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chr1:92,065,464-94,426,916

Best TWAS P=7.92e-13 · Best GWAS P=1.25e-09 conditioned to 1

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
12	GTEx	Cells Transformed fibroblasts	EVI5	0.18	0.11	enet	28	0.20	5.9e-15	-5.9	-7.2	7.9e-13	-0.16	0.04	0.96	TRUE
39	The Cancer Genome Atlas	Brain Lower Grade Glioma	EVI5	0.18	0.16	lasso	7	0.15	2.0e-16	-6.0	-6.4	1.3e-10	-0.22	0.02	0.98	TRUE
17	GTEx	Esophagus Mucosa	EVI5	0.12	0.19	lasso	4	0.19	6.0e-13	-5.7	-6.4	1.8e-10	-0.14	0.05	0.95	TRUE
1	CommonMind	Brain Pre-frontal Cortex	EVI5	0.03	0.01	blup	335	0.02	1.3e-03	-6.0	-6.0	1.6e-09	-0.32	0.04	0.92	TRUE
45	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	DR1	0.09	0.09	lasso	2	0.07	4.7e-04	6.0	6.0	1.9e-09	1.00	0.01	0.83	TRUE
2	CommonMind	Brain Pre-frontal Cortex	FAM69A	0.10	0.13	lasso	4	0.14	1.2e-16	-5.0	-6.0	2.2e-09	-0.12	0.51	0.49	TRUE
21	GTEx	Lung	EVI5	0.11	0.08	lasso	11	0.13	7.0e-10	-5.8	-6.8	7.2e-12	-0.14	0.03	0.97	FALSE
15	GTEx	Colon Transverse	EVI5	0.21	0.08	lasso	9	0.14	4.2e-07	-5.7	-6.8	8.1e-12	-0.10	0.04	0.96	FALSE
23	GTEx	Nerve Tibial	FAM69A	0.17	0.03	enet	19	0.05	1.4e-04	-5.4	6.8	1.5e-11	0.29	0.19	0.79	FALSE
37	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	EVI5	0.07	0.05	blup	96	0.06	2.5e-07	-5.7	-6.5	6.9e-11	-0.11	0.04	0.96	FALSE
16	GTEx	Esophagus Gastroesophageal Junction	EVI5	0.22	0.10	lasso	7	0.06	2.3e-03	-5.7	-6.5	7.5e-11	-0.14	0.04	0.95	FALSE
3	CommonMind	Brain Pre-frontal Cortex	RPAP2	0.20	0.06	enet	29	0.16	8.6e-19	-5.3	-6.5	7.7e-11	-0.09	0.20	0.80	FALSE
31	GTEx	Whole Blood	EVI5	0.03	0.01	lasso	2	0.01	6.8e-02	-5.9	-6.5	9.4e-11	-0.19	0.04	0.94	FALSE
33	The Cancer Genome Atlas	Breast Invasive Carcinoma	EVI5	0.03	0.03	lasso	4	0.04	3.6e-09	-5.7	-6.5	1.0e-10	-0.16	0.04	0.96	FALSE
29	GTEx	Thyroid	FAM69A	0.43	0.18	enet	41	0.20	5.5e-15	4.5	6.3	2.1e-10	0.27	0.99	0.01	FALSE
24	GTEx	Skin Not Sun Exposed Suprapubic	EVI5	0.07	0.05	lasso	6	0.08	2.2e-05	-5.7	-6.3	2.5e-10	-0.08	0.05	0.93	FALSE
8	GTEx	Brain Cerebellar Hemisphere	TMED5	0.37	0.06	enet	21	0.11	1.1e-03	6.0	-6.3	2.8e-10	-0.87	0.08	0.79	FALSE
11	GTEx	Breast Mammary Tissue	EVI5	0.07	0.06	lasso	4	0.07	2.3e-04	-5.9	-6.2	6.6e-10	-0.22	0.04	0.95	FALSE
9	GTEx	Brain Cortex	EVI5	0.25	0.33	lasso	13	0.30	4.1e-09	-6.0	-6.2	7.9e-10	-0.23	0.04	0.96	FALSE
35	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	EVI5	0.08	0.04	blup	96	0.06	8.6e-08	-5.7	-6.1	9.0e-10	-0.17	0.03	0.97	FALSE
20	GTEx	Heart Left Ventricle	EVI5	0.07	0.11	lasso	5	0.08	7.7e-05	-5.9	-6.1	9.2e-10	-0.23	0.04	0.96	FALSE
22	GTEx	Nerve Tibial	EVI5	0.17	0.13	enet	25	0.18	4.5e-13	-5.7	-6.0	1.4e-09	-0.12	0.07	0.93	FALSE
10	GTEx	Brain Hypothalamus	EVI5	0.16	0.12	lasso	13	0.05	2.1e-02	-6.0	-6.0	1.5e-09	-0.26	0.04	0.73	FALSE
41	The Cancer Genome Atlas	Lung Adenocarcinoma	EVI5	0.05	0.07	lasso	5	0.07	5.6e-09	-5.7	-6.0	1.6e-09	-0.13	0.05	0.95	FALSE
34	The Cancer Genome Atlas	Colon Adenocarcinoma	EVI5	0.07	0.04	blup	93	0.03	4.7e-03	-5.0	-6.0	1.8e-09	-0.13	0.04	0.79	FALSE
19	GTEx	Heart Atrial Appendage	EVI5	0.09	0.06	lasso	7	0.05	4.2e-03	-6.0	-6.0	1.9e-09	-0.24	0.04	0.90	FALSE
40	The Cancer Genome Atlas	Brain Lower Grade Glioma	TMED5	0.08	0.06	enet	12	0.07	3.5e-08	5.5	-6.0	1.9e-09	-0.83	0.01	0.99	FALSE
47	The Cancer Genome Atlas	Prostate Adenocarcinoma	DR1	0.10	0.09	blup	29	0.08	3.9e-09	6.1	5.9	3.3e-09	0.98	0.01	0.99	FALSE
14	GTEx	Colon Sigmoid	EVI5	0.13	0.16	lasso	3	0.12	7.0e-05	-5.9	-5.9	3.6e-09	-0.24	0.04	0.96	FALSE
48	The Cancer Genome Atlas	Prostate Adenocarcinoma	EVI5	0.06	0.10	blup	94	0.10	1.7e-10	-5.9	-5.9	3.8e-09	-0.20	0.03	0.97	FALSE
43	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	EVI5	0.04	0.04	blup	93	0.03	4.8e-04	-5.7	-5.9	4.2e-09	-0.17	0.04	0.95	FALSE
7	GTEx	Artery Coronary	FAM69A	0.25	0.25	lasso	2	0.26	3.4e-09	-5.7	5.8	5.2e-09	0.11	0.12	0.86	FALSE
18	GTEx	Esophagus Muscularis	EVI5	0.16	0.23	lasso	5	0.23	4.9e-14	-5.7	-5.8	5.9e-09	-0.11	0.04	0.96	FALSE
13	GTEx	Cells Transformed fibroblasts	FAM69A	0.24	0.19	lasso	7	0.17	4.9e-13	-5.7	5.8	6.9e-09	0.11	0.17	0.83	FALSE
5	GTEx	Adipose Subcutaneous	FAM69A	0.08	0.06	lasso	7	0.04	3.8e-04	-5.7	5.8	7.1e-09	0.17	0.07	0.91	FALSE
42	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	DR1	0.03	0.02	blup	29	0.02	3.2e-03	5.4	5.8	7.5e-09	0.98	0.01	0.89	FALSE
46	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	EVI5	0.10	0.06	blup	94	0.08	2.9e-04	-5.9	-5.8	8.6e-09	-0.20	0.03	0.92	FALSE
6	GTEx	Adipose Visceral Omentum	EVI5	0.13	0.08	lasso	2	0.07	2.3e-04	-5.7	-5.7	1.0e-08	-0.07	0.06	0.88	FALSE
25	GTEx	Spleen	CCDC18	0.29	0.07	lasso	10	0.15	9.2e-05	5.5	-5.7	1.2e-08	-0.89	0.06	0.83	FALSE
4	GTEx	Adipose Subcutaneous	EVI5	0.09	0.07	lasso	3	0.09	1.2e-07	-5.0	-5.7	1.5e-08	-0.08	0.10	0.90	FALSE
36	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	FAM69A	0.05	0.03	blup	62	0.05	4.4e-06	-5.0	-5.6	2.7e-08	-0.04	0.06	0.92	FALSE
26	GTEx	Stomach	EVI5	0.12	0.13	lasso	6	0.14	4.7e-07	-5.7	-5.5	2.8e-08	-0.02	0.07	0.93	FALSE
51	The Cancer Genome Atlas	Thyroid Carcinoma	EVI5	0.05	0.01	blup	94	0.03	5.7e-04	-6.0	5.5	2.9e-08	-0.02	0.03	0.90	FALSE
50	The Cancer Genome Atlas	Thyroid Carcinoma	DR1	0.16	0.18	blup	29	0.19	4.1e-18	5.4	5.5	3.0e-08	0.95	0.02	0.98	FALSE
32	The Cancer Genome Atlas	Breast Invasive Carcinoma	DR1	0.04	0.04	lasso	3	0.04	1.5e-08	6.0	5.5	3.9e-08	0.98	0.01	0.99	FALSE
38	The Cancer Genome Atlas	Brain Lower Grade Glioma	DR1	0.03	0.03	blup	29	0.03	1.1e-04	6.1	5.4	5.2e-08	0.98	0.01	0.98	FALSE
30	GTEx	Uterus	EVI5	0.23	0.12	enet	27	0.16	4.3e-04	-6.0	-5.4	8.5e-08	-0.20	0.06	0.84	FALSE
44	The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	EVI5	0.05	0.02	blup	96	0.03	2.3e-03	-5.1	-5.3	1.1e-07	-0.17	0.06	0.81	FALSE
28	GTEx	Thyroid	RPAP2	0.04	0.03	enet	15	0.03	4.2e-03	3.3	-5.3	1.4e-07	-0.01	0.23	0.17	FALSE
27	GTEx	Testis	TMED5	0.27	0.31	lasso	5	0.30	6.9e-14	5.4	-5.3	1.5e-07	-0.95	0.21	0.79	FALSE
49	The Cancer Genome Atlas	Stomach Adenocarcinoma	EVI5	0.14	0.07	lasso	3	0.08	3.4e-06	-5.7	-5.1	2.9e-07	-0.07	0.05	0.95	FALSE