Best TWAS P=3.16e-09 · Best GWAS P=1.99e-10 conditioned to 1.82e-06
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Brain Frontal Cortex BA9 | ADAM17 | 0.20 | 0.14 | lasso | 5 | 0.15 | 7.8e-05 | -5.1 | 5.2 | 2.2e-07 | 0.05 | 0.40 | 0.24 | FALSE |
| 2 | GTEx | Muscle Skeletal | ADAM17 | 0.07 | 0.07 | enet | 5 | 0.05 | 4.5e-06 | -5.6 | -5.3 | 1.0e-07 | -0.11 | 0.22 | 0.78 | FALSE |
| 3 | GTEx | Thyroid | GRHL1 | 0.15 | 0.04 | enet | 30 | 0.02 | 1.2e-02 | -3.2 | 5.9 | 3.2e-09 | 0.31 | 0.18 | 0.22 | TRUE |
| 4 | NTR | Blood | IAH1 | 0.03 | 0.03 | lasso | 10 | 0.04 | 8.8e-12 | -4.9 | 5.2 | 1.8e-07 | 0.08 | 0.10 | 0.90 | FALSE |
| 5 | The Cancer Genome Atlas | Testicular Germ Cell Tumors | ADAM17 | 0.10 | 0.14 | lasso | 2 | 0.13 | 3.2e-05 | -5.3 | -5.5 | 3.8e-08 | -0.11 | 0.02 | 0.97 | FALSE |