[Hub]/) : Traits : Comparative height size at age 10 :

chr2:15,703-988,346

Best TWAS P=2.91e-21 · Best GWAS P=2.38e-33 conditioned to 4.11e-32

Associated models

# Study Tissue Gene h2 eQTL R2 model # weights model R2 model R2 P eQTL GWAS Z TWAS Z TWAS P Top SNP corr PP3 PP4 joint
1 CommonMind Brain Pre-frontal Cortex FAM110C 0.09 0.00 bslmm 232 0.01 8.2e-03 -1.1 -5.5 2.8e-08 -0.03 0.24 0.43 FALSE
2 GTEx Adipose Subcutaneous SH3YL1 0.08 0.10 lasso 1 0.08 4.1e-07 8.5 8.5 1.7e-17 -0.06 1.00 0.00 FALSE
3 GTEx Adipose Visceral Omentum SH3YL1 0.15 0.03 lasso 4 0.01 6.5e-02 6.7 8.1 6.2e-16 -0.02 0.17 0.04 FALSE
4 GTEx Adrenal Gland SH3YL1 0.21 0.10 lasso 7 0.08 8.1e-04 6.7 -7.5 5.6e-14 0.12 0.24 0.12 FALSE
5 GTEx Artery Tibial SH3YL1 0.10 0.02 lasso 3 0.01 2.9e-02 8.4 6.6 5.0e-11 0.08 0.65 0.02 FALSE
6 GTEx Artery Tibial ACP1 0.13 0.07 lasso 12 0.11 4.4e-09 -3.1 -5.2 2.7e-07 0.13 0.99 0.00 FALSE
7 GTEx Cells Transformed fibroblasts SH3YL1 0.16 0.09 lasso 7 0.10 3.3e-08 -5.7 5.7 1.0e-08 0.03 0.99 0.00 FALSE
8 GTEx Colon Sigmoid SH3YL1 0.20 0.14 lasso 3 0.14 1.3e-05 8.6 7.9 3.1e-15 -0.08 0.42 0.03 FALSE
9 GTEx Colon Transverse SH3YL1 0.36 0.25 lasso 7 0.26 1.2e-12 8.5 -8.3 9.1e-17 0.05 1.00 0.00 FALSE
10 GTEx Esophagus Gastroesophageal Junction SH3YL1 0.21 0.09 lasso 7 0.14 1.3e-05 5.8 6.9 4.0e-12 0.03 0.52 0.02 FALSE
11 GTEx Esophagus Mucosa SH3YL1 0.60 0.67 lasso 4 0.66 9.2e-58 8.6 -8.5 1.8e-17 0.06 1.00 0.00 FALSE
12 GTEx Esophagus Muscularis SH3YL1 0.30 0.23 enet 50 0.28 4.6e-17 8.6 8.1 7.7e-16 -0.05 1.00 0.00 FALSE
13 GTEx Heart Atrial Appendage SH3YL1 0.27 0.23 lasso 6 0.22 2.1e-10 8.4 8.6 1.2e-17 -0.10 1.00 0.00 FALSE
14 GTEx Heart Left Ventricle SH3YL1 0.14 0.11 enet 16 0.10 8.2e-06 8.2 9.3 1.4e-20 -0.06 0.80 0.01 FALSE
15 GTEx Lung SH3YL1 0.09 0.08 lasso 5 0.05 8.5e-05 8.2 -8.1 8.5e-16 0.10 0.82 0.02 FALSE
16 GTEx Muscle Skeletal SH3YL1 0.12 0.10 lasso 3 0.09 4.1e-09 8.6 8.5 1.6e-17 -0.08 1.00 0.00 FALSE
17 GTEx Nerve Tibial SH3YL1 0.33 0.23 enet 35 0.25 5.6e-18 8.6 6.9 5.2e-12 0.07 1.00 0.00 FALSE
18 GTEx Pancreas SH3YL1 0.48 0.43 lasso 11 0.41 6.9e-19 8.6 -8.5 2.6e-17 0.06 1.00 0.00 FALSE
19 GTEx Skin Not Sun Exposed Suprapubic SH3YL1 0.47 0.53 lasso 2 0.53 2.1e-33 8.5 -8.5 1.6e-17 0.06 1.00 0.00 FALSE
20 GTEx Skin Sun Exposed Lower leg SH3YL1 0.42 0.44 lasso 5 0.45 3.3e-41 8.5 -8.4 3.7e-17 0.06 1.00 0.00 FALSE
21 GTEx Stomach SH3YL1 0.33 0.21 lasso 6 0.20 3.8e-10 8.2 -8.1 6.7e-16 0.05 1.00 0.00 FALSE
22 GTEx Thyroid SH3YL1 0.29 0.32 lasso 4 0.31 2.9e-24 8.6 -8.5 1.5e-17 0.07 1.00 0.00 FALSE
23 GTEx Whole Blood SH3YL1 0.21 0.17 lasso 6 0.18 2.6e-16 8.6 -8.5 1.7e-17 0.06 1.00 0.00 FALSE
24 METSIM Adipose SH3YL1 0.03 0.02 lasso 3 0.02 9.5e-04 5.8 6.4 2.1e-10 0.01 0.55 0.02 FALSE
25 NTR Blood SH3YL1 0.12 0.17 lasso 5 0.16 6.2e-51 8.5 -8.3 6.6e-17 0.06 1.00 0.00 FALSE
26 ROSMAP Brain Pre-frontal Cortex SH3YL1 0.15 0.12 bslmm 364 0.13 3.3e-16 -3.1 -8.0 1.7e-15 0.23 1.00 0.00 FALSE
27 ROSMAP Brain Pre-frontal Cortex ACP1 0.03 0.04 lasso 2 0.02 4.7e-04 8.2 -7.3 3.1e-13 0.02 0.61 0.01 FALSE
28 ROSMAP Brain Pre-frontal Cortex FAM150B 0.06 0.01 bslmm 381 0.03 9.9e-05 -5.5 -7.0 3.1e-12 -0.05 0.40 0.02 FALSE
29 YFS Blood SH3YL1 0.48 0.40 enet 100 0.46 3.2e-171 8.5 -9.1 1.4e-19 0.12 1.00 0.00 FALSE
30 The Cancer Genome Atlas Bladder Urothelial Carcinoma SH3YL1 0.25 0.15 blup 67 0.18 2.8e-15 8.6 -8.0 1.0e-15 0.06 0.01 0.99 FALSE
31 The Cancer Genome Atlas Breast Invasive Carcinoma SH3YL1 0.19 0.31 lasso 5 0.32 2.5e-66 8.5 -8.3 1.1e-16 0.07 0.01 0.99 FALSE
32 The Cancer Genome Atlas Cervical Squamous Cell Carcinoma SH3YL1 0.32 0.27 enet 14 0.28 6.6e-14 8.6 -8.0 1.9e-15 0.07 0.01 0.99 FALSE
33 The Cancer Genome Atlas Colon Adenocarcinoma SH3YL1 0.32 0.34 lasso 6 0.35 2.8e-21 8.6 -8.4 5.7e-17 0.07 0.01 0.99 FALSE
34 The Cancer Genome Atlas Esophageal Carcinoma SH3YL1 0.16 0.02 blup 67 0.08 1.9e-03 8.2 -9.5 2.9e-21 0.03 0.01 0.93 TRUE
35 The Cancer Genome Atlas Head and Neck Squamous Cell Carcinoma SH3YL1 0.24 0.25 lasso 4 0.25 8.1e-28 8.2 -8.3 7.6e-17 0.07 0.01 0.99 FALSE
36 The Cancer Genome Atlas Kidney Renal Clear Cell Carcinoma SH3YL1 0.16 0.04 blup 67 0.06 5.6e-07 8.5 -7.4 1.4e-13 0.03 0.01 0.99 FALSE
37 The Cancer Genome Atlas Kidney Renal Papillary Cell Carcinoma SH3YL1 0.20 0.05 blup 67 0.09 9.5e-06 8.5 -6.3 3.5e-10 0.05 0.01 0.98 FALSE
38 The Cancer Genome Atlas Brain Lower Grade Glioma FAM150B 0.07 0.07 lasso 2 0.06 5.8e-07 8.5 -8.5 1.5e-17 0.07 0.00 1.00 FALSE
39 The Cancer Genome Atlas Lung Adenocarcinoma SH3YL1 0.17 0.24 enet 15 0.24 5.8e-28 8.6 -8.1 8.1e-16 0.07 0.01 0.99 FALSE
40 The Cancer Genome Atlas Lung Squamous Cell Carcinoma SH3YL1 0.11 0.10 lasso 5 0.10 4.5e-11 8.6 -7.7 1.2e-14 0.07 0.01 0.99 FALSE
41 The Cancer Genome Atlas Ovarian Serous Cystadenocarcinoma SH3YL1 0.11 0.13 enet 8 0.13 3.7e-09 8.6 -7.5 4.4e-14 0.08 0.01 0.99 FALSE
42 The Cancer Genome Atlas Pancreatic Adenocarcinoma SH3YL1 0.21 0.18 lasso 1 0.15 9.6e-07 8.2 -8.2 2.8e-16 0.07 0.01 0.99 FALSE
43 The Cancer Genome Atlas Rectum Adenocarcinoma SH3YL1 0.51 0.29 blup 67 0.38 6.8e-10 8.6 -8.9 4.6e-19 0.06 0.01 0.99 FALSE
44 The Cancer Genome Atlas Soft Tissue Sarcoma SH3YL1 0.07 0.04 enet 9 0.05 1.0e-03 -5.6 6.4 1.5e-10 0.00 0.09 0.08 FALSE
45 The Cancer Genome Atlas Stomach Adenocarcinoma SH3YL1 0.19 0.21 enet 12 0.23 2.1e-16 8.5 -7.8 4.6e-15 0.05 0.01 0.99 FALSE
46 The Cancer Genome Atlas Thyroid Carcinoma SH3YL1 0.54 0.56 lasso 4 0.57 1.1e-67 8.6 -8.3 1.4e-16 0.07 0.00 1.00 FALSE
47 The Cancer Genome Atlas Uterine Corpus Endometrial Carcinoma SH3YL1 0.16 0.14 lasso 2 0.09 1.8e-03 8.5 -7.9 2.4e-15 0.07 0.01 0.93 FALSE