Best TWAS P=1.35e-16 · Best GWAS P=6.94e-17 conditioned to 0.00184
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | MAX | 0.15 | 0.16 | lasso | 2 | 0.16 | 1.2e-18 | -8.0 | 8.0 | 1.6e-15 | -0.89 | 0.02 | 0.98 | FALSE |
| 2 | GTEx | Cells Transformed fibroblasts | RAB15 | 0.64 | 0.08 | enet | 41 | 0.33 | 1.3e-25 | -3.1 | -5.2 | 2.2e-07 | 0.53 | 1.00 | 0.00 | FALSE |
| 3 | GTEx | Esophagus Muscularis | RAB15 | 0.35 | 0.06 | enet | 23 | 0.17 | 1.2e-10 | -3.1 | -5.3 | 9.4e-08 | 0.47 | 0.99 | 0.01 | FALSE |
| 4 | GTEx | Muscle Skeletal | FNTB | 0.05 | 0.02 | lasso | 6 | 0.01 | 5.8e-02 | -6.9 | 7.2 | 5.9e-13 | -0.84 | 0.07 | 0.84 | FALSE |
| 5 | GTEx | Pituitary | RAB15 | 0.32 | 0.03 | enet | 16 | 0.10 | 1.9e-03 | -7.2 | -6.3 | 3.0e-10 | 0.76 | 0.07 | 0.76 | FALSE |
| 6 | METSIM | Adipose | RAB15 | 0.10 | 0.04 | enet | 22 | 0.08 | 3.8e-12 | -4.9 | -5.6 | 1.7e-08 | 0.54 | 0.97 | 0.03 | FALSE |
| 7 | YFS | Blood | MAX | 0.04 | 0.02 | lasso | 4 | 0.02 | 2.8e-06 | -7.9 | 8.3 | 1.3e-16 | -0.77 | 0.02 | 0.98 | TRUE |
| 8 | The Cancer Genome Atlas | Breast Invasive Carcinoma | FNTB | 0.02 | 0.03 | enet | 8 | 0.03 | 2.0e-07 | -5.7 | 5.3 | 1.5e-07 | -0.52 | 0.88 | 0.11 | FALSE |
| 9 | The Cancer Genome Atlas | Breast Invasive Carcinoma | RAB15 | 0.02 | 0.01 | blup | 49 | 0.02 | 6.7e-05 | -3.9 | -6.2 | 4.5e-10 | 0.53 | 0.11 | 0.80 | FALSE |
| 10 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | RAB15 | 0.03 | 0.00 | blup | 49 | 0.01 | 1.8e-02 | -7.1 | -5.4 | 5.3e-08 | 0.52 | 0.01 | 0.95 | FALSE |
| 11 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | RAB15 | 0.14 | 0.07 | enet | 15 | 0.09 | 5.5e-10 | -6.9 | -6.6 | 4.3e-11 | 0.60 | 0.01 | 0.99 | FALSE |
| 12 | The Cancer Genome Atlas | Lung Adenocarcinoma | RAB15 | 0.04 | 0.01 | enet | 5 | 0.03 | 1.9e-04 | -6.1 | -5.3 | 1.4e-07 | 0.52 | 0.03 | 0.83 | FALSE |
| 13 | The Cancer Genome Atlas | Ovarian Serous Cystadenocarcinoma | RAB15 | 0.11 | 0.01 | enet | 12 | 0.06 | 1.1e-04 | -4.5 | -6.7 | 2.8e-11 | 0.48 | 0.02 | 0.88 | FALSE |
| 14 | The Cancer Genome Atlas | Prostate Adenocarcinoma | RAB15 | 0.04 | 0.00 | blup | 49 | 0.01 | 6.9e-02 | -6.9 | -6.7 | 2.0e-11 | 0.62 | 0.00 | 0.96 | FALSE |
| 15 | The Cancer Genome Atlas | Thyroid Carcinoma | FNTB | 0.14 | 0.06 | enet | 18 | 0.14 | 1.4e-13 | -1.6 | 6.3 | 3.5e-10 | -0.59 | 0.72 | 0.28 | FALSE |