Hub : Genes

PKN2

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Adipose Visceral Omentum	0.0860	0.0360	1.2e-03	0.041	NA	0.051	NA	0.040	3.2e-03	NA	0.00120	NA	3.7e-03
2	GTEx	Colon Transverse	0.2300	0.0800	1.6e-04	0.079	NA	0.044	NA	0.082	1.3e-04	NA	0.00370	NA	1.0e-04
3	GTEx	Small Intestine Terminal Ileum	0.2610	0.1120	6.9e-03	0.341	NA	0.160	NA	0.230	1.8e-08	NA	0.00021	NA	7.0e-06
4	TCGA	Breast Invasive Carcinoma	0.0174	0.0119	9.5e-03	0.014	0.003	0.011	NA	0.010	4.8e-04	0.0810	0.00230	NA	2.8e-03
5	TCGA	Brain Lower Grade Glioma	0.0453	0.0236	3.9e-05	0.008	0.016	0.021	NA	0.016	3.7e-02	0.0059	0.00160	NA	4.9e-03

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5
Bipolar Disorder (2018)	0.1	0.2	0.4	0.1	0.5	0.6	-0.4	0.4
Bipolar Disorder or Schizophrenia	0.5	1.2	3.4	0.3	1.0	1.9	-1.1	-0.3
Depressed Affect (Nagel 2018)	0.1	0.2	0.7	0.1	-0.8	-0.3	-0.2	0.6
Depression (Nagel 2018)	0.1	0.2	0.3	-0.2	-0.2	0.3	-0.6	-0.5
Intelligence (Savage-Jansen 2018)	5.5	17.0	20.2	-4.4	3.5	4.5	-4.0	-4.1
Neuroticism (Nagel 2018)	1.0	2.3	5.2	1.2	-2.3	-1.0	1.1	1.6
Schizophrenia (2018)	0.6	1.2	3.5	0.3	0.9	1.9	-1.1	-0.7
Schizophrenia vs Biploar Disorder	1.7	2.3	4.7	1.4	-1.2	-1.2	2.2	1.2
Worry (Nagel 2018)	1.7	3.5	6.8	2.6	-2.0	-0.5	1.9	1.7
Alzheimer’s Disease (in mother)	0.4	0.5	0.9	-0.7	0.6	0.8	-1.0	0.1
Alzheimer’s Disease (in father)	2.6	2.8	5.9	-1.5	0.9	1.0	-2.4	-1.9
Alzheimer’s Disease (including proxy)	3.0	4.3	8.7	-1.7	1.8	1.9	-3.0	-1.8
Crohns Disease (2017)	1.6	3.6	8.4	2.9	-1.4	-1.6	1.8	1.3
Irritable Bowel Disease (IBD)	1.2	2.8	8.5	2.9	-0.7	-0.7	1.6	1.5
Ulcerative Colitis (UC)	0.6	1.1	3.2	1.8	-0.1	0.0	0.8	1.2
Major Depression (MDD)	1.3	1.5	3.6	-1.2	-1.3	-1.9	0.9	0.2
Reaction Time	0.2	0.4	0.7	0.4	-0.6	-0.5	0.7	0.9
Verbal and Numeric Reasoning (VNR)	1.3	3.2	5.2	-2.3	1.4	2.0	-1.6	-1.6
Breast Cancer	4.5	10.9	13.7	3.5	-2.9	-2.8	3.7	3.5
Ovarian Cancer	0.1	0.2	0.4	-0.2	-0.1	0.2	-0.5	-0.7
Prostate Cancer	0.3	0.4	1.6	0.2	0.3	-1.3	0.1	-0.4
Age at First Birth	2.1	3.1	5.0	-1.6	1.6	1.2	-1.9	-2.2
Bipolar Disorder (2011)	0.6	0.6	1.4	0.8	1.2	0.8	-0.2	0.5
Body Mass Index (BMI) (2010)	0.6	0.9	1.6	0.8	-1.2	-0.6	0.6	1.3
Coronary Artery Disease (CAD)	3.3	3.9	6.3	2.3	-1.1	-1.1	2.3	2.5
Crohns Disease (2012)	1.8	2.9	3.9	2.0	-1.7	-1.9	1.4	1.4
Mean Putamen Volume	0.2	0.2	0.5	-0.0	-0.5	0.7	-0.1	-0.3
Fasting Glucose	0.6	0.7	3.3	1.8	-0.4	0.3	0.2	0.1
HbA1C	0.7	0.8	1.9	0.5	-1.4	-0.9	0.9	0.6
HDL Cholesterol	0.1	0.2	0.6	0.8	0.2	-0.1	-0.7	0.1
LDL Cholesterol	1.5	2.3	3.4	-0.6	1.8	1.9	-1.7	-1.3
Lupus	0.4	0.6	1.6	-0.1	1.3	0.8	-0.3	-0.6
Neuroticism (2016)	1.8	2.6	3.7	1.9	-1.9	-1.0	1.3	1.7
Primary Biliary Cirrhosis	1.0	1.4	2.6	-0.3	0.8	1.5	-1.6	-1.1
Rheumatoid Arthritis	2.2	3.0	5.7	2.4	-2.4	-1.5	0.7	0.9
Schizophrenia (2014)	0.4	0.8	2.5	0.8	0.8	1.6	-0.0	-0.4
Triglycerides	0.1	0.1	0.3	0.2	-0.5	-0.1	-0.2	0.3
Type 2 Diabetes (T2D) (2012)	1.8	2.1	4.1	2.0	-0.1	-0.2	1.6	2.0
Ulcerative Colitis	0.3	0.4	0.7	0.7	0.4	0.8	-0.3	0.8
Blood Eosinophil Count	0.7	5.1	8.2	1.1	-2.9	-2.5	1.7	2.6
Blood Platelet Count	1.2	14.0	27.0	4.2	-2.8	-2.6	3.4	5.2
Blood Red Count	3.7	36.1	63.0	7.9	-4.1	-5.0	5.6	6.7
Blood White Count	0.7	5.1	10.2	3.2	0.0	-1.3	1.8	3.2
Heel T-Score	6.1	48.6	59.9	6.9	-6.6	-6.0	7.5	7.7
BMI	1.0	6.0	11.7	3.4	-0.9	-2.1	2.0	3.1
Height	8.8	169.6	216.1	-12.9	11.7	12.1	-13.5	-14.7
Waist Hip Ratio (WHR)	3.1	13.7	16.6	-3.9	3.6	3.1	-4.1	-3.8
Systolic Blood Pressure	7.0	35.0	57.8	7.6	-3.7	-3.8	7.0	6.3
Smoking Status	1.6	3.9	7.4	-0.5	-2.7	-2.6	1.1	2.0
Allergy or Eczema	2.0	5.3	7.6	1.8	-2.0	-2.6	2.8	2.2
Cardiovascular Disease	2.8	9.3	21.2	4.6	-0.8	-0.9	4.1	2.7
Hypothyroidism (self reported)	0.7	1.6	2.8	0.3	-1.4	-1.7	1.1	1.5
Respiratory disease	0.6	1.4	4.7	-2.2	0.0	-0.1	-1.2	-1.0
Type 2 Diabetes (T2D) (2018)	0.2	0.4	1.5	1.2	0.5	-0.2	0.2	0.2
Lung FEV1/FVC ratio	1.4	7.0	10.6	1.4	-3.3	-2.5	3.2	2.4
Lung FVC	0.2	1.2	2.4	-0.1	-1.2	-1.6	1.3	0.7
Neuroticism	1.2	3.0	5.0	1.4	-2.2	-1.3	1.9	1.7
Chronotype (morning person)	1.8	4.2	9.2	3.0	-2.5	-0.8	0.6	2.2
Hair Pigment	0.2	4.7	9.7	3.1	-0.7	-1.3	2.0	2.7
Tanning	0.2	2.2	4.9	-0.0	-1.6	-1.8	2.2	0.6
Hand grip strength (left)	1.2	3.1	9.3	-3.0	2.0	0.4	-0.7	-1.2
Number of treatments/medications taken	1.6	3.0	5.8	1.5	-1.6	-0.9	2.4	1.8
Average weekly spirits intake	0.1	0.1	0.3	0.1	-0.4	0.0	0.6	0.2
Sensitivity / hurt feelings	0.7	1.3	4.8	-2.2	0.3	0.4	-0.9	-0.7
Frequency of depressed mood in last 2 weeks	0.3	0.5	0.7	0.8	-0.8	-0.7	-0.4	0.6
Hearing difficulty/problems: Yes	0.5	0.8	2.1	-0.3	-0.3	-1.2	1.4	0.7
Relative age of first facial hair	0.1	0.3	0.6	-0.4	0.3	0.7	-0.8	-0.2
Other serious medical condition/disability diagnosed by doctor	0.3	0.4	0.5	-0.4	-0.6	-0.6	0.7	0.6
Ever used hormone-replacement therapy (HRT)	0.1	0.1	0.3	0.0	-0.5	0.1	0.1	0.4
Ever had hysterectomy (womb removed)	1.7	1.9	4.1	0.6	1.9	2.0	-1.0	-0.7
Systolic blood pressure, automated reading	5.7	16.6	37.0	6.1	-1.8	-1.8	3.7	5.1
Eye problems/disorders: Diabetes related eye disease	0.2	0.2	0.5	-0.7	-0.5	-0.2	-0.2	-0.4
Angina	2.1	2.7	5.1	0.9	-1.3	-1.8	2.3	1.6
Medication for hormone replacement therapy	0.4	0.5	1.0	-0.2	-0.7	-1.0	0.4	0.7
Vitamin and mineral supplements	0.9	1.2	3.0	1.5	-0.3	-0.3	0.8	1.7
Supplements: Zinc	0.4	0.4	0.7	0.1	0.7	0.8	-0.6	-0.8
Medication: Co-codamol	0.5	0.6	2.2	-0.6	-1.5	-0.0	-0.0	-0.8
Medication: Metformin	0.5	0.7	2.0	1.4	0.6	-0.0	0.3	0.9
Diabetes (father)	0.2	0.3	0.5	-0.1	-0.7	-0.7	0.2	0.5
Diabetes (mother)	0.5	0.6	1.9	0.5	-0.8	-1.4	-0.2	-0.5
Severe depression (siblings)	0.3	0.3	0.6	0.3	0.2	0.8	-0.6	-0.7
Pack years adult smoking proportion	2.1	3.2	5.5	-2.1	0.6	1.4	-2.3	-1.9
Impedance of leg (right)	0.1	0.4	1.5	0.4	0.0	1.2	-0.6	-0.0
Leg fat-free mass (left)	1.1	5.9	9.3	-2.2	3.0	1.3	-2.2	-3.0
Trunk fat percentage	0.2	0.8	1.7	1.3	1.2	0.9	-0.3	0.6
Hand grip strength (right)	1.8	4.8	9.1	-3.0	2.6	1.0	-1.7	-2.1
Townsend deprivation index at recruitment	0.2	0.3	1.1	-1.0	-0.1	-0.1	-0.4	-0.5
Current tobacco smoking	0.2	0.4	0.6	-0.8	-0.5	-0.4	-0.8	-0.4
Average weekly fortified wine intake	3.2	3.7	7.1	1.0	2.7	2.1	-1.9	-1.5
Maternal smoking around birth	0.2	0.3	0.8	0.0	-0.9	-0.6	0.6	0.3
Fed-up feelings	0.1	0.2	0.7	0.1	-0.8	-0.3	-0.4	0.3
Frequency of unenthusiasm / disinterest in last 2 weeks	1.4	1.9	3.5	-1.2	1.0	0.9	-1.9	-1.7
Relative age voice broke	0.6	0.9	1.8	-1.2	0.1	0.8	-1.4	-0.5
Taking other prescription medications	0.9	1.4	2.4	-0.2	-1.4	-1.5	1.5	0.8
Age when periods started (menarche)	0.2	0.4	1.2	-1.1	0.1	0.3	-0.1	-0.9
Bilateral oophorectomy (both ovaries removed)	3.1	3.6	9.0	0.3	1.6	3.0	-2.2	-1.2
Heel bone mineral density (BMD) T-score, automated (left)	3.8	8.5	11.9	2.3	-2.3	-3.2	3.5	3.1
Tinnitus: Yes, but not now, but have in the past	0.8	0.9	1.5	-1.2	-1.2	-0.7	1.1	-0.1
Qualifications: CSEs or equivalent	1.9	2.5	4.4	2.1	-1.2	-1.6	1.6	1.3
Serious illness, injury or assault to yourself	0.8	0.9	2.2	-0.5	1.1	1.5	-0.7	-0.7
High blood pressure	4.5	12.6	22.8	4.8	-2.0	-1.4	4.3	4.0
Hayfever, allergic rhinitis or eczema	2.1	4.5	6.3	1.5	-2.4	-2.5	2.4	1.5
Multivitamins +/- minerals	0.7	0.9	2.7	-1.6	-0.2	-0.2	-0.1	-1.3
Stomach or abdominal pain in last month	0.4	0.4	1.1	-1.0	0.3	-0.6	-0.5	-0.7
Supplements: Glucosamine	0.1	0.2	0.5	-0.1	0.4	0.5	-0.1	-0.7
Diverticular disease/diverticulitis (self-reported)	0.3	0.3	0.9	0.7	-1.0	-0.4	0.0	-0.1
Medication: Atenolol	7.9	9.8	17.5	3.3	-2.6	-2.5	4.2	2.9
Medication: Levothyroxine sodium	1.7	2.9	6.2	0.2	-1.7	-2.5	1.5	1.8
Sitting height	6.1	43.0	60.8	-6.6	6.0	5.7	-6.5	-7.8
Chronic bronchitis/emphysema (father)	0.7	0.8	1.7	-0.1	0.7	1.3	-0.9	-1.1
High blood pressure (mother)	3.5	4.8	9.2	1.6	-0.9	-2.6	3.0	2.2
Body mass index (BMI)	1.8	7.5	11.4	3.4	-1.2	-2.6	2.7	3.3
Impedance of leg (left)	0.1	0.5	2.0	0.2	0.2	1.4	-0.7	-0.1
Leg predicted mass (left)	1.1	6.0	9.2	-2.2	3.0	1.3	-2.3	-3.0
Trunk fat mass	0.3	1.2	3.7	0.5	1.9	1.0	-0.9	-0.4
Waist circumference	0.4	1.3	3.7	-0.3	1.9	0.7	-1.3	-0.9
Number of incorrect matches in round	1.6	2.6	4.5	1.8	-1.5	-1.2	1.4	2.1
Past tobacco smoking	2.1	3.9	7.5	-0.4	2.7	2.0	-1.4	-2.4
Alcohol usually taken with meals	0.1	0.1	0.4	0.5	-0.1	0.0	0.6	0.0
Nervous feelings	1.9	3.6	5.1	2.3	-1.8	-1.4	1.9	2.1
Frequency of tenseness / restlessness in last 2 weeks	0.3	0.5	2.0	1.4	0.2	-0.2	-0.2	0.6
Hearing difficulty/problems with background noise	0.6	0.9	4.4	-2.1	-0.2	0.2	0.2	0.3
Hair/balding pattern: Pattern 2	2.7	3.5	6.4	-2.5	1.4	1.0	-1.4	-2.5
Had menopause	0.9	1.1	2.2	-0.6	1.0	1.1	-1.5	-0.8
Had other major operations	0.5	0.7	1.1	0.1	1.1	0.9	-0.9	-0.7
Forced vital capacity (FVC)	2.1	8.0	12.7	-3.6	2.6	2.0	-2.2	-3.3
Heel bone mineral density (BMD) T-score, automated (right)	3.2	7.3	11.0	2.6	-2.1	-2.0	3.1	3.3
Ever unenthusiastic/disinterested for a whole week	0.9	1.1	2.0	-1.1	-0.6	0.6	-1.4	-1.3
Qualifications: None of the above	3.9	8.3	10.0	3.2	-3.1	-2.6	2.8	2.6
Financial difficulties in last 2 years	0.6	0.8	1.8	-1.3	0.3	-0.6	-0.0	-1.3
Mouth/teeth dental problems	0.8	1.3	3.2	0.6	-1.0	-1.0	1.8	1.1
Heart attack	2.0	2.6	3.3	1.7	-1.4	-1.5	1.8	1.6
Allergy	0.8	1.8	3.2	-0.9	1.4	1.8	-1.4	-0.9
Pain all over the body in last month	0.6	0.7	1.4	-0.4	-1.2	-0.9	0.7	0.7
Diabetes (self-reported)	0.1	0.2	0.7	0.0	0.2	0.1	-0.8	-0.4
Hayfever/allergic rhinitis (self-reported)	0.5	0.7	1.4	1.2	-0.6	-0.3	1.1	0.6
Medication: Ramipril	2.3	2.9	9.8	3.1	-0.9	-0.6	1.5	1.2
Medication: Simvastatin	0.3	0.5	1.9	1.4	0.5	-0.2	0.4	0.1
Fluid intelligence score	3.8	7.9	9.8	-2.8	3.1	3.0	-2.1	-2.8
Illnesses of siblings	3.8	5.3	11.2	-3.4	1.6	1.3	-2.3	-2.4
Neuroticism score	0.8	1.6	3.3	1.1	-1.8	-0.9	0.9	1.4
Weight	0.5	2.7	6.9	-0.8	2.6	1.1	-1.3	-1.7
Impedance of arm (right)	2.0	9.3	16.6	-2.4	3.0	4.1	-3.2	-2.2
Arm fat percentage (right)	1.2	4.6	8.7	2.9	-0.4	-1.6	1.8	2.9
Trunk fat-free mass	1.1	6.3	11.6	-2.4	2.9	1.2	-2.1	-3.4
Hip circumference	0.1	0.6	1.9	0.8	1.4	0.5	-0.4	-0.3
Time employed in main current job	0.2	0.3	0.7	-0.0	-0.8	0.4	0.5	-0.5
Alcohol intake versus 10 years previously	3.6	5.4	7.0	2.6	-2.3	-2.5	2.2	1.9
Father’s age at death	0.1	0.2	0.5	-0.2	0.1	0.7	0.0	-0.5
Worrier / anxious feelings	0.8	1.4	2.0	1.4	-1.4	-0.0	1.4	1.2
Frequency of tiredness / lethargy in last 2 weeks	0.0	0.1	0.1	0.2	-0.2	-0.3	0.0	0.3
Falls in the last year	0.1	0.2	0.4	-0.2	-0.5	0.3	-0.6	-0.3
Hair/balding pattern: Pattern 3	0.2	0.3	0.6	0.1	-0.6	-0.4	0.6	0.8
Number of live births	0.1	0.1	0.3	0.2	-0.2	-0.5	-0.2	-0.0
Forced expiratory volume in 1-second (FEV1)	0.5	1.6	3.8	-1.9	1.1	0.3	-0.0	-1.7
Pulse rate	1.0	1.6	6.1	-0.7	2.5	0.7	-1.0	-0.5
Happiness	1.3	1.6	2.9	-0.7	1.1	1.2	-1.4	-1.7
Noisy workplace	5.4	6.7	10.1	2.3	-3.2	-2.7	1.8	2.8
Qualifications: A levels/AS levels or equivalent	1.1	2.4	5.5	-2.3	1.1	0.8	-0.1	-2.1
Serious illness, injury or assault of a close relative in last 2 years	1.9	2.2	4.6	2.1	-0.4	-1.4	1.3	1.7
Mouth/teeth dental problems: Dentures	0.2	0.3	1.0	1.0	-0.3	0.2	-0.4	0.5
Asthma	0.6	1.1	2.6	-1.6	0.5	-0.0	-0.9	-1.4
Medication: Ibuprofen (e.g. Nurofen)	0.4	0.5	0.9	-0.8	0.2	0.9	-0.6	-0.6
Medication: Cholesterol lowering	0.4	0.7	3.0	1.7	0.1	-0.3	0.5	-0.2
Depression (self-reported)	0.6	0.7	2.2	-0.5	-1.5	-0.8	0.7	0.2
Medication: Lansoprazole	1.0	1.2	1.8	1.1	-0.9	-1.2	1.4	0.7
Prospective memory result	3.7	4.6	6.4	2.5	-2.1	-1.3	2.2	2.4
Lung cancer (father)	0.3	0.3	1.2	-0.4	0.0	-0.0	0.6	1.1
Illnesses of mother	3.0	3.8	6.2	-1.4	0.9	2.0	-2.4	-2.5
Forced expiratory volume in 1-second (FEV1), Best measure	0.7	2.2	5.5	-2.3	1.1	0.6	-0.4	-1.9
Pulse wave Arterial Stiffness index	0.1	0.1	0.4	-0.6	-0.1	-0.0	-0.3	0.1
Impedance of arm (left)	2.7	12.4	20.4	-2.9	3.1	4.5	-3.9	-2.9
Arm fat mass (right)	0.3	1.4	3.4	1.9	0.4	-0.7	0.8	1.5
Trunk predicted mass	1.0	5.9	10.8	-2.3	2.9	1.1	-2.0	-3.3
Standing height	8.3	82.6	114.5	-8.9	8.6	8.3	-8.8	-10.7
Length of working week for main job	0.1	0.1	0.5	0.0	-0.7	-0.2	-0.1	0.0
Exposure to tobacco smoke at home	1.3	1.5	4.2	-2.0	0.4	1.1	-0.6	-1.2
Breastfed as a baby	0.9	1.1	2.0	1.1	-0.6	-1.4	0.3	1.3
Tense / ‘highly strung’	1.6	2.7	5.2	1.4	-1.7	-1.1	2.3	1.4
Seen doctor (GP) for nerves, anxiety, tension or depression	0.3	0.5	1.1	-1.1	0.8	0.2	-0.5	-0.7
Hair/balding pattern: Pattern 4	2.3	5.6	9.4	3.1	-1.2	-1.9	2.3	2.8
Birth weight of first child	8.0	14.6	18.1	-4.2	3.8	3.0	-3.8	-4.2
Peak expiratory flow (PEF)	0.4	1.0	2.0	-1.4	1.1	0.2	-0.1	-1.3
Pulse wave reflection index	3.9	4.9	9.7	1.8	-3.1	-2.1	1.9	1.8
Ever highly irritable/argumentative for 2 days	1.3	1.5	2.7	1.6	-1.0	-1.1	1.0	1.4
Loud music exposure frequency	0.4	0.5	1.3	-0.1	1.2	0.3	-0.8	-0.6
Qualifications: O levels/GCSEs or equivalent	0.3	0.5	1.4	-0.8	0.0	-1.2	0.7	0.2
Mouth/teeth dental problems: Bleeding gums	0.5	0.6	1.4	-0.4	0.7	0.2	-1.0	-1.2
Blood clot in the leg (DVT)	0.0	0.0	0.1	-0.1	-0.3	-0.0	-0.2	0.1
Medication: Paracetamol	0.8	1.3	4.0	0.3	-2.0	-0.6	1.4	0.3
Headache pain in last month	1.8	3.1	6.9	-2.6	0.8	1.5	-1.6	-1.7
Medication for cholesterol, blood pressure or diabetes	2.0	3.4	9.2	-3.0	0.8	0.9	-1.9	-1.6
Glaucoma (self-reported)	0.5	0.5	1.3	-0.0	0.7	1.2	-0.5	-0.8
Gout (self-reported)	1.9	2.6	3.7	0.8	1.9	1.8	-1.9	-1.2
Hypothyroidism/myxoedema (self-reported)	1.5	3.0	5.2	0.4	-1.6	-2.3	1.8	2.0
Medication: Amlodipine	0.9	1.2	2.1	1.5	-1.3	0.2	0.8	1.3
Medication: Ventolin 100micrograms inhaler	0.3	0.4	0.9	-0.9	-0.3	-0.6	0.5	-0.7
Birth weight	1.3	2.8	12.2	-3.5	0.2	-0.4	-0.6	-1.1
Chronic bronchitis/emphysema (mother)	0.9	1.0	2.5	0.1	0.0	-0.4	1.6	1.6
High blood pressure (siblings)	2.6	3.8	5.3	1.6	-2.3	-2.1	2.0	1.6
Forced vital capacity (FVC), Best measure	2.3	8.6	14.7	-3.8	2.5	2.1	-2.4	-3.4
Body fat percentage	0.5	2.1	5.7	2.4	0.2	-0.5	0.9	1.9
Leg fat percentage (right)	3.4	12.3	19.6	4.4	-1.8	-2.9	3.5	4.3
Arm fat-free mass (right)	0.6	3.0	6.8	-1.6	1.9	0.5	-1.4	-2.6
Exposure to tobacco smoke outside home	1.1	1.4	3.6	-0.7	0.1	1.5	-0.8	-1.9
Comparative body size at age 10	0.1	0.4	1.5	-0.4	1.2	0.2	-0.0	-0.2
Number of full brothers	0.1	0.2	0.4	0.2	0.0	-0.7	-0.3	-0.5
Worry too long after embarrassment	0.3	0.4	1.8	-1.3	-0.4	-0.0	0.5	-0.3
Seen a psychiatrist for nerves, anxiety, tension or depression	0.5	0.6	1.5	0.9	0.1	-1.2	0.2	0.8
Wheeze or whistling in the chest in last year	1.6	2.8	6.4	-1.7	1.1	1.0	-1.6	-2.5
Number of children fathered	1.8	2.0	4.0	2.0	-1.1	-0.5	1.8	1.2
Reason for reducing amount of alcohol drunk: Health precaution	0.3	0.4	0.9	-0.6	1.0	0.6	-0.6	0.1
Age at first live birth	2.3	4.1	8.8	-3.0	1.9	1.0	-1.2	-2.4
Pulse wave peak to peak time	0.3	0.4	1.0	-0.1	0.7	0.5	-0.3	-1.0
Health satisfaction	0.2	0.3	0.7	0.7	-0.1	-0.1	0.4	0.8
Shortness of breath walking on level ground	0.2	0.2	0.9	-0.0	-0.4	0.1	0.2	0.9
Qualifications: College or University degree	3.9	12.1	19.1	-4.4	4.0	2.9	-2.5	-3.2
Eye problems/disorders: None of the above	0.8	0.9	2.1	0.7	-1.0	-1.5	0.6	0.6
Mouth/teeth dental problems: Loose teeth	4.0	4.7	8.2	-2.9	2.4	1.7	-1.5	-2.2
Emphysema/chronic bronchitis	0.2	0.3	0.9	-0.3	-0.4	-0.5	-0.9	-0.0
Medication for pain relief, constipation, heartburn	1.0	1.6	3.6	-1.2	1.9	0.7	-1.5	-0.5
Neck or shoulder pain in last month	0.2	0.3	0.7	0.8	-0.4	0.2	0.1	0.8
Medication: Blood pressure	4.1	7.3	12.8	3.6	-2.6	-1.9	2.9	2.3
Angina (self-reported)	2.6	3.4	5.9	1.0	-1.6	-2.0	2.4	2.0
Migraine (self-reported)	0.3	0.4	0.9	-0.8	0.9	0.5	-0.3	-0.3
Medication: Ibuprofen	0.0	0.0	0.1	-0.2	-0.2	0.2	-0.1	0.3
Medication: Allopurinol	3.6	4.8	6.7	1.5	2.6	2.6	-2.1	-2.0
Medication: Omeprazole	0.2	0.3	0.4	0.6	0.5	-0.6	0.5	-0.2
Medication: Seretide 50 evohaler	2.8	3.2	4.3	-1.3	2.1	1.8	-1.7	-2.0
Mean time to correctly identify matches	0.0	0.0	0.2	-0.4	-0.2	-0.0	0.1	0.1
Heart disease (mother)	1.1	1.4	3.1	1.2	-0.4	-0.8	1.2	1.8
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.7	0.9	2.7	-0.8	-1.6	-0.5	0.9	-0.0
Whole body fat mass	0.1	0.5	1.2	1.0	1.1	0.1	-0.1	0.4
Leg fat mass (right)	0.8	3.0	6.2	2.5	0.0	-1.5	1.5	2.0
Arm predicted mass (right)	0.5	2.8	6.6	-1.3	1.9	0.5	-1.4	-2.6
Pulse rate, automated reading	0.2	0.7	2.9	0.0	1.7	0.1	-0.7	0.4
Alcohol intake frequency.	0.2	0.5	1.7	-1.3	-0.0	0.5	0.1	-0.6
Comparative height size at age 10	3.9	21.7	33.3	-4.0	5.2	4.0	-4.0	-5.8
Number of full sisters	0.2	0.2	0.5	-0.1	0.2	-0.4	-0.7	-0.6
Suffer from ‘nerves’	0.1	0.2	0.4	0.6	-0.3	0.2	0.2	0.4
Overall health rating	0.0	0.1	0.5	-0.7	0.1	0.1	-0.0	0.0
Chest pain or discomfort	0.2	0.3	1.0	1.0	0.4	-0.1	-0.2	-0.6
Had major operations	1.4	1.7	3.6	-0.2	1.9	1.2	-1.5	-1.1
Age at last live birth	2.2	3.2	5.8	-2.4	1.3	0.6	-1.6	-2.4
Family relationship satisfaction	0.5	0.7	1.3	-0.9	0.4	0.1	-1.1	-1.0
Leg pain on walking	0.2	0.3	0.7	0.3	-0.8	0.5	-0.4	-0.4
Qualifications: NVQ or HND or HNC or equivalent	0.1	0.1	0.3	-0.1	-0.5	-0.1	-0.5	-0.0
Commuting to job workplace: Car/motor vehicle	3.2	3.7	5.1	1.9	-2.0	-1.5	2.3	1.9
Illness, injury, bereavement, stress in last 2 years	0.2	0.3	0.5	-0.7	-0.6	-0.4	0.0	0.6
Medication: Aspirin	1.7	2.3	4.7	2.2	-1.0	-0.9	1.9	1.2
Supplements: Vitamin C	0.3	0.4	0.7	0.4	0.8	0.5	-0.7	-0.7
Knee pain experienced in last month	1.6	2.5	4.8	1.5	-2.2	-1.5	1.5	1.0
Hypertension (Self-reported)	3.7	10.3	21.2	4.6	-1.6	-0.8	3.9	3.5
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.3	0.4	1.6	0.4	-0.3	0.1	0.5	-1.2
Illnesses of father: Heart disease	2.4	3.3	5.0	1.0	-2.0	-1.9	2.2	1.7
Illnesses of siblings: Diabetes	2.2	2.7	5.7	1.8	-0.2	-1.4	2.4	1.6
Smoking status: Previous	2.1	3.2	5.5	0.5	-2.2	-1.8	1.4	2.3
Forced expiratory volume in 1-second (FEV1), predicted	4.4	9.1	16.2	-4.0	2.5	2.1	-2.4	-3.6
Whole body fat-free mass	1.2	6.8	11.6	-2.6	3.0	1.3	-2.3	-3.4
Leg fat-free mass (right)	1.3	7.1	10.6	-2.6	3.1	1.4	-2.5	-3.3
Arm fat percentage (left)	0.9	3.8	7.4	2.7	-0.3	-1.5	1.5	2.6
Average weekly red wine intake	0.8	1.2	2.4	-1.5	1.5	0.4	-0.3	-1.0
Handedness (chirality/laterality): Left-handed	0.6	0.7	1.5	-0.8	-1.2	-0.4	0.5	0.9
Mood swings	0.8	1.4	2.6	1.1	-1.6	-1.1	0.9	1.1
Loneliness, isolation	3.7	5.2	7.4	-2.2	1.8	2.1	-2.7	-2.4
Long-standing illness, disability or infirmity	0.0	0.1	0.2	0.2	0.4	0.3	0.2	0.0
Ever had bowel cancer screening	0.4	0.4	0.7	-0.9	0.6	0.8	-0.7	-0.2
Diabetes diagnosed by doctor	0.1	0.2	0.5	0.7	0.7	0.0	-0.3	-0.0
Ever had stillbirth, spontaneous miscarriage or termination	1.5	1.7	4.0	-0.1	-1.7	-2.0	1.0	0.4
Friendships satisfaction	0.4	0.6	1.1	-0.3	1.1	0.9	-0.6	-0.5
Qualifications: nursing, teaching	0.9	1.4	1.9	-1.4	1.2	1.3	-1.0	-1.1
Commuting to job workplace: Walk	0.7	0.8	1.5	-0.4	1.2	0.8	-1.2	-0.4
Eye problems/disorders: Cataract	0.9	1.0	2.3	-1.5	0.9	1.0	-0.1	-0.9
Mouth/teeth dental problems: Mouth ulcers	0.4	0.6	1.5	-1.0	0.3	0.3	-0.7	-1.2
Medication for cholesterol	3.3	4.9	8.9	-3.0	1.2	0.6	-2.8	-2.5
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.6	0.7	1.5	0.0	-0.8	-1.2	1.2	0.2
Back pain experienced in last month	0.4	0.6	2.7	-1.6	0.1	0.3	-0.3	-0.5
Mineral and other dietary supplements	3.9	5.3	8.4	2.2	-2.1	-2.3	1.9	2.9
Breast cancer (self-reported)	0.4	0.5	1.5	-0.9	0.3	0.1	-1.2	-0.4
Asthma (self-reported)	0.6	1.2	2.8	-1.7	0.3	-0.1	-0.9	-1.5
Osteoporosis (self-reported)	0.1	0.1	0.3	-0.4	-0.6	0.3	-0.3	-0.3
Osteoarthritis (self-reported)	0.1	0.2	0.5	0.2	-0.2	-0.1	-0.3	0.7
Medication: Aspirin	1.5	1.9	3.7	1.9	-0.8	-0.8	1.8	1.2
Medication: Gliclazide	1.4	1.6	6.1	2.5	0.6	0.7	0.0	1.1
Illnesses of father: None of the above (group 1)	0.1	0.1	0.2	0.2	0.4	0.2	-0.4	-0.4
Smoking status: Current	0.3	0.5	1.0	-1.0	-0.8	-0.4	-0.8	-0.2
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.1	0.3	0.6	-0.7	-0.4	-0.6	0.5	-0.0
Whole body water mass	1.1	6.2	11.0	-2.4	2.8	1.2	-2.2	-3.3
Leg predicted mass (right)	1.4	7.3	11.3	-2.6	3.1	1.5	-2.5	-3.4
Arm fat mass (left)	0.3	1.2	3.1	1.8	0.5	-0.7	0.7	1.2
Number of self-reported non-cancer illnesses	0.9	1.6	4.3	1.4	-0.7	-0.5	2.1	0.9
Average weekly champagne plus white wine intake	0.3	0.5	1.1	-1.1	0.2	0.9	-0.5	-0.5
Miserableness	0.1	0.1	0.2	-0.3	-0.5	-0.3	-0.0	0.5
Guilty feelings	0.1	0.2	0.6	0.0	-0.2	0.5	-0.8	0.2
Wears glasses or contact lenses	0.1	0.1	0.2	-0.3	0.4	0.3	0.0	0.4
Ever taken oral contraceptive pill	0.6	0.7	2.2	-1.5	0.2	-0.2	-0.4	-1.0
Hearing aid user	0.3	0.4	0.7	0.7	-0.8	-0.0	0.7	0.5
Mother’s age at death	0.6	0.7	1.7	-0.0	-1.3	-1.0	0.8	0.2
Financial situation satisfaction	0.3	0.4	0.8	-0.9	-0.3	-0.8	0.6	0.2
Tinnitus: Yes, now most or all of the time	0.8	0.9	1.9	1.4	-1.3	-0.7	0.1	0.6
Commuting to job workplace: Public transport	0.1	0.1	0.5	-0.3	0.7	0.3	0.2	0.3
Eye problems/disorders: Glaucoma	0.2	0.2	0.5	0.7	-0.5	0.3	0.3	0.3
Medication: Blood pressure	5.8	11.1	23.5	4.8	-1.5	-0.6	4.1	3.6
Pain type(s) experienced in last month: Hip pain	2.0	2.5	5.3	-0.9	-2.3	-1.6	1.6	1.1
Supplements: Fish oil (including cod liver oil)	1.7	2.2	3.6	-1.2	1.2	1.8	-1.1	-1.9
High cholesterol (Self-reported)	0.4	0.7	2.6	1.6	-0.4	-0.1	0.7	0.4
Medication: Bendroflumethiazide	2.8	4.3	8.3	2.6	-1.3	0.1	2.9	2.1
Medication: Paracetamol	1.8	2.7	5.5	0.8	-2.3	-1.2	2.0	1.4
Medication: Lisinopril	1.0	1.3	2.2	1.5	-0.0	-0.6	1.4	1.3
Medication: Atorvastatin	0.4	0.5	0.8	0.9	-0.7	0.2	0.9	0.4
Illnesses of father: High blood pressure	2.2	2.7	5.2	1.2	-0.7	-2.1	2.3	1.4
Alcohol drinker status: Never	0.7	0.8	1.9	0.8	0.9	1.4	-0.9	0.1
Ever smoked	1.0	1.7	5.1	0.3	-2.3	-1.2	0.6	1.3
Basal metabolic rate	0.9	5.2	8.6	-2.0	2.8	1.2	-2.0	-2.9
Leg fat percentage (left)	3.0	10.8	17.1	4.1	-1.6	-2.7	3.2	4.1
Arm fat-free mass (left)	0.3	1.6	3.4	-1.2	1.5	0.1	-1.0	-1.8
Number of operations (self-reported)	0.9	1.3	2.2	-0.5	1.4	1.5	-1.3	-0.8
Average weekly beer plus cider intake	0.3	0.4	1.5	-0.0	-1.2	-0.2	0.1	0.6
Irritability	3.5	6.0	11.4	2.5	-2.4	-2.0	1.6	3.4
Risk taking	0.5	0.7	1.6	-1.3	-0.3	0.4	-1.1	-0.7
Ever had prostate specific antigen (PSA) test	0.9	1.0	2.2	0.2	1.4	1.5	-0.9	-0.0
Fractured/broken bones in last 5 years	0.1	0.1	0.2	0.1	0.3	0.2	-0.4	0.1
Age started oral contraceptive pill	1.4	1.8	2.9	-1.5	1.3	1.7	-1.2	-0.7
Diastolic blood pressure, automated reading	1.0	3.2	8.4	2.9	0.9	-0.0	1.6	2.0
Ever depressed for a whole week	0.6	0.8	1.7	-1.3	-0.3	0.2	-1.0	-1.0
Unable to work because of sickness or disability	1.1	1.4	3.4	1.8	-0.8	-0.8	0.6	1.5
Commuting to job workplace: Cycle	0.7	0.8	3.1	-1.8	-0.0	-0.8	0.4	-0.1
Myopia	0.3	0.4	1.1	0.1	0.9	0.1	-0.6	-1.1
Vascular/heart problems diagnosed by doctor	5.6	15.2	25.9	-5.1	2.2	1.8	-4.7	-4.5
Cholesterol lowering medication	0.2	0.2	0.5	0.4	-0.5	0.3	0.7	0.5
Medication: Omeprazole (e.g. Zanprol)	0.2	0.3	0.6	-0.5	0.7	-0.2	0.1	-0.8
Pain experienced in last month	0.3	0.5	1.4	0.5	1.2	0.1	-0.4	-0.7
Supplements: Calcium	6.7	7.4	12.3	-2.7	2.8	2.4	-2.1	-3.5
Basal cell carcinoma (self-reported)	0.2	0.3	0.7	-0.5	-0.1	0.3	-0.6	-0.8
Heart attack/myocardial infarction (self-reported)	2.7	3.5	4.5	1.8	-1.8	-1.7	2.1	2.0
Deep venous thrombosis (DVT) (self-reported)	0.0	0.1	0.1	-0.2	-0.3	0.1	-0.2	0.2
Heart disease (siblings)	3.4	4.2	7.8	2.8	-1.6	-1.0	1.9	2.5
Alcohol drinker status: Previous	0.8	0.9	2.5	-1.6	1.2	0.5	-0.4	-0.2
Pack years of smoking	1.6	2.4	4.4	-1.5	0.5	1.6	-2.1	-1.7
Impedance of whole body	1.1	5.6	11.3	-1.7	2.0	3.4	-2.7	-1.7
Leg fat mass (left)	0.6	2.5	5.2	2.3	0.0	-1.4	1.3	1.9
Arm predicted mass (left)	0.3	1.3	3.0	-1.0	1.4	-0.1	-0.7	-1.7