Best TWAS P=5.96e-13 · Best GWAS P=1.41e-16 conditioned to 2.15e-08
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Adipose Subcutaneous | PIP4K2B | 0.15 | 0.07 | lasso | 5 | 0.07 | 2.2e-06 | -7.1 | -6.7 | 2.1e-11 | 0.07 | 0.00 | 1.00 | FALSE |
| 2 | GTEx | Adipose Subcutaneous | MSL1 | 0.15 | 0.12 | lasso | 2 | 0.12 | 3.9e-10 | 6.1 | -6.1 | 8.6e-10 | 0.29 | 1.00 | 0.00 | FALSE |
| 3 | GTEx | Adipose Visceral Omentum | PSMB3 | 0.14 | 0.01 | enet | 9 | 0.03 | 1.2e-02 | -1.5 | -5.2 | 1.7e-07 | 0.02 | 0.07 | 0.53 | FALSE |
| 4 | GTEx | Artery Aorta | PSMB3 | 0.23 | 0.17 | enet | 26 | 0.22 | 2.1e-12 | -7.1 | -6.2 | 7.2e-10 | 0.05 | 0.00 | 1.00 | FALSE |
| 5 | GTEx | Artery Tibial | PSMB3 | 0.10 | 0.02 | enet | 12 | 0.03 | 1.2e-03 | -7.1 | -6.8 | 8.4e-12 | 0.06 | 0.00 | 0.99 | FALSE |
| 6 | GTEx | Artery Tibial | PIP4K2B | 0.37 | 0.16 | enet | 49 | 0.22 | 2.1e-17 | -7.1 | -6.2 | 5.0e-10 | 0.04 | 0.00 | 1.00 | FALSE |
| 7 | GTEx | Artery Tibial | MSL1 | 0.19 | 0.14 | lasso | 2 | 0.15 | 4.9e-12 | 6.1 | -6.3 | 3.1e-10 | 0.25 | 1.00 | 0.00 | FALSE |
| 8 | GTEx | Breast Mammary Tissue | MSL1 | 0.20 | 0.06 | lasso | 6 | 0.07 | 2.2e-04 | 6.1 | -5.5 | 4.1e-08 | 0.18 | 0.40 | 0.14 | FALSE |
| 9 | GTEx | Breast Mammary Tissue (Female) | MSL1 | 0.09 | 0.00 | enet | 9 | 0.03 | 5.8e-02 | 6.1 | -5.8 | 7.7e-09 | 0.08 | 0.03 | 0.08 | FALSE |
| 10 | GTEx | Colon Transverse | MSL1 | 0.18 | 0.11 | lasso | 3 | 0.05 | 2.1e-03 | 6.1 | -6.3 | 2.8e-10 | 0.28 | 0.23 | 0.04 | FALSE |
| 11 | GTEx | Esophagus Muscularis | MSL1 | 0.25 | 0.18 | lasso | 8 | 0.22 | 1.7e-13 | 5.7 | -5.5 | 3.9e-08 | 0.22 | 1.00 | 0.00 | FALSE |
| 12 | GTEx | Nerve Tibial | MSL1 | 0.33 | 0.25 | lasso | 4 | 0.24 | 6.3e-17 | 6.1 | -6.2 | 4.5e-10 | 0.27 | 1.00 | 0.00 | FALSE |
| 13 | GTEx | Pituitary | CWC25 | 0.30 | 0.00 | enet | 18 | 0.07 | 7.4e-03 | -5.9 | -5.2 | 2.5e-07 | 0.02 | 0.08 | 0.29 | FALSE |
| 14 | GTEx | Pituitary | MSL1 | 0.40 | 0.27 | lasso | 7 | 0.24 | 1.3e-06 | 5.8 | -6.5 | 5.9e-11 | 0.25 | 0.20 | 0.22 | FALSE |
| 15 | GTEx | Skin Not Sun Exposed Suprapubic | MSL1 | 0.18 | 0.15 | lasso | 4 | 0.15 | 2.1e-08 | 6.1 | -5.9 | 3.2e-09 | 0.30 | 0.90 | 0.02 | FALSE |
| 16 | GTEx | Skin Sun Exposed Lower leg | MSL1 | 0.08 | 0.04 | lasso | 2 | 0.05 | 8.1e-05 | 4.1 | -5.4 | 6.5e-08 | 0.19 | 0.52 | 0.03 | FALSE |
| 17 | GTEx | Testis | PSMB3 | 0.30 | 0.24 | lasso | 4 | 0.21 | 8.9e-10 | -7.1 | -7.2 | 6.0e-13 | 0.07 | 0.00 | 1.00 | TRUE |
| 18 | METSIM | Adipose | MSL1 | 0.12 | 0.06 | lasso | 10 | 0.06 | 1.8e-09 | 6.1 | -6.3 | 3.0e-10 | 0.29 | 0.99 | 0.00 | FALSE |
| 19 | METSIM | Adipose | PSMB3 | 0.04 | 0.02 | lasso | 5 | 0.01 | 2.3e-03 | -5.2 | -5.9 | 3.6e-09 | 0.01 | 0.14 | 0.33 | FALSE |
| 20 | NTR | Blood | PIP4K2B | 0.02 | 0.01 | lasso | 3 | 0.01 | 6.4e-04 | -7.1 | 7.0 | 2.5e-12 | -0.09 | 0.00 | 0.99 | FALSE |
| 21 | The Cancer Genome Atlas | Bladder Urothelial Carcinoma | PSMB3 | 0.04 | 0.00 | blup | 37 | 0.02 | 6.7e-03 | -2.6 | -5.3 | 1.2e-07 | 0.05 | 0.01 | 0.66 | FALSE |
| 22 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | PIP4K2B | 0.04 | 0.01 | blup | 56 | 0.03 | 6.3e-04 | -6.8 | -5.9 | 3.7e-09 | 0.11 | 0.00 | 0.93 | FALSE |
| 23 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | PSMB3 | 0.14 | 0.05 | blup | 42 | 0.05 | 8.9e-07 | -6.8 | -5.5 | 4.3e-08 | 0.06 | 0.00 | 1.00 | FALSE |
| 24 | The Cancer Genome Atlas | Kidney Renal Papillary Cell Carcinoma | RAPGEFL1 | 0.13 | 0.02 | enet | 9 | 0.06 | 4.3e-04 | 5.4 | -6.8 | 7.6e-12 | 0.38 | 0.01 | 0.85 | TRUE |
| 25 | The Cancer Genome Atlas | Brain Lower Grade Glioma | IGFBP4 | 0.04 | 0.02 | blup | 38 | 0.03 | 5.9e-04 | -8.3 | -5.7 | 1.1e-08 | 0.80 | 0.00 | 0.97 | FALSE |
| 26 | The Cancer Genome Atlas | Prostate Adenocarcinoma | PIP4K2B | 0.05 | 0.04 | blup | 56 | 0.05 | 5.3e-06 | -6.1 | -6.6 | 3.2e-11 | 0.10 | 0.00 | 0.99 | FALSE |
| 27 | The Cancer Genome Atlas | Testicular Germ Cell Tumors | PSMB3 | 0.12 | 0.09 | lasso | 3 | 0.06 | 3.0e-03 | -6.8 | -7.0 | 3.1e-12 | 0.08 | 0.00 | 0.94 | FALSE |
| 28 | The Cancer Genome Atlas | Thyroid Carcinoma | PSMB3 | 0.05 | 0.06 | lasso | 1 | 0.05 | 2.4e-05 | -7.1 | -7.1 | 1.7e-12 | 0.07 | 0.00 | 1.00 | FALSE |