0.6	-1.0	0.1	1.1	1.1	1.0	0.3
Diabetes (mother)	1.5	2.0	4.5	1.3	-0.5	0.8	1.2	1.1	1.4	-1.8	-1.6	-1.4	-1.4	-2.1
Severe depression (siblings)	0.2	0.3	0.7	-0.8	-0.1	-0.8	-0.6	-0.7	-0.2	0.8	0.1	0.3	0.2	0.3
Pack years adult smoking proportion	0.8	1.2	4.0	-1.0	-0.6	-1.5	-1.7	-0.2	-1.0	2.0	-0.0	0.9	1.2	-0.0
Impedance of leg (right)	0.6	2.9	8.5	1.3	2.6	2.9	1.4	0.7	0.6	1.1	1.7	-0.3	-0.6	2.9
Leg fat-free mass (left)	3.1	16.2	34.0	-4.3	-5.8	-5.0	-4.6	-4.8	-4.1	-0.9	1.6	3.7	4.0	-2.7
Trunk fat percentage	0.8	3.3	12.2	-1.3	-3.5	-0.9	-0.7	-2.2	-0.2	-1.9	-0.8	0.0	0.2	-3.4
Hand grip strength (right)	1.4	3.9	11.2	-1.2	1.5	-0.5	-1.7	-0.1	-2.0	3.3	1.5	1.9	2.0	3.3
Townsend deprivation index at recruitment	0.6	0.8	3.5	-0.0	1.1	0.5	0.1	-0.2	0.6	1.4	-1.9	-0.9	-0.6	0.3
Current tobacco smoking	0.4	0.7	2.9	-0.7	0.7	-1.6	-0.5	-0.0	0.1	1.7	-0.6	-0.1	0.0	0.6
Average weekly fortified wine intake	0.4	0.5	1.1	0.9	1.0	1.1	0.9	0.2	0.5	-0.2	0.2	-0.4	-0.5	1.0
Maternal smoking around birth	0.3	0.5	1.1	0.6	-0.6	-0.5	0.3	0.7	0.6	-0.2	-1.1	-0.9	-0.8	-1.0
Fed-up feelings	0.3	0.5	1.6	1.3	1.1	0.7	0.6	-0.5	0.2	-0.3	0.6	0.0	-0.2	0.8
Frequency of unenthusiasm / disinterest in last 2 weeks	0.7	1.0	5.3	1.0	2.3	0.6	0.6	0.2	0.5	1.2	-0.6	-0.5	-0.5	1.1
Relative age voice broke	0.8	1.3	2.4	1.3	0.6	1.5	1.4	0.8	1.2	-1.2	-0.7	-1.2	-1.3	-0.7
Taking other prescription medications	0.1	0.2	1.4	-0.3	-0.6	0.0	0.1	-0.5	-0.1	-1.2	0.1	0.1	0.1	-0.4
Age when periods started (menarche)	0.8	1.9	4.1	2.0	0.1	1.2	1.7	1.1	1.6	-1.4	-0.8	-1.6	-1.7	-0.9
Bilateral oophorectomy (both ovaries removed)	0.3	0.4	1.7	-1.0	-0.3	-1.3	-0.6	-0.6	-0.3	0.1	-0.3	0.3	0.3	-0.5
Heel bone mineral density (BMD) T-score, automated (left)	1.3	3.0	12.0	-0.8	2.2	1.3	-0.5	0.2	-0.5	3.5	0.4	0.6	0.6	3.4
Tinnitus: Yes, but not now, but have in the past	0.2	0.2	0.6	-0.0	-0.3	0.8	-0.3	-0.4	-0.5	-0.5	-0.1	0.4	0.5	-0.2
Qualifications: CSEs or equivalent	1.4	1.9	5.2	-1.3	-2.3	-1.7	-1.2	-0.8	-1.3	-1.5	0.5	1.1	1.2	-1.4
Serious illness, injury or assault to yourself	1.4	1.7	6.2	1.1	2.2	2.5	1.0	1.0	0.7	0.7	0.5	-0.4	-0.6	1.7
High blood pressure	1.0	2.9	5.6	2.2	0.9	2.1	2.4	1.0	2.1	-1.7	-0.6	-2.0	-2.0	0.2
Hayfever, allergic rhinitis or eczema	0.4	0.8	3.8	-0.2	1.4	0.3	-0.1	-0.5	-0.7	0.7	1.0	0.8	0.7	1.9
Multivitamins +/- minerals	0.8	1.1	1.9	-0.9	-0.2	-0.8	-0.9	-1.2	-1.4	0.1	1.2	1.4	1.4	0.8
Stomach or abdominal pain in last month	0.9	1.2	5.2	-0.3	-1.3	0.7	0.7	-1.8	0.4	-2.3	0.6	-0.2	-0.3	-1.0
Supplements: Glucosamine	1.1	1.5	2.8	1.1	0.4	1.6	1.6	1.7	1.2	-1.6	-0.1	-1.1	-1.2	-0.5
Diverticular disease/diverticulitis (self-reported)	1.1	1.3	3.1	-1.8	-1.6	-1.2	-1.3	-1.4	-0.6	0.0	-0.7	0.5	0.7	-1.5
Medication: Atenolol	2.2	2.8	5.4	1.6	0.6	1.6	2.0	1.2	2.1	-1.1	-2.0	-2.3	-2.1	-0.7
Medication: Levothyroxine sodium	0.5	0.9	2.1	-1.2	-1.4	-1.0	-1.1	-0.5	-1.0	-0.3	0.2	0.9	0.9	-1.0
Sitting height	1.5	10.9	20.0	-3.0	-4.5	-3.9	-3.9	-3.0	-3.9	-0.7	2.7	3.7	3.7	-0.9
Chronic bronchitis/emphysema (father)	0.3	0.3	1.3	-0.3	-0.6	0.2	-0.2	-0.1	0.1	-0.5	-1.1	-0.3	-0.1	-1.1
High blood pressure (mother)	0.0	0.1	0.1	0.1	0.2	-0.2	-0.1	-0.2	-0.3	-0.0	0.4	0.3	0.3	0.3
Body mass index (BMI)	0.7	3.0	12.6	-0.6	-2.7	-0.7	0.2	-0.9	0.9	-2.1	-2.0	-1.1	-0.9	-3.5
Impedance of leg (left)	0.8	3.9	10.5	1.5	3.2	3.0	1.4	1.4	0.8	2.0	0.9	-0.6	-0.8	3.2
Leg predicted mass (left)	3.1	16.3	33.5	-4.3	-5.8	-5.0	-4.6	-4.8	-4.1	-0.9	1.7	3.8	4.0	-2.6
Trunk fat mass	1.3	5.7	21.7	-2.1	-4.7	-2.0	-1.7	-2.9	-1.1	-2.1	-0.2	0.9	1.1	-3.7
Waist circumference	0.7	2.7	11.2	-1.5	-3.4	-1.3	-1.3	-2.1	-0.8	-1.0	-0.4	0.5	0.7	-2.5
Number of incorrect matches in round	0.3	0.5	1.7	-0.2	-0.8	-1.0	-0.3	0.9	0.2	-0.2	-0.8	-0.2	-0.1	-1.3
Past tobacco smoking	3.1	5.7	10.1	-2.6	-2.6	-2.2	-3.2	-1.2	-3.1	0.7	1.9	3.0	3.1	-0.7
Alcohol usually taken with meals	2.6	4.2	11.7	2.1	-0.5	1.9	2.4	1.5	2.2	-3.4	-1.0	-2.1	-2.2	-1.8
Nervous feelings	0.7	1.3	5.2	1.8	1.8	0.4	0.3	0.0	-0.3	0.4	1.3	0.5	0.4	2.3
Frequency of tenseness / restlessness in last 2 weeks	0.3	0.5	2.9	-0.1	1.7	0.2	0.0	-0.4	0.2	1.1	-0.2	-0.0	-0.1	1.1
Hearing difficulty/problems with background noise	0.2	0.3	1.7	-0.4	-0.2	-0.4	-0.0	-0.6	0.3	0.1	-1.3	-0.6	-0.4	-0.5
Hair/balding pattern: Pattern 2	1.9	2.5	7.3	2.1	2.2	2.7	2.0	1.2	1.2	-0.5	0.1	-1.1	-1.2	1.1
Had menopause	0.4	0.5	2.0	-0.4	-0.1	1.4	0.3	-0.0	0.0	-1.4	0.7	0.2	0.1	-0.6
Had other major operations	0.7	0.9	2.7	0.0	1.6	1.3	0.9	-0.5	0.1	-0.1	1.1	0.1	-0.2	1.6
Forced vital capacity (FVC)	1.9	7.3	12.2	-2.4	-2.6	-2.4	-3.3	-2.4	-3.5	0.8	3.0	3.3	3.4	0.9
Heel bone mineral density (BMD) T-score, automated (right)	0.8	1.8	7.6	-0.9	1.6	1.0	-0.6	-0.3	-0.6	2.8	0.5	0.6	0.7	2.5
Ever unenthusiastic/disinterested for a whole week	1.2	1.4	4.2	0.3	1.0	1.3	0.9	1.4	1.4	0.5	-2.0	-1.4	-1.3	-0.4
Qualifications: None of the above	1.5	3.2	8.4	-1.7	-0.7	-2.1	-2.7	-1.6	-1.8	2.9	0.2	1.7	1.7	0.2
Financial difficulties in last 2 years	0.2	0.3	1.7	-0.0	-0.4	-0.0	0.9	-0.2	0.7	-1.3	0.3	-0.4	-0.5	-0.1
Mouth/teeth dental problems	0.8	1.2	4.9	1.4	1.5	0.5	0.7	2.2	0.5	1.2	0.1	-0.4	-0.4	1.4
Heart attack	2.0	2.5	6.4	2.0	2.5	1.1	1.2	1.6	1.1	1.4	-0.4	-1.1	-1.0	2.5
Allergy	0.1	0.2	1.3	0.2	-0.5	0.2	-0.2	1.1	0.2	0.3	-0.1	-0.2	-0.2	-0.6
Pain all over the body in last month	0.7	0.8	2.5	-0.4	1.1	0.2	-0.7	-0.6	-0.8	1.4	0.4	0.7	0.7	1.6
Diabetes (self-reported)	1.8	2.8	6.5	-1.8	-2.5	-2.0	-1.9	-1.2	-1.7	-0.4	0.8	1.6	1.8	-1.4
Hayfever/allergic rhinitis (self-reported)	1.2	1.6	6.5	0.3	2.0	0.0	0.4	1.0	0.3	2.2	-0.8	-0.5	-0.4	2.5
Medication: Ramipril	1.9	2.4	5.2	1.6	2.1	2.1	1.2	2.1	0.8	1.2	0.1	-0.9	-1.0	2.3
Medication: Simvastatin	0.4	0.6	1.2	0.4	-0.8	0.3	0.5	1.0	0.8	-0.6	-1.1	-0.9	-0.8	-1.0
Fluid intelligence score	2.1	4.5	14.8	3.2	1.9	2.1	2.3	3.8	1.7	-0.9	-0.7	-1.7	-1.8	0.6
Illnesses of siblings	0.2	0.4	1.5	0.3	0.6	-0.4	-0.1	1.2	0.3	1.0	-0.7	-0.4	-0.3	0.3
Neuroticism score	0.7	1.5	6.0	1.2	1.8	-0.3	-0.3	-0.4	-0.8	0.9	1.5	1.1	0.9	2.4
Weight	1.8	9.0	28.9	-3.1	-5.4	-3.1	-2.9	-3.7	-2.3	-1.6	0.5	2.0	2.3	-3.3
Impedance of arm (right)	0.2	0.9	2.8	-0.0	-1.4	0.3	-0.5	-1.2	-0.9	-1.1	1.7	1.0	0.8	-0.4
Arm fat percentage (right)	1.4	5.5	22.9	-0.3	-3.8	-0.4	0.5	-1.2	1.2	-3.5	-1.9	-1.3	-1.1	-4.8
Trunk fat-free mass	2.6	14.8	26.1	-4.2	-5.1	-4.7	-4.5	-4.3	-4.2	-0.4	2.2	4.0	4.2	-1.6
Hip circumference	2.4	10.3	37.4	-2.7	-6.1	-3.1	-2.5	-3.6	-1.9	-3.0	0.3	1.7	1.9	-4.6
Time employed in main current job	0.2	0.2	0.9	0.7	0.5	0.8	-0.2	1.0	-0.1	0.4	-0.1	0.2	0.2	0.6
Alcohol intake versus 10 years previously	0.4	0.5	2.9	0.8	0.6	0.1	0.3	0.3	0.7	0.5	-1.7	-0.8	-0.6	-0.2
Father’s age at death	0.3	0.4	2.0	-0.4	-0.5	0.9	-0.0	-1.4	-0.3	-0.6	0.8	0.4	0.3	-0.0
Worrier / anxious feelings	1.0	1.9	3.4	-0.2	1.3	-0.9	-1.1	-1.8	-1.5	1.3	1.5	1.6	1.5	1.8
Frequency of tiredness / lethargy in last 2 weeks	0.9	1.5	3.5	-1.9	-0.7	-1.8	-1.5	-1.3	-1.2	1.0	0.5	1.1	1.2	0.2
Falls in the last year	0.4	0.6	1.4	0.8	0.6	0.7	1.2	-0.4	1.0	-0.0	0.0	-0.9	-0.9	0.7
Hair/balding pattern: Pattern 3	2.5	3.7	6.9	-1.6	1.3	0.2	-1.5	-1.4	-2.0	2.6	2.6	2.1	1.9	2.6
Number of live births	0.2	0.4	1.3	-0.6	-0.5	-0.1	-0.3	-0.7	-0.5	0.4	1.1	0.5	0.5	0.5
Forced expiratory volume in 1-second (FEV1)	1.8	6.1	11.1	-2.4	-1.8	-2.1	-3.0	-1.9	-3.3	0.9	2.8	3.2	3.2	1.3
Pulse rate	0.5	0.9	2.6	0.8	1.6	0.2	-0.4	-0.6	-0.6	1.4	0.9	0.9	0.7	1.2
Happiness	1.1	1.4	3.1	-1.5	-0.8	-1.8	-1.5	-1.3	-1.2	0.5	0.5	1.2	1.3	-0.3
Noisy workplace	1.0	1.2	2.8	0.5	0.6	-0.2	1.2	-0.4	1.7	-0.0	-1.6	-1.6	-1.6	-0.3
Qualifications: A levels/AS levels or equivalent	0.6	1.4	8.9	1.1	-0.2	0.9	1.2	-0.8	0.5	-3.0	0.5	-0.3	-0.4	-1.0
Serious illness, injury or assault of a close relative in last 2 years	0.2	0.3	0.7	0.6	0.8	0.8	0.6	-0.5	0.2	-0.4	0.2	-0.1	-0.2	0.5
Mouth/teeth dental problems: Dentures	2.6	4.4	11.4	-2.8	-3.4	-3.1	-2.3	-1.4	-1.3	-0.2	-1.0	0.9	1.2	-2.8
Asthma	1.4	2.7	9.8	-2.3	-1.2	-2.2	-1.5	-3.1	-1.4	0.2	0.5	1.3	1.4	-0.2
Medication: Ibuprofen (e.g. Nurofen)	0.3	0.3	1.0	-0.4	-0.5	-1.0	-1.0	-0.0	-0.7	0.5	0.1	0.6	0.6	0.2
Medication: Cholesterol lowering	0.4	0.6	1.5	-1.2	-0.6	-0.8	-1.1	-0.0	-0.8	0.7	-0.3	0.7	0.9	-0.1
Depression (self-reported)	0.8	1.0	3.2	0.9	1.8	0.3	0.7	0.8	0.8	1.0	-1.3	-0.8	-0.7	1.2
Medication: Lansoprazole	0.1	0.1	0.7	-0.1	-0.6	-0.6	-0.2	-0.8	0.0	0.0	-0.2	-0.2	-0.0	-0.1
Prospective memory result	0.2	0.2	0.7	-0.4	0.2	0.1	-0.2	-0.8	-0.5	0.0	0.9	0.5	0.5	0.6
Lung cancer (father)	0.1	0.1	0.4	-0.1	-0.5	-0.7	-0.4	-0.6	-0.3	0.1	0.3	0.2	0.3	0.2
Illnesses of mother	0.5	0.7	2.0	-1.1	-1.1	-1.4	-0.8	-0.2	-0.2	0.4	-1.0	0.1	0.2	-1.0
Forced expiratory volume in 1-second (FEV1), Best measure	1.4	4.4	8.2	-2.0	-1.5	-1.1	-2.5	-1.7	-2.9	1.1	2.5	2.7	2.6	1.4
Pulse wave Arterial Stiffness index	1.1	1.3	4.9	-1.2	-1.0	0.7	-1.0	-2.2	-1.3	-0.3	1.3	1.2	1.2	0.2
Impedance of arm (left)	0.1	0.5	2.0	-0.0	-0.7	0.3	-0.6	-0.7	-0.9	-0.4	1.4	1.0	0.8	0.1
Arm fat mass (right)	1.3	5.2	20.5	-1.8	-4.5	-1.7	-1.1	-2.5	-0.4	-2.6	-0.7	0.2	0.4	-4.0
Trunk predicted mass	2.6	15.1	26.4	-4.2	-5.1	-4.7	-4.6	-4.3	-4.2	-0.4	2.3	4.0	4.2	-1.6
Standing height	3.6	35.7	55.2	-6.0	-6.2	-5.9	-7.3	-6.2	-7.4	1.2	5.6	7.2	7.2	0.3
Length of working week for main job	0.4	0.4	1.0	0.3	-0.6	-0.6	0.3	0.3	0.7	-0.7	-0.9	-0.8	-0.6	-1.0
Exposure to tobacco smoke at home	0.3	0.3	0.6	0.5	-0.0	0.8	0.7	0.7	0.6	-0.8	0.2	-0.5	-0.6	-0.3
Breastfed as a baby	0.9	1.2	6.5	0.8	-1.5	0.1	0.4	0.3	0.1	-2.5	0.4	-0.0	-0.1	-1.7
Tense / ‘highly strung’	0.9	1.5	3.9	-0.7	0.7	-2.0	-1.4	-1.3	-0.9	1.7	0.0	1.0	1.1	1.3
Seen doctor (GP) for nerves, anxiety, tension or depression	0.6	0.9	2.8	0.0	1.7	0.5	-0.1	-1.2	-0.6	0.7	0.8	0.6	0.7	1.6
Hair/balding pattern: Pattern 4	0.2	0.4	1.6	1.3	0.5	0.5	0.6	0.7	0.5	-0.5	-0.5	-0.5	-0.4	0.3
Birth weight of first child	0.4	0.8	3.4	-1.3	-1.2	-1.9	-0.8	-1.0	-0.2	0.5	-0.5	0.1	0.2	-0.3
Peak expiratory flow (PEF)	1.4	3.3	10.8	-0.8	1.0	0.6	-1.2	-0.6	-2.1	1.7	2.6	2.0	1.9	3.3
Pulse wave reflection index	1.0	1.2	3.8	-1.6	-1.2	0.2	-0.8	-1.9	-1.1	-0.9	1.3	1.0	0.9	-0.2
Ever highly irritable/argumentative for 2 days	0.1	0.1	0.4	0.0	0.3	-0.6	-0.3	0.2	-0.2	0.5	0.0	0.2	0.1	0.6
Loud music exposure frequency	0.3	0.4	1.2	0.3	-0.0	-0.4	0.3	0.1	0.5	-0.9	-1.1	-0.5	-0.4	-0.9
Qualifications: O levels/GCSEs or equivalent	1.5	2.4	4.4	1.3	0.8	1.5	2.1	1.1	1.8	-1.9	-1.2	-1.9	-1.8	-0.6
Mouth/teeth dental problems: Bleeding gums	0.6	0.7	4.2	0.9	0.7	2.0	1.0	-0.6	0.4	-0.7	0.6	-0.3	-0.5	0.2
Blood clot in the leg (DVT)	0.3	0.4	1.2	-0.1	0.8	0.3	0.1	0.0	-0.6	-0.0	1.0	0.7	0.5	1.1
Medication: Paracetamol	0.5	0.8	3.4	0.1	-0.3	0.2	0.4	1.0	0.8	-0.2	-1.9	-1.0	-0.8	-1.2
Headache pain in last month	2.6	4.4	11.4	1.7	-0.5	1.8	2.5	0.5	2.4	-3.4	-1.5	-2.3	-2.4	-2.2
Medication for cholesterol, blood pressure or diabetes	0.6	1.0	2.2	-1.2	-1.0	-1.5	-1.1	-1.2	-1.0	0.2	0.6	1.0	1.0	-0.8
Glaucoma (self-reported)	3.2	3.8	7.3	-2.7	-2.0	-2.2	-2.3	-2.6	-2.0	0.6	1.2	1.9	2.0	-0.5
Gout (self-reported)	2.5	3.4	8.8	-2.1	-0.6	-2.9	-2.5	-1.1	-1.7	3.0	-0.3	1.4	1.6	0.6
Hypothyroidism/myxoedema (self-reported)	0.3	0.6	3.0	-0.7	-1.7	-0.4	-0.6	-0.4	-0.4	-0.7	0.1	0.3	0.3	-1.1
Medication: Amlodipine	3.5	4.9	8.7	2.9	1.3	1.9	2.9	2.2	2.6	-1.8	-1.5	-2.7	-2.6	-0.3
Medication: Ventolin 100micrograms inhaler	0.9	1.2	2.9	0.9	0.1	0.3	1.7	-0.7	1.5	-1.2	-0.9	-1.5	-1.5	-0.2
Birth weight	0.4	0.8	2.1	-0.5	0.3	-1.1	-1.0	0.1	-0.9	1.4	0.6	1.0	0.9	0.9
Chronic bronchitis/emphysema (mother)	0.3	0.4	1.3	0.2	-0.7	0.1	0.7	-0.3	0.8	-1.2	0.3	-0.6	-0.7	-0.6
High blood pressure (siblings)	1.8	2.6	5.6	2.1	1.4	2.2	2.4	1.1	1.7	-1.3	0.1	-1.6	-1.7	0.8
Forced vital capacity (FVC), Best measure	1.5	5.4	8.5	-2.0	-2.7	-1.9	-2.8	-2.3	-2.9	0.6	2.6	2.8	2.7	0.5
Body fat percentage	0.8	3.0	12.5	-0.7	-3.1	-0.3	0.0	-1.5	0.6	-2.2	-1.3	-0.7	-0.6	-3.5
Leg fat percentage (right)	0.9	3.3	9.4	0.6	-1.8	1.4	1.5	-0.6	1.7	-2.8	-1.4	-1.7	-1.7	-3.1
Arm fat-free mass (right)	2.2	11.3	18.0	-3.9	-3.9	-4.1	-4.2	-3.6	-3.9	0.7	1.7	3.6	3.8	-0.8
Exposure to tobacco smoke outside home	2.4	3.2	6.1	1.4	0.6	1.2	2.1	1.8	2.5	-0.8	-2.0	-2.4	-2.5	-0.9
Comparative body size at age 10	0.3	0.9	1.4	1.0	0.4	0.8	1.2	1.1	1.2	-0.9	-1.0	-1.1	-1.2	-0.4
Number of full brothers	0.3	0.4	1.5	-0.1	-0.1	0.1	0.2	1.2	0.6	0.1	-1.1	-0.7	-0.6	-0.8
Worry too long after embarrassment	1.0	1.7	5.3	1.4	1.6	-0.6	-0.5	0.5	-1.2	1.0	1.7	1.3	1.2	2.3
Seen a psychiatrist for nerves, anxiety, tension or depression	1.0	1.3	3.2	0.2	1.0	0.8	-0.5	-1.4	-1.2	0.6	1.8	1.3	1.2	1.6
Wheeze or whistling in the chest in last year	0.9	1.6	3.3	-0.3	0.2	0.3	1.3	-1.3	1.6	-1.3	-1.8	-1.6	-1.6	-1.1
Number of children fathered	0.9	1.1	4.4	-2.1	-0.3	-0.9	-1.2	-1.6	-0.8	0.6	-0.2	0.7	0.8	-0.5
Reason for reducing amount of alcohol drunk: Health precaution	0.5	0.6	1.3	0.7	-0.3	1.1	0.8	-0.0	1.1	-0.1	-0.8	-1.1	-1.1	-0.6
Age at first live birth	0.6	1.0	3.2	1.1	1.1	1.5	1.1	1.0	0.2	-0.1	1.2	-0.2	-0.3	1.8
Pulse wave peak to peak time	0.6	0.7	3.0	0.7	0.3	-1.1	0.4	1.7	0.7	0.1	-0.9	-0.7	-0.6	-0.5
Health satisfaction	0.2	0.2	0.8	0.5	0.6	0.1	0.3	0.0	0.6	0.4	-0.9	-0.6	-0.5	0.0
Shortness of breath walking on level ground	0.9	1.0	3.7	-0.9	-0.3	-1.1	-0.9	-1.9	-0.9	0.9	0.8	1.0	1.0	0.7
Qualifications: College or University degree	2.2	6.8	14.0	3.7	1.5	3.0	3.6	1.9	2.9	-2.6	-1.1	-2.8	-2.9	-0.5
Eye problems/disorders: None of the above	0.1	0.1	0.4	0.5	-0.3	0.6	0.2	0.1	0.1	-0.5	-0.2	-0.2	-0.2	-0.4
Mouth/teeth dental problems: Loose teeth	1.6	1.9	5.8	-1.8	1.1	-0.9	-1.4	-1.4	-1.2	2.4	0.2	1.0	1.2	1.6
Emphysema/chronic bronchitis	6.3	7.1	12.4	2.1	-0.8	1.4	2.8	2.0	3.3	-2.5	-3.1	-3.5	-3.2	-3.0
Medication for pain relief, constipation, heartburn	0.2	0.4	2.2	0.2	-0.7	-0.1	0.5	-0.1	0.3	-1.5	0.1	-0.2	-0.3	-1.0
Neck or shoulder pain in last month	1.5	2.2	4.9	-2.2	-1.3	-1.5	-2.1	-0.2	-1.9	0.5	0.7	1.8	1.9	-0.3
Medication: Blood pressure	2.3	4.0	7.8	2.4	1.5	2.8	2.6	2.0	2.3	-1.1	-1.0	-2.3	-2.3	0.6
Angina (self-reported)	0.7	0.9	3.5	0.0	1.7	0.7	-0.2	0.2	-0.2	1.5	0.3	0.3	0.3	1.9
Migraine (self-reported)	0.9	1.1	5.4	-0.0	-1.6	0.1	-0.2	-0.5	-0.6	-2.3	1.0	0.7	0.6	-1.3
Medication: Ibuprofen	0.1	0.1	0.4	0.0	-0.4	-0.6	-0.6	0.4	-0.1	0.3	-0.5	0.1	0.1	0.0
Medication: Allopurinol	1.6	2.2	6.2	-1.7	-1.6	-2.5	-2.0	-0.8	-1.3	1.8	-0.2	1.0	1.2	-0.1
Medication: Omeprazole	0.5	0.6	4.5	-0.9	-1.0	-0.3	-0.5	-2.1	-0.2	0.2	-0.1	0.2	0.3	-0.3
Medication: Seretide 50 evohaler	0.4	0.5	2.2	-0.8	0.4	-0.9	-0.7	-0.2	-0.5	1.5	0.1	0.4	0.4	0.6
Mean time to correctly identify matches	1.1	2.0	4.4	1.5	-0.6	1.2	1.6	1.7	1.6	-2.1	-0.5	-1.4	-1.4	-1.0
Heart disease (mother)	1.4	1.7	4.8	1.8	1.2	2.2	1.3	0.5	0.4	-0.3	1.8	-0.2	-0.4	1.7
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.2	0.3	1.0	-0.3	0.6	0.2	-0.2	-1.0	-0.4	0.6	0.3	0.5	0.5	0.8
Whole body fat mass	1.2	4.8	19.0	-1.8	-4.4	-1.7	-1.4	-2.6	-0.8	-2.0	-0.6	0.6	0.8	-3.7
Leg fat mass (right)	0.9	3.6	13.7	-1.4	-3.7	-1.1	-0.6	-2.3	-0.1	-2.2	-0.8	-0.1	0.1	-3.5
Arm predicted mass (right)	2.5	12.7	20.1	-4.2	-4.0	-4.3	-4.5	-4.0	-4.1	0.8	1.8	3.8	4.0	-0.8
Pulse rate, automated reading	0.1	0.2	0.8	-0.3	0.0	-0.9	-0.2	-0.8	-0.1	0.1	0.3	0.3	0.3	-0.4
Alcohol intake frequency.	0.6	1.5	4.5	-0.8	-2.1	-0.7	-0.8	-1.6	-0.9	-1.7	0.5	0.9	1.0	-1.3
Comparative height size at age 10	3.5	19.4	31.0	-5.4	-4.6	-4.6	-5.6	-4.3	-5.2	1.6	3.3	5.0	5.1	0.0
Number of full sisters	3.9	4.7	9.5	1.8	1.3	1.1	2.5	2.3	2.9	-0.4	-2.7	-3.1	-2.9	-0.3
Suffer from ‘nerves’	0.7	1.2	5.2	1.2	1.9	0.1	-0.0	0.0	-0.2	1.3	0.7	0.5	0.4	2.3
Overall health rating	0.3	0.7	1.9	-0.9	0.2	-0.4	-1.0	-1.4	-0.8	1.1	0.1	0.8	0.9	0.5
Chest pain or discomfort	0.5	0.7	2.5	-1.6	-0.5	-1.2	-0.5	-1.3	-0.5	-0.6	0.8	0.6	0.5	-0.2
Had major operations	0.9	1.0	3.8	-0.7	-2.0	-1.0	-0.7	-1.6	-0.2	-0.9	0.0	0.2	0.3	-1.4
Age at last live birth	0.4	0.5	2.2	0.0	0.9	0.4	0.6	1.5	0.0	0.5	0.6	-0.2	-0.2	1.4
Family relationship satisfaction	0.7	0.9	2.9	-0.7	1.1	-0.7	-1.0	0.2	-0.9	1.7	0.3	0.9	0.9	1.2
Leg pain on walking	0.9	1.1	2.8	0.5	0.8	0.4	1.0	0.5	1.6	-0.3	-1.7	-1.5	-1.5	-0.4
Qualifications: NVQ or HND or HNC or equivalent	1.0	1.2	2.7	-1.1	-1.5	-0.2	-0.7	-1.3	-1.0	-1.2	1.6	1.1	1.0	-0.6
Commuting to job workplace: Car/motor vehicle	0.2	0.3	1.2	-0.7	-0.4	-0.4	0.4	-1.1	0.5	-0.2	-0.3	-0.4	-0.4	-0.3
Illness, injury, bereavement, stress in last 2 years	1.3	1.6	2.9	-1.3	-1.5	-1.7	-1.7	0.1	-1.6	0.6	0.7	1.3	1.5	-0.7
Medication: Aspirin	0.8	1.0	3.8	0.7	2.0	1.1	0.6	0.8	0.4	1.0	0.2	-0.3	-0.3	1.9
Supplements: Vitamin C	0.5	0.6	2.2	-1.0	0.5	-1.3	-0.6	0.0	-0.5	1.5	-0.4	0.3	0.4	0.8
Knee pain experienced in last month	0.3	0.5	1.8	0.4	0.3	0.5	0.6	1.3	0.9	0.0	-0.5	-0.8	-0.8	-0.4
Hypertension (Self-reported)	0.8	2.3	5.1	2.0	1.0	2.3	2.1	0.8	1.7	-1.4	-0.0	-1.6	-1.6	0.7
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.9	1.1	5.2	0.2	-0.3	-0.3	-0.2	-2.3	-0.9	-0.7	1.4	1.0	1.0	0.8
Illnesses of father: Heart disease	0.3	0.4	1.7	-0.6	1.1	0.2	0.2	0.3	-0.1	0.8	0.5	0.2	-0.0	1.3
Illnesses of siblings: Diabetes	3.5	4.3	7.6	-2.5	-2.7	-1.6	-2.3	-1.7	-2.3	-1.1	1.7	2.4	2.3	-1.2
Smoking status: Previous	2.1	3.1	6.6	2.1	1.9	1.5	2.6	0.5	2.2	-0.8	-1.1	-2.2	-2.2	0.6
Forced expiratory volume in 1-second (FEV1), predicted	3.1	6.4	18.3	-2.4	-1.5	-2.9	-2.8	-4.3	-2.9	0.9	1.4	2.8	2.8	0.9
Whole body fat-free mass	2.7	15.2	27.5	-4.2	-5.2	-4.8	-4.6	-4.4	-4.2	-0.4	1.9	3.9	4.1	-1.9
Leg fat-free mass (right)	2.8	14.9	29.3	-4.2	-5.4	-5.1	-4.6	-4.3	-4.0	-0.5	1.3	3.6	3.9	-2.5
Arm fat percentage (left)	1.2	4.8	20.3	-0.4	-3.6	-0.5	0.4	-1.1	1.0	-3.2	-2.0	-1.2	-1.0	-4.5
Average weekly red wine intake	0.7	1.0	1.9	1.4	0.5	0.8	1.3	1.3	1.1	-1.0	-0.2	-1.1	-1.1	0.2
Handedness (chirality/laterality): Left-handed	0.4	0.5	1.2	1.0	0.7	1.1	0.8	0.7	0.6	0.7	0.4	-0.5	-0.6	0.7
Mood swings	0.8	1.5	3.3	-0.7	0.3	-0.8	-1.2	-1.7	-1.3	0.6	1.8	1.6	1.4	0.7
Loneliness, isolation	0.4	0.6	2.3	0.8	1.4	0.0	0.2	-0.4	0.1	1.0	0.0	-0.0	-0.0	1.5
Long-standing illness, disability or infirmity	0.3	0.4	2.5	0.8	-0.2	0.0	0.7	0.0	0.5	-1.6	0.3	-0.3	-0.4	-0.0
Ever had bowel cancer screening	1.5	1.7	5.6	-2.2	0.8	-0.3	-1.6	-0.7	-1.3	2.4	-0.5	1.0	1.2	0.7
Diabetes diagnosed by doctor	1.2	2.0	6.7	-1.3	-2.6	-1.6	-1.1	-1.6	-0.9	-1.2	0.4	0.9	1.0	-1.8
Ever had stillbirth, spontaneous miscarriage or termination	0.7	0.8	2.9	1.0	0.6	1.4	0.9	0.1	0.3	-0.9	1.7	-0.0	-0.3	0.7
Friendships satisfaction	0.2	0.2	0.6	0.2	0.4	-0.5	-0.3	0.8	0.2	0.5	-0.8	-0.2	-0.1	-0.4
Qualifications: nursing, teaching	0.7	1.2	6.7	1.1	-0.5	0.8	1.0	0.5	0.5	-2.6	0.2	-0.4	-0.5	-1.4
Commuting to job workplace: Walk	0.6	0.6	1.9	0.1	-1.4	-0.9	-0.9	0.5	-0.6	-0.8	0.0	0.6	0.7	-1.3
Eye problems/disorders: Cataract	0.8	0.9	1.7	1.1	1.2	0.6	1.3	0.3	1.2	-0.1	0.0	-1.0	-1.2	0.8
Mouth/teeth dental problems: Mouth ulcers	0.6	1.0	4.0	0.2	1.1	2.0	0.4	-1.4	0.1	-0.2	1.2	0.3	-0.0	1.4
Medication for cholesterol	0.2	0.3	1.1	-0.5	-0.5	-0.4	-0.7	-0.3	-0.6	1.0	0.1	0.5	0.5	-0.1
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.6	1.8	6.2	-1.7	0.7	-1.0	-1.9	-0.5	-1.4	2.5	-0.1	1.2	1.4	0.7
Back pain experienced in last month	0.9	1.3	4.8	-1.5	-1.7	-0.9	-0.9	-2.2	-0.7	-0.6	0.2	0.6	0.7	-0.9
Mineral and other dietary supplements	0.2	0.2	0.5	0.2	-0.5	-0.2	0.1	-0.2	0.6	0.4	-0.7	-0.7	-0.6	-0.6
Breast cancer (self-reported)	0.4	0.4	1.3	0.6	-0.9	0.4	0.4	0.8	0.5	-0.8	0.2	-0.5	-0.6	-1.1
Asthma (self-reported)	1.3	2.6	10.0	-2.3	-1.1	-2.0	-1.4	-3.2	-1.4	0.2	0.6	1.3	1.3	-0.0
Osteoporosis (self-reported)	0.4	0.4	1.0	0.3	0.9	1.0	1.0	-0.6	0.5	-0.6	0.7	-0.3	-0.5	0.5
Osteoarthritis (self-reported)	1.4	1.8	4.9	-1.3	0.7	-0.3	-1.5	-1.2	-1.4	2.2	0.6	1.3	1.5	1.6
Medication: Aspirin	1.0	1.3	4.9	0.9	2.2	1.1	0.7	1.4	0.6	1.1	-0.2	-0.6	-0.6	1.7
Medication: Gliclazide	2.5	2.8	5.3	-2.3	-1.4	-1.7	-2.0	-1.8	-2.0	0.8	1.3	1.9	1.9	-0.0
Illnesses of father: None of the above (group 1)	0.4	0.5	2.4	0.2	-0.7	-1.6	-0.8	-0.4	-0.6	0.8	0.2	0.4	0.6	0.0
Smoking status: Current	0.4	0.6	2.5	-0.8	0.3	-1.6	-0.5	0.1	0.2	1.5	-0.6	-0.1	-0.0	0.2
Forced expiratory volume in 1-second (FEV1), predicted percentage	1.3	2.8	4.9	-2.0	-1.4	-1.2	-2.1	-1.4	-2.2	0.7	1.7	2.0	2.1	0.6
Whole body water mass	2.7	15.2	28.6	-4.2	-5.3	-4.9	-4.6	-4.4	-4.2	-0.4	1.9	3.9	4.1	-2.0
Leg predicted mass (right)	2.8	15.1	29.4	-4.3	-5.4	-5.1	-4.6	-4.3	-4.0	-0.4	1.3	3.7	3.9	-2.5
Arm fat mass (left)	1.2	5.1	19.2	-1.6	-4.4	-1.6	-0.9	-2.1	-0.2	-2.7	-1.2	-0.1	0.2	-4.2
Number of self-reported non-cancer illnesses	0.2	0.3	1.2	0.2	0.4	1.1	0.7	-0.5	0.4	-0.9	0.1	-0.3	-0.4	0.6
Average weekly champagne plus white wine intake	1.0	1.4	7.1	1.4	-0.1	-0.1	1.0	2.7	1.1	-0.5	-0.7	-1.2	-1.1	-0.6
Miserableness	0.4	0.6	2.8	1.0	1.7	1.1	0.2	0.2	0.1	0.8	0.1	-0.0	-0.1	1.2
Guilty feelings	1.3	1.9	7.5	1.4	2.7	0.7	1.2	0.1	0.8	1.0	0.6	-0.5	-0.8	2.5
Wears glasses or contact lenses	0.4	0.5	2.9	0.4	-0.8	0.3	0.5	0.2	0.2	-1.7	0.8	-0.0	-0.2	-0.8
Ever taken oral contraceptive pill	1.5	1.7	3.8	1.7	0.4	-0.1	1.1	1.2	1.6	0.2	-1.9	-1.7	-1.6	-0.9
Hearing aid user	1.0	1.1	2.8	-1.2	-1.2	-1.6	-0.6	-1.1	0.0	-0.1	-1.7	-0.2	-0.0	-1.7
Mother’s age at death	1.7	2.1	7.2	-1.2	-2.7	-1.9	-1.1	-1.6	-0.6	-1.1	0.7	0.7	0.6	-2.1
Financial situation satisfaction	0.5	0.7	1.5	0.1	-0.2	-0.2	0.8	0.7	1.2	-0.5	-1.2	-1.2	-1.2	-0.6
Tinnitus: Yes, now most or all of the time	0.4	0.5	0.9	-0.4	-0.9	-0.9	-0.9	-0.6	-0.9	-0.1	0.1	0.7	0.9	-0.3
Commuting to job workplace: Public transport	0.6	0.7	2.7	0.4	-1.4	0.4	-0.0	0.9	-0.2	-1.6	0.9	0.2	0.2	-1.0
Eye problems/disorders: Glaucoma	0.6	0.7	1.6	-1.3	-1.1	-0.7	-0.6	-1.3	-0.6	-0.5	0.6	0.6	0.6	-0.5
Medication: Blood pressure	1.0	2.0	3.9	2.0	0.6	1.4	1.9	0.7	1.6	-1.9	-0.6	-1.6	-1.5	-0.3
Pain type(s) experienced in last month: Hip pain	1.9	2.4	5.2	2.3	0.3	1.6	1.8	2.3	1.5	-1.8	-0.4	-1.5	-1.5	-0.3
Supplements: Fish oil (including cod liver oil)	1.4	1.9	3.5	-1.7	-0.5	-1.7	-1.7	-0.7	-1.8	0.4	0.8	1.8	1.9	0.6
High cholesterol (Self-reported)	0.1	0.2	0.6	0.2	0.6	0.6	-0.0	0.3	-0.1	0.5	0.1	0.1	0.2	0.8
Medication: Bendroflumethiazide	0.6	0.8	2.2	1.0	1.5	1.4	1.3	0.3	0.7	-0.8	0.1	-0.6	-0.7	0.6
Medication: Paracetamol	0.4	0.7	3.6	-0.0	-0.0	0.3	0.2	0.9	0.7	0.3	-1.9	-1.0	-0.7	-1.1
Medication: Lisinopril	1.5	1.9	3.2	1.8	1.1	1.1	1.8	1.0	1.8	-0.8	-1.2	-1.8	-1.7	-0.2
Medication: Atorvastatin	0.7	0.8	1.3	-1.1	0.5	-0.8	-0.8	-0.8	-0.8	1.2	0.9	0.9	0.8	1.1
Illnesses of father: High blood pressure	3.5	4.3	9.2	1.8	2.0	2.9	3.0	1.7	2.4	-1.6	-0.7	-2.2	-2.5	0.4
Alcohol drinker status: Never	0.2	0.3	1.7	1.3	0.2	0.7	0.4	0.6	0.1	-0.4	0.3	-0.1	-0.0	0.1
Ever smoked	5.2	9.1	16.0	3.4	3.5	3.3	4.0	1.6	3.8	-0.9	-2.1	-3.6	-3.7	1.1
Basal metabolic rate	2.6	14.4	29.5	-4.1	-5.4	-4.6	-4.4	-4.5	-3.9	-0.6	1.7	3.6	3.8	-2.3
Leg fat percentage (left)	1.0	3.5	9.9	0.7	-1.5	1.5	1.6	-0.1	2.0	-2.5	-1.9	-2.0	-1.9	-3.1
Arm fat-free mass (left)	2.1	10.5	17.0	-3.8	-4.1	-4.1	-4.0	-3.7	-3.5	0.4	1.4	3.2	3.5	-1.1
Number of operations (self-reported)	0.5	0.8	4.0	-1.6	-0.3	-0.4	-0.7	-2.0	-0.6	0.2	0.2	0.6	0.6	0.3
Average weekly beer plus cider intake	0.4	0.6	3.0	-0.8	0.3	-1.4	-0.6	0.3	-0.4	1.7	-0.0	0.2	0.3	0.7
Irritability	1.0	1.7	4.3	-0.4	1.0	-0.8	-1.0	-0.8	-1.5	0.9	1.7	1.6	1.5	2.1
Risk taking	1.3	1.8	3.4	1.0	1.1	0.8	1.5	1.6	1.8	0.1	-1.5	-1.8	-1.8	0.3
Ever had prostate specific antigen (PSA) test	0.4	0.5	1.3	0.2	0.7	1.1	0.8	0.2	0.8	-0.6	-1.0	-0.8	-0.6	-0.5
Fractured/broken bones in last 5 years	1.1	1.4	5.2	-0.8	0.9	-0.8	-0.6	-1.3	-0.8	1.8	0.8	0.8	0.7	2.3
Age started oral contraceptive pill	1.2	1.5	2.5	1.6	0.4	1.4	1.4	1.5	1.4	-1.0	-0.6	-1.3	-1.4	-0.9
Diastolic blood pressure, automated reading	0.4	1.2	2.7	1.0	1.6	1.7	1.5	0.8	1.0	-0.1	-0.3	-1.0	-0.9	1.2
Ever depressed for a whole week	0.7	0.8	2.1	0.5	1.4	0.9	0.7	1.3	0.7	1.0	-0.9	-0.7	-0.7	0.9
Unable to work because of sickness or disability	1.3	1.7	3.0	-1.7	0.2	-0.5	-1.4	-1.6	-1.5	1.2	1.1	1.5	1.4	1.1
Commuting to job workplace: Cycle	0.5	0.6	1.5	1.2	0.1	0.6	1.0	0.7	0.8	-1.1	-0.4	-0.7	-0.7	-0.6
Myopia	0.7	1.1	2.4	-0.9	-1.2	-0.9	-1.1	0.4	-1.3	-0.4	1.5	1.4	1.2	-0.3
Vascular/heart problems diagnosed by doctor	1.4	3.7	7.1	-2.7	-1.8	-2.3	-2.5	-1.6	-2.2	0.9	0.8	2.1	2.0	-1.0
Cholesterol lowering medication	0.3	0.5	1.1	0.8	0.7	1.0	0.8	0.3	0.9	0.0	-0.3	-0.8	-0.8	0.6
Medication: Omeprazole (e.g. Zanprol)	0.6	0.8	6.1	-0.9	-0.9	0.3	-0.4	-2.5	-0.1	0.2	-0.1	0.2	0.3	-0.5
Pain experienced in last month	0.3	0.5	1.0	-0.7	-0.6	-1.0	-0.7	-0.8	-0.7	0.2	0.9	0.8	0.7	-0.1
Supplements: Calcium	1.0	1.1	5.3	0.1	0.7	0.0	0.1	-0.5	-1.0	-0.3	2.3	1.1	0.9	1.7
Basal cell carcinoma (self-reported)	0.9	1.0	3.8	0.1	1.9	1.9	0.5	0.3	-0.0	0.6	0.9	0.1	-0.0	1.6
Heart attack/myocardial infarction (self-reported)	2.3	2.9	7.7	2.0	2.8	1.2	1.2	1.9	1.1	1.6	-0.7	-1.2	-1.1	2.6
Deep venous thrombosis (DVT) (self-reported)	0.3	0.4	1.2	-0.0	0.8	0.5	0.1	0.1	-0.5	-0.0	1.0	0.6	0.5	1.1
Heart disease (siblings)	0.2	0.3	0.6	-0.8	-0.4	-0.7	-0.7	-0.4	-0.4	0.7	-0.3	0.4	0.5	-0.2
Alcohol drinker status: Previous	1.1	1.3	3.4	-0.7	-1.4	-0.8	-0.9	-1.2	-1.2	-0.6	1.9	1.3	1.2	0.3
Pack years of smoking	0.5	0.7	3.2	-0.7	-0.4	-1.0	-1.2	0.3	-0.5	1.8	-0.5	0.4	0.7	-0.2
Impedance of whole body	0.1	0.8	2.3	0.6	1.1	1.4	0.2	0.2	-0.2	0.8	1.3	0.3	0.2	1.5
Leg fat mass (left)	0.8	3.3	11.9	-1.3	-3.5	-0.9	-0.5	-2.0	0.1	-2.1	-1.0	-0.2	-0.1	-3.5
Arm predicted mass (left)	2.1	10.6	19.0	-3.7	-4.4	-4.2	-3.9	-3.7	-3.4	0.1	1.3	3.1	3.4	-1.6