Best TWAS P=2.32e-10 · Best GWAS P=2.14e-10 conditioned to 1
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | GTEx | Artery Aorta | N4BP2L2 | 0.13 | 0.10 | lasso | 3 | 0.09 | 1.1e-05 | 6.2 | 6.2 | 4.2e-10 | 0.96 | 0.02 | 0.98 | FALSE |
2 | The Cancer Genome Atlas | Bladder Urothelial Carcinoma | CG030 | 0.06 | 0.01 | blup | 38 | 0.03 | 6.0e-04 | -3.9 | -5.4 | 5.5e-08 | -0.81 | 0.01 | 0.82 | FALSE |
3 | The Cancer Genome Atlas | Breast Invasive Carcinoma | CG030 | 0.04 | 0.01 | lasso | 3 | 0.02 | 2.1e-04 | 6.2 | -5.8 | 5.1e-09 | -0.95 | 0.00 | 1.00 | FALSE |
4 | The Cancer Genome Atlas | Breast Invasive Carcinoma | N4BP2L2 | 0.02 | 0.02 | lasso | 2 | 0.01 | 1.4e-03 | 6.3 | 6.3 | 2.3e-10 | 0.98 | 0.00 | 0.97 | TRUE |
5 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | N4BP2L2 | 0.04 | 0.03 | blup | 69 | 0.02 | 9.4e-04 | 6.2 | 5.9 | 4.2e-09 | 0.95 | 0.01 | 0.98 | FALSE |
6 | The Cancer Genome Atlas | Brain Lower Grade Glioma | N4BP2L2 | 0.10 | 0.10 | lasso | 4 | 0.11 | 5.2e-12 | 6.2 | 5.8 | 8.8e-09 | 0.95 | 0.01 | 0.99 | FALSE |
7 | The Cancer Genome Atlas | Lung Adenocarcinoma | N4BP2L2 | 0.03 | 0.02 | lasso | 4 | 0.02 | 2.8e-03 | 6.1 | 5.7 | 1.3e-08 | 0.87 | 0.01 | 0.95 | FALSE |
8 | The Cancer Genome Atlas | Lung Squamous Cell Carcinoma | N4BP2L2 | 0.04 | 0.04 | lasso | 2 | 0.03 | 1.5e-04 | 6.3 | 6.2 | 6.7e-10 | 0.98 | 0.00 | 0.99 | FALSE |
9 | The Cancer Genome Atlas | Thyroid Carcinoma | N4BP2L2 | 0.12 | 0.14 | enet | 7 | 0.16 | 1.1e-15 | 4.9 | 5.8 | 6.1e-09 | 0.96 | 0.01 | 0.99 | FALSE |
10 | The Cancer Genome Atlas | Thyroid Carcinoma | PDS5B | 0.02 | 0.01 | blup | 78 | 0.02 | 1.2e-02 | 6.3 | -5.2 | 1.9e-07 | -0.91 | 0.01 | 0.87 | FALSE |