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chr19:1,400,866-5,153,606

Best TWAS P=3.54e-27 · Best GWAS P=5.38e-30 conditioned to 1

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	GTEx	Adipose Visceral Omentum	NFIC	0.20	0.00	lasso	5	0.02	2.2e-02	5.6	-5.8	7.0e-09	0.07	0.02	0.71	TRUE
2	GTEx	Artery Tibial	DOT1L	0.09	0.06	lasso	5	0.05	7.3e-05	10.2	9.6	6.9e-22	-0.89	0.03	0.96	FALSE
3	GTEx	Artery Tibial	NFIC	0.14	0.13	enet	11	0.12	7.6e-10	5.6	-5.1	3.1e-07	0.02	0.02	0.98	FALSE
4	GTEx	Brain Cerebellar Hemisphere	AC007292.6	0.28	0.11	lasso	5	0.18	2.0e-05	4.4	-5.4	8.2e-08	-0.04	0.27	0.25	FALSE
5	GTEx	Breast Mammary Tissue (Female)	CTB-50L17.5	0.24	0.03	lasso	5	0.02	6.0e-02	4.4	-5.5	2.9e-08	-0.03	0.06	0.05	TRUE
6	GTEx	Colon Sigmoid	MAP2K2	0.20	0.11	lasso	3	0.13	3.0e-05	5.5	5.8	5.2e-09	0.00	0.00	0.96	FALSE
7	GTEx	Colon Transverse	CHAF1A	0.28	0.06	lasso	10	0.15	1.4e-07	-4.1	-5.2	2.5e-07	-0.04	0.99	0.00	FALSE
8	GTEx	Esophagus Gastroesophageal Junction	CHAF1A	0.30	0.25	enet	16	0.29	5.1e-11	4.4	-5.2	2.2e-07	-0.04	0.98	0.01	FALSE
9	GTEx	Esophagus Muscularis	DOT1L	0.12	0.03	lasso	5	0.05	6.3e-04	10.2	7.0	3.1e-12	-0.82	0.01	0.97	FALSE
10	GTEx	Esophagus Muscularis	CHAF1A	0.45	0.37	enet	17	0.49	4.2e-33	4.4	-5.2	2.4e-07	-0.03	0.99	0.01	FALSE
11	GTEx	Esophagus Muscularis	CTB-50L17.5	0.28	0.17	lasso	3	0.19	6.7e-12	4.8	-5.2	2.5e-07	-0.05	0.99	0.01	FALSE
12	GTEx	Nerve Tibial	IZUMO4	0.23	0.07	lasso	6	0.14	1.9e-10	-4.5	-8.1	8.1e-16	0.70	0.03	0.97	FALSE
13	GTEx	Prostate	UBXN6	0.27	0.15	enet	19	0.14	2.4e-04	4.1	-5.2	2.2e-07	-0.04	0.12	0.07	FALSE
14	GTEx	Skin Sun Exposed Lower leg	AC004490.1	0.09	0.07	enet	11	0.10	2.3e-08	-6.8	6.2	7.2e-10	-0.52	0.82	0.12	FALSE
15	GTEx	Testis	SH3GL1	0.20	0.03	enet	40	0.04	5.7e-03	-3.8	-5.3	1.4e-07	0.00	0.23	0.11	FALSE
16	NTR	Blood	C19orf35	0.03	0.01	enet	9	0.02	3.7e-07	-1.6	-5.3	1.1e-07	0.38	0.96	0.02	FALSE
17	NTR	Blood	TMPRSS9	0.04	0.02	lasso	4	0.04	1.3e-11	-2.5	-6.1	7.9e-10	0.33	0.99	0.01	FALSE
18	YFS	Blood	MAP2K2	0.02	0.00	blup	373	0.01	5.9e-03	-2.8	-6.0	1.7e-09	-0.02	0.02	0.87	TRUE
19	YFS	Blood	PIAS4	0.06	0.02	bslmm	369	0.04	4.8e-14	4.3	5.3	1.0e-07	0.05	0.04	0.95	FALSE
20	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	AP3D1	0.05	0.00	blup	49	0.02	1.7e-02	-3.6	5.7	1.4e-08	-0.31	0.03	0.07	FALSE
21	The Cancer Genome Atlas	Breast Invasive Carcinoma	AP3D1	0.01	0.01	blup	52	0.01	5.4e-03	-3.6	8.1	7.8e-16	-0.54	0.05	0.11	FALSE
22	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	DOT1L	0.08	0.12	enet	8	0.10	2.5e-11	10.2	10.8	3.5e-27	-0.96	0.02	0.98	TRUE
23	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	JSRP1	0.07	0.04	blup	33	0.03	7.8e-03	-2.6	5.3	9.9e-08	-0.43	0.01	0.19	FALSE
24	The Cancer Genome Atlas	Liver Hepatocellular Carcinoma	DOT1L	0.09	0.08	blup	60	0.07	4.1e-04	-8.6	9.3	2.0e-20	-0.87	0.02	0.95	FALSE
25	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	CHAF1A	0.04	0.03	enet	8	0.03	2.4e-04	-3.8	-5.3	1.1e-07	-0.06	0.02	0.42	FALSE
26	The Cancer Genome Atlas	Testicular Germ Cell Tumors	DOT1L	0.40	-0.01	enet	20	0.03	3.6e-02	-2.5	7.9	2.5e-15	-0.44	0.01	0.21	FALSE