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chr12:101,262,876-103,148,974

Best TWAS P=2.82e-11 · Best GWAS P=5.9e-15 conditioned to 2.73e-12

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
17	GTEx	Spleen	CCDC53	0.25	0.19	lasso	11	0.16	5.8e-05	6.6	-6.7	2.8e-11	-0.06	0.50	0.07	TRUE
21	YFS	Blood	DRAM1	0.33	0.13	enet	101	0.19	1.6e-58	5.4	6.6	4.7e-11	0.05	1.00	0.00	TRUE
15	GTEx	Nerve Tibial	MYBPC1	0.24	0.02	lasso	7	0.02	1.1e-02	-5.5	-5.1	2.8e-07	-0.02	0.88	0.01	TRUE
8	GTEx	Cells Transformed fibroblasts	CCDC53	0.10	0.18	lasso	1	0.17	1.5e-12	6.6	-6.6	4.8e-11	-0.05	0.90	0.10	FALSE
33	The Cancer Genome Atlas	Stomach Adenocarcinoma	CCDC53	0.04	0.07	lasso	4	0.06	2.1e-05	6.6	-6.6	5.0e-11	-0.05	0.50	0.40	FALSE
19	METSIM	Adipose	DRAM1	0.12	0.03	enet	24	0.08	1.1e-12	3.9	6.6	5.1e-11	0.06	1.00	0.00	FALSE
13	GTEx	Lung	CCDC53	0.12	0.10	lasso	3	0.11	6.8e-09	6.6	-6.5	7.9e-11	-0.06	0.93	0.06	FALSE
23	The Cancer Genome Atlas	Colon Adenocarcinoma	CCDC53	0.07	0.07	blup	55	0.06	1.3e-04	5.1	-6.3	3.1e-10	-0.08	0.74	0.21	FALSE
34	The Cancer Genome Atlas	Thyroid Carcinoma	CCDC53	0.31	0.16	enet	21	0.18	6.2e-17	6.6	-6.2	4.1e-10	-0.12	0.57	0.43	FALSE
12	GTEx	Heart Left Ventricle	CCDC53	0.14	0.20	lasso	4	0.18	9.6e-10	6.6	-6.2	4.3e-10	-0.05	0.92	0.08	FALSE
3	GTEx	Adipose Subcutaneous	CCDC53	0.14	0.16	lasso	13	0.15	1.5e-12	6.6	-6.1	9.3e-10	-0.05	0.92	0.08	FALSE
25	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	CCDC53	0.06	0.10	lasso	3	0.10	7.3e-11	6.6	-6.1	9.7e-10	-0.05	0.56	0.44	FALSE
1	CommonMind	Brain Pre-frontal Cortex	CCDC53	0.21	0.15	blup	448	0.19	2.4e-22	4.5	-6.1	1.2e-09	-0.16	0.99	0.01	FALSE
18	GTEx	Thyroid	CCDC53	0.15	0.12	lasso	6	0.12	4.3e-09	6.5	-6.0	2.0e-09	-0.05	0.91	0.09	FALSE
9	GTEx	Colon Transverse	CCDC53	0.21	0.02	enet	38	0.03	1.3e-02	4.4	-6.0	2.2e-09	-0.05	0.65	0.03	FALSE
24	The Cancer Genome Atlas	Esophageal Carcinoma	CCDC53	0.14	0.08	blup	50	0.08	1.8e-03	6.6	-6.0	2.8e-09	-0.12	0.12	0.18	FALSE
6	GTEx	Artery Aorta	DRAM1	0.20	0.03	lasso	9	0.03	6.3e-03	-5.5	5.9	3.1e-09	0.08	0.75	0.01	FALSE
4	GTEx	Adipose Subcutaneous	DRAM1	0.12	0.01	lasso	3	0.00	3.5e-01	-4.6	5.9	4.1e-09	0.11	0.05	0.04	FALSE
26	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	CCDC53	0.08	0.09	lasso	3	0.09	4.9e-10	6.6	-5.8	6.0e-09	-0.01	0.53	0.47	FALSE
32	The Cancer Genome Atlas	Prostate Adenocarcinoma	CCDC53	0.10	0.18	lasso	4	0.18	1.6e-18	6.6	-5.8	6.6e-09	-0.05	0.52	0.48	FALSE
27	The Cancer Genome Atlas	Brain Lower Grade Glioma	CCDC53	0.05	0.05	lasso	3	0.05	2.3e-06	6.6	-5.8	8.0e-09	-0.06	0.63	0.35	FALSE
2	GTEx	Adipose Subcutaneous	GNPTAB	0.08	0.02	enet	13	0.03	8.2e-04	2.4	-5.7	9.4e-09	-0.15	0.18	0.12	FALSE
10	GTEx	Esophagus Mucosa	CCDC53	0.31	0.41	enet	17	0.43	1.0e-30	4.7	-5.7	1.0e-08	-0.05	0.93	0.07	FALSE
5	GTEx	Artery Aorta	CCDC53	0.16	0.16	enet	12	0.17	7.0e-10	4.6	-5.7	1.1e-08	-0.06	0.95	0.04	FALSE
29	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	C12orf48	0.03	0.03	blup	62	0.02	6.8e-04	4.8	5.7	1.3e-08	0.03	0.07	0.43	FALSE
31	The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	CCDC53	0.06	0.07	lasso	4	0.06	3.0e-03	4.6	-5.6	1.9e-08	-0.04	0.10	0.09	FALSE
20	YFS	Blood	CCDC53	0.17	0.34	lasso	9	0.36	2.0e-124	4.6	-5.5	3.4e-08	-0.04	1.00	0.00	FALSE
14	GTEx	Muscle Skeletal	CCDC53	0.14	0.17	enet	23	0.18	2.9e-17	4.8	-5.4	6.2e-08	-0.05	0.92	0.08	FALSE
30	The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	C12orf48	0.05	0.05	blup	62	0.04	7.0e-04	6.5	5.4	7.0e-08	0.05	0.06	0.90	FALSE
22	The Cancer Genome Atlas	Breast Invasive Carcinoma	CCDC53	0.03	0.05	enet	5	0.05	4.3e-10	4.5	-5.2	1.6e-07	-0.05	0.66	0.34	FALSE
28	The Cancer Genome Atlas	Liver Hepatocellular Carcinoma	C12orf48	0.09	0.08	lasso	4	0.07	3.5e-04	5.1	5.2	1.6e-07	0.02	0.10	0.60	FALSE
16	GTEx	Pancreas	CCDC53	0.14	0.16	lasso	8	0.14	1.0e-06	4.7	-5.2	1.8e-07	-0.04	0.94	0.06	FALSE
7	GTEx	Artery Tibial	CCDC53	0.21	0.17	lasso	6	0.18	3.2e-14	4.6	-5.2	2.2e-07	-0.05	0.97	0.03	FALSE
11	GTEx	Heart Atrial Appendage	CCDC53	0.13	0.08	enet	21	0.09	1.1e-04	4.4	-5.2	2.3e-07	0.00	0.29	0.04	FALSE