Hub : Genes

PKN2

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 GTEx Adipose Visceral Omentum 0.0860 0.0360 1.2e-03 0.041 NA 0.051 NA 0.040 3.2e-03 NA 0.00120 NA 3.7e-03
2 GTEx Colon Transverse 0.2300 0.0800 1.6e-04 0.079 NA 0.044 NA 0.082 1.3e-04 NA 0.00370 NA 1.0e-04
3 GTEx Small Intestine Terminal Ileum 0.2610 0.1120 6.9e-03 0.341 NA 0.160 NA 0.230 1.8e-08 NA 0.00021 NA 7.0e-06
4 TCGA Breast Invasive Carcinoma 0.0174 0.0119 9.5e-03 0.014 0.003 0.011 NA 0.010 4.8e-04 0.0810 0.00230 NA 2.8e-03
5 TCGA Brain Lower Grade Glioma 0.0453 0.0236 3.9e-05 0.008 0.016 0.021 NA 0.016 3.7e-02 0.0059 0.00160 NA 4.9e-03

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5
Bipolar Disorder (2018) 0.1 0.2 0.4 0.1 0.5 0.6 -0.4 0.4
Bipolar Disorder or Schizophrenia 0.5 1.2 3.4 0.3 1.0 1.9 -1.1 -0.3
Depressed Affect (Nagel 2018) 0.1 0.2 0.7 0.1 -0.8 -0.3 -0.2 0.6
Depression (Nagel 2018) 0.1 0.2 0.3 -0.2 -0.2 0.3 -0.6 -0.5
Intelligence (Savage-Jansen 2018) 5.5 17.0 20.2 -4.4 3.5 4.5 -4.0 -4.1
Neuroticism (Nagel 2018) 1.0 2.3 5.2 1.2 -2.3 -1.0 1.1 1.6
Schizophrenia (2018) 0.6 1.2 3.5 0.3 0.9 1.9 -1.1 -0.7
Schizophrenia vs Biploar Disorder 1.7 2.3 4.7 1.4 -1.2 -1.2 2.2 1.2
Worry (Nagel 2018) 1.7 3.5 6.8 2.6 -2.0 -0.5 1.9 1.7
Alzheimer’s Disease (in mother) 0.4 0.5 0.9 -0.7 0.6 0.8 -1.0 0.1
Alzheimer’s Disease (in father) 2.6 2.8 5.9 -1.5 0.9 1.0 -2.4 -1.9
Alzheimer’s Disease (including proxy) 3.0 4.3 8.7 -1.7 1.8 1.9 -3.0 -1.8
Crohns Disease (2017) 1.6 3.6 8.4 2.9 -1.4 -1.6 1.8 1.3
Irritable Bowel Disease (IBD) 1.2 2.8 8.5 2.9 -0.7 -0.7 1.6 1.5
Ulcerative Colitis (UC) 0.6 1.1 3.2 1.8 -0.1 0.0 0.8 1.2
Major Depression (MDD) 1.3 1.5 3.6 -1.2 -1.3 -1.9 0.9 0.2
Reaction Time 0.2 0.4 0.7 0.4 -0.6 -0.5 0.7 0.9
Verbal and Numeric Reasoning (VNR) 1.3 3.2 5.2 -2.3 1.4 2.0 -1.6 -1.6
Breast Cancer 4.5 10.9 13.7 3.5 -2.9 -2.8 3.7 3.5
Ovarian Cancer 0.1 0.2 0.4 -0.2 -0.1 0.2 -0.5 -0.7
Prostate Cancer 0.3 0.4 1.6 0.2 0.3 -1.3 0.1 -0.4
Age at First Birth 2.1 3.1 5.0 -1.6 1.6 1.2 -1.9 -2.2
Bipolar Disorder (2011) 0.6 0.6 1.4 0.8 1.2 0.8 -0.2 0.5
Body Mass Index (BMI) (2010) 0.6 0.9 1.6 0.8 -1.2 -0.6 0.6 1.3
Coronary Artery Disease (CAD) 3.3 3.9 6.3 2.3 -1.1 -1.1 2.3 2.5
Crohns Disease (2012) 1.8 2.9 3.9 2.0 -1.7 -1.9 1.4 1.4
Mean Putamen Volume 0.2 0.2 0.5 -0.0 -0.5 0.7 -0.1 -0.3
Fasting Glucose 0.6 0.7 3.3 1.8 -0.4 0.3 0.2 0.1
HbA1C 0.7 0.8 1.9 0.5 -1.4 -0.9 0.9 0.6
HDL Cholesterol 0.1 0.2 0.6 0.8 0.2 -0.1 -0.7 0.1
LDL Cholesterol 1.5 2.3 3.4 -0.6 1.8 1.9 -1.7 -1.3
Lupus 0.4 0.6 1.6 -0.1 1.3 0.8 -0.3 -0.6
Neuroticism (2016) 1.8 2.6 3.7 1.9 -1.9 -1.0 1.3 1.7
Primary Biliary Cirrhosis 1.0 1.4 2.6 -0.3 0.8 1.5 -1.6 -1.1
Rheumatoid Arthritis 2.2 3.0 5.7 2.4 -2.4 -1.5 0.7 0.9
Schizophrenia (2014) 0.4 0.8 2.5 0.8 0.8 1.6 -0.0 -0.4
Triglycerides 0.1 0.1 0.3 0.2 -0.5 -0.1 -0.2 0.3
Type 2 Diabetes (T2D) (2012) 1.8 2.1 4.1 2.0 -0.1 -0.2 1.6 2.0
Ulcerative Colitis 0.3 0.4 0.7 0.7 0.4 0.8 -0.3 0.8
Blood Eosinophil Count 0.7 5.1 8.2 1.1 -2.9 -2.5 1.7 2.6
Blood Platelet Count 1.2 14.0 27.0 4.2 -2.8 -2.6 3.4 5.2
Blood Red Count 3.7 36.1 63.0 7.9 -4.1 -5.0 5.6 6.7
Blood White Count 0.7 5.1 10.2 3.2 0.0 -1.3 1.8 3.2
Heel T-Score 6.1 48.6 59.9 6.9 -6.6 -6.0 7.5 7.7
BMI 1.0 6.0 11.7 3.4 -0.9 -2.1 2.0 3.1
Height 8.8 169.6 216.1 -12.9 11.7 12.1 -13.5 -14.7
Waist Hip Ratio (WHR) 3.1 13.7 16.6 -3.9 3.6 3.1 -4.1 -3.8
Systolic Blood Pressure 7.0 35.0 57.8 7.6 -3.7 -3.8 7.0 6.3
Smoking Status 1.6 3.9 7.4 -0.5 -2.7 -2.6 1.1 2.0
Allergy or Eczema 2.0 5.3 7.6 1.8 -2.0 -2.6 2.8 2.2
Cardiovascular Disease 2.8 9.3 21.2 4.6 -0.8 -0.9 4.1 2.7
Hypothyroidism (self reported) 0.7 1.6 2.8 0.3 -1.4 -1.7 1.1 1.5
Respiratory disease 0.6 1.4 4.7 -2.2 0.0 -0.1 -1.2 -1.0
Type 2 Diabetes (T2D) (2018) 0.2 0.4 1.5 1.2 0.5 -0.2 0.2 0.2
Lung FEV1/FVC ratio 1.4 7.0 10.6 1.4 -3.3 -2.5 3.2 2.4
Lung FVC 0.2 1.2 2.4 -0.1 -1.2 -1.6 1.3 0.7
Neuroticism 1.2 3.0 5.0 1.4 -2.2 -1.3 1.9 1.7
Chronotype (morning person) 1.8 4.2 9.2 3.0 -2.5 -0.8 0.6 2.2
Hair Pigment 0.2 4.7 9.7 3.1 -0.7 -1.3 2.0 2.7
Tanning 0.2 2.2 4.9 -0.0 -1.6 -1.8 2.2 0.6
Hand grip strength (left) 1.2 3.1 9.3 -3.0 2.0 0.4 -0.7 -1.2
Number of treatments/medications taken 1.6 3.0 5.8 1.5 -1.6 -0.9 2.4 1.8
Average weekly spirits intake 0.1 0.1 0.3 0.1 -0.4 0.0 0.6 0.2
Sensitivity / hurt feelings 0.7 1.3 4.8 -2.2 0.3 0.4 -0.9 -0.7
Frequency of depressed mood in last 2 weeks 0.3 0.5 0.7 0.8 -0.8 -0.7 -0.4 0.6
Hearing difficulty/problems: Yes 0.5 0.8 2.1 -0.3 -0.3 -1.2 1.4 0.7
Relative age of first facial hair 0.1 0.3 0.6 -0.4 0.3 0.7 -0.8 -0.2
Other serious medical condition/disability diagnosed by doctor 0.3 0.4 0.5 -0.4 -0.6 -0.6 0.7 0.6
Ever used hormone-replacement therapy (HRT) 0.1 0.1 0.3 0.0 -0.5 0.1 0.1 0.4
Ever had hysterectomy (womb removed) 1.7 1.9 4.1 0.6 1.9 2.0 -1.0 -0.7
Systolic blood pressure, automated reading 5.7 16.6 37.0 6.1 -1.8 -1.8 3.7 5.1
Eye problems/disorders: Diabetes related eye disease 0.2 0.2 0.5 -0.7 -0.5 -0.2 -0.2 -0.4
Angina 2.1 2.7 5.1 0.9 -1.3 -1.8 2.3 1.6
Medication for hormone replacement therapy 0.4 0.5 1.0 -0.2 -0.7 -1.0 0.4 0.7
Vitamin and mineral supplements 0.9 1.2 3.0 1.5 -0.3 -0.3 0.8 1.7
Supplements: Zinc 0.4 0.4 0.7 0.1 0.7 0.8 -0.6 -0.8
Medication: Co-codamol 0.5 0.6 2.2 -0.6 -1.5 -0.0 -0.0 -0.8
Medication: Metformin 0.5 0.7 2.0 1.4 0.6 -0.0 0.3 0.9
Diabetes (father) 0.2 0.3 0.5 -0.1 -0.7 -0.7 0.2 0.5
Diabetes (mother) 0.5 0.6 1.9 0.5 -0.8 -1.4 -0.2 -0.5
Severe depression (siblings) 0.3 0.3 0.6 0.3 0.2 0.8 -0.6 -0.7
Pack years adult smoking proportion 2.1 3.2 5.5 -2.1 0.6 1.4 -2.3 -1.9
Impedance of leg (right) 0.1 0.4 1.5 0.4 0.0 1.2 -0.6 -0.0
Leg fat-free mass (left) 1.1 5.9 9.3 -2.2 3.0 1.3 -2.2 -3.0
Trunk fat percentage 0.2 0.8 1.7 1.3 1.2 0.9 -0.3 0.6
Hand grip strength (right) 1.8 4.8 9.1 -3.0 2.6 1.0 -1.7 -2.1
Townsend deprivation index at recruitment 0.2 0.3 1.1 -1.0 -0.1 -0.1 -0.4 -0.5
Current tobacco smoking 0.2 0.4 0.6 -0.8 -0.5 -0.4 -0.8 -0.4
Average weekly fortified wine intake 3.2 3.7 7.1 1.0 2.7 2.1 -1.9 -1.5
Maternal smoking around birth 0.2 0.3 0.8 0.0 -0.9 -0.6 0.6 0.3
Fed-up feelings 0.1 0.2 0.7 0.1 -0.8 -0.3 -0.4 0.3
Frequency of unenthusiasm / disinterest in last 2 weeks 1.4 1.9 3.5 -1.2 1.0 0.9 -1.9 -1.7
Relative age voice broke 0.6 0.9 1.8 -1.2 0.1 0.8 -1.4 -0.5
Taking other prescription medications 0.9 1.4 2.4 -0.2 -1.4 -1.5 1.5 0.8
Age when periods started (menarche) 0.2 0.4 1.2 -1.1 0.1 0.3 -0.1 -0.9
Bilateral oophorectomy (both ovaries removed) 3.1 3.6 9.0 0.3 1.6 3.0 -2.2 -1.2
Heel bone mineral density (BMD) T-score, automated (left) 3.8 8.5 11.9 2.3 -2.3 -3.2 3.5 3.1
Tinnitus: Yes, but not now, but have in the past 0.8 0.9 1.5 -1.2 -1.2 -0.7 1.1 -0.1
Qualifications: CSEs or equivalent 1.9 2.5 4.4 2.1 -1.2 -1.6 1.6 1.3
Serious illness, injury or assault to yourself 0.8 0.9 2.2 -0.5 1.1 1.5 -0.7 -0.7
High blood pressure 4.5 12.6 22.8 4.8 -2.0 -1.4 4.3 4.0
Hayfever, allergic rhinitis or eczema 2.1 4.5 6.3 1.5 -2.4 -2.5 2.4 1.5
Multivitamins +/- minerals 0.7 0.9 2.7 -1.6 -0.2 -0.2 -0.1 -1.3
Stomach or abdominal pain in last month 0.4 0.4 1.1 -1.0 0.3 -0.6 -0.5 -0.7
Supplements: Glucosamine 0.1 0.2 0.5 -0.1 0.4 0.5 -0.1 -0.7
Diverticular disease/diverticulitis (self-reported) 0.3 0.3 0.9 0.7 -1.0 -0.4 0.0 -0.1
Medication: Atenolol 7.9 9.8 17.5 3.3 -2.6 -2.5 4.2 2.9
Medication: Levothyroxine sodium 1.7 2.9 6.2 0.2 -1.7 -2.5 1.5 1.8
Sitting height 6.1 43.0 60.8 -6.6 6.0 5.7 -6.5 -7.8
Chronic bronchitis/emphysema (father) 0.7 0.8 1.7 -0.1 0.7 1.3 -0.9 -1.1
High blood pressure (mother) 3.5 4.8 9.2 1.6 -0.9 -2.6 3.0 2.2
Body mass index (BMI) 1.8 7.5 11.4 3.4 -1.2 -2.6 2.7 3.3
Impedance of leg (left) 0.1 0.5 2.0 0.2 0.2 1.4 -0.7 -0.1
Leg predicted mass (left) 1.1 6.0 9.2 -2.2 3.0 1.3 -2.3 -3.0
Trunk fat mass 0.3 1.2 3.7 0.5 1.9 1.0 -0.9 -0.4
Waist circumference 0.4 1.3 3.7 -0.3 1.9 0.7 -1.3 -0.9
Number of incorrect matches in round 1.6 2.6 4.5 1.8 -1.5 -1.2 1.4 2.1
Past tobacco smoking 2.1 3.9 7.5 -0.4 2.7 2.0 -1.4 -2.4
Alcohol usually taken with meals 0.1 0.1 0.4 0.5 -0.1 0.0 0.6 0.0
Nervous feelings 1.9 3.6 5.1 2.3 -1.8 -1.4 1.9 2.1
Frequency of tenseness / restlessness in last 2 weeks 0.3 0.5 2.0 1.4 0.2 -0.2 -0.2 0.6
Hearing difficulty/problems with background noise 0.6 0.9 4.4 -2.1 -0.2 0.2 0.2 0.3
Hair/balding pattern: Pattern 2 2.7 3.5 6.4 -2.5 1.4 1.0 -1.4 -2.5
Had menopause 0.9 1.1 2.2 -0.6 1.0 1.1 -1.5 -0.8
Had other major operations 0.5 0.7 1.1 0.1 1.1 0.9 -0.9 -0.7
Forced vital capacity (FVC) 2.1 8.0 12.7 -3.6 2.6 2.0 -2.2 -3.3
Heel bone mineral density (BMD) T-score, automated (right) 3.2 7.3 11.0 2.6 -2.1 -2.0 3.1 3.3
Ever unenthusiastic/disinterested for a whole week 0.9 1.1 2.0 -1.1 -0.6 0.6 -1.4 -1.3
Qualifications: None of the above 3.9 8.3 10.0 3.2 -3.1 -2.6 2.8 2.6
Financial difficulties in last 2 years 0.6 0.8 1.8 -1.3 0.3 -0.6 -0.0 -1.3
Mouth/teeth dental problems 0.8 1.3 3.2 0.6 -1.0 -1.0 1.8 1.1
Heart attack 2.0 2.6 3.3 1.7 -1.4 -1.5 1.8 1.6
Allergy 0.8 1.8 3.2 -0.9 1.4 1.8 -1.4 -0.9
Pain all over the body in last month 0.6 0.7 1.4 -0.4 -1.2 -0.9 0.7 0.7
Diabetes (self-reported) 0.1 0.2 0.7 0.0 0.2 0.1 -0.8 -0.4
Hayfever/allergic rhinitis (self-reported) 0.5 0.7 1.4 1.2 -0.6 -0.3 1.1 0.6
Medication: Ramipril 2.3 2.9 9.8 3.1 -0.9 -0.6 1.5 1.2
Medication: Simvastatin 0.3 0.5 1.9 1.4 0.5 -0.2 0.4 0.1
Fluid intelligence score 3.8 7.9 9.8 -2.8 3.1 3.0 -2.1 -2.8
Illnesses of siblings 3.8 5.3 11.2 -3.4 1.6 1.3 -2.3 -2.4
Neuroticism score 0.8 1.6 3.3 1.1 -1.8 -0.9 0.9 1.4
Weight 0.5 2.7 6.9 -0.8 2.6 1.1 -1.3 -1.7
Impedance of arm (right) 2.0 9.3 16.6 -2.4 3.0 4.1 -3.2 -2.2
Arm fat percentage (right) 1.2 4.6 8.7 2.9 -0.4 -1.6 1.8 2.9
Trunk fat-free mass 1.1 6.3 11.6 -2.4 2.9 1.2 -2.1 -3.4
Hip circumference 0.1 0.6 1.9 0.8 1.4 0.5 -0.4 -0.3
Time employed in main current job 0.2 0.3 0.7 -0.0 -0.8 0.4 0.5 -0.5
Alcohol intake versus 10 years previously 3.6 5.4 7.0 2.6 -2.3 -2.5 2.2 1.9
Father’s age at death 0.1 0.2 0.5 -0.2 0.1 0.7 0.0 -0.5
Worrier / anxious feelings 0.8 1.4 2.0 1.4 -1.4 -0.0 1.4 1.2
Frequency of tiredness / lethargy in last 2 weeks 0.0 0.1 0.1 0.2 -0.2 -0.3 0.0 0.3
Falls in the last year 0.1 0.2 0.4 -0.2 -0.5 0.3 -0.6 -0.3
Hair/balding pattern: Pattern 3 0.2 0.3 0.6 0.1 -0.6 -0.4 0.6 0.8
Number of live births 0.1 0.1 0.3 0.2 -0.2 -0.5 -0.2 -0.0
Forced expiratory volume in 1-second (FEV1) 0.5 1.6 3.8 -1.9 1.1 0.3 -0.0 -1.7
Pulse rate 1.0 1.6 6.1 -0.7 2.5 0.7 -1.0 -0.5
Happiness 1.3 1.6 2.9 -0.7 1.1 1.2 -1.4 -1.7
Noisy workplace 5.4 6.7 10.1 2.3 -3.2 -2.7 1.8 2.8
Qualifications: A levels/AS levels or equivalent 1.1 2.4 5.5 -2.3 1.1 0.8 -0.1 -2.1
Serious illness, injury or assault of a close relative in last 2 years 1.9 2.2 4.6 2.1 -0.4 -1.4 1.3 1.7
Mouth/teeth dental problems: Dentures 0.2 0.3 1.0 1.0 -0.3 0.2 -0.4 0.5
Asthma 0.6 1.1 2.6 -1.6 0.5 -0.0 -0.9 -1.4
Medication: Ibuprofen (e.g. Nurofen) 0.4 0.5 0.9 -0.8 0.2 0.9 -0.6 -0.6
Medication: Cholesterol lowering 0.4 0.7 3.0 1.7 0.1 -0.3 0.5 -0.2
Depression (self-reported) 0.6 0.7 2.2 -0.5 -1.5 -0.8 0.7 0.2
Medication: Lansoprazole 1.0 1.2 1.8 1.1 -0.9 -1.2 1.4 0.7
Prospective memory result 3.7 4.6 6.4 2.5 -2.1 -1.3 2.2 2.4
Lung cancer (father) 0.3 0.3 1.2 -0.4 0.0 -0.0 0.6 1.1
Illnesses of mother 3.0 3.8 6.2 -1.4 0.9 2.0 -2.4 -2.5
Forced expiratory volume in 1-second (FEV1), Best measure 0.7 2.2 5.5 -2.3 1.1 0.6 -0.4 -1.9
Pulse wave Arterial Stiffness index 0.1 0.1 0.4 -0.6 -0.1 -0.0 -0.3 0.1
Impedance of arm (left) 2.7 12.4 20.4 -2.9 3.1 4.5 -3.9 -2.9
Arm fat mass (right) 0.3 1.4 3.4 1.9 0.4 -0.7 0.8 1.5
Trunk predicted mass 1.0 5.9 10.8 -2.3 2.9 1.1 -2.0 -3.3
Standing height 8.3 82.6 114.5 -8.9 8.6 8.3 -8.8 -10.7
Length of working week for main job 0.1 0.1 0.5 0.0 -0.7 -0.2 -0.1 0.0
Exposure to tobacco smoke at home 1.3 1.5 4.2 -2.0 0.4 1.1 -0.6 -1.2
Breastfed as a baby 0.9 1.1 2.0 1.1 -0.6 -1.4 0.3 1.3
Tense / ‘highly strung’ 1.6 2.7 5.2 1.4 -1.7 -1.1 2.3 1.4
Seen doctor (GP) for nerves, anxiety, tension or depression 0.3 0.5 1.1 -1.1 0.8 0.2 -0.5 -0.7
Hair/balding pattern: Pattern 4 2.3 5.6 9.4 3.1 -1.2 -1.9 2.3 2.8
Birth weight of first child 8.0 14.6 18.1 -4.2 3.8 3.0 -3.8 -4.2
Peak expiratory flow (PEF) 0.4 1.0 2.0 -1.4 1.1 0.2 -0.1 -1.3
Pulse wave reflection index 3.9 4.9 9.7 1.8 -3.1 -2.1 1.9 1.8
Ever highly irritable/argumentative for 2 days 1.3 1.5 2.7 1.6 -1.0 -1.1 1.0 1.4
Loud music exposure frequency 0.4 0.5 1.3 -0.1 1.2 0.3 -0.8 -0.6
Qualifications: O levels/GCSEs or equivalent 0.3 0.5 1.4 -0.8 0.0 -1.2 0.7 0.2
Mouth/teeth dental problems: Bleeding gums 0.5 0.6 1.4 -0.4 0.7 0.2 -1.0 -1.2
Blood clot in the leg (DVT) 0.0 0.0 0.1 -0.1 -0.3 -0.0 -0.2 0.1
Medication: Paracetamol 0.8 1.3 4.0 0.3 -2.0 -0.6 1.4 0.3
Headache pain in last month 1.8 3.1 6.9 -2.6 0.8 1.5 -1.6 -1.7
Medication for cholesterol, blood pressure or diabetes 2.0 3.4 9.2 -3.0 0.8 0.9 -1.9 -1.6
Glaucoma (self-reported) 0.5 0.5 1.3 -0.0 0.7 1.2 -0.5 -0.8
Gout (self-reported) 1.9 2.6 3.7 0.8 1.9 1.8 -1.9 -1.2
Hypothyroidism/myxoedema (self-reported) 1.5 3.0 5.2 0.4 -1.6 -2.3 1.8 2.0
Medication: Amlodipine 0.9 1.2 2.1 1.5 -1.3 0.2 0.8 1.3
Medication: Ventolin 100micrograms inhaler 0.3 0.4 0.9 -0.9 -0.3 -0.6 0.5 -0.7
Birth weight 1.3 2.8 12.2 -3.5 0.2 -0.4 -0.6 -1.1
Chronic bronchitis/emphysema (mother) 0.9 1.0 2.5 0.1 0.0 -0.4 1.6 1.6
High blood pressure (siblings) 2.6 3.8 5.3 1.6 -2.3 -2.1 2.0 1.6
Forced vital capacity (FVC), Best measure 2.3 8.6 14.7 -3.8 2.5 2.1 -2.4 -3.4
Body fat percentage 0.5 2.1 5.7 2.4 0.2 -0.5 0.9 1.9
Leg fat percentage (right) 3.4 12.3 19.6 4.4 -1.8 -2.9 3.5 4.3
Arm fat-free mass (right) 0.6 3.0 6.8 -1.6 1.9 0.5 -1.4 -2.6
Exposure to tobacco smoke outside home 1.1 1.4 3.6 -0.7 0.1 1.5 -0.8 -1.9
Comparative body size at age 10 0.1 0.4 1.5 -0.4 1.2 0.2 -0.0 -0.2
Number of full brothers 0.1 0.2 0.4 0.2 0.0 -0.7 -0.3 -0.5
Worry too long after embarrassment 0.3 0.4 1.8 -1.3 -0.4 -0.0 0.5 -0.3
Seen a psychiatrist for nerves, anxiety, tension or depression 0.5 0.6 1.5 0.9 0.1 -1.2 0.2 0.8
Wheeze or whistling in the chest in last year 1.6 2.8 6.4 -1.7 1.1 1.0 -1.6 -2.5
Number of children fathered 1.8 2.0 4.0 2.0 -1.1 -0.5 1.8 1.2
Reason for reducing amount of alcohol drunk: Health precaution 0.3 0.4 0.9 -0.6 1.0 0.6 -0.6 0.1
Age at first live birth 2.3 4.1 8.8 -3.0 1.9 1.0 -1.2 -2.4
Pulse wave peak to peak time 0.3 0.4 1.0 -0.1 0.7 0.5 -0.3 -1.0
Health satisfaction 0.2 0.3 0.7 0.7 -0.1 -0.1 0.4 0.8
Shortness of breath walking on level ground 0.2 0.2 0.9 -0.0 -0.4 0.1 0.2 0.9
Qualifications: College or University degree 3.9 12.1 19.1 -4.4 4.0 2.9 -2.5 -3.2
Eye problems/disorders: None of the above 0.8 0.9 2.1 0.7 -1.0 -1.5 0.6 0.6
Mouth/teeth dental problems: Loose teeth 4.0 4.7 8.2 -2.9 2.4 1.7 -1.5 -2.2
Emphysema/chronic bronchitis 0.2 0.3 0.9 -0.3 -0.4 -0.5 -0.9 -0.0
Medication for pain relief, constipation, heartburn 1.0 1.6 3.6 -1.2 1.9 0.7 -1.5 -0.5
Neck or shoulder pain in last month 0.2 0.3 0.7 0.8 -0.4 0.2 0.1 0.8
Medication: Blood pressure 4.1 7.3 12.8 3.6 -2.6 -1.9 2.9 2.3
Angina (self-reported) 2.6 3.4 5.9 1.0 -1.6 -2.0 2.4 2.0
Migraine (self-reported) 0.3 0.4 0.9 -0.8 0.9 0.5 -0.3 -0.3
Medication: Ibuprofen 0.0 0.0 0.1 -0.2 -0.2 0.2 -0.1 0.3
Medication: Allopurinol 3.6 4.8 6.7 1.5 2.6 2.6 -2.1 -2.0
Medication: Omeprazole 0.2 0.3 0.4 0.6 0.5 -0.6 0.5 -0.2
Medication: Seretide 50 evohaler 2.8 3.2 4.3 -1.3 2.1 1.8 -1.7 -2.0
Mean time to correctly identify matches 0.0 0.0 0.2 -0.4 -0.2 -0.0 0.1 0.1
Heart disease (mother) 1.1 1.4 3.1 1.2 -0.4 -0.8 1.2 1.8
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.7 0.9 2.7 -0.8 -1.6 -0.5 0.9 -0.0
Whole body fat mass 0.1 0.5 1.2 1.0 1.1 0.1 -0.1 0.4
Leg fat mass (right) 0.8 3.0 6.2 2.5 0.0 -1.5 1.5 2.0
Arm predicted mass (right) 0.5 2.8 6.6 -1.3 1.9 0.5 -1.4 -2.6
Pulse rate, automated reading 0.2 0.7 2.9 0.0 1.7 0.1 -0.7 0.4
Alcohol intake frequency. 0.2 0.5 1.7 -1.3 -0.0 0.5 0.1 -0.6
Comparative height size at age 10 3.9 21.7 33.3 -4.0 5.2 4.0 -4.0 -5.8
Number of full sisters 0.2 0.2 0.5 -0.1 0.2 -0.4 -0.7 -0.6
Suffer from ‘nerves’ 0.1 0.2 0.4 0.6 -0.3 0.2 0.2 0.4
Overall health rating 0.0 0.1 0.5 -0.7 0.1 0.1 -0.0 0.0
Chest pain or discomfort 0.2 0.3 1.0 1.0 0.4 -0.1 -0.2 -0.6
Had major operations 1.4 1.7 3.6 -0.2 1.9 1.2 -1.5 -1.1
Age at last live birth 2.2 3.2 5.8 -2.4 1.3 0.6 -1.6 -2.4
Family relationship satisfaction 0.5 0.7 1.3 -0.9 0.4 0.1 -1.1 -1.0
Leg pain on walking 0.2 0.3 0.7 0.3 -0.8 0.5 -0.4 -0.4
Qualifications: NVQ or HND or HNC or equivalent 0.1 0.1 0.3 -0.1 -0.5 -0.1 -0.5 -0.0
Commuting to job workplace: Car/motor vehicle 3.2 3.7 5.1 1.9 -2.0 -1.5 2.3 1.9
Illness, injury, bereavement, stress in last 2 years 0.2 0.3 0.5 -0.7 -0.6 -0.4 0.0 0.6
Medication: Aspirin 1.7 2.3 4.7 2.2 -1.0 -0.9 1.9 1.2
Supplements: Vitamin C 0.3 0.4 0.7 0.4 0.8 0.5 -0.7 -0.7
Knee pain experienced in last month 1.6 2.5 4.8 1.5 -2.2 -1.5 1.5 1.0
Hypertension (Self-reported) 3.7 10.3 21.2 4.6 -1.6 -0.8 3.9 3.5
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.3 0.4 1.6 0.4 -0.3 0.1 0.5 -1.2
Illnesses of father: Heart disease 2.4 3.3 5.0 1.0 -2.0 -1.9 2.2 1.7
Illnesses of siblings: Diabetes 2.2 2.7 5.7 1.8 -0.2 -1.4 2.4 1.6
Smoking status: Previous 2.1 3.2 5.5 0.5 -2.2 -1.8 1.4 2.3
Forced expiratory volume in 1-second (FEV1), predicted 4.4 9.1 16.2 -4.0 2.5 2.1 -2.4 -3.6
Whole body fat-free mass 1.2 6.8 11.6 -2.6 3.0 1.3 -2.3 -3.4
Leg fat-free mass (right) 1.3 7.1 10.6 -2.6 3.1 1.4 -2.5 -3.3
Arm fat percentage (left) 0.9 3.8 7.4 2.7 -0.3 -1.5 1.5 2.6
Average weekly red wine intake 0.8 1.2 2.4 -1.5 1.5 0.4 -0.3 -1.0
Handedness (chirality/laterality): Left-handed 0.6 0.7 1.5 -0.8 -1.2 -0.4 0.5 0.9
Mood swings 0.8 1.4 2.6 1.1 -1.6 -1.1 0.9 1.1
Loneliness, isolation 3.7 5.2 7.4 -2.2 1.8 2.1 -2.7 -2.4
Long-standing illness, disability or infirmity 0.0 0.1 0.2 0.2 0.4 0.3 0.2 0.0
Ever had bowel cancer screening 0.4 0.4 0.7 -0.9 0.6 0.8 -0.7 -0.2
Diabetes diagnosed by doctor 0.1 0.2 0.5 0.7 0.7 0.0 -0.3 -0.0
Ever had stillbirth, spontaneous miscarriage or termination 1.5 1.7 4.0 -0.1 -1.7 -2.0 1.0 0.4
Friendships satisfaction 0.4 0.6 1.1 -0.3 1.1 0.9 -0.6 -0.5
Qualifications: nursing, teaching 0.9 1.4 1.9 -1.4 1.2 1.3 -1.0 -1.1
Commuting to job workplace: Walk 0.7 0.8 1.5 -0.4 1.2 0.8 -1.2 -0.4
Eye problems/disorders: Cataract 0.9 1.0 2.3 -1.5 0.9 1.0 -0.1 -0.9
Mouth/teeth dental problems: Mouth ulcers 0.4 0.6 1.5 -1.0 0.3 0.3 -0.7 -1.2
Medication for cholesterol 3.3 4.9 8.9 -3.0 1.2 0.6 -2.8 -2.5
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.6 0.7 1.5 0.0 -0.8 -1.2 1.2 0.2
Back pain experienced in last month 0.4 0.6 2.7 -1.6 0.1 0.3 -0.3 -0.5
Mineral and other dietary supplements 3.9 5.3 8.4 2.2 -2.1 -2.3 1.9 2.9
Breast cancer (self-reported) 0.4 0.5 1.5 -0.9 0.3 0.1 -1.2 -0.4
Asthma (self-reported) 0.6 1.2 2.8 -1.7 0.3 -0.1 -0.9 -1.5
Osteoporosis (self-reported) 0.1 0.1 0.3 -0.4 -0.6 0.3 -0.3 -0.3
Osteoarthritis (self-reported) 0.1 0.2 0.5 0.2 -0.2 -0.1 -0.3 0.7
Medication: Aspirin 1.5 1.9 3.7 1.9 -0.8 -0.8 1.8 1.2
Medication: Gliclazide 1.4 1.6 6.1 2.5 0.6 0.7 0.0 1.1
Illnesses of father: None of the above (group 1) 0.1 0.1 0.2 0.2 0.4 0.2 -0.4 -0.4
Smoking status: Current 0.3 0.5 1.0 -1.0 -0.8 -0.4 -0.8 -0.2
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.1 0.3 0.6 -0.7 -0.4 -0.6 0.5 -0.0
Whole body water mass 1.1 6.2 11.0 -2.4 2.8 1.2 -2.2 -3.3
Leg predicted mass (right) 1.4 7.3 11.3 -2.6 3.1 1.5 -2.5 -3.4
Arm fat mass (left) 0.3 1.2 3.1 1.8 0.5 -0.7 0.7 1.2
Number of self-reported non-cancer illnesses 0.9 1.6 4.3 1.4 -0.7 -0.5 2.1 0.9
Average weekly champagne plus white wine intake 0.3 0.5 1.1 -1.1 0.2 0.9 -0.5 -0.5
Miserableness 0.1 0.1 0.2 -0.3 -0.5 -0.3 -0.0 0.5
Guilty feelings 0.1 0.2 0.6 0.0 -0.2 0.5 -0.8 0.2
Wears glasses or contact lenses 0.1 0.1 0.2 -0.3 0.4 0.3 0.0 0.4
Ever taken oral contraceptive pill 0.6 0.7 2.2 -1.5 0.2 -0.2 -0.4 -1.0
Hearing aid user 0.3 0.4 0.7 0.7 -0.8 -0.0 0.7 0.5
Mother’s age at death 0.6 0.7 1.7 -0.0 -1.3 -1.0 0.8 0.2
Financial situation satisfaction 0.3 0.4 0.8 -0.9 -0.3 -0.8 0.6 0.2
Tinnitus: Yes, now most or all of the time 0.8 0.9 1.9 1.4 -1.3 -0.7 0.1 0.6
Commuting to job workplace: Public transport 0.1 0.1 0.5 -0.3 0.7 0.3 0.2 0.3
Eye problems/disorders: Glaucoma 0.2 0.2 0.5 0.7 -0.5 0.3 0.3 0.3
Medication: Blood pressure 5.8 11.1 23.5 4.8 -1.5 -0.6 4.1 3.6
Pain type(s) experienced in last month: Hip pain 2.0 2.5 5.3 -0.9 -2.3 -1.6 1.6 1.1
Supplements: Fish oil (including cod liver oil) 1.7 2.2 3.6 -1.2 1.2 1.8 -1.1 -1.9
High cholesterol (Self-reported) 0.4 0.7 2.6 1.6 -0.4 -0.1 0.7 0.4
Medication: Bendroflumethiazide 2.8 4.3 8.3 2.6 -1.3 0.1 2.9 2.1
Medication: Paracetamol 1.8 2.7 5.5 0.8 -2.3 -1.2 2.0 1.4
Medication: Lisinopril 1.0 1.3 2.2 1.5 -0.0 -0.6 1.4 1.3
Medication: Atorvastatin 0.4 0.5 0.8 0.9 -0.7 0.2 0.9 0.4
Illnesses of father: High blood pressure 2.2 2.7 5.2 1.2 -0.7 -2.1 2.3 1.4
Alcohol drinker status: Never 0.7 0.8 1.9 0.8 0.9 1.4 -0.9 0.1
Ever smoked 1.0 1.7 5.1 0.3 -2.3 -1.2 0.6 1.3
Basal metabolic rate 0.9 5.2 8.6 -2.0 2.8 1.2 -2.0 -2.9
Leg fat percentage (left) 3.0 10.8 17.1 4.1 -1.6 -2.7 3.2 4.1
Arm fat-free mass (left) 0.3 1.6 3.4 -1.2 1.5 0.1 -1.0 -1.8
Number of operations (self-reported) 0.9 1.3 2.2 -0.5 1.4 1.5 -1.3 -0.8
Average weekly beer plus cider intake 0.3 0.4 1.5 -0.0 -1.2 -0.2 0.1 0.6
Irritability 3.5 6.0 11.4 2.5 -2.4 -2.0 1.6 3.4
Risk taking 0.5 0.7 1.6 -1.3 -0.3 0.4 -1.1 -0.7
Ever had prostate specific antigen (PSA) test 0.9 1.0 2.2 0.2 1.4 1.5 -0.9 -0.0
Fractured/broken bones in last 5 years 0.1 0.1 0.2 0.1 0.3 0.2 -0.4 0.1
Age started oral contraceptive pill 1.4 1.8 2.9 -1.5 1.3 1.7 -1.2 -0.7
Diastolic blood pressure, automated reading 1.0 3.2 8.4 2.9 0.9 -0.0 1.6 2.0
Ever depressed for a whole week 0.6 0.8 1.7 -1.3 -0.3 0.2 -1.0 -1.0
Unable to work because of sickness or disability 1.1 1.4 3.4 1.8 -0.8 -0.8 0.6 1.5
Commuting to job workplace: Cycle 0.7 0.8 3.1 -1.8 -0.0 -0.8 0.4 -0.1
Myopia 0.3 0.4 1.1 0.1 0.9 0.1 -0.6 -1.1
Vascular/heart problems diagnosed by doctor 5.6 15.2 25.9 -5.1 2.2 1.8 -4.7 -4.5
Cholesterol lowering medication 0.2 0.2 0.5 0.4 -0.5 0.3 0.7 0.5
Medication: Omeprazole (e.g. Zanprol) 0.2 0.3 0.6 -0.5 0.7 -0.2 0.1 -0.8
Pain experienced in last month 0.3 0.5 1.4 0.5 1.2 0.1 -0.4 -0.7
Supplements: Calcium 6.7 7.4 12.3 -2.7 2.8 2.4 -2.1 -3.5
Basal cell carcinoma (self-reported) 0.2 0.3 0.7 -0.5 -0.1 0.3 -0.6 -0.8
Heart attack/myocardial infarction (self-reported) 2.7 3.5 4.5 1.8 -1.8 -1.7 2.1 2.0
Deep venous thrombosis (DVT) (self-reported) 0.0 0.1 0.1 -0.2 -0.3 0.1 -0.2 0.2
Heart disease (siblings) 3.4 4.2 7.8 2.8 -1.6 -1.0 1.9 2.5
Alcohol drinker status: Previous 0.8 0.9 2.5 -1.6 1.2 0.5 -0.4 -0.2
Pack years of smoking 1.6 2.4 4.4 -1.5 0.5 1.6 -2.1 -1.7
Impedance of whole body 1.1 5.6 11.3 -1.7 2.0 3.4 -2.7 -1.7
Leg fat mass (left) 0.6 2.5 5.2 2.3 0.0 -1.4 1.3 1.9
Arm predicted mass (left) 0.3 1.3 3.0 -1.0 1.4 -0.1 -0.7 -1.7