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chr17:27,200,734-30,884,028

Best TWAS P=4.31e-42 · Best GWAS P=1.83e-49 conditioned to NaN

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
7	GTEx	Artery Tibial	RP11-848P1.7	0.54	0.00	lasso	10	0.02	7.3e-03	-7.928	-13.6	4.3e-42	0.47	0.02	0.06	TRUE
9	GTEx	Brain Cerebellum	CRLF3	0.52	0.12	lasso	27	0.20	1.3e-06	-12.398	-10.4	4.1e-25	0.56	0.09	0.74	TRUE
6	GTEx	Artery Aorta	CRLF3	0.12	0.03	enet	33	0.06	3.8e-04	1.598	-8.5	2.0e-17	0.53	0.25	0.70	TRUE
33	METSIM	Adipose	CTD-2349P21.5	0.02	0.00	bslmm	252	0.01	3.0e-03	-10.466	-8.1	4.9e-16	0.33	0.04	0.31	TRUE
45	The Cancer Genome Atlas	Colon Adenocarcinoma	LRRC37B2	0.09	0.00	enet	11	0.03	7.3e-03	1.977	-6.6	3.2e-11	0.47	0.01	0.26	TRUE
28	GTEx	Thyroid	TP53I13	0.14	0.16	enet	7	0.14	6.0e-11	-6.363	6.5	9.9e-11	0.05	1.00	0.00	TRUE
54	The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	GOSR1	0.15	0.00	blup	56	0.04	1.1e-03	-2.042	6.3	2.6e-10	-0.35	0.04	0.22	TRUE
56	The Cancer Genome Atlas	Prostate Adenocarcinoma	ATAD5	0.14	0.08	enet	11	0.09	4.1e-10	1.545	5.7	9.3e-09	-0.41	0.99	0.01	TRUE
36	METSIM	Adipose	TP53I13	0.05	0.02	enet	8	0.03	2.7e-05	-3.647	5.7	1.5e-08	-0.04	0.87	0.01	TRUE
35	METSIM	Adipose	TEFM	0.08	0.06	blup	246	0.06	8.8e-10	-14.785	-8.4	3.3e-17	0.57	0.00	1.00	FALSE
5	GTEx	Artery Aorta	TEFM	0.13	0.02	enet	34	0.03	5.8e-03	1.564	-8.2	2.0e-16	0.57	0.15	0.78	FALSE
44	The Cancer Genome Atlas	Breast Invasive Carcinoma	OMG	0.03	0.04	lasso	1	0.04	1.1e-08	7.977	-8.0	1.5e-15	0.23	0.01	0.99	FALSE
4	GTEx	Artery Aorta	ABHD15	0.20	0.03	enet	36	0.06	2.9e-04	-6.363	-7.9	2.3e-15	0.08	0.03	0.54	FALSE
43	The Cancer Genome Atlas	Breast Invasive Carcinoma	GOSR1	0.02	0.01	enet	4	0.01	1.7e-02	-7.910	7.9	3.7e-15	-0.27	0.01	0.82	FALSE
16	GTEx	Esophagus Muscularis	CRLF3	0.17	0.12	lasso	6	0.18	5.1e-11	2.080	-7.8	4.1e-15	0.46	0.94	0.05	FALSE
46	The Cancer Genome Atlas	Esophageal Carcinoma	OMG	0.09	0.09	blup	31	0.11	2.0e-04	8.007	-7.7	1.1e-14	0.18	0.02	0.92	FALSE
61	The Cancer Genome Atlas	Thyroid Carcinoma	OMG	0.02	0.01	blup	32	0.02	4.8e-03	7.749	-7.7	1.3e-14	0.18	0.02	0.87	FALSE
49	The Cancer Genome Atlas	Liver Hepatocellular Carcinoma	NF1	0.04	0.03	blup	111	0.03	1.3e-02	7.876	7.7	1.7e-14	-0.19	0.05	0.67	FALSE
55	The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	OMG	0.05	0.03	blup	32	0.03	5.6e-03	7.749	-7.6	2.1e-14	0.25	0.01	0.79	FALSE
15	GTEx	Esophagus Muscularis	BLMH	0.15	0.02	lasso	8	0.01	1.0e-01	-5.927	7.6	2.3e-14	-0.13	0.04	0.46	FALSE
26	GTEx	Spleen	OMG	0.41	0.10	enet	26	0.08	4.5e-03	7.749	7.6	3.2e-14	-0.23	0.64	0.03	FALSE
11	GTEx	Cells EBV-transformed lymphocytes	EVI2A	0.13	0.03	lasso	4	0.01	1.5e-01	7.844	-7.6	3.7e-14	0.17	0.16	0.04	FALSE
12	GTEx	Cells Transformed fibroblasts	OMG	0.06	0.02	lasso	2	0.01	2.5e-02	7.749	7.5	4.4e-14	-0.22	0.14	0.07	FALSE
17	GTEx	Heart Atrial Appendage	ANKRD13B	0.14	0.09	enet	8	0.11	1.2e-05	-6.363	-7.5	5.2e-14	0.04	0.39	0.16	FALSE
47	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	OMG	0.02	0.02	blup	31	0.03	6.9e-04	7.862	-7.5	5.2e-14	0.17	0.02	0.90	FALSE
34	METSIM	Adipose	NF1	0.04	0.00	blup	396	0.01	5.5e-03	7.034	7.5	6.0e-14	-0.30	0.80	0.02	FALSE
38	YFS	Blood	EVI2B	0.01	0.00	blup	339	0.00	6.4e-02	0.079	7.5	9.4e-14	-0.26	0.07	0.02	FALSE
25	GTEx	Spleen	EVI2A	0.22	0.12	lasso	4	0.07	8.3e-03	6.482	-7.5	9.5e-14	0.17	0.11	0.05	FALSE
48	The Cancer Genome Atlas	Brain Lower Grade Glioma	EVI2A	0.03	0.03	blup	38	0.04	3.0e-05	6.361	-7.5	9.5e-14	0.16	0.04	0.96	FALSE
40	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	OMG	0.02	0.02	blup	31	0.02	3.2e-03	6.485	-7.3	2.0e-13	0.15	0.03	0.77	FALSE
51	The Cancer Genome Atlas	Lung Adenocarcinoma	EVI2A	0.04	0.06	blup	38	0.06	3.0e-07	6.475	-7.3	3.7e-13	0.15	0.13	0.87	FALSE
31	GTEx	Whole Blood	EVI2A	0.07	0.04	lasso	4	0.04	2.6e-04	6.586	-7.2	4.6e-13	0.14	0.89	0.00	FALSE
57	The Cancer Genome Atlas	Prostate Adenocarcinoma	EVI2A	0.08	0.12	lasso	3	0.12	1.3e-12	7.034	-7.0	2.5e-12	0.12	0.60	0.40	FALSE
41	The Cancer Genome Atlas	Breast Invasive Carcinoma	ABHD15	0.04	0.03	lasso	2	0.02	1.4e-05	-6.363	-7.0	3.5e-12	-0.01	0.47	0.01	FALSE
59	The Cancer Genome Atlas	Stomach Adenocarcinoma	EVI2A	0.05	0.03	enet	7	0.04	4.8e-04	5.520	-6.9	6.0e-12	0.13	0.04	0.63	FALSE
42	The Cancer Genome Atlas	Breast Invasive Carcinoma	EVI2A	0.03	0.03	blup	38	0.03	6.9e-07	6.421	-6.6	3.7e-11	0.12	0.32	0.68	FALSE
22	GTEx	Ovary	CRLF3	0.21	0.14	lasso	4	0.11	1.0e-03	2.080	-6.5	8.6e-11	0.40	0.06	0.58	FALSE
37	YFS	Blood	EVI2A	0.03	0.05	lasso	4	0.04	1.0e-13	6.482	-6.4	1.4e-10	0.10	1.00	0.00	FALSE
39	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	EVI2A	0.03	0.03	blup	37	0.03	2.3e-03	6.348	-6.4	1.5e-10	0.10	0.06	0.35	FALSE
14	GTEx	Esophagus Mucosa	ABHD15	0.21	0.13	lasso	1	0.10	1.7e-07	-6.363	-6.4	2.0e-10	0.00	0.98	0.00	FALSE
1	CommonMind	Brain Pre-frontal Cortex	NF1	0.06	0.01	blup	410	0.04	1.1e-05	7.844	6.3	2.2e-10	-0.20	0.95	0.00	FALSE
20	GTEx	Nerve Tibial	CRLF3	0.38	0.16	lasso	14	0.19	3.0e-13	2.120	-6.3	2.4e-10	0.38	1.00	0.00	FALSE
53	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	EVI2A	0.03	0.03	lasso	1	0.02	2.4e-03	6.335	-6.3	2.4e-10	0.10	0.05	0.16	FALSE
23	GTEx	Pituitary	SUZ12P	0.29	0.23	lasso	9	0.32	6.0e-09	2.403	-6.3	2.6e-10	0.40	0.86	0.07	FALSE
30	GTEx	Thyroid	CRLF3	0.10	0.04	enet	35	0.08	1.1e-06	2.120	-6.2	4.7e-10	0.38	0.91	0.05	FALSE
50	The Cancer Genome Atlas	Lung Adenocarcinoma	C17orf42	0.04	0.02	enet	5	0.04	5.4e-05	-1.653	-6.2	6.3e-10	0.46	0.17	0.46	FALSE
13	GTEx	Colon Transverse	CRLF3	0.16	0.07	lasso	6	0.05	1.5e-03	1.598	-6.1	9.6e-10	0.42	0.15	0.64	FALSE
19	GTEx	Nerve Tibial	TEFM	0.16	0.01	lasso	4	0.06	2.7e-05	1.598	-6.1	1.2e-09	0.43	0.26	0.59	FALSE
8	GTEx	Brain Cerebellar Hemisphere	CRLF3	0.38	0.35	enet	26	0.35	6.0e-10	2.402	-6.1	1.3e-09	0.32	0.97	0.01	FALSE
27	GTEx	Testis	CRLF3	0.26	0.19	enet	23	0.17	3.8e-08	2.128	-5.8	8.9e-09	0.38	0.99	0.00	FALSE
52	The Cancer Genome Atlas	Lung Adenocarcinoma	OMG	0.05	0.03	lasso	5	0.04	3.6e-05	6.514	-5.6	2.3e-08	0.10	0.09	0.80	FALSE
3	GTEx	Adipose Visceral Omentum	TEFM	0.12	0.02	lasso	14	0.05	1.0e-03	1.510	-5.5	3.9e-08	0.21	0.08	0.09	FALSE
18	GTEx	Lung	ANKRD13B	0.13	0.09	lasso	6	0.08	6.8e-07	-5.219	-5.5	4.7e-08	-0.10	0.99	0.00	FALSE
21	GTEx	Nerve Tibial	RP11-68I3.4	0.17	0.12	lasso	5	0.10	6.8e-08	-6.363	5.5	5.0e-08	0.02	1.00	0.00	FALSE
32	METSIM	Adipose	ANKRD13B	0.04	0.03	lasso	3	0.05	1.4e-07	3.987	-5.3	8.6e-08	-0.14	1.00	0.00	FALSE
10	GTEx	Breast Mammary Tissue	CRLF3	0.10	0.10	lasso	3	0.05	9.6e-04	2.570	-5.3	1.3e-07	0.31	0.09	0.62	FALSE
24	GTEx	Skin Sun Exposed Lower leg	ANKRD13B	0.08	0.04	lasso	5	0.06	1.4e-05	-3.156	-5.2	1.8e-07	0.01	0.74	0.02	FALSE
58	The Cancer Genome Atlas	Rectum Adenocarcinoma	TP53I13	0.22	0.09	lasso	1	0.04	4.4e-02	-5.219	5.2	1.8e-07	0.10	0.03	0.05	FALSE
29	GTEx	Thyroid	COPRS	0.17	0.00	enet	43	0.01	1.2e-01	3.827	-5.2	1.9e-07	0.13	0.04	0.18	FALSE
2	GTEx	Adipose Subcutaneous	ANKRD13B	0.14	0.14	lasso	5	0.15	2.0e-12	-5.219	-5.2	2.4e-07	-0.09	1.00	0.00	FALSE
60	The Cancer Genome Atlas	Stomach Adenocarcinoma	SUZ12P	0.05	0.05	blup	29	0.04	5.1e-04	2.570	-5.2	2.4e-07	0.32	0.16	0.16	FALSE