Best TWAS P=1.84e-14 · Best GWAS P=3.18e-18 conditioned to 1.44e-06
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | GTEx | Adipose Subcutaneous | C14orf39 | 0.08 | 0.05 | lasso | 8 | 0.06 | 2.1e-05 | 5.8 | -5.5 | 2.9e-08 | -0.41 | 0.92 | 0.02 | FALSE |
2 | GTEx | Liver | MNAT1 | 0.21 | 0.00 | lasso | 4 | -0.01 | 5.4e-01 | 1.3 | -5.2 | 2.5e-07 | -0.44 | 0.08 | 0.20 | FALSE |
3 | GTEx | Muscle Skeletal | C14orf39 | 0.06 | 0.05 | lasso | 3 | 0.05 | 2.7e-05 | 5.8 | -7.7 | 1.8e-14 | -0.67 | 0.13 | 0.86 | TRUE |
4 | GTEx | Pituitary | C14orf39 | 0.39 | 0.38 | enet | 20 | 0.35 | 1.0e-09 | 5.8 | -5.5 | 4.6e-08 | -0.34 | 0.98 | 0.00 | FALSE |
5 | GTEx | Skin Not Sun Exposed Suprapubic | PCNXL4 | 0.15 | 0.05 | enet | 15 | 0.12 | 6.2e-07 | 1.2 | -5.2 | 1.6e-07 | -0.61 | 0.67 | 0.20 | FALSE |
6 | The Cancer Genome Atlas | Lung Adenocarcinoma | C14orf39 | 0.02 | 0.02 | blup | 37 | 0.02 | 4.2e-03 | 5.5 | -6.6 | 5.2e-11 | -0.55 | 0.06 | 0.48 | FALSE |
7 | The Cancer Genome Atlas | Pheochromocytoma and Paraganglioma | C14orf39 | 0.08 | 0.05 | blup | 37 | 0.05 | 4.2e-03 | 4.9 | -6.2 | 6.2e-10 | -0.51 | 0.09 | 0.34 | FALSE |
8 | The Cancer Genome Atlas | Prostate Adenocarcinoma | C14orf39 | 0.08 | 0.09 | blup | 37 | 0.11 | 1.8e-11 | 5.0 | -6.2 | 5.6e-10 | -0.51 | 0.99 | 0.01 | FALSE |