Best TWAS P=1.29e-09 · Best GWAS P=3.24e-12 conditioned to 0.000221
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | CommonMind | Brain Pre-frontal Cortex | CCBL2 | 0.58 | 0.68 | lasso | 7 | 0.69 | 1.4e-117 | -4.7 | 5.2 | 2.1e-07 | -0.75 | 1.00 | 0.00 | FALSE |
2 | GTEx | Adipose Subcutaneous | CCBL2 | 0.26 | 0.21 | enet | 15 | 0.23 | 1.2e-18 | -4.8 | 5.4 | 5.3e-08 | -0.68 | 1.00 | 0.00 | FALSE |
3 | GTEx | Adipose Visceral Omentum | CCBL2 | 0.21 | 0.10 | enet | 7 | 0.15 | 5.2e-08 | -4.7 | 5.6 | 2.6e-08 | -0.73 | 0.89 | 0.10 | FALSE |
4 | GTEx | Artery Aorta | CCBL2 | 0.29 | 0.20 | enet | 24 | 0.24 | 1.5e-13 | -4.7 | 5.3 | 8.8e-08 | -0.70 | 0.99 | 0.01 | FALSE |
5 | GTEx | Artery Tibial | CCBL2 | 0.30 | 0.24 | lasso | 8 | 0.29 | 4.9e-23 | -4.7 | 6.1 | 1.3e-09 | -0.74 | 1.00 | 0.00 | TRUE |
6 | GTEx | Brain Cerebellar Hemisphere | CCBL2 | 0.31 | 0.18 | lasso | 5 | 0.23 | 1.7e-06 | -5.4 | 5.9 | 3.4e-09 | -0.84 | 0.20 | 0.74 | FALSE |
7 | GTEx | Brain Cerebellum | CCBL2 | 0.39 | 0.30 | enet | 23 | 0.33 | 1.7e-10 | -4.7 | 5.3 | 1.4e-07 | -0.65 | 0.52 | 0.47 | FALSE |
8 | GTEx | Brain Cortex | CCBL2 | 0.59 | 0.39 | enet | 13 | 0.37 | 3.0e-11 | -5.4 | 5.2 | 2.5e-07 | -0.76 | 0.93 | 0.07 | FALSE |
9 | GTEx | Brain Frontal Cortex BA9 | CCBL2 | 0.47 | 0.38 | enet | 25 | 0.48 | 1.5e-14 | -4.7 | 5.2 | 1.5e-07 | -0.79 | 0.79 | 0.21 | FALSE |
10 | GTEx | Brain Nucleus accumbens basal ganglia | CCBL2 | 0.38 | 0.44 | enet | 20 | 0.32 | 2.1e-09 | -4.7 | 5.5 | 3.8e-08 | -0.82 | 0.46 | 0.54 | FALSE |
11 | GTEx | Brain Putamen basal ganglia | CCBL2 | 0.35 | 0.26 | enet | 21 | 0.25 | 1.2e-06 | -4.7 | 5.6 | 1.7e-08 | -0.75 | 0.09 | 0.86 | FALSE |
12 | GTEx | Cells Transformed fibroblasts | CCBL2 | 0.65 | 0.61 | enet | 32 | 0.67 | 6.1e-67 | -4.7 | 5.2 | 2.0e-07 | -0.74 | 1.00 | 0.00 | FALSE |
13 | GTEx | Colon Transverse | PKN2 | 0.23 | 0.08 | lasso | 7 | 0.08 | 1.0e-04 | 4.0 | 5.2 | 1.8e-07 | -0.67 | 0.30 | 0.62 | FALSE |
14 | GTEx | Colon Transverse | CCBL2 | 0.30 | 0.19 | lasso | 8 | 0.26 | 1.2e-12 | -4.7 | 5.6 | 1.7e-08 | -0.75 | 0.95 | 0.05 | FALSE |
15 | GTEx | Esophagus Mucosa | CCBL2 | 0.35 | 0.19 | enet | 27 | 0.30 | 2.7e-20 | -4.7 | 5.3 | 1.2e-07 | -0.58 | 0.96 | 0.04 | FALSE |
16 | GTEx | Esophagus Muscularis | CCBL2 | 0.25 | 0.29 | enet | 18 | 0.28 | 1.6e-17 | -4.8 | 5.3 | 1.1e-07 | -0.76 | 1.00 | 0.00 | FALSE |
17 | GTEx | Lung | CCBL2 | 0.15 | 0.13 | enet | 13 | 0.17 | 4.8e-13 | -4.7 | 5.6 | 2.3e-08 | -0.70 | 0.96 | 0.04 | FALSE |
18 | GTEx | Nerve Tibial | CCBL2 | 0.42 | 0.33 | enet | 38 | 0.38 | 3.4e-28 | -4.7 | 5.3 | 1.4e-07 | -0.76 | 1.00 | 0.00 | FALSE |
19 | GTEx | Pancreas | CCBL2 | 0.26 | 0.21 | lasso | 4 | 0.23 | 5.3e-10 | -5.4 | 6.0 | 1.8e-09 | -0.62 | 0.73 | 0.21 | FALSE |
20 | GTEx | Pituitary | CCBL2 | 0.45 | 0.30 | lasso | 2 | 0.26 | 2.7e-07 | -5.4 | 5.4 | 6.3e-08 | -0.76 | 0.74 | 0.20 | FALSE |
21 | GTEx | Skin Sun Exposed Lower leg | CCBL2 | 0.18 | 0.09 | enet | 12 | 0.17 | 4.0e-14 | -4.7 | 5.8 | 5.4e-09 | -0.66 | 0.88 | 0.12 | FALSE |
22 | GTEx | Stomach | CCBL2 | 0.16 | 0.08 | lasso | 4 | 0.15 | 9.0e-08 | -4.7 | 6.0 | 2.5e-09 | -0.88 | 0.03 | 0.97 | FALSE |
23 | GTEx | Thyroid | CCBL2 | 0.22 | 0.15 | enet | 22 | 0.22 | 9.8e-17 | -5.4 | 5.8 | 8.5e-09 | -0.66 | 0.99 | 0.01 | FALSE |
24 | GTEx | Thyroid | RBMXL1 | 0.09 | 0.02 | enet | 19 | 0.04 | 2.7e-04 | -3.2 | 5.6 | 2.3e-08 | -0.50 | 0.16 | 0.52 | FALSE |
25 | METSIM | Adipose | CCBL2 | 0.27 | 0.14 | lasso | 6 | 0.18 | 6.4e-27 | -4.8 | 5.3 | 1.1e-07 | -0.75 | 1.00 | 0.00 | FALSE |
26 | ROSMAP | Brain Pre-frontal Cortex | CCBL2 | 0.43 | 0.56 | enet | 31 | 0.56 | 1.1e-87 | -4.8 | 5.3 | 8.7e-08 | -0.79 | 1.00 | 0.00 | FALSE |
27 | YFS | Blood | CCBL2 | 0.10 | 0.05 | bslmm | 366 | 0.08 | 2.8e-26 | -4.7 | 5.2 | 2.7e-07 | -0.45 | 1.00 | 0.00 | FALSE |
28 | The Cancer Genome Atlas | Brain Lower Grade Glioma | PKN2 | 0.05 | 0.01 | enet | 8 | 0.02 | 1.6e-03 | -6.2 | -5.8 | 7.9e-09 | 0.91 | 0.02 | 0.97 | FALSE |